{"id":"https://openalex.org/W2969959090","doi":"https://doi.org/10.1109/transducers.2019.8808384","title":"Unique Impedametric Cell Deformability Assay Using a Multi-Constriction Microfluidic Biosensor","display_name":"Unique Impedametric Cell Deformability Assay Using a Multi-Constriction Microfluidic Biosensor","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W2969959090","doi":"https://doi.org/10.1109/transducers.2019.8808384","mag":"2969959090"},"language":"en","primary_location":{"id":"doi:10.1109/transducers.2019.8808384","doi":"https://doi.org/10.1109/transducers.2019.8808384","is_oa":false,"landing_page_url":"https://doi.org/10.1109/transducers.2019.8808384","pdf_url":null,"source":{"id":"https://openalex.org/S4306419851","display_name":"International Conference on Solid-State Sensors, Actuators and Microsystems","issn_l":"2167-0021","issn":["2167-0021"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052996577","display_name":"Parham Ghassemi","orcid":"https://orcid.org/0000-0002-2957-015X","observed_orcids":["https://orcid.org/0000-0002-2957-015X"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parham Ghassemi","raw_affiliation_strings":["VT MEMS Lab, Virginia Tech, Blacksburg, Virginia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VT MEMS Lab, Virginia Tech, Blacksburg, Virginia, United States","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052698723","display_name":"Masoud Agah","orcid":"https://orcid.org/0000-0001-6117-4539","observed_orcids":["https://orcid.org/0000-0001-6117-4539"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masoud Agah","raw_affiliation_strings":["VT MEMS Lab, Virginia Tech, Blacksburg, Virginia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VT MEMS Lab, Virginia Tech, Blacksburg, Virginia, United States","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I859038795"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13287929,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1059","last_page":"1062"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-deformability","display_name":"cell deformability","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cell-impedance","display_name":"cell impedance","score":0.367000013589859},{"id":"https://openalex.org/keywords/microelectrodes","display_name":"microelectrodes","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bioelectrical-properties","display_name":"bioelectrical properties","score":0.6740000247955322},{"id":"https://openalex.org/keywords/tissue-mechanics","display_name":"tissue mechanics","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tumor-cell-detection","display_name":"cancer cell detection","score":0.6320000290870667},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.925000011920929},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.7770000100135803},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"single-cell analysis","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7525155544281006},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.6762784123420715},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6051695942878723},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5757806301116943},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.5594719648361206},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44601067900657654},{"id":"https://openalex.org/C174940676","wikidata":"https://www.wikidata.org/wiki/Q495626","display_name":"Constriction","level":2,"score":0.4212706983089447},{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.41710755228996277},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.41547220945358276},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3359273672103882},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.32668185234069824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22516897320747375},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18801018595695496},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.1694413125514984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12855663895606995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06518387794494629},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/transducers.2019.8808384","doi":"https://doi.org/10.1109/transducers.2019.8808384","is_oa":false,"landing_page_url":"https://doi.org/10.1109/transducers.2019.8808384","pdf_url":null,"source":{"id":"https://openalex.org/S4306419851","display_name":"International Conference on Solid-State Sensors, Actuators and Microsystems","issn_l":"2167-0021","issn":["2167-0021"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1975553175","https://openalex.org/W2012416957","https://openalex.org/W2084077221","https://openalex.org/W2111621259","https://openalex.org/W2180684074","https://openalex.org/W2212939981","https://openalex.org/W2213276966","https://openalex.org/W2568205257","https://openalex.org/W2582189733","https://openalex.org/W2597169829"],"related_works":["https://openalex.org/W2316635420","https://openalex.org/W2964170335","https://openalex.org/W2969996184","https://openalex.org/W2094787115","https://openalex.org/W2768335332","https://openalex.org/W2921351802","https://openalex.org/W2023801969","https://openalex.org/W2012416957","https://openalex.org/W2568205257","https://openalex.org/W6992268125"],"abstract_inverted_index":{"A":[0],"unique":[1],"microfluidic":[2,8],"device":[3],"consisting":[4],"of":[5,18,37,42,66,94,102],"a":[6],"multi-constriction":[7],"channel":[9],"with":[10],"embedded":[11],"microelectrodes":[12],"analyzes":[13],"bioelectrical":[14,103],"and":[15,27,39,48,69,81],"biomechanical":[16,87],"attributes":[17],"single":[19,97],"cells.":[20],"The":[21,100],"biosensor":[22],"can":[23],"differentiate":[24],"cancer":[25,50],"cells":[26,84],"their":[28],"non-tumorigenic":[29],"counterparts.":[30],"This":[31],"study":[32],"reports":[33],"the":[34,43,55,58,106],"first":[35,59],"analysis":[36],"mechanical":[38],"electrical":[40],"properties":[41,88],"normal":[44,80],"prostate":[45,49,83],"cell-line":[46,51],"(PWR-1E)":[47],"(LNCaP":[52],"C4-2B).":[53],"Also,":[54],"system":[56],"is":[57],"that":[60],"utilizes":[61],"sensors":[62],"for":[63,111],"rapid":[64],"measurements":[65],"cell":[67,98,113],"velocities":[68],"bioimpedance":[70],"as":[71],"they":[72],"transit":[73],"through":[74],"multiple":[75],"iterative":[76],"constrictions.":[77],"Distinguishing":[78],"these":[79],"tumorigenic":[82],"using":[85],"solely":[86],"resulted":[89],"in":[90],"an":[91],"identification":[92,107],"accuracy":[93],"85%":[95],"at":[96],"level.":[99],"addition":[101],"parameters":[104],"enhanced":[105],"power":[108],"to":[109],"92%":[110],"both":[112],"types.":[114]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-08-29T00:00:00"}