{"id":"https://openalex.org/W2969905737","doi":"https://doi.org/10.1097/01.tp.0000575476.80749.79","title":"310.5: Early Intestinal Barrier Dysfunction Early Post Intestinal Transplantation Is Driven by the Absence of Protective Type 3 Innate Lymphoid Cells and the Persistence of Proinflammatory Type 1 Innate Lymphoid Cells","display_name":"310.5: Early Intestinal Barrier Dysfunction Early Post Intestinal Transplantation Is Driven by the Absence of Protective Type 3 Innate Lymphoid Cells and the Persistence of Proinflammatory Type 1 Innate Lymphoid Cells","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2969905737","doi":"https://doi.org/10.1097/01.tp.0000575476.80749.79","mag":"2969905737"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0000575476.80749.79","doi":"https://doi.org/10.1097/01.tp.0000575476.80749.79","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000575476.80749.79","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004246015","display_name":"Ji\u2010Man Kang","orcid":"https://orcid.org/0000-0002-0678-4964","observed_orcids":["https://orcid.org/0000-0002-0678-4964"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiman Kang","raw_affiliation_strings":["MedStar Georgetown Transplant Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown Transplant Institute","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051482425","display_name":"Leonid A. Belyayev","orcid":"https://orcid.org/0000-0002-2880-7231","observed_orcids":["https://orcid.org/0000-0002-2880-7231"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonid Belyayev","raw_affiliation_strings":["MedStar Georgetown Transplant Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown Transplant Institute","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043504064","display_name":"Katrina S. Loh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrina Loh","raw_affiliation_strings":["MedStar Georgetown Transplant Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown Transplant Institute","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063542524","display_name":"Stuart S. Kaufman","orcid":"https://orcid.org/0000-0002-5308-4565","observed_orcids":["https://orcid.org/0000-0002-5308-4565"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart Kaufman","raw_affiliation_strings":["MedStar Georgetown Transplant Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown Transplant Institute","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004105156","display_name":"Khalid Khan","orcid":"https://orcid.org/0000-0003-0375-2411","observed_orcids":["https://orcid.org/0000-0003-0375-2411"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khalid Khan","raw_affiliation_strings":["MedStar Georgetown Transplant Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown Transplant Institute","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080174724","display_name":"Jason Solomon Hawksworth","orcid":"https://orcid.org/0000-0001-9432-8258","observed_orcids":["https://orcid.org/0000-0001-9432-8258"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Hawksworth","raw_affiliation_strings":["MedStar Georgetown Transplant Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown Transplant Institute","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061730679","display_name":"Cal Matsumoto","orcid":"https://orcid.org/0000-0002-6364-1927","observed_orcids":["https://orcid.org/0000-0002-6364-1927"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cal Matsumoto","raw_affiliation_strings":["MedStar Georgetown Transplant Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown Transplant Institute","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033473134","display_name":"MICHAEL A. ZASLOFF","orcid":"https://orcid.org/0000-0002-1453-9328","observed_orcids":["https://orcid.org/0000-0002-1453-9328"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Zasloff","raw_affiliation_strings":["MedStar Georgetown Transplant Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown Transplant Institute","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053229497","display_name":"Thomas Fishbein","orcid":"https://orcid.org/0009-0009-8181-1828","observed_orcids":["https://orcid.org/0009-0009-8181-1828"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Fishbein","raw_affiliation_strings":["MedStar Georgetown Transplant Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown Transplant Institute","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016783165","display_name":"Alexander Kroemer","orcid":"https://orcid.org/0000-0002-9842-4973","observed_orcids":["https://orcid.org/0000-0002-9842-4973"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Kroemer","raw_affiliation_strings":["MedStar Georgetown Transplant Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown Transplant Institute","institution_ids":["https://openalex.org/I2802534011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802534011"],"apc_list":null,"apc_paid":null,"fwci":0.1003,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4203235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"103","issue":"7S2","first_page":"S13","last_page":"S13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-transplantation","display_name":"intestinal transplantation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/innate-lymphoid-cells","display_name":"innate lymphoid cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ilc3","display_name":"ILC3","score":0.9049999713897705},{"id":"https://openalex.org/keywords/type-1-innate-lymphoid-cells","display_name":"type 1 innate lymphoid cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nkp44","display_name":"NKp44","score":0.9129999876022339},{"id":"https://openalex.org/keywords/intestinal-barrier-dysfunction","display_name":"intestinal barrier dysfunction","score":0.8190000057220459},{"id":"https://openalex.org/keywords/mucosal-immunity","display_name":"mucosal immunity","score":0.7319999933242798},{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9620000123977661},{"id":"https://openalex.org/keywords/beta-defensins","display_name":"beta-defensins","score":0.8880000114440918},{"id":"https://openalex.org/keywords/regiiigamma","display_name":"RegIII\u03b3","score":0.8169999718666077},{"id":"https://openalex.org/keywords/lamina-propria","display_name":"lamina propria","score":0.6359999775886536},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.8987219929695129},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8296289443969727},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5861589908599854},{"id":"https://openalex.org/C123982805","wikidata":"https://www.wikidata.org/wiki/Q6046964","display_name":"Interleukin-7 receptor","level":5,"score":0.5700274705886841},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4319693148136139},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.43160197138786316},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4204104244709015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4115748107433319},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3804559111595154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3605605363845825},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.27874526381492615},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.1684369444847107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16450923681259155},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.tp.0000575476.80749.79","doi":"https://doi.org/10.1097/01.tp.0000575476.80749.79","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000575476.80749.79","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5400000214576721}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3037345378","https://openalex.org/W2694749138","https://openalex.org/W3017013054","https://openalex.org/W1914790546","https://openalex.org/W2560402236","https://openalex.org/W3014461887","https://openalex.org/W1933455844","https://openalex.org/W1989391020","https://openalex.org/W2883733923","https://openalex.org/W6906359605"],"abstract_inverted_index":{"Introduction:":[0],"Innate":[1],"lymphoid":[2,11],"cells":[3,47],"(ILCs),":[4],"the":[5,26,51,229,269],"most":[6],"recently":[7],"described":[8],"family":[9],"of":[10,28,75,150,203,231,271,293,311,319],"cells,":[12],"play":[13],"fundamental":[14],"roles":[15,34],"in":[16,35,101,132,138,158,174,223,268,275],"mucosal":[17],"barrier":[18,253,307,329],"immunity,":[19],"tissue":[20,278,282],"homeostasis,":[21],"and":[22,50,70,79,91,156,161,170,191,197,219,246,322,331],"immune":[23],"regulation":[24],"through":[25,309],"activation":[27],"host-derived":[29],"cytokine":[30,181],"expression;":[31],"however,":[32],"their":[33],"intestinal":[36,252],"transplantation":[37],"(ITx)":[38],"has":[39],"yet":[40],"to":[41,113,136,280,327],"be":[42,325],"defined.":[43],"Methods:":[44],"Lamina":[45],"propria":[46],"were":[48,65,84,129],"isolated":[49],"following":[52],"phenotypic":[53],"definition":[54],"was":[55,264],"used":[56],"for":[57,251],"ILCs:":[58],"lineage":[59],"negative,":[60],"viable":[61],"lymphocytes":[62],"expressing":[63],"CD45":[64],"identified":[66],"as":[67,87],"type":[68],"1":[69,213,283],"3":[71],"ILCs":[72,221],"by":[73,212],"expression":[74,243],"CD56,":[76],"NKp44,":[77],"CD117,":[78],"CD127.":[80],"Four":[81],"distinct":[82],"subsets":[83,173],"further":[85,260],"defined":[86],"NKp44-ILC1,":[88],"NKp44-ILC3,":[89],"NKp44+ILC1":[90],"NKp44+ILC3.":[92],"Results:":[93],"We":[94],"compared":[95,135,279],"ILC":[96,172],"phenotypes":[97],"via":[98],"flow":[99],"cytometry":[100],"stable":[102,139,162,178],"ITx":[103,112,115,163,205,224,277],"recipients":[104,116,140,206],"with":[105,237,257,304],"healthy":[106,276],"functioning":[107],"allografts":[108,134],">6":[109],"months":[110,142],"after":[111,120,285],"fresh":[114,133,160,175,204],"at":[117],"day":[118],"0":[119],"reperfusion.":[121],"Surprisingly,":[122],"we":[123,146,259],"found":[124,147],"that":[125,184,208,217,262,291],"protective":[126,169,187,209,218,233,272,294],"NKp44+ILC3s":[127,137],"(p=0.02)":[128],"significantly":[130],"diminished":[131],"6":[141],"out.":[143],"In":[144,255,316],"addition,":[145],"comparable":[148],"numbers":[149],"potentially":[151],"proinflammatory":[152,171,220,320],"ILC1s":[153,190],"(NKp44-ILC1,":[154],"NKp44+ILC1)":[155],"NKp44-ILC3":[157,192],"both":[159],"recipients,":[164],"indicating":[165],"a":[166,265],"dysbalance":[167],"between":[168],"but":[176],"not":[177],"recipients.":[179],"Intracellular":[180],"staining":[182],"confirmed":[183],"NKp44+ILC3":[185,210,234],"produced":[186,193],"IL-22,":[188],"while":[189],"pro-inflammatory":[194],"IFN-g,":[195],"TNF-\u03b1,":[196],"IL-17.":[198],"Importantly,":[199],"serial":[200],"prospective":[201],"immunomonitoring":[202],"revealed":[207],"repopulates":[211],"month":[214,284],"postoperatively,":[215],"suggesting":[216],"re-equilibrate":[222],"patients":[225],"over":[226],"time.":[227],"Critically,":[228],"frequencies":[230],"repopulating":[232],"correlated":[235],"positively":[236,302],"IL-22":[238,312],"dependent":[239,313],"antimicrobial":[240],"peptide":[241],"(AMP)":[242],"including":[244],"\u03b2-defensins":[245],"RegIII\u03b3,":[247],"which":[248,296],"are":[249],"important":[250],"protection.":[254],"line":[256],"this,":[258],"noted":[261],"there":[263],"significant":[266],"increase":[267,310],"frequency":[270],"NKp44+":[273],"ILC3":[274,323],"inflamed":[281],"ITx.":[286],"Conclusion:":[287],"Our":[288],"study":[289],"indicates":[290],"reconstitution":[292],"ILC3,":[295],"is":[297],"absent":[298],"immediately":[299],"post":[300],"transplant,":[301],"correlates":[303],"improved":[305],"epithelial":[306,328],"function":[308],"AMP":[314],"expression.":[315],"contrast,":[317],"abundance":[318],"ILC1":[321],"may":[324],"contributing":[326],"breakdown":[330],"early":[332],"clinical":[333],"complications.":[334]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-08-29T00:00:00"}