{"id":"https://openalex.org/W2969900914","doi":"https://doi.org/10.1111/papr.12831","title":"Burst and Tonic Spinal Cord Stimulation Both Activate Spinal GABAergic Mechanisms to Attenuate Pain in a Rat Model of Chronic Neuropathic Pain","display_name":"Burst and Tonic Spinal Cord Stimulation Both Activate Spinal GABAergic Mechanisms to Attenuate Pain in a Rat Model of Chronic Neuropathic Pain","publication_year":2019,"publication_date":"2019-08-19","ids":{"openalex":"https://openalex.org/W2969900914","doi":"https://doi.org/10.1111/papr.12831","mag":"2969900914","pmid":"https://pubmed.ncbi.nlm.nih.gov/31424152","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7004135"},"language":"en","primary_location":{"id":"doi:10.1111/papr.12831","doi":"https://doi.org/10.1111/papr.12831","is_oa":true,"landing_page_url":"https://doi.org/10.1111/papr.12831","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/papr.12831","source":{"id":"https://openalex.org/S72618935","display_name":"Pain Practice","issn_l":"1530-7085","issn":["1530-7085","1533-2500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/papr.12831","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063932611","display_name":"Koen P.V. Meuwissen","orcid":"https://orcid.org/0000-0001-9255-6513","observed_orcids":["https://orcid.org/0000-0001-9255-6513"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Koen P.V. Meuwissen","raw_affiliation_strings":["Department of Anesthesiology and Pain Management Pain Management and Research Centre MUMC<sup>+</sup> Maastricht The Netherlands","School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands","Department of Anesthesiology and Pain Management Pain Management and Research Centre MUMC+ Maastricht The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-9255-6513","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Management Pain Management and Research Centre MUMC<sup>+</sup> Maastricht The Netherlands","institution_ids":["https://openalex.org/I2800191616"]},{"raw_affiliation_string":"School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Department of Anesthesiology and Pain Management Pain Management and Research Centre MUMC+ Maastricht The Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105368305","display_name":"Luuk E. de Vries","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Luuk E. de Vries","raw_affiliation_strings":["School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103787242","display_name":"Jianwen Wendy Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948663404","display_name":"Boston Scientific (United States)","ror":"https://ror.org/0385es521","country_code":"US","type":"company","lineage":["https://openalex.org/I2948663404"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianwen Wendy Gu","raw_affiliation_strings":["Boston Scientific: Neuromodulation, Research and Advanced Concepts Team, Valencia, California, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Scientific: Neuromodulation, Research and Advanced Concepts Team, Valencia, California, U.S.A","institution_ids":["https://openalex.org/I2948663404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012873284","display_name":"Tianhe C. Zhang","orcid":"https://orcid.org/0000-0001-7418-3792","observed_orcids":["https://orcid.org/0000-0001-7418-3792"]},"institutions":[{"id":"https://openalex.org/I2948663404","display_name":"Boston Scientific (United States)","ror":"https://ror.org/0385es521","country_code":"US","type":"company","lineage":["https://openalex.org/I2948663404"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianhe C. Zhang","raw_affiliation_strings":["Boston Scientific: Neuromodulation, Research and Advanced Concepts Team, Valencia, California, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Scientific: Neuromodulation, Research and Advanced Concepts Team, Valencia, California, U.S.A","institution_ids":["https://openalex.org/I2948663404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109089600","display_name":"Elbert A.J. Joosten","orcid":"https://orcid.org/0000-0002-4212-7750","observed_orcids":["https://orcid.org/0000-0002-4212-7750"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elbert A.J. Joosten","raw_affiliation_strings":["Department of Anesthesiology and Pain Management Pain Management and Research Centre MUMC<sup>+</sup> Maastricht The Netherlands","School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands","Department of Anesthesiology and Pain Management Pain Management and Research Centre MUMC+ Maastricht The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Management Pain Management and Research Centre MUMC<sup>+</sup> Maastricht The Netherlands","institution_ids":["https://openalex.org/I2800191616"]},{"raw_affiliation_string":"School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Department of Anesthesiology and Pain Management Pain Management and Research Centre MUMC+ Maastricht The Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063932611"],"corresponding_institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":7.6562,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.97696884,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"75","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.06530000269412994,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-stimulation","display_name":"spinal cord stimulation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/burst-stimulation","display_name":"burst stimulation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tonic-stimulation","display_name":"tonic stimulation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gabaergic-mechanisms","display_name":"GABAergic mechanisms","score":0.7360000014305115},{"id":"https://openalex.org/keywords/chronic-neuropathic-pain","display_name":"chronic neuropathic pain","score":0.9079999923706055},{"id":"https://openalex.org/keywords/partial-sciatic-nerve-ligation","display_name":"partial sciatic nerve ligation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.8299999833106995},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.7089999914169312},{"id":"https://openalex.org/keywords/gabab-receptors","display_name":"GABAB receptors","score":0.953000009059906},{"id":"https://openalex.org/keywords/bicuculline","display_name":"bicuculline","score":0.9769999980926514},{"id":"https://openalex.org/keywords/phaclofen","display_name":"phaclofen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.824999988079071},{"id":"https://openalex.org/keywords/intrathecal-administration","display_name":"intrathecal administration","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2780763569","wikidata":"https://www.wikidata.org/wiki/Q3639734","display_name":"Bicuculline","level":4,"score":0.786561131477356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7131624221801758},{"id":"https://openalex.org/C127573956","wikidata":"https://www.wikidata.org/wiki/Q7821376","display_name":"Tonic (physiology)","level":2,"score":0.6986461877822876},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6809136271476746},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.6723850965499878},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5886759757995605},{"id":"https://openalex.org/C79636183","wikidata":"https://www.wikidata.org/wiki/Q5512770","display_name":"GABA receptor antagonist","level":5,"score":0.5302523970603943},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.5147619247436523},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.3481147289276123},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33524268865585327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23505353927612305},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12822389602661133},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062187","descriptor_name":"Spinal Cord Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1111/papr.12831","doi":"https://doi.org/10.1111/papr.12831","is_oa":true,"landing_page_url":"https://doi.org/10.1111/papr.12831","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/papr.12831","source":{"id":"https://openalex.org/S72618935","display_name":"Pain Practice","issn_l":"1530-7085","issn":["1530-7085","1533-2500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Practice","raw_type":"journal-article"},{"id":"pmid:31424152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31424152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain practice : the official journal of World Institute of Pain","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7004135","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7004135/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Pract","raw_type":"Text"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/34e7b3e3-3401-4ff9-9b26-20d5d3b683c7","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/34e7b3e3-3401-4ff9-9b26-20d5d3b683c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Meuwissen, K P, de Vries, L E, Gu, J W, Zhang, T C & Joosten, E A J 2020, 'Burst and Tonic Spinal Cord Stimulation Both Activate Spinal GABAergic Mechanisms to Attenuate Pain in a Rat Model of Chronic Neuropathic Pain', Pain Practice, vol. 20, no. 1, pp. 75-87. https://doi.org/10.1111/papr.12831","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/34e7b3e3-3401-4ff9-9b26-20d5d3b683c7","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/34e7b3e3-3401-4ff9-9b26-20d5d3b683c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pain Practice, 20(1), 75 - 87. Wiley","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/papr.12831","doi":"https://doi.org/10.1111/papr.12831","is_oa":true,"landing_page_url":"https://doi.org/10.1111/papr.12831","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/papr.12831","source":{"id":"https://openalex.org/S72618935","display_name":"Pain Practice","issn_l":"1530-7085","issn":["1530-7085","1533-2500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1922867259","display_name":null,"funder_award_id":"ISRNO060009","funder_id":"https://openalex.org/F4320310567","funder_display_name":"Boston Scientific Corporation"}],"funders":[{"id":"https://openalex.org/F4320310567","display_name":"Boston Scientific Corporation","ror":"https://ror.org/0385es521"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2969900914.pdf","grobid_xml":"https://content.openalex.org/works/W2969900914.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W161003123","https://openalex.org/W1510664177","https://openalex.org/W1536421754","https://openalex.org/W1552338815","https://openalex.org/W1789030317","https://openalex.org/W1836044296","https://openalex.org/W1863086576","https://openalex.org/W1945096581","https://openalex.org/W1967549103","https://openalex.org/W1969489922","https://openalex.org/W1970259831","https://openalex.org/W1971062901","https://openalex.org/W1976267456","https://openalex.org/W1978132541","https://openalex.org/W1980016883","https://openalex.org/W1989755128","https://openalex.org/W1997113796","https://openalex.org/W2014779151","https://openalex.org/W2016084727","https://openalex.org/W2018459912","https://openalex.org/W2027662788","https://openalex.org/W2029360289","https://openalex.org/W2029773359","https://openalex.org/W2036867592","https://openalex.org/W2037009531","https://openalex.org/W2041641217","https://openalex.org/W2059841743","https://openalex.org/W2061702272","https://openalex.org/W2065226043","https://openalex.org/W2067329045","https://openalex.org/W2067924690","https://openalex.org/W2070319582","https://openalex.org/W2074867537","https://openalex.org/W2078906750","https://openalex.org/W2083875276","https://openalex.org/W2084752974","https://openalex.org/W2088134605","https://openalex.org/W2107684736","https://openalex.org/W2141379298","https://openalex.org/W2148160596","https://openalex.org/W2155140981","https://openalex.org/W2155287559","https://openalex.org/W2158305308","https://openalex.org/W2172201406","https://openalex.org/W2243442961","https://openalex.org/W2346102553","https://openalex.org/W2346488691","https://openalex.org/W2528292128","https://openalex.org/W2557961831","https://openalex.org/W2601240869","https://openalex.org/W2617115877","https://openalex.org/W2758438169","https://openalex.org/W2768872959","https://openalex.org/W2773613492","https://openalex.org/W2789281664","https://openalex.org/W2801008672","https://openalex.org/W2893201465","https://openalex.org/W2911630338","https://openalex.org/W3021100218"],"related_works":["https://openalex.org/W2027662788","https://openalex.org/W2993338904","https://openalex.org/W4238300632","https://openalex.org/W2074867537","https://openalex.org/W4242951904","https://openalex.org/W3025679108","https://openalex.org/W2065226043","https://openalex.org/W324881477","https://openalex.org/W2156188783","https://openalex.org/W2405656492"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Experimental":[2],"and":[3,45,50,121,153,204,247,255,274],"clinical":[4],"studies":[5],"have":[6],"shown":[7],"that":[8,27,97,139,178],"tonic":[9,46,154,205,248,275],"spinal":[10,20,34,40,82,172,280],"cord":[11,83],"stimulation":[12],"(SCS)":[13],"releases":[14],"gamma\u2010aminobutyric":[15],"acid":[16],"(GABA)":[17],"in":[18,52,75,95,171,237,260],"the":[19,76,109,115,122,162,217,227,240,267],"dorsal":[21,81,173],"horn.":[22],"Recently,":[23],"it":[24],"was":[25,84],"suggested":[26],"burst":[28,44,152,181,245,272],"SCS":[29,94,155,182,196,206,246,273,276],"does":[30],"not":[31],"act":[32],"via":[33,279],"GABAergic":[35,281],"mechanisms.":[36,282],"Therefore,":[37],"we":[38],"studied":[39],"GABA":[41,73,169,190],"release":[42],"during":[43,148],"SCS,":[47],"both":[48,244,271],"anatomically":[49],"pharmacologically,":[51],"a":[53,105],"well\u2010established":[54,262],"chronic":[55,263],"neuropathic":[56,264],"pain":[57],"model.":[58],"Methods":[59],"Animals":[60],"underwent":[61],"partial":[62],"sciatic":[63],"nerve":[64],"ligation":[65],"(PSNL).":[66],"Quantitative":[67,165],"immunohistochemical":[68],"(IHC)":[69],"analysis":[70,167],"of":[71,89,111,114,137,151,161,168,176,216,239,270],"intracellular":[72,189],"levels":[74,191],"lumbar":[77],"L4":[78],"to":[79,133,194],"L6":[80],"performed":[85],"after":[86,158],"60":[87,149],"minutes":[88,150,157],"burst,":[90],"tonic,":[91],"or":[92,226],"sham":[93,195],"rats":[96,138],"had":[98,140,179],"undergone":[99,141],"PSNL":[100,142],"(n":[101,143,183,198,208],"=":[102,144,184,199,202,209,212,224,234],"16).":[103],"In":[104,251],"second":[106],"pharmacological":[107,256],"experiment,":[108],"effects":[110,269],"intrathecal":[112,159],"administration":[113,160],"GABAA":[116,218],"antagonist":[117,124,219,229],"bicuculline":[118,220],"(5":[119,126,221,231],"\u03bcg)":[120,127],"GABAB":[123,228],"phaclofen":[125,230],"were":[128,146],"assessed.":[129],"Paw":[130],"withdrawal":[131],"thresholds":[132],"von":[134],"Frey":[135],"filaments":[136],"20)":[145],"tested":[147],"30":[156],"drugs.":[163],"Results":[164],"IHC":[166],"immunoreactivity":[170],"horn":[174],"sections":[175,197,207],"animals":[177],"received":[180],"5)":[185],"showed":[186],"significantly":[187],"lower":[188],"when":[192],"compared":[193],"4;":[200],"P":[201,211],"0.0201)":[203],"7;":[210],"0.0077).":[213],"Intrathecal":[214],"application":[215],"\u03bcg;":[222,232],"n":[223,233],"10)":[225,235],"resulted":[236],"ablation":[238],"analgesic":[241,268],"effect":[242],"for":[243],"SCS.":[249],"Conclusions":[250],"conclusion,":[252],"our":[253],"anatomical":[254],"data":[257],"demonstrate":[258],"that,":[259],"this":[261],"animal":[265],"model,":[266],"are":[277],"mediated":[278]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-08-29T00:00:00"}