{"id":"https://openalex.org/W2969810951","doi":"https://doi.org/10.3389/fphys.2019.01147","title":"Influence of Social Isolation During Prolonged Simulated Weightlessness by Hindlimb Unloading","display_name":"Influence of Social Isolation During Prolonged Simulated Weightlessness by Hindlimb Unloading","publication_year":2019,"publication_date":"2019-09-13","ids":{"openalex":"https://openalex.org/W2969810951","doi":"https://doi.org/10.3389/fphys.2019.01147","mag":"2969810951","pmid":"https://pubmed.ncbi.nlm.nih.gov/31572207","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6753329"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2019.01147","doi":"https://doi.org/10.3389/fphys.2019.01147","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.01147","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.01147/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.01147/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064276499","display_name":"Candice Ginn T. Tahimic","orcid":"https://orcid.org/0000-0001-5862-2652","observed_orcids":["https://orcid.org/0000-0001-5862-2652"]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I153156064","display_name":"KBR (United States)","ror":"https://ror.org/01g1xae87","country_code":"US","type":"company","lineage":["https://openalex.org/I153156064"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Candice G. T. Tahimic","raw_affiliation_strings":["KBR, Houston, TX, United States","Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KBR, Houston, TX, United States","institution_ids":["https://openalex.org/I153156064"]},{"raw_affiliation_string":"Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041881133","display_name":"Amber M. Paul","orcid":"https://orcid.org/0000-0002-1657-3618","observed_orcids":["https://orcid.org/0000-0002-1657-3618"]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I1329765538","display_name":"Universities Space Research Association","ror":"https://ror.org/043pgqy52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1329765538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amber M. Paul","raw_affiliation_strings":["Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","Universities Space Research Association, Columbia, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]},{"raw_affiliation_string":"Universities Space Research Association, Columbia, MD, United States","institution_ids":["https://openalex.org/I1329765538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029373657","display_name":"Ann\u2010Sofie Schreurs","orcid":"https://orcid.org/0000-0002-9503-032X","observed_orcids":["https://orcid.org/0000-0002-9503-032X"]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I153156064","display_name":"KBR (United States)","ror":"https://ror.org/01g1xae87","country_code":"US","type":"company","lineage":["https://openalex.org/I153156064"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann-Sofie Schreurs","raw_affiliation_strings":["KBR, Houston, TX, United States","Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KBR, Houston, TX, United States","institution_ids":["https://openalex.org/I153156064"]},{"raw_affiliation_string":"Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112336616","display_name":"Samantha M. Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210154041","display_name":"Blue Marble Space Institute of Science","ror":"https://ror.org/04yhya597","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210144256","https://openalex.org/I4210154041"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha M. Torres","raw_affiliation_strings":["Blue Marble Space Institute of Science, Seattle, WA, United States","Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blue Marble Space Institute of Science, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210154041"]},{"raw_affiliation_string":"Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067022941","display_name":"Linda Rubinstein","orcid":"https://orcid.org/0000-0001-8161-8512","observed_orcids":["https://orcid.org/0000-0001-8161-8512"]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I1329765538","display_name":"Universities Space Research Association","ror":"https://ror.org/043pgqy52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1329765538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Rubinstein","raw_affiliation_strings":["Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","Universities Space Research Association, Columbia, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]},{"raw_affiliation_string":"Universities Space Research Association, Columbia, MD, United States","institution_ids":["https://openalex.org/I1329765538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019483678","display_name":"Sonette Steczina","orcid":"https://orcid.org/0000-0002-5415-828X","observed_orcids":["https://orcid.org/0000-0002-5415-828X"]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210154041","display_name":"Blue Marble Space Institute of Science","ror":"https://ror.org/04yhya597","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210144256","https://openalex.org/I4210154041"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonette Steczina","raw_affiliation_strings":["Blue Marble Space Institute of Science, Seattle, WA, United States","Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blue Marble Space Institute of Science, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210154041"]},{"raw_affiliation_string":"Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055870646","display_name":"Moniece G. Lowe","orcid":"https://orcid.org/0000-0002-0230-8928","observed_orcids":["https://orcid.org/0000-0002-0230-8928"]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210154041","display_name":"Blue Marble Space Institute of Science","ror":"https://ror.org/04yhya597","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210144256","https://openalex.org/I4210154041"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moniece Lowe","raw_affiliation_strings":["Blue Marble Space Institute of Science, Seattle, WA, United States","Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blue Marble Space Institute of Science, Seattle, WA, United States","institution_ids":["https://openalex.org/I4210154041"]},{"raw_affiliation_string":"Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016289062","display_name":"Sharmila Bhattacharya","orcid":"https://orcid.org/0000-0002-1562-2692","observed_orcids":["https://orcid.org/0000-0002-1562-2692"]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharmila Bhattacharya","raw_affiliation_strings":["Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047643332","display_name":"Joshua S. Alwood","orcid":"https://orcid.org/0000-0002-6702-6673","observed_orcids":["https://orcid.org/0000-0002-6702-6673"]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua S. Alwood","raw_affiliation_strings":["Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031466291","display_name":"April E. Ronca","orcid":"https://orcid.org/0000-0001-8821-1299","observed_orcids":["https://orcid.org/0000-0001-8821-1299"]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"April E. Ronca","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, United States","Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC, United States","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062582492","display_name":"Ruth K. Globus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth K. Globus","raw_affiliation_strings":["Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5064276499"],"corresponding_institution_ids":["https://openalex.org/I1280536761","https://openalex.org/I153156064"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":4.9791,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.96147881,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"1147","last_page":"1147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hindlimb-unloading","display_name":"hindlimb unloading","score":0.9570000171661377},{"id":"https://openalex.org/keywords/simulated-microgravity","display_name":"simulated microgravity","score":0.8640000224113464},{"id":"https://openalex.org/keywords/social-isolation","display_name":"social isolation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/social-housing","display_name":"social housing","score":0.8650000095367432},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/adrenal-mass","display_name":"adrenal mass","score":0.9169999957084656},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C37752432","wikidata":"https://www.wikidata.org/wiki/Q4299309","display_name":"Weightlessness","level":2,"score":0.8846601247787476},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.8041940927505493},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.4443672001361847},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3703852891921997},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2712275981903076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23678088188171387},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.18074366450309753},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.16275614500045776},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1537758708000183},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphys.2019.01147","doi":"https://doi.org/10.3389/fphys.2019.01147","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.01147","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.01147/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6753329","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6753329","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:31572207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31572207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:commons.erau.edu:publication-3163","doi":null,"is_oa":true,"landing_page_url":"https://commons.erau.edu/publication/1968","pdf_url":null,"source":{"id":"https://openalex.org/S4377196356","display_name":"Scholarly Commons (Embry\u2013Riddle Aeronautical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84475105","host_organization_name":"Embry\u2013Riddle Aeronautical University","host_organization_lineage":["https://openalex.org/I84475105"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:259c5e8237774417acb4f6a047182e50","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/259c5e8237774417acb4f6a047182e50","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 10 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2019.01147","doi":"https://doi.org/10.3389/fphys.2019.01147","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.01147","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.01147/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2052372325","display_name":"WE HYPOTHESIZE THAT STIMULI FROM THE SPACE ENVIRONMENT WILL ALSO ALTER THE VIRULENCE OF THE PARASITIC WASPS, AND THEREFORE THEIR SUCCESS ON THE FLY H","funder_award_id":"NNX15AB42G","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G5593669978","display_name":"THE DETRIMENTAL EFFECTS OF SPACEFLIGHT ON THE CARDIOVASCULAR SYSTEM ARE WELL KNOWN. IT IS BELIEVED THAT THESE EFFECTS MAY LEAD TO CLINICALLY SIGNIFIC","funder_award_id":"NNX13AN38G","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G8380624458","display_name":null,"funder_award_id":"NNH14ZTT001N","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"}],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2969810951.pdf","grobid_xml":"https://content.openalex.org/works/W2969810951.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W20479761","https://openalex.org/W51805046","https://openalex.org/W77493494","https://openalex.org/W174716201","https://openalex.org/W800023145","https://openalex.org/W1518648676","https://openalex.org/W1529876590","https://openalex.org/W1599204041","https://openalex.org/W1768302124","https://openalex.org/W1852131826","https://openalex.org/W1930140667","https://openalex.org/W1964359453","https://openalex.org/W1964560277","https://openalex.org/W1976559398","https://openalex.org/W1983673891","https://openalex.org/W1988020052","https://openalex.org/W1990891254","https://openalex.org/W1992323207","https://openalex.org/W1992567157","https://openalex.org/W1994402517","https://openalex.org/W2002933536","https://openalex.org/W2003069223","https://openalex.org/W2003578107","https://openalex.org/W2003742995","https://openalex.org/W2004199365","https://openalex.org/W2004957459","https://openalex.org/W2006291375","https://openalex.org/W2010768582","https://openalex.org/W2014313490","https://openalex.org/W2018941298","https://openalex.org/W2027618039","https://openalex.org/W2029026864","https://openalex.org/W2032606415","https://openalex.org/W2037156220","https://openalex.org/W2044325937","https://openalex.org/W2051134261","https://openalex.org/W2051442825","https://openalex.org/W2052374281","https://openalex.org/W2053020350","https://openalex.org/W2058404065","https://openalex.org/W2059337573","https://openalex.org/W2059658263","https://openalex.org/W2066749771","https://openalex.org/W2068856136","https://openalex.org/W2068941322","https://openalex.org/W2078506500","https://openalex.org/W2085466629","https://openalex.org/W2085887584","https://openalex.org/W2088550413","https://openalex.org/W2088627501","https://openalex.org/W2089332722","https://openalex.org/W2090169509","https://openalex.org/W2091666243","https://openalex.org/W2091973725","https://openalex.org/W2092099741","https://openalex.org/W2093868059","https://openalex.org/W2093970855","https://openalex.org/W2099026046","https://openalex.org/W2100676784","https://openalex.org/W2104361200","https://openalex.org/W2106504012","https://openalex.org/W2110802982","https://openalex.org/W2117517043","https://openalex.org/W2118025530","https://openalex.org/W2118603956","https://openalex.org/W2129536482","https://openalex.org/W2140067684","https://openalex.org/W2143327145","https://openalex.org/W2148003491","https://openalex.org/W2149333392","https://openalex.org/W2150252868","https://openalex.org/W2150440782","https://openalex.org/W2152535965","https://openalex.org/W2153536161","https://openalex.org/W2163985900","https://openalex.org/W2167559194","https://openalex.org/W2169633867","https://openalex.org/W2178361011","https://openalex.org/W2181034614","https://openalex.org/W2223105696","https://openalex.org/W2234176399","https://openalex.org/W2272797373","https://openalex.org/W2287987188","https://openalex.org/W2346142947","https://openalex.org/W2400856411","https://openalex.org/W2416066546","https://openalex.org/W2432760286","https://openalex.org/W2464084408","https://openalex.org/W2473929794","https://openalex.org/W2503267861","https://openalex.org/W2591398637","https://openalex.org/W2594591188","https://openalex.org/W2605076090","https://openalex.org/W2726962080","https://openalex.org/W2728636755","https://openalex.org/W2740192234","https://openalex.org/W2755918827","https://openalex.org/W2769233578","https://openalex.org/W2790430637","https://openalex.org/W2800499513","https://openalex.org/W2806272602","https://openalex.org/W2808186163","https://openalex.org/W2890507673","https://openalex.org/W2911203605"],"related_works":["https://openalex.org/W3186106235","https://openalex.org/W2773919919","https://openalex.org/W4386255206","https://openalex.org/W3169200644","https://openalex.org/W2272797373","https://openalex.org/W1990891254","https://openalex.org/W2027618039","https://openalex.org/W754128333","https://openalex.org/W1934956395","https://openalex.org/W103889376"],"abstract_inverted_index":{"The":[0],"hindlimb":[1],"unloading":[2],"(HU)":[3],"model":[4,298],"has":[5,77],"been":[6,71,78],"used":[7],"extensively":[8],"to":[9,25,80,93,100,103,112,121,188,194,238,256,287],"simulate":[10],"the":[11,82,95,113,131,183,293,296],"cephalad":[12],"fluid":[13],"shift":[14],"and":[15,29,53,55,157,175,249,271],"musculoskeletal":[16,163,254],"disuse":[17],"observed":[18],"in":[19,125,154,197,202,207,217,232,246,269],"spaceflight":[20,305],"with":[21,41,141,265],"its":[22],"application":[23],"expanding":[24],"study":[26],"immune,":[27],"cardiovascular":[28],"central":[30],"nervous":[31],"system":[32,120],"responses":[33,102,178,255,286],"among":[34],"others.":[35],"Most":[36],"HU":[37,59,63,88,119,139,152,159,184,192,212,235,297],"studies":[38],"are":[39,259],"performed":[40],"singly":[42,148,203,222],"housed":[43,209,219,223,251],"animals,":[44],"although":[45,73],"social":[46,85,98,123,158,185,226,263],"isolation":[47,86,99,227],"also":[48,236],"can":[49,280],"substantially":[50],"impact":[51],"behavior":[52],"physiology,":[54],"therefore":[56],"may":[57],"confound":[58],"experimental":[60],"results.":[61],"Other":[62],"variants":[64],"that":[65,145,277],"allow":[66],"for":[67,299],"paired":[68],"housing":[69,118,124,160,166],"have":[70],"developed":[72,109],"no":[74],"systematic":[75],"assessment":[76],"made":[79],"understand":[81],"effect":[83],"of":[84,97,130,262,295,304],"on":[87],"outcomes.":[89],"Hence,":[90],"we":[91,108],"aimed":[92],"determine":[94],"contribution":[96],"tissue":[101],"HU.":[104,288],"To":[105],"accomplish":[106],"this,":[107],"a":[110,136,195,266],"refinement":[111],"traditional":[114],"NASA":[115],"Ames":[116],"single":[117,156],"accommodate":[122],"pairs":[126],"retaining":[127],"desirable":[128],"features":[129],"original":[132],"design.":[133],"We":[134],"conducted":[135],"30":[137,245],"day":[138,244],"experiment":[140],"adult,":[142],"female":[143],"mice":[144],"were":[146,179],"either":[147],"or":[149],"socially":[150,208,218,250],"housed.":[151],"animals":[153],"both":[155,247],"displayed":[161],"expected":[162],"deficits":[164],"versus":[165],"matched,":[167],"normally":[168],"loaded":[169],"(NL)":[170],"controls.":[171,191,234],"However,":[172],"select":[173,285],"immune":[174,272],"HPA":[176],"axis":[177],"differentially":[180],"impacted":[181],"by":[182],"environment":[186,264],"relative":[187],"matched":[189],"NL":[190,233],"led":[193,237],"reduction":[196],"%":[198],"CD4+":[199],"T":[200],"cells":[201],"housed,":[204],"but":[205,220],"not":[206,221,282],"mice.":[210,252],"Unexpectedly,":[211],"increased":[213,228],"adrenal":[214,229,270],"gland":[215,230],"mass":[216,231],"mice,":[224],"while":[225],"elevated":[239],"plasma":[240],"corticosterone":[241],"levels":[242],"at":[243],"singly-":[248],"Thus,":[253],"simulated":[257],"weightlessness":[258],"similar":[260],"regardless":[261],"few":[267],"differences":[268],"responses.":[273],"Our":[274],"findings":[275,290],"show":[276],"combined":[278,302],"stressors":[279],"mask,":[281],"only":[283],"exacerbate,":[284],"These":[289],"further":[291],"expand":[292],"utility":[294],"studying":[300],"possible":[301],"effects":[303],"stressors.":[306]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-08-29T00:00:00"}