{"id":"https://openalex.org/W2969786102","doi":"https://doi.org/10.1016/j.ophtha.2019.08.010","title":"Panretinal Photocoagulation for Diabetic Retinopathy in the RIDE and RISE Trials","display_name":"Panretinal Photocoagulation for Diabetic Retinopathy in the RIDE and RISE Trials","publication_year":2019,"publication_date":"2019-08-21","ids":{"openalex":"https://openalex.org/W2969786102","doi":"https://doi.org/10.1016/j.ophtha.2019.08.010","mag":"2969786102","pmid":"https://pubmed.ncbi.nlm.nih.gov/31668888"},"language":"en","primary_location":{"id":"doi:10.1016/j.ophtha.2019.08.010","doi":"https://doi.org/10.1016/j.ophtha.2019.08.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ophtha.2019.08.010","pdf_url":null,"source":{"id":"https://openalex.org/S207341048","display_name":"Ophthalmology","issn_l":"0161-6420","issn":["0161-6420","1549-4713"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ophtha.2019.08.010","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035700046","display_name":"V\u00edctor H. Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-4146-1634","observed_orcids":["https://orcid.org/0000-0002-4146-1634"]},"institutions":[{"id":"https://openalex.org/I4210161463","display_name":"Valley Retina Institute","ror":"https://ror.org/05x1ct167","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210161463"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Victor H. Gonzalez","raw_affiliation_strings":["Valley Retina Institute, McAllen, Texas. Electronic address: maculadoc@aol.com","Valley Retina Institute, McAllen, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Valley Retina Institute, McAllen, Texas. Electronic address: maculadoc@aol.com","institution_ids":["https://openalex.org/I4210161463"]},{"raw_affiliation_string":"Valley Retina Institute, McAllen, Texas","institution_ids":["https://openalex.org/I4210161463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041378794","display_name":"Pin-wen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pin-wen Wang","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022744977","display_name":"Carlos Quezada-Ruiz","orcid":"https://orcid.org/0000-0002-9909-6553","observed_orcids":["https://orcid.org/0000-0002-9909-6553"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Quezada Ruiz","raw_affiliation_strings":["Genentech, Inc., South San Francisco, California; Clinica de Ojos Garza Viejo, San Pedro Garza Garcia, NL, Mexico","Clinica de Ojos Garza Viejo, San Pedro Garza Garcia, NL, Mexico","Genentech, Inc., South San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California; Clinica de Ojos Garza Viejo, San Pedro Garza Garcia, NL, Mexico","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Clinica de Ojos Garza Viejo, San Pedro Garza Garcia, NL, Mexico","institution_ids":[]},{"raw_affiliation_string":"Genentech, Inc., South San Francisco, California","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035700046"],"corresponding_institution_ids":["https://openalex.org/I4210161463"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":1.9332,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.83751925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"128","issue":"10","first_page":"1448","last_page":"1457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/panretinal-photocoagulation","display_name":"panretinal photocoagulation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/diabetic-macular-edema","display_name":"diabetic macular edema","score":1.0},{"id":"https://openalex.org/keywords/ranibizumab","display_name":"ranibizumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-patterns","display_name":"treatment patterns","score":0.593999981880188},{"id":"https://openalex.org/keywords/retreatment","display_name":"retreatment","score":0.6740000247955322},{"id":"https://openalex.org/keywords/proliferative-diabetic-retinopathy","display_name":"proliferative diabetic retinopathy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/retinal-neovascularization","display_name":"retinal neovascularization","score":0.609000027179718},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/retinal-disease-progression","display_name":"retinal disease progression","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2908627140","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Panretinal photocoagulation","level":4,"score":0.9579771757125854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9445394277572632},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.7884540557861328},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5730265974998474},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.5570460557937622},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.46009084582328796},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3353102505207062},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.04943767189979553}],"mesh":[{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017075","descriptor_name":"Laser Coagulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ophtha.2019.08.010","doi":"https://doi.org/10.1016/j.ophtha.2019.08.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ophtha.2019.08.010","pdf_url":null,"source":{"id":"https://openalex.org/S207341048","display_name":"Ophthalmology","issn_l":"0161-6420","issn":["0161-6420","1549-4713"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology","raw_type":"journal-article"},{"id":"pmid:31668888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31668888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology","raw_type":"Clinical Trial, Phase III"}],"best_oa_location":{"id":"doi:10.1016/j.ophtha.2019.08.010","doi":"https://doi.org/10.1016/j.ophtha.2019.08.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ophtha.2019.08.010","pdf_url":null,"source":{"id":"https://openalex.org/S207341048","display_name":"Ophthalmology","issn_l":"0161-6420","issn":["0161-6420","1549-4713"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W922383587","https://openalex.org/W1966206262","https://openalex.org/W1982179488","https://openalex.org/W1999957425","https://openalex.org/W2017706900","https://openalex.org/W2027957604","https://openalex.org/W2053307526","https://openalex.org/W2055408595","https://openalex.org/W2057789225","https://openalex.org/W2097325635","https://openalex.org/W2102463203","https://openalex.org/W2105822541","https://openalex.org/W2111693183","https://openalex.org/W2177844192","https://openalex.org/W2178156144","https://openalex.org/W2320477745","https://openalex.org/W2591137745","https://openalex.org/W2610772121","https://openalex.org/W2616361514","https://openalex.org/W2771661807","https://openalex.org/W2786422555","https://openalex.org/W2797981803","https://openalex.org/W2883798682","https://openalex.org/W4232979084","https://openalex.org/W4236519347","https://openalex.org/W4240531687","https://openalex.org/W4244248663"],"related_works":["https://openalex.org/W7120366909","https://openalex.org/W1989444622","https://openalex.org/W2585889897","https://openalex.org/W7120801896","https://openalex.org/W2769953754","https://openalex.org/W4237837339","https://openalex.org/W2991811333","https://openalex.org/W2786422555","https://openalex.org/W2885579130","https://openalex.org/W4366683624"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"evaluate":[2],"panretinal":[3],"photocoagulation":[4,58],"(PRP)":[5],"treatment":[6,44,59,69,80,111,228,315,336,340,344,352],"and":[7,16,33,61,75,106,116,126,158,166,261,269,312,320,332,345],"re-treatment":[8,326],"patterns":[9,60],"in":[10,104,120,244,263,278,328],"patients":[11,51,103,119,133,145,161,181,193,205,236,245,264,280,289,329],"with":[12,156,182,206,246,276,323,331],"diabetic":[13,17],"retinopathy":[14],"(DR)":[15],"macular":[18],"edema":[19],"(DME).":[20],"DESIGN:":[21],"Post":[22],"hoc":[23],"analysis":[24],"of":[25,40,45,77,102,118,143,160,191,253,349],"the":[26,43,121,251],"phase":[27],"3":[28],"RIDE":[29,105,311],"(clinicaltrials.gov":[30,35],"identifier,":[31,36],"NCT00473382)":[32],"RISE":[34,107],"NCT00473330)":[37],"clinical":[38,62,232,304],"trials":[39],"ranibizumab":[41,123,127,163,167,176,223,266,270],"for":[42,54,174,221],"DME.":[46],"PARTICIPANTS:":[47],"Seven":[48],"hundred":[49],"fifty-nine":[50],"were":[52,64,291],"randomized":[53],"treatment.":[55],"METHODS:":[56],"Panretinal":[57],"experiences":[63],"assessed":[65],"by":[66],"baseline":[67,138,186,210,295],"PRP":[68,79,110,136,150,184,198,208,214,248,292,314,325,335,343,351],"status.":[70],"MAIN":[71],"OUTCOME":[72],"MEASURES:":[73],"Number":[74],"timing":[76],"on-study":[78,213,324,342],"sessions":[81],"undergone":[82,109],"through":[83,152,200,215],"month":[84,153,201,216,242],"24.":[85,202],"Time":[86],"to":[87,299],"new":[88,256],"proliferative":[89,257],"event":[90,258],"(composite":[91],"end":[92],"point)":[93],"was":[94,259,316],"also":[95,229],"assessed.":[96],"RESULTS:":[97],"At":[98],"baseline,":[99,250],"approximately":[100],"25%":[101],"had":[108],"before":[112],"enrollment":[113],"(22.2%,":[114],"24.4%,":[115],"25.4%":[117],"sham,":[122],"0.3":[124,164,267],"mg,":[125,169],"0.5":[128,168,271],"mg":[129,165,268,272],"arms,":[130],"respectively).":[131],"In":[132,180,310],"without":[134,333],"prior":[135,183,207,239,247,334,350],"at":[137,185,209,249,294,337,354],"(n":[139,187],"=":[140,188],"577),":[141],"9.5%":[142],"sham-treated":[144,192,279,285],"underwent":[146,194,238],"1":[147,195],"or":[148,196],"more":[149,197,303],"treatments":[151,199],"24,":[154],"compared":[155,275],"1.1%":[157],"1.6%":[159],"receiving":[162,265],"respectively":[170],"(P":[171,218,281],"<":[172,219,282],"0.001":[173,220],"both":[175,222,330],"arms":[177,224],"vs.":[178,225],"sham).":[179,226],"182),":[189],"19.3%":[190],"No":[203],"ranibizumab-treated":[204,307],"required":[211],"additional":[212],"24":[217,243],"Ranibizumab":[227,339],"significantly":[230],"reduced":[231,341],"DR":[233,346],"progression":[234,347],"among":[235],"who":[237,290,296],"PRP.":[240],"By":[241],"probability":[252],"experiencing":[254],"a":[255,318],"10.3%":[260],"9.9%":[262],"treatment,":[273],"respectively,":[274],"39.4%":[277],"0.0001).":[283],"Overall,":[284],"patients,":[286],"including":[287],"those":[288],"na\u00efve":[293],"went":[297],"on":[298],"require":[300],"PRP,":[301],"experienced":[302],"events":[305],"than":[306],"patients.":[308],"CONCLUSIONS:":[309],"RISE,":[313],"not":[317],"\"1":[319],"done\"":[321],"procedure,":[322],"occurring":[327],"baseline.":[338,355],"regardless":[348],"status":[353]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-08-29T00:00:00"}