{"id":"https://openalex.org/W2969718979","doi":"https://doi.org/10.1007/s00280-019-03916-0","title":"A phase Ib study of the combination regorafenib with PF-03446962 in patients with refractory metastatic colorectal cancer (REGAL-1 trial)","display_name":"A phase Ib study of the combination regorafenib with PF-03446962 in patients with refractory metastatic colorectal cancer (REGAL-1 trial)","publication_year":2019,"publication_date":"2019-08-23","ids":{"openalex":"https://openalex.org/W2969718979","doi":"https://doi.org/10.1007/s00280-019-03916-0","mag":"2969718979","pmid":"https://pubmed.ncbi.nlm.nih.gov/31444620","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6769092"},"language":"en","primary_location":{"id":"doi:10.1007/s00280-019-03916-0","doi":"https://doi.org/10.1007/s00280-019-03916-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00280-019-03916-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00280-019-03916-0.pdf","source":{"id":"https://openalex.org/S117498271","display_name":"Cancer Chemotherapy and Pharmacology","issn_l":"0344-5704","issn":["0344-5704","1432-0843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Chemotherapy and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00280-019-03916-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070881158","display_name":"Jeffrey Melson Clarke","orcid":"https://orcid.org/0000-0001-5647-0245","observed_orcids":["https://orcid.org/0000-0001-5647-0245"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey Melson Clarke","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA. jeffrey.clarke@duke.edu","Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA. jeffrey.clarke@duke.edu","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298","https://openalex.org/I4390039326"]},{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020182936","display_name":"Gerard C. Blobe","orcid":"https://orcid.org/0000-0002-4274-8901","observed_orcids":["https://orcid.org/0000-0002-4274-8901"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard C. Blobe","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005968330","display_name":"John H. Strickler","orcid":"https://orcid.org/0000-0001-7579-1175","observed_orcids":["https://orcid.org/0000-0001-7579-1175"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Strickler","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000347168","display_name":"Hope Elizabeth Uronis","orcid":"https://orcid.org/0009-0000-1565-1939","observed_orcids":["https://orcid.org/0009-0000-1565-1939"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hope Elizabeth Uronis","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016569209","display_name":"S. Yousuf Zafar","orcid":"https://orcid.org/0000-0002-9039-5258","observed_orcids":["https://orcid.org/0000-0002-9039-5258"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Yousuf Zafar","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074731037","display_name":"Michael Andrew Morse","orcid":"https://orcid.org/0000-0002-5725-4533","observed_orcids":["https://orcid.org/0000-0002-5725-4533"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Morse","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079790497","display_name":"Evan Dropkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan Dropkin","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104145272","display_name":"Leigh A. Howard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leigh Howard","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015821554","display_name":"Margot O\u2019Neill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margot O\u2019Neill","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070264002","display_name":"Christel N. Rushing","orcid":"https://orcid.org/0000-0001-7453-2120","observed_orcids":["https://orcid.org/0000-0001-7453-2120"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christel N. Rushing","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073130519","display_name":"Donna Niedzwiecki","orcid":"https://orcid.org/0000-0002-3566-0450","observed_orcids":["https://orcid.org/0000-0002-3566-0450"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna Niedzwiecki","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hollie Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hollie Watson","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025268913","display_name":"Emily K. Bolch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Bolch","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113878292","display_name":"Christy Arrowood","orcid":"https://orcid.org/0009-0000-3263-9659","observed_orcids":["https://orcid.org/0009-0000-3263-9659"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christy Arrowood","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037380551","display_name":"Yingmiao Liu","orcid":"https://orcid.org/0000-0003-3516-5844","observed_orcids":["https://orcid.org/0000-0003-3516-5844"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingmiao Liu","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044586794","display_name":"Andrew B. Nixon","orcid":"https://orcid.org/0000-0003-3971-2964","observed_orcids":["https://orcid.org/0000-0003-3971-2964"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew B. Nixon","raw_affiliation_strings":["Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University Medical Center, 20 Medicine Circle, Morris Building, Rm 25178, DUMC Box 3198, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046311492","display_name":"Herbert I. Hurwitz","orcid":"https://orcid.org/0000-0003-3242-9197","observed_orcids":["https://orcid.org/0000-0003-3242-9197"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert I. Hurwitz","raw_affiliation_strings":["Genentech, Inc, San Francisco, CA, 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc, San Francisco, CA, 94080, USA","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070881158"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298","https://openalex.org/I4390039326"],"apc_list":{"value":3760,"currency":"USD","value_usd":3760},"apc_paid":{"value":3760,"currency":"USD","value_usd":3760},"fwci":1.1465,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.79553537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"84","issue":"4","first_page":"909","last_page":"917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regorafenib","display_name":"regorafenib","score":0.9810000061988831},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.7210000157356262},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7120000123977661},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.9390000104904175},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.5249999761581421},{"id":"https://openalex.org/keywords/tumor-growth-factors","display_name":"tumor growth factors","score":0.7770000100135803},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.904792308807373},{"id":"https://openalex.org/C2776248978","wikidata":"https://www.wikidata.org/wiki/Q3891664","display_name":"Regorafenib","level":4,"score":0.839577317237854},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7005792260169983},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6580561995506287},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.6339187622070312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6281998157501221},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5214616656303406},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4997594356536865},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.46482279896736145},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.44791847467422485},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.41309142112731934},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40613308548927307},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4050687849521637},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3994958996772766},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35684603452682495},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.31210848689079285},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2959936857223511},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020714","descriptor_name":"Maximum Tolerated Dose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030301","descriptor_name":"Activin Receptors, Type II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D057239","descriptor_name":"Early Termination of Clinical Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00280-019-03916-0","doi":"https://doi.org/10.1007/s00280-019-03916-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00280-019-03916-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00280-019-03916-0.pdf","source":{"id":"https://openalex.org/S117498271","display_name":"Cancer Chemotherapy and Pharmacology","issn_l":"0344-5704","issn":["0344-5704","1432-0843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Chemotherapy and Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5749928","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6769092","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6769092","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6769092","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Chemother Pharmacol","raw_type":"Text"},{"id":"pmid:31444620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31444620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer chemotherapy and pharmacology","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":{"id":"doi:10.1007/s00280-019-03916-0","doi":"https://doi.org/10.1007/s00280-019-03916-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00280-019-03916-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00280-019-03916-0.pdf","source":{"id":"https://openalex.org/S117498271","display_name":"Cancer Chemotherapy and Pharmacology","issn_l":"0344-5704","issn":["0344-5704","1432-0843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Chemotherapy and Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G8687457250","display_name":null,"funder_award_id":"WI178914","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G9000914840","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014236","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2969718979.pdf","grobid_xml":"https://content.openalex.org/works/W2969718979.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1587020653","https://openalex.org/W1975616120","https://openalex.org/W1985335252","https://openalex.org/W1992101966","https://openalex.org/W2017322644","https://openalex.org/W2023921074","https://openalex.org/W2078139160","https://openalex.org/W2100446922","https://openalex.org/W2113058482","https://openalex.org/W2113980589","https://openalex.org/W2146026405","https://openalex.org/W2147834058","https://openalex.org/W2247505779","https://openalex.org/W2340207507","https://openalex.org/W2462071496","https://openalex.org/W2491676082","https://openalex.org/W2610302449","https://openalex.org/W2747395148","https://openalex.org/W2795306280","https://openalex.org/W2858223152"],"related_works":["https://openalex.org/W2891279210","https://openalex.org/W2328819506","https://openalex.org/W2247505779","https://openalex.org/W3160449450","https://openalex.org/W2561067672","https://openalex.org/W4400492765","https://openalex.org/W2590477980","https://openalex.org/W2938383858","https://openalex.org/W2093444721","https://openalex.org/W4229029683"],"abstract_inverted_index":{"PURPOSE:":[0],"This":[1],"study":[2,53],"aimed":[3],"to":[4,102,116,175,213],"evaluate":[5],"the":[6,20,154,179],"maximum":[7],"tolerated":[8],"dose":[9,15,137],"(MTD)":[10],"and":[11,22,119,140,161,199,221,228],"recommended":[12],"phase":[13],"II":[14],"(RPTD),":[16],"as":[17,19],"well":[18],"safety":[21],"tolerability":[23],"of":[24,51,64,72,80,88,96,113,126,178,219],"PF-03446962,":[25],"a":[26,55,81],"monoclonal":[27],"antibody":[28],"targeting":[29],"activin":[30],"receptor":[31],"like":[32],"kinase":[33],"1":[34,160],"(ALK-1),":[35],"in":[36,40,158,163,235],"combination":[37],"with":[38,42,69,225,237],"regorafenib":[39,73,220],"patients":[41,236],"refractory":[43,238],"metastatic":[44,239],"colorectal":[45,240],"cancer.":[46,241],"METHODS:":[47],"The":[48,217],"first":[49],"stage":[50],"this":[52],"was":[54,107,171,223],"standard":[56],"\"3":[57],"+":[58],"3\"":[59],"open-label":[60],"dose-escalation":[61,155],"scheme.":[62],"Cohorts":[63],"3-6":[65],"subjects":[66,123,133],"were":[67,99,124,129,134,142,151,185],"started":[68,173],"120":[70],"mg":[71],"given":[74,90],"PO":[75],"daily":[76],"for":[77,109,206],"3":[78],"weeks":[79],"4":[82],"week":[83],"cycle,":[84],"plus":[85],"4.5":[86],"mg/kg":[87],"PF-03446962":[89,222],"IV":[91],"every":[92],"2":[93],"weeks.":[94],"Doses":[95],"both":[97],"drugs":[98],"adjusted":[100],"according":[101],"dose-limiting":[103],"toxicities":[104],"(DLT).":[105],"Plasma":[106],"collected":[108],"multiplexed":[110],"ELISA":[111],"analysis":[112],"factors":[114],"related":[115],"tumor":[117],"growth":[118],"angiogenesis.":[120],"RESULTS:":[121],"Seventeen":[122],"enrolled,":[125],"whom":[127],"11":[128],"deemed":[130],"evaluable.":[131],"Seven":[132],"enrolled":[135,143],"at":[136,144],"level":[138,145,159,164],"1,":[139],"four":[141],"-":[146,165],"1.":[147,166],"Overall,":[148],"three":[149],"DLTs":[150],"observed":[152],"during":[153],"phase:":[156],"two":[157],"one":[162],"A":[167],"planned":[168],"dose-expansion":[169],"cohort":[170],"not":[172,230],"due":[174,212],"early":[176],"termination":[177],"clinical":[180,233],"trial.":[181],"Common":[182],"adverse":[183,214],"events":[184],"infusion-related":[186],"reaction,":[187],"fatigue,":[188],"palmar-plantar":[189],"erythrodysesthesia":[190],"syndrome,":[191],"abdominal":[192],"pain,":[193,197],"dehydration,":[194],"nausea,":[195],"back":[196],"anorexia,":[198],"diarrhea.":[200],"One":[201],"subject":[202],"achieved":[203],"stable":[204],"disease":[205],"5.5":[207],"months,":[208],"but":[209],"discontinued":[210],"treatment":[211],"events.":[215],"CONCLUSIONS:":[216],"regimen":[218],"associated":[224],"unacceptable":[226],"toxicity":[227],"did":[229],"demonstrate":[231],"notable":[232],"activity":[234]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-08-29T00:00:00"}
