{"id":"https://openalex.org/W2969717668","doi":"https://doi.org/10.1111/jfbc.13021","title":"Momordica charantia reverses type II diabetes in rat","display_name":"Momordica charantia reverses type II diabetes in rat","publication_year":2019,"publication_date":"2019-08-23","ids":{"openalex":"https://openalex.org/W2969717668","doi":"https://doi.org/10.1111/jfbc.13021","mag":"2969717668","pmid":"https://pubmed.ncbi.nlm.nih.gov/31441956"},"language":"en","primary_location":{"id":"doi:10.1111/jfbc.13021","doi":"https://doi.org/10.1111/jfbc.13021","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jfbc.13021","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jfbc.13021","source":{"id":"https://openalex.org/S53703007","display_name":"Journal of Food Biochemistry","issn_l":"0145-8884","issn":["0145-8884","1745-4514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jfbc.13021","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042344590","display_name":"Hossein Malekshahi","orcid":"https://orcid.org/0000-0001-5818-9510","observed_orcids":["https://orcid.org/0000-0001-5818-9510"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hossein Malekshahi","raw_affiliation_strings":["School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077080358","display_name":"Gholamreza Bahrami","orcid":"https://orcid.org/0000-0002-5917-3040","observed_orcids":["https://orcid.org/0000-0002-5917-3040","https://orcid.org/0000-0002-9181-3634"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Gholamreza Bahrami","raw_affiliation_strings":["Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":"https://orcid.org/0000-0002-9181-3634","affiliations":[{"raw_affiliation_string":"Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]},{"raw_affiliation_string":"School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shahram Miraghaee","orcid":"https://orcid.org/0000-0001-8934-2493","observed_orcids":["https://orcid.org/0000-0001-8934-2493"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Shahram Miraghaee","raw_affiliation_strings":["Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":"https://orcid.org/0000-0001-8934-2493","affiliations":[{"raw_affiliation_string":"Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103622278","display_name":"Seyed Ali Ahmadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyed Ali Ahmadi","raw_affiliation_strings":["Tehran University of medical sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tehran University of medical sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065460242","display_name":"Soraya Sajadimajd","orcid":"https://orcid.org/0000-0002-9188-1426","observed_orcids":["https://orcid.org/0000-0002-9188-1426"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Soraya Sajadimajd","raw_affiliation_strings":["Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019360399","display_name":"Razieh Hatami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Razieh Hatami","raw_affiliation_strings":["Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067432225","display_name":"Bahareh Mohammadi","orcid":"https://orcid.org/0000-0001-5742-9279","observed_orcids":["https://orcid.org/0000-0001-5742-9279"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Bahareh Mohammadi","raw_affiliation_strings":["Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014483676","display_name":"Samira Keshavarzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Samira Keshavarzi","raw_affiliation_strings":["Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077080358"],"corresponding_institution_ids":["https://openalex.org/I39642139"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.5779,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.87310655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"43","issue":"11","first_page":"e13021","last_page":"e13021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/momordica-charantia","display_name":"Momordica charantia","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/blood-glucose-normalization","display_name":"blood glucose normalization","score":0.7429999709129333},{"id":"https://openalex.org/keywords/insulin-expression","display_name":"insulin gene expression","score":0.7540000081062317},{"id":"https://openalex.org/keywords/pdx1","display_name":"PDX1","score":0.8410000205039978},{"id":"https://openalex.org/keywords/glut2","display_name":"GLUT2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.9319999814033508},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.6520000100135803},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9769999980926514},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.8140000104904175},{"id":"https://openalex.org/keywords/antidiabetic-plants","display_name":"antidiabetic plants","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2778686829","wikidata":"https://www.wikidata.org/wiki/Q179937","display_name":"Momordica","level":2,"score":0.9906018972396851},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7088408470153809},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6473504900932312},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.632118284702301},{"id":"https://openalex.org/C2779050171","wikidata":"https://www.wikidata.org/wiki/Q18027973","display_name":"PDX1","level":4,"score":0.5462058782577515},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5267077088356018},{"id":"https://openalex.org/C2777901630","wikidata":"https://www.wikidata.org/wiki/Q24722849","display_name":"GLUT2","level":4,"score":0.5200481414794922},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45263636112213135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4204102158546448},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38331031799316406},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3345297873020172},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.24004226922988892},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029777","descriptor_name":"Momordica charantia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051273","descriptor_name":"Glucose Transporter Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051273","descriptor_name":"Glucose Transporter Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jfbc.13021","doi":"https://doi.org/10.1111/jfbc.13021","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jfbc.13021","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jfbc.13021","source":{"id":"https://openalex.org/S53703007","display_name":"Journal of Food Biochemistry","issn_l":"0145-8884","issn":["0145-8884","1745-4514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food Biochemistry","raw_type":"journal-article"},{"id":"pmid:31441956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31441956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of food biochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/jfbc.13021","doi":"https://doi.org/10.1111/jfbc.13021","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jfbc.13021","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jfbc.13021","source":{"id":"https://openalex.org/S53703007","display_name":"Journal of Food Biochemistry","issn_l":"0145-8884","issn":["0145-8884","1745-4514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4781992636","display_name":null,"funder_award_id":"958365","funder_id":"https://openalex.org/F4320327486","funder_display_name":"National Institute for Medical Research Development"}],"funders":[{"id":"https://openalex.org/F4320323227","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741"},{"id":"https://openalex.org/F4320327486","display_name":"National Institute for Medical Research Development","ror":"https://ror.org/046k81c97"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2969717668.pdf","grobid_xml":"https://content.openalex.org/works/W2969717668.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W37545008","https://openalex.org/W39959022","https://openalex.org/W1810533596","https://openalex.org/W1931911624","https://openalex.org/W1963644695","https://openalex.org/W1968675383","https://openalex.org/W1979099108","https://openalex.org/W1987313755","https://openalex.org/W1992257277","https://openalex.org/W2002317151","https://openalex.org/W2006243734","https://openalex.org/W2007817096","https://openalex.org/W2008832041","https://openalex.org/W2013667470","https://openalex.org/W2020267609","https://openalex.org/W2022417334","https://openalex.org/W2026087399","https://openalex.org/W2029486574","https://openalex.org/W2037787080","https://openalex.org/W2041182684","https://openalex.org/W2062636861","https://openalex.org/W2080860314","https://openalex.org/W2085500476","https://openalex.org/W2086999040","https://openalex.org/W2093884294","https://openalex.org/W2101508556","https://openalex.org/W2112499810","https://openalex.org/W2119744230","https://openalex.org/W2120855287","https://openalex.org/W2136317437","https://openalex.org/W2187088392","https://openalex.org/W3129042175"],"related_works":["https://openalex.org/W363344670","https://openalex.org/W4313071582","https://openalex.org/W4401913864","https://openalex.org/W4406918424","https://openalex.org/W2389769908","https://openalex.org/W2153852471","https://openalex.org/W2118184723","https://openalex.org/W2087802449","https://openalex.org/W4387847552","https://openalex.org/W3090356587"],"abstract_inverted_index":{"Diabetes,":[0],"a":[1,11,37,53],"disease":[2],"with":[3],"abnormal":[4],"production":[5],"or":[6],"use":[7],"of":[8,40,77,92,120,148,154,167],"insulin,":[9],"is":[10,26,177],"growing":[12],"concern":[13],"that":[14,50,126,179],"affects":[15],"many":[16,20],"individuals":[17],"globally.":[18],"Although":[19],"attempts":[21],"have":[22,34,96,161],"been":[23,35],"made,":[24],"there":[25],"no":[27],"satisfactory":[28],"treatment":[29,39],"for":[30,173],"diabetes.":[31,175],"Recently,":[32],"scientists":[33],"exploring":[36],"promising":[38],"diabetes":[41,155],"involving":[42],"herbal":[43],"medicine.":[44],"In":[45],"this":[46],"line,":[47],"we":[48,160],"show":[49],"Momordica":[51,149],"charantia,":[52],"tendril-bearing":[54],"vine":[55],"belonging":[56],"to":[57,67,145,163,169],"the":[58,75,84,88,93,117,130,146,165,180],"Cucurbitaceae":[59],"family,":[60],"permanently":[61],"normalizes":[62],"blood":[63],"glucose":[64],"levels":[65],"comparable":[66],"healthy":[68],"rats.":[69],"Most":[70],"importantly,":[71],"M.":[72,121,127],"charantia":[73],"increases":[74],"expression":[76,85],"Insulin":[78],"and":[79,90,105,138],"Pdx1":[80],"genes":[81],"while":[82],"lowers":[83],"Glut2.":[86],"Moreover,":[87],"number":[89],"size":[91],"pancreatic":[94,135],"islets":[95],"remarkably":[97],"increased":[98],"in":[99,113,152,156,185],"treated":[100,114],"animals.":[101],"Liver":[102],"ALT,":[103],"AST,":[104],"ALP":[106],"enzyme":[107],"activities":[108],"fell":[109],"into":[110],"normal":[111],"range":[112],"animals":[115],"suggesting":[116],"protective":[118],"effect":[119],"charantia.":[122],"These":[123],"data":[124],"indicate":[125],"Charantia":[128,150,168],"improves":[129],"pancreas":[131],"function":[132],"by":[133],"activating":[134],"beta":[136],"cells":[137],"protecting":[139],"liver":[140],"tissue.":[141],"PRACTICAL":[142],"APPLICATIONS:":[143],"Owing":[144],"effectiveness":[147],"extracts":[151],"management":[153],"STZ-induced":[157],"diabetic":[158],"rats,":[159],"intention":[162],"evaluate":[164],"powder":[166],"discover":[170],"novel":[171],"drug":[172],"treating":[174],"It":[176],"expected":[178],"results":[181],"could":[182],"be":[183],"translated":[184],"clinical":[186],"trials.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2019-08-29T00:00:00"}