{"id":"https://openalex.org/W2969638545","doi":"https://doi.org/10.1161/circ.132.suppl_3.11931","title":"Abstract 11931: Plasma Metabolite Profiling in Heart Failure Patients: Risk Association and Heritability","display_name":"Abstract 11931: Plasma Metabolite Profiling in Heart Failure Patients: Risk Association and Heritability","publication_year":2015,"publication_date":"2015-11-10","ids":{"openalex":"https://openalex.org/W2969638545","doi":"https://doi.org/10.1161/circ.132.suppl_3.11931","mag":"2969638545"},"language":"en","primary_location":{"id":"doi:10.1161/circ.132.suppl_3.11931","doi":"https://doi.org/10.1161/circ.132.suppl_3.11931","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.132.suppl_3.11931","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108705493","display_name":"David Lanfear","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Lanfear","raw_affiliation_strings":["Heart and Vascular Institute, Henry Ford Hosp, Detroit, MI","David Lanfear"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart and Vascular Institute, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"David Lanfear","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087470378","display_name":"Albert M. Levin","orcid":"https://orcid.org/0000-0002-6993-1669","observed_orcids":["https://orcid.org/0000-0002-6993-1669"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert Levin","raw_affiliation_strings":["Public Health Sciences, Henry Ford Hosp, Detroit, MI","Albert Levin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Sciences, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Albert Levin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064554209","display_name":"Jia Li","orcid":"https://orcid.org/0000-0002-3606-3949","observed_orcids":["https://orcid.org/0000-0002-3606-3949"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Li","raw_affiliation_strings":["Public Health Sciences, Henry Ford Hosp, Detroit, MI","Jia Li"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Sciences, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Jia Li","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113836088","display_name":"Ruicong She","orcid":"https://orcid.org/0000-0002-5087-9362","observed_orcids":["https://orcid.org/0000-0002-5087-9362"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruicong She","raw_affiliation_strings":["Public Health Sciences, Henry Ford Hosp, Detroit, MI","Ruicong She"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Sciences, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Ruicong She","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Wang","raw_affiliation_strings":["Public Health Sciences, Henry Ford Hosp, Detroit, MI","Yun Wang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Sciences, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Yun Wang","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111211999","display_name":"L. Keoki Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Keoki Williams","raw_affiliation_strings":["Health Services Rsch, Henry Ford Hosp, Detroit, MI","L. Keoki Williams"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Services Rsch, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"L. Keoki Williams","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033584402","display_name":"Stephen J. Gardell","orcid":"https://orcid.org/0000-0002-3798-8230","observed_orcids":["https://orcid.org/0000-0002-3798-8230"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Gardell","raw_affiliation_strings":["Metabolomics Core, Sanford Burnham Med Rsch Institute, Orlando, FL","Stephen Gardell"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolomics Core, Sanford Burnham Med Rsch Institute, Orlando, FL","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Stephen Gardell","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091291156","display_name":"Hani N. Sabbah","orcid":"https://orcid.org/0000-0002-2850-6105","observed_orcids":["https://orcid.org/0000-0002-2850-6105"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hani Sabbah","raw_affiliation_strings":["Heart and Vascular Institute, Henry Ford Hosp, Detroit, MI","Hani Sabbah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart and Vascular Institute, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Hani Sabbah","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"suppl_3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8109999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8109999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.14180000126361847,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9950000047683716},{"id":"https://openalex.org/keywords/plasma-metabolite-profiling","display_name":"plasma metabolite profiling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.8339999914169312},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.8130000233650208},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.9100000262260437},{"id":"https://openalex.org/keywords/organic-acids","display_name":"organic acids","score":0.9869999885559082},{"id":"https://openalex.org/keywords/acylcarnitines","display_name":"acylcarnitines","score":0.9850000143051147},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6669999957084656},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.527999997138977},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9185177683830261},{"id":"https://openalex.org/C2994400308","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolite profiling","level":3,"score":0.7451066970825195},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5877284407615662},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5749260187149048},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.570925772190094},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.46266627311706543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4231346547603607},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32206565141677856},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21355712413787842},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.132.suppl_3.11931","doi":"https://doi.org/10.1161/circ.132.suppl_3.11931","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.132.suppl_3.11931","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2765938685","https://openalex.org/W4400474967","https://openalex.org/W3014582242","https://openalex.org/W4380795432","https://openalex.org/W7213316416","https://openalex.org/W7223549211","https://openalex.org/W2214949480","https://openalex.org/W7138899500","https://openalex.org/W3162247708","https://openalex.org/W3095391317"],"abstract_inverted_index":{"Background:":[0],"Metabolite":[1],"profiling":[2],"can":[3],"unveil":[4],"biomarker":[5],"signatures":[6],"for":[7,44,118],"health":[8],"and":[9,30,53,55,58,68,149,163,176,180,246],"disease.":[10],"We":[11,110,134],"tested":[12,88,101],"whether":[13,31],"the":[14,32,112,138,170,206],"plasma":[15,56],"metabolite":[16,33,235,248],"profile":[17,236],"in":[18,102,114,146,228],"heart":[19],"failure":[20],"(HF)":[21],"patients":[22],"could":[23],"predict":[24],"survival":[25,86,242],"independent":[26,239],"of":[27,83,137,174,193,212,241],"established":[28],"factors,":[29],"levels":[34,249],"are":[35],"heritable.":[36,252],"Methods:":[37],"Patients":[38],"(n=400)":[39],"who":[40],"met":[41],"Framingham":[42],"criteria":[43],"HF":[45,244],"were":[46,51,71],"included.":[47],"Fasting":[48],"blood":[49],"samples":[50],"obtained,":[52],"DNA":[54],"isolated":[57],"stored":[59],"at":[60,178],"-70":[61],"o":[62],"C.":[63],"Amino":[64],"acids,":[65,67],"organic":[66],"acyl":[69],"carnitines":[70],"quantified":[72],"using":[73,89,106,141],"mass":[74],"spectrometry.":[75],"Genome":[76],"wide":[77],"genotyping":[78],"was":[79,87,100,154,186],"also":[80],"performed.":[81],"Association":[82],"metabolites":[84],"with":[85,188],"lasso":[90],"penalized":[91],"Cox":[92,115],"regression;":[93],"a":[94,189,202,210],"resulting":[95],"multi-metabolite":[96],"risk":[97,192,204],"score":[98],"(MRS)":[99],"10-fold":[103],"cross":[104],"validation":[105],"time-dependent":[107],"ROC":[108],"curves.":[109],"retested":[111],"MRS":[113,139,171,185,207,221],"models":[116],"adjusted":[117],"conventional":[119,203],"covariates":[120],"(age,":[121],"gender,":[122],"race,":[123],"ejection":[124],"fraction":[125],"(EF),":[126],"CAD,":[127],"COPD,":[128],"creatinine,":[129],"atrial":[130],"fibrillation,":[131],"stroke,":[132],"NTproBNP).":[133],"estimated":[135],"heritability":[136,225],"components":[140],"genome-wide":[142],"data,":[143],"calculated":[144],"separately":[145],"African":[147,156],"Americans":[148],"whites.":[150],"Results:":[151],"The":[152],"cohort":[153],"50%":[155,158],"American,":[157],"female,":[159],"67%":[160],"low":[161],"EF,":[162],"mean":[164],"age":[165],"70":[166],"y.":[167],"In":[168],"cross-validation":[169],"had":[172,224],"AUC":[173],"0.705":[175],"0.658":[177],"1":[179],"5":[181],"years,":[182],"respectively.":[183],"Dichotomized":[184],"associated":[187],"4.5":[190],"fold":[191],"death":[194],"(FDR=1.49x10":[195],"-8":[196],",":[197],"Figure).":[198],"When":[199],"added":[200],"to":[201],"model,":[205],"still":[208],"carried":[209],"HR":[211],"2.6":[213],"(p=2.38":[214],"x":[215],"10":[216],"-4":[217],").":[218],"Among":[219],"14":[220],"analytes,":[222],"4":[223],"estimates":[226],">20%":[227],"each":[229],"race":[230],"group":[231],"(Table).":[232],"Conclusion:":[233],"Plasma":[234],"is":[237,254],"an":[238],"predictor":[240],"among":[243],"patients,":[245],"risk-associated":[247],"may":[250],"be":[251],"Validation":[253],"needed.":[255]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-08-29T00:00:00"}