{"id":"https://openalex.org/W2969619219","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.lb155","title":"Bipolar Disorder in Youth is Associated with Increased Low Molecular Weight Fraction of Vitamin D Binding Protein","display_name":"Bipolar Disorder in Youth is Associated with Increased Low Molecular Weight Fraction of Vitamin D Binding Protein","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2969619219","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.lb155","mag":"2969619219"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.30.1_supplement.lb155","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.lb155","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.lb155","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089831044","display_name":"Brawnie Petrov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brawnie Petrov","raw_affiliation_strings":["Human Nutrition, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Nutrition, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057373237","display_name":"Ayat Aldoori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayat Aldoori","raw_affiliation_strings":["Human Nutrition, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Nutrition, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046667973","display_name":"Guillermo P\u00e9rez Algorta","orcid":"https://orcid.org/0000-0001-6610-4951","observed_orcids":["https://orcid.org/0000-0001-6610-4951"]},"institutions":[{"id":"https://openalex.org/I67415387","display_name":"Lancaster University","ror":"https://ror.org/04f2nsd36","country_code":"GB","type":"education","lineage":["https://openalex.org/I67415387"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Guillermo Perez Algorta","raw_affiliation_strings":["Division of Health Research, Lancaster University, Lancaster, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Health Research, Lancaster University, Lancaster, United Kingdom","institution_ids":["https://openalex.org/I67415387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042886878","display_name":"Kefeng Yang","orcid":"https://orcid.org/0000-0002-6973-6150","observed_orcids":["https://orcid.org/0000-0002-6973-6150"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kefeng Yang","raw_affiliation_strings":["Human Nutrition, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Nutrition, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039372620","display_name":"Rumana Yasmeen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rumana Yasmeen","raw_affiliation_strings":["Human Nutrition, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Nutrition, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066786431","display_name":"Barbara Gracious","orcid":"https://orcid.org/0000-0003-1882-465X","observed_orcids":["https://orcid.org/0000-0003-1882-465X"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Gracious","raw_affiliation_strings":["The Research Institute at Nationwide Children's Hospital, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Research Institute at Nationwide Children's Hospital, Columbus, OH","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018948811","display_name":"Mary A. Fristad","orcid":"https://orcid.org/0000-0002-3189-2166","observed_orcids":["https://orcid.org/0000-0002-3189-2166"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Fristad","raw_affiliation_strings":["The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025426780","display_name":"Ouliana Ziouzenkova","orcid":"https://orcid.org/0000-0003-2449-2591","observed_orcids":["https://orcid.org/0000-0003-2449-2591"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ouliana Ziouzenkova","raw_affiliation_strings":["Human Nutrition, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Nutrition, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32491094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9900000095367432},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.8650000095367432},{"id":"https://openalex.org/keywords/vitamin-d-binding-protein","display_name":"vitamin D binding protein","score":0.9079999923706055},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.49799999594688416},{"id":"https://openalex.org/keywords/major-mood-disorders","display_name":"major mood disorders","score":0.8149999976158142},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.7540000081062317},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.6290000081062317},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.859000027179718},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.4429999887943268},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.44999998807907104},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C153639570","wikidata":"https://www.wikidata.org/wiki/Q906435","display_name":"Vitamin D-binding protein","level":3,"score":0.7856802344322205},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.5938783884048462},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5899103879928589},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5085231065750122},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.5031790137290955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4991018772125244},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49522462487220764},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.4164721369743347},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4106406569480896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33095884323120117},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.23921740055084229},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.30.1_supplement.lb155","doi":"https://doi.org/10.1096/fasebj.30.1_supplement.lb155","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.30.1_supplement.lb155","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7699999809265137,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2447481771","display_name":"The Ohio State University Center for Clinical and Translational Science (UL1)","funder_award_id":"UL1RR025755","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3775745605","display_name":"Developing models for identification of therapeutic cell populations","funder_award_id":"R21OD017244","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2790752701","https://openalex.org/W2346699692","https://openalex.org/W4200429872","https://openalex.org/W2944065938","https://openalex.org/W1482330867","https://openalex.org/W7140301935","https://openalex.org/W3207341947","https://openalex.org/W4304787557","https://openalex.org/W4415215180","https://openalex.org/W2588548093"],"abstract_inverted_index":{"In":[0,341],"recent":[1],"years,":[2],"the":[3,34,56,144,205,255,261,266,285,348,375,485,503,523,537],"United":[4],"States":[5],"adolescent":[6,121,489],"population":[7],"has":[8,195,329],"seen":[9],"an":[10,277,315,330,390],"epidemic":[11],"increase":[12,461],"in":[13,40,67,74,116,149,229,284,287,307,318,339,383,407,411,424,448,462,484],"major":[14,24],"mood":[15],"disorders":[16],"(MMD),":[17],"such":[18],"as":[19,51,53,80,82,474],"bipolar":[20],"disorder":[21,26],"(BP)":[22],"and":[23,48,63,88,174,198,217,248,257,271,301,333,354,363,369,413,480,490,508,530,534],"depressive":[25],"(MDD).":[27],"MMD":[28,45,68,115,132,175,319,364,408,492],"continues":[29],"to":[30,106,138,264,335,352,401,451,460,468],"be":[31],"one":[32],"of":[33,44,58,102,109,120,147,165,204,214,223,350,377,393,398,417,426,434,446,488],"most":[35],"under\u2010diagnosed":[36],"mental":[37],"health":[38],"problems":[39],"adolescents.":[41],"The":[42,100,251,514],"dependence":[43],"on":[46,185],"genetic":[47],"dietary":[49],"factors,":[50],"well":[52,81],"inflammation,":[54,72],"impedes":[55],"identification":[57],"biomarkers":[59],"for":[60,157,360,478,526,540],"sensitive":[61],"diagnostics":[62],"therapies.":[64],"Recent":[65],"studies":[66],"patients":[69,122,289,309,320,365,385,456],"identified":[70],"deregulated":[71],"mediated":[73],"concert":[75],"by":[76,92,232,254,304,357,502,518,522,536],"immunomodulatory":[77],"vitamin":[78,181,188,281,403],"D":[79,182,189,282,404],"cytokine":[83],"monocyte":[84],"chemotactic":[85],"protein\u20101":[86],"(MCP\u20101)":[87],"interleukin\u20106":[89],"(IL\u20106)":[90],"regulated":[91],"a":[93,117,458,475],"transcriptional":[94],"regulator":[95],"nuclear":[96],"factor\u2010kappa":[97],"B":[98],"(NF\u2010\u03baB).":[99],"goal":[101],"our":[103],"study":[104],"was":[105,295,344,500,516],"test":[107],"association":[108],"these":[110,150],"previously":[111],"reported":[112],"factors":[113,168],"with":[114,130,280,380],"mixed":[118],"cohort":[119,487],"(age":[123],"range":[124],"10\u201317,":[125],"age":[126],"mean":[127],"13.71":[128],"\u00b11.86)":[129],"different":[131,171,212],"(MDD:":[133],"n=12,":[134],"BP":[135,362,449,479],"n=11)":[136],"compared":[137,450,467],"healthy":[139,173,308,384,452],"(n=13).":[140],"We":[141,177,438],"also":[142,194,419],"assessed":[143],"overall":[145],"level":[146],"inflammation":[148],"subjects":[151],"using":[152],"cell":[153],"based":[154],"reporter":[155],"assay":[156,241],"NF\u03baB":[158],"activation.":[159],"Initially,":[160],"we":[161,225],"found":[162,439],"that":[163,180,327],"levels":[164,228,442],"all":[166],"measured":[167,253,303,356],"were":[169],"not":[170],"between":[172,268,299,347],"youth.":[176],"then":[178],"considered":[179],"function":[183,197,397,406],"depends":[184],"its":[186,482],"carrier,":[187],"binding":[190],"protein":[191],"(VDBP).":[192],"VDBP":[193,206,227,252,302,355,399,418,436],"inflammatory":[196,391],"activates":[199],"macrophages":[200],"after":[201],"enzymatic":[202],"processing":[203],"O\u2010linked":[207],"carbohydrate.":[208],"Taking":[209],"into":[210],"account":[211],"functions":[213],"low":[215,422],"(VDBP\u2010L)":[216],"high":[218],"molecular":[219],"weight":[220],"(VDBP\u2010H)":[221],"fractions":[222],"VDBP,":[224],"investigated":[226],"patients\u2019":[230],"plasma":[231],"three":[233],"methods:":[234],"western":[235],"blot,":[236],"mono\u2010and":[237],"polyclonal":[238,258,414],"enzyme\u2010linked":[239],"immunosorbent":[240],"(ELISA).":[242],"Western":[243,428],"blot":[244,429],"revealed":[245],"heterogeneous":[246,435],"VDBP\u2010L":[247,351,394,447,463,473],"VDBP\u2010H":[249,300,328,353],"fractions.":[250,437],"mono\u2010":[256,412],"ELISA":[259,275,306,359,415],"lacked":[260],"necessary":[262],"specificity":[263],"recognize":[265],"differences":[267],"healthy,":[269],"BP,":[270],"MDD":[272,288,455],"patients.":[273,409,493],"Polyclonal":[274],"showed":[276,457],"inverse":[278,316,345],"correlation":[279,298,317,346],"concentrations":[283],"blood":[286],"(r=":[290,310,321],"\u22120.71,":[291],"P":[292,312,323,367,371,387,444,465],"=0.013).":[293],"There":[294],"significant":[296],"positive":[297],"monoclonal":[305,336,358],"0.64,":[311],"=0.018),":[313],"but":[314],"\u22120.44,":[322],"=":[324],"0.035),":[325],"suggesting":[326],"altered":[331],"structure":[332],"affinity":[334],"anti\u2010VDBP":[337],"antibody":[338],"MMD.":[340],"consonance,":[342],"there":[343],"ratio":[349],"both":[361],"(r=0.79,":[366],"=0.002":[368],"r=0.63,":[370],"=0.001,":[372],"respectively).":[373],"Moreover,":[374],"ratios":[376],"VDBP\u2010L:VDBP\u2010H":[378],"correlate":[379],"NF\u2010\u03baB":[381],"activation":[382],"(r=0.55,":[386],"=0.05),":[388],"indicating":[389],"contribution":[392],"fraction.":[395],"Inflammatory":[396],"appears":[400],"overcome":[402],"transport":[405],"Differences":[410],"measurements":[416],"highlight":[420],"their":[421],"accuracy":[423],"measurement":[425],"VDBP.":[427],"method":[430],"enables":[431],"quantitative":[432],"analyses":[433],"significantly":[440],"increased":[441],"(130.5%,":[443],"=0.02)":[445],"(100%)":[453],"subjects.":[454],"trend":[459],"(119%,":[464],"=0.08)":[466],"healthy.":[469],"Our":[470],"data":[471],"suggests":[472],"candidate":[476],"marker":[477],"warranted":[481],"validation":[483],"larger":[486],"adult":[491],"Support":[494],"or":[495],"Funding":[496],"Information":[497],"This":[498],"research":[499],"supported":[501,517,535],"American":[504],"Egg":[505],"Board":[506],"(20020728)":[507],"from":[509],"Novo":[510],"Nordisk":[511],"Pharmaceuticals":[512],"(10040042).":[513],"project":[515],"NIH":[519,538],"grants":[520],"R21OD017244,":[521],"National":[524],"Center":[525],"Research":[527],"Resources":[528],"UL1RR025755":[529],"NCI":[531],"P30CA16058":[532],"(OSUCCC),":[533],"Roadmap":[539],"Medical":[541],"Research.":[542]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-08-29T00:00:00"}
