{"id":"https://openalex.org/W29695501","doi":null,"title":"Weight reduction with a high protein, low carbohydrate, calorie-restricted diet: effects on blood pressure, glucose and insulin levels.","display_name":"Weight reduction with a high protein, low carbohydrate, calorie-restricted diet: effects on blood pressure, glucose and insulin levels.","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W29695501","mag":"29695501","pmid":"https://pubmed.ncbi.nlm.nih.gov/2699654"},"language":"en","primary_location":{"id":"pmid:2699654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2699654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Netherlands journal of medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049482554","display_name":"Frank R. E. Nobels","orcid":"https://orcid.org/0000-0002-8058-8734","observed_orcids":["https://orcid.org/0000-0002-8058-8734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Nobels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109345483","display_name":"L. Van Gaal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L van Gaal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000580136","display_name":"I. De Leeuw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I de Leeuw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.00506757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"35","issue":"5-6","first_page":"295","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.15449999272823334,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8370000123977661},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7009999752044678},{"id":"https://openalex.org/keywords/high-protein-low-carbohydrate-diet","display_name":"high-protein low-carbohydrate diet","score":0.9139999747276306},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8080000281333923},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/postprandial-blood-glucose","display_name":"postprandial blood glucose","score":0.7940000295639038},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7870000004768372},{"id":"https://openalex.org/keywords/dietary-therapy","display_name":"dietary therapy","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.9286963939666748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8548355102539062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7825383543968201},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7522790431976318},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7367175817489624},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6776461005210876},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5959868431091309},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5731878280639648},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.5392571687698364},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5343961119651794},{"id":"https://openalex.org/C2778707264","wikidata":"https://www.wikidata.org/wiki/Q1332886","display_name":"Calorie restriction","level":2,"score":0.5182631015777588},{"id":"https://openalex.org/C40438245","wikidata":"https://www.wikidata.org/wiki/Q130964","display_name":"Calorie","level":2,"score":0.4908023774623871},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4546629786491394},{"id":"https://openalex.org/C2778977261","wikidata":"https://www.wikidata.org/wiki/Q11358","display_name":"Carbohydrate","level":2,"score":0.44594326615333557},{"id":"https://openalex.org/C170964787","wikidata":"https://www.wikidata.org/wiki/Q7611170","display_name":"Stepwise regression","level":2,"score":0.43698522448539734},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.27754008769989014}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004038","descriptor_name":"Diet, Reducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005526","descriptor_name":"Food, Formulated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2699654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2699654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Netherlands journal of medicine","raw_type":"Journal Article"},{"id":"mag:29695501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2699654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982738715","https://openalex.org/W2072822057","https://openalex.org/W2462503338","https://openalex.org/W2068716422","https://openalex.org/W1975170834","https://openalex.org/W2078745555","https://openalex.org/W2439262743","https://openalex.org/W2154259533","https://openalex.org/W239590666","https://openalex.org/W1977617928"],"abstract_inverted_index":{"A":[0],"clear":[1,56],"relationship":[2],"exists":[3],"between":[4,24],"obesity":[5,171],"and":[6,30,39,44,61,103,109,112,115,177],"hypertension.":[7],"In":[8],"this":[9],"study,":[10],"blood":[11,71,140,175],"pressure":[12,28,141,176],"was":[13,55],"examined":[14],"in":[15,93,107,110,139,147,183],"215":[16],"obese":[17],"patients.":[18],"Significant":[19],"positive":[20],"correlations":[21],"were":[22,64,81,123],"demonstrated":[23],"the":[25,65,120,148,156,181],"mean":[26,95],"arterial":[27,70],"(MAP)":[29],"age,":[31],"body":[32,34,58],"weight,":[33,59],"mass":[35],"index":[36],"(BMI),":[37],"fasting":[38,111],"2":[40],"h":[41],"postprandial":[42,45,113],"glucose":[43,114,159,184],"insulin":[46,116],"concentrations.":[47,117],"Using":[48],"a":[49,74,84,94,104,163],"stepwise":[50],"multiple":[51],"regression":[52],"analysis,":[53],"it":[54],"that":[57],"age":[60],"glycaemic":[62],"parameters":[63,157],"most":[66],"important":[67],"determinants":[68],"of":[69,76,98,119,151,155,158],"pressure.":[72],"During":[73],"period":[75],"6":[77],"months,":[78],"113":[79],"patients":[80,121],"treated":[82],"with":[83],"high":[85],"protein,":[86],"low":[87],"carbohydrate,":[88],"calorie-restricted":[89],"diet.":[90],"This":[91],"resulted":[92],"weight":[96],"loss":[97],"17":[99],"+/-":[100],"7.9":[101],"kg":[102],"considerable":[105],"drop":[106],"MAP,":[108],"None":[118],"who":[122],"hypertensive":[124],"before":[125],"treatment":[126],"(n":[127],"=":[128],"17)":[129],"remained":[130],"so":[131],"afterwards.":[132],"We":[133],"can":[134],"conclude":[135],"that:":[136],"(1)":[137],"changes":[138,146],"are":[142],"always":[143],"accompanied":[144],"by":[145],"same":[149],"direction":[150],"one":[152],"or":[153],"more":[154],"homeostasis,":[160],"which":[161],"suggests":[162],"common":[164],"link;":[165],"(2)":[166],"The":[167],"dietary":[168],"approach":[169],"to":[170,179],"therapy":[172],"successfully":[173],"lowers":[174],"helps":[178],"rectify":[180],"abnormalities":[182],"metabolism.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}