{"id":"https://openalex.org/W296949840","doi":null,"title":"The interaction of dietary antioxidant vitamins and oxidative stress on cough reflex in guinea-pigs after long term oxygen therapy.","display_name":"The interaction of dietary antioxidant vitamins and oxidative stress on cough reflex in guinea-pigs after long term oxygen therapy.","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W296949840","mag":"296949840","pmid":"https://pubmed.ncbi.nlm.nih.gov/17072029"},"language":"en","primary_location":{"id":"pmid:17072029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17072029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010798016","display_name":"Mariana Brozmanov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"M Brozmanova","raw_affiliation_strings":["Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. brozmanova@jfmed.uniba.sk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. brozmanova@jfmed.uniba.sk","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021480371","display_name":"Jana Plevkov\u00e1","orcid":"https://orcid.org/0000-0003-2857-0593","observed_orcids":["https://orcid.org/0000-0003-2857-0593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Plevkova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012065329","display_name":"V Bartos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Bartos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059474354","display_name":"Luk\u00e1\u0161 Plank","orcid":"https://orcid.org/0000-0002-1153-1160","observed_orcids":["https://orcid.org/0000-0002-1153-1160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Plank","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029091102","display_name":"Michal Javorka","orcid":"https://orcid.org/0000-0001-7562-5193","observed_orcids":["https://orcid.org/0000-0001-7562-5193"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Javorka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113833373","display_name":"M Tat\u00e1r","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tatar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7925,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.75977524,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"57 Suppl 4","issue":null,"first_page":"45","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cough-reflex","display_name":"cough reflex","score":0.8370000123977661},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6899999976158142},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.906000018119812},{"id":"https://openalex.org/keywords/long-term-oxygen-therapy","display_name":"long-term oxygen therapy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.8090000152587891},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/citric-acid-induced-cough","display_name":"citric acid-induced cough","score":0.8759999871253967},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.6759999990463257},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.8126970529556274},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7537006139755249},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7295237183570862},{"id":"https://openalex.org/C40956017","wikidata":"https://www.wikidata.org/wiki/Q975803","display_name":"Cough reflex","level":3,"score":0.6720913052558899},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5884113311767578},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5260177254676819},{"id":"https://openalex.org/C2779032678","wikidata":"https://www.wikidata.org/wiki/Q159683","display_name":"Citric acid","level":2,"score":0.5151628255844116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4754053056240082},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46800747513771057},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.46291711926460266},{"id":"https://openalex.org/C20564796","wikidata":"https://www.wikidata.org/wiki/Q1428108","display_name":"Room air distribution","level":2,"score":0.4363560378551483},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.38334596157073975},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35899055004119873},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24702438712120056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21007627248764038},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.20049834251403809},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003371","descriptor_name":"Cough","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003371","descriptor_name":"Cough","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010102","descriptor_name":"Oxygen Inhalation Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010812","descriptor_name":"Physical Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019343","descriptor_name":"Citric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17072029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17072029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:296949840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17072029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W9790566","https://openalex.org/W590541548","https://openalex.org/W1929511087","https://openalex.org/W1977818019","https://openalex.org/W1987821993","https://openalex.org/W1988846711","https://openalex.org/W1997124012","https://openalex.org/W1997589561","https://openalex.org/W2030325789","https://openalex.org/W2031679199","https://openalex.org/W2051704043","https://openalex.org/W2061083890","https://openalex.org/W2071452423","https://openalex.org/W2075226452","https://openalex.org/W2091201487","https://openalex.org/W2100068043","https://openalex.org/W2120659958","https://openalex.org/W2132119356","https://openalex.org/W2140477655","https://openalex.org/W2157313480","https://openalex.org/W2235701907","https://openalex.org/W7213500245"],"related_works":["https://openalex.org/W7213979703","https://openalex.org/W2793394069","https://openalex.org/W2140477655","https://openalex.org/W7213500245","https://openalex.org/W2009410335","https://openalex.org/W2246398613","https://openalex.org/W1968001041","https://openalex.org/W2040480114","https://openalex.org/W1867965563","https://openalex.org/W2019851749"],"abstract_inverted_index":{"Inhalation":[0],"of":[1,4,37,45,102,117,130,138,150,166,200,231],"high":[2],"concentration":[3,124],"oxygen":[5,167],"produces":[6],"oxidative":[7,56],"stress":[8,57],"in":[9,24,58,121,157,177,181,187],"men":[10],"and":[11,52,60,79,86,104,133,153,184,219],"experimental":[12,68,218],"animals.":[13,222],"Our":[14,169],"previous":[15],"experiments":[16],"showed":[17,171],"that":[18],"the":[19,43,128,136,164,217],"cough":[20,65,180,201,211,236],"reflex":[21],"is":[22],"suppressed":[23],"guinea":[25],"pigs":[26],"after":[27,163,192],"exposure":[28,139],"to":[29,41,89,140,174],"100%":[30,90,107,141],"O(2)":[31,91,108],"for":[32,83,92,109],"60":[33,93,110],"hours.":[34,94,111],"The":[35,67],"aim":[36],"this":[38],"study":[39],"was":[40,72,113,144],"determine":[42],"effects":[44],"dietary":[46],"antioxidant":[47,131,190,232],"supplementation":[48,233],"with":[49,74,189],"vitamins":[50,75],"C":[51,76],"E":[53,80],"on":[54,64,234],"hyperoxia-induced":[55,198],"airway":[59],"lung":[61],"tissues":[62],"directed":[63],"reflex.":[66],"group":[69,96],"(T-H,":[70],"n=8)":[71,98],"pretreated":[73],"(500":[77],"mg/kg)":[78,82],"(300":[81],"4":[84],"weeks":[85],"subsequently":[87],"exposed":[88],"Hyperoxic":[95],"(H,":[97],"received":[99],"saline":[100],"instead":[101],"antioxidants":[103],"then":[105,134],"inhaled":[106],"Cough":[112,143],"induced":[114,146],"by":[115,147],"inhalation":[116],"citric":[118,178],"acid":[119],"aerosol":[120],"gradually":[122],"increased":[123],"(0.05-1.6":[125],"M)":[126],"at":[127,135],"end":[129,137,165],"therapy":[132,191,195],"O(2).":[142],"also":[145,205],"mechanical":[148],"stimulation":[149],"laryngopharyngeal":[151],"(LPh)":[152],"tracheobronchial":[154],"(TBr)":[155],"region":[156],"anaesthetized":[158],"animals":[159,183,188],"just":[160],"1":[161],"hour":[162],"exposure.":[168],"results":[170,226],"a":[172,175,228],"tendency":[173],"decrease":[176],"acid-induced":[179],"hyperoxic":[182,220],"an":[185],"increase":[186],"hyperoxia.":[193],"Antioxidant":[194],"significantly":[196],"unblocked":[197],"down-regulation":[199],"(P=0.004).":[202],"Significant":[203],"changes":[204],"were":[206],"obtained":[207],"from":[208],"mechanically-induced":[209],"TBr":[210],"[2.5(1-4)":[212],"vs.":[213],"1.0(1-2);":[214],"P<0.01]":[215],"between":[216],"(control)":[221],"In":[223],"conclusion,":[224],"our":[225],"indicate":[227],"protective":[229],"effect":[230],"oxidant-mediated":[235],"depression.":[237]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}