{"id":"https://openalex.org/W2969442014","doi":"https://doi.org/10.18203/2349-3291.ijcp20193709","title":"Cystatin C- an early marker indicative of renal dysfunction in critically ill children: a prospective cohort study","display_name":"Cystatin C- an early marker indicative of renal dysfunction in critically ill children: a prospective cohort study","publication_year":2019,"publication_date":"2019-08-23","ids":{"openalex":"https://openalex.org/W2969442014","doi":"https://doi.org/10.18203/2349-3291.ijcp20193709","mag":"2969442014"},"language":"en","primary_location":{"id":"doi:10.18203/2349-3291.ijcp20193709","doi":"https://doi.org/10.18203/2349-3291.ijcp20193709","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2349-3291.ijcp20193709","pdf_url":"https://www.ijpediatrics.com/index.php/ijcp/article/download/2460/1850","source":{"id":"https://openalex.org/S2764499903","display_name":"International Journal of Contemporary Pediatrics","issn_l":"2349-3283","issn":["2349-3283","2349-3291"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Contemporary Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ijpediatrics.com/index.php/ijcp/article/download/2460/1850","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078003048","display_name":"Hawwa M.S. Siddiqua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800507371","display_name":"Jubilee Mission Medical College and Research Institute","ror":"https://ror.org/02bqwx915","country_code":"IN","type":"education","lineage":["https://openalex.org/I2800507371"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hawwa M.S. Siddiqua","raw_affiliation_strings":["Department of Pediatrics, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India","institution_ids":["https://openalex.org/I2800507371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004762585","display_name":"Mathew John","orcid":"https://orcid.org/0000-0002-8856-9984","observed_orcids":["https://orcid.org/0000-0002-8856-9984"]},"institutions":[{"id":"https://openalex.org/I2800507371","display_name":"Jubilee Mission Medical College and Research Institute","ror":"https://ror.org/02bqwx915","country_code":"IN","type":"education","lineage":["https://openalex.org/I2800507371"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mathew John","raw_affiliation_strings":["Jubilee Centre for Medical Research, Thrissur, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jubilee Centre for Medical Research, Thrissur, Kerala, India","institution_ids":["https://openalex.org/I2800507371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111124806","display_name":"Varanattu C Manoj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800507371","display_name":"Jubilee Mission Medical College and Research Institute","ror":"https://ror.org/02bqwx915","country_code":"IN","type":"education","lineage":["https://openalex.org/I2800507371"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"V. C. Manoj","raw_affiliation_strings":["Department of Neonatology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India","institution_ids":["https://openalex.org/I2800507371"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003847447","display_name":"Rati Santhakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800507371","display_name":"Jubilee Mission Medical College and Research Institute","ror":"https://ror.org/02bqwx915","country_code":"IN","type":"education","lineage":["https://openalex.org/I2800507371"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rati Santhakumar","raw_affiliation_strings":["Department of Pediatrics, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India","institution_ids":["https://openalex.org/I2800507371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800507371"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"6","issue":"5","first_page":"1981","last_page":"1981"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":1.0},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.6809999942779541},{"id":"https://openalex.org/keywords/critically-ill-children","display_name":"critically ill children","score":0.984000027179718},{"id":"https://openalex.org/keywords/pediatric-intensive-care","display_name":"pediatric intensive care","score":0.8270000219345093},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.8659999966621399},{"id":"https://openalex.org/keywords/early-biomarkers","display_name":"early biomarkers","score":0.7009999752044678},{"id":"https://openalex.org/keywords/prifle-criteria","display_name":"pRIFLE criteria","score":0.9210000038146973},{"id":"https://openalex.org/keywords/serum-cystatin-c","display_name":"serum cystatin C","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9283970594406128},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.87220698595047},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.7820361256599426},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.7478756904602051},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5980254411697388},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5009617805480957},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.48102623224258423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47172871232032776},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.45880451798439026},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4529591202735901},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3926786184310913},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.36222511529922485},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32791560888290405}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18203/2349-3291.ijcp20193709","doi":"https://doi.org/10.18203/2349-3291.ijcp20193709","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2349-3291.ijcp20193709","pdf_url":"https://www.ijpediatrics.com/index.php/ijcp/article/download/2460/1850","source":{"id":"https://openalex.org/S2764499903","display_name":"International Journal of Contemporary Pediatrics","issn_l":"2349-3283","issn":["2349-3283","2349-3291"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Contemporary Pediatrics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18203/2349-3291.ijcp20193709","doi":"https://doi.org/10.18203/2349-3291.ijcp20193709","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2349-3291.ijcp20193709","pdf_url":"https://www.ijpediatrics.com/index.php/ijcp/article/download/2460/1850","source":{"id":"https://openalex.org/S2764499903","display_name":"International Journal of Contemporary Pediatrics","issn_l":"2349-3283","issn":["2349-3283","2349-3291"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Contemporary Pediatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2969442014.pdf","grobid_xml":"https://content.openalex.org/works/W2969442014.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W616201845","https://openalex.org/W1980855945","https://openalex.org/W2007940520","https://openalex.org/W2013320146","https://openalex.org/W2019442978","https://openalex.org/W2026477188","https://openalex.org/W2031212414","https://openalex.org/W2036789134","https://openalex.org/W2037397334","https://openalex.org/W2051873425","https://openalex.org/W2072488914","https://openalex.org/W2122069741","https://openalex.org/W2141348928","https://openalex.org/W2332249129"],"related_works":["https://openalex.org/W2564050697","https://openalex.org/W2519292205","https://openalex.org/W3028868694","https://openalex.org/W2069595084","https://openalex.org/W2052823302","https://openalex.org/W2891293918","https://openalex.org/W2030279490","https://openalex.org/W2330831319","https://openalex.org/W4405670120","https://openalex.org/W7168016296"],"abstract_inverted_index":{"Background:":[0],"Acute":[1,83],"kidney":[2,10,13,84],"injury":[3,85],"(AKI)":[4],"is":[5,43,63,249],"a":[6,18,22,212],"sudden":[7],"onset":[8],"of":[9,49,68,126,152,173,184,194,259],"failure":[11],"or":[12,21],"damage":[14],"that":[15],"happens":[16],"within":[17],"few":[19,23],"hours":[20,125,221,227],"days":[24],"and":[25,35,41,75,123,128,130,145,161,222,232],"can":[26,81],"also":[27],"affect":[28],"other":[29],"organs":[30],"such":[31],"as":[32],"brain,":[33],"heart":[34],"the":[36,47,50,192,257],"lungs.":[37],"Hence":[38],"early":[39,65,237],"diagnosis":[40,258],"intervention":[42],"needed":[44],"to":[45,58,76,189,197,239],"improve":[46],"outcome":[48],"children.":[51,245],"In":[52],"these":[53],"studies":[54],"this":[55,181],"objective":[56],"was":[57,94,159,164],"determine":[59,77],"if":[60,78],"cystatin":[61,135,153,217,234,247,254],"C":[62,80,136,154,218,235,248,255],"an":[64],"marker":[66],"indicative":[67],"renal":[69],"dysfunction":[70],"in":[71,96,180,242],"critically":[72,114,175,243],"ill":[73,115,176,244],"children":[74,116,177,187],"Cystatin":[79],"detect":[82],"earlier":[86],"than":[87,252],"serum":[88,118,129,157,223],"creatinine.Methods:":[89],"This":[90],"prospective":[91],"cohort":[92],"study":[93],"undertaken":[95],"PICU":[97],"at":[98,121,138,219,225],"Jubilee":[99],"Mission":[100],"Medical":[101],"College":[102],"from":[103,112],"December":[104],"2016-":[105],"May":[106],"2018.":[107],"Blood":[108],"samples":[109],"were":[110,132,141,178],"collected":[111,133],"34":[113,174],"for":[117,134,256],"creatinine":[119,158,224],"estimation":[120,137],"0,24":[122],"48":[124,226],"admission":[127],"urine":[131,253],"admission.":[139],"Children":[140],"categorized":[142],"into":[143],"AKI":[144,190,229,241],"NON-AKI":[146],"based":[147],"on":[148],"pRIFLE":[149],"criteria.":[150,209],"Comparison":[151],"values":[155],"with":[156],"performed":[160],"Statistical":[162],"analysis":[163],"done":[165],"using":[166],"IBM":[167],"SPSS":[168],"version":[169],"20.Results:":[170],"A":[171],"total":[172],"enrolled":[179],"study,":[182],"out":[183],"which":[185],"12":[186],"progressed":[188],"during":[191],"course":[193],"illness":[195],"according":[196],"modified":[198],"Pediatric":[199],"Risk,":[200],"Injury,":[201],"Failure,":[202],"Loss,":[203],"End":[204],"Stage":[205],"Renal":[206],"Disease":[207],"(pRIFLE)":[208],"We":[210],"found":[211],"strong":[213],"positive":[214],"correlation":[215],"between":[216],"0":[220],"among":[228],"groups.Conclusions:":[230],"Serum":[231,246],"Urine":[233],"are":[236],"markers":[238],"diagnose":[240],"more":[250],"sensitive":[251],"AKI.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-08-29T00:00:00"}
