{"id":"https://openalex.org/W2969367127","doi":"https://doi.org/10.1038/s41467-019-11728-2","title":"Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity","display_name":"Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity","publication_year":2019,"publication_date":"2019-08-21","ids":{"openalex":"https://openalex.org/W2969367127","doi":"https://doi.org/10.1038/s41467-019-11728-2","mag":"2969367127","pmid":"https://pubmed.ncbi.nlm.nih.gov/31434881","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6704146"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-019-11728-2","doi":"https://doi.org/10.1038/s41467-019-11728-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-11728-2","pdf_url":"https://www.nature.com/articles/s41467-019-11728-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-019-11728-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034761993","display_name":"Greta Garrido","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greta Garrido","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069594367","display_name":"Brett Schrand","orcid":"https://orcid.org/0000-0003-2886-2211","observed_orcids":["https://orcid.org/0000-0003-2886-2211"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett Schrand","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026879931","display_name":"Ailem Rabasa","orcid":"https://orcid.org/0000-0002-4250-2725","observed_orcids":["https://orcid.org/0000-0002-4250-2725"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ailem Rabasa","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070692584","display_name":"Agata K. Levay","orcid":"https://orcid.org/0000-0001-9404-4503","observed_orcids":["https://orcid.org/0000-0001-9404-4503"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agata Levay","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079284622","display_name":"Francesca D\u2019Eramo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca D\u2019Eramo","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102822234","display_name":"Alexey Berezhnoy","orcid":"https://orcid.org/0000-0002-7886-5181","observed_orcids":["https://orcid.org/0000-0002-7886-5181"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexey Berezhnoy","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101984383","display_name":"Shrey Modi","orcid":"https://orcid.org/0000-0003-4865-1809","observed_orcids":["https://orcid.org/0000-0003-4865-1809"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shrey Modi","raw_affiliation_strings":["Department of Surgery, University of Miami, Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Miami, Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070368522","display_name":"Tal Gefen","orcid":"https://orcid.org/0000-0001-5968-0547","observed_orcids":["https://orcid.org/0000-0001-5968-0547"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tal Gefen","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053448915","display_name":"Koen A. Marijt","orcid":"https://orcid.org/0000-0003-4396-0047","observed_orcids":["https://orcid.org/0000-0003-4396-0047"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Koen Marijt","raw_affiliation_strings":["Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-4396-0047","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045097901","display_name":"Elien M. Doorduijn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elien Doorduijn","raw_affiliation_strings":["Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076908226","display_name":"Vikas Dudeja","orcid":"https://orcid.org/0000-0001-9224-777X","observed_orcids":["https://orcid.org/0000-0001-9224-777X","https://orcid.org/0009-0008-9011-7638"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikas Dudeja","raw_affiliation_strings":["Department of Surgery, University of Miami, Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Miami, Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068769338","display_name":"Thorbald van Hall","orcid":"https://orcid.org/0000-0002-9115-558X","observed_orcids":["https://orcid.org/0000-0002-9115-558X"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Thorbald van Hall","raw_affiliation_strings":["Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-9115-558X","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068892519","display_name":"Eli Gilboa","orcid":"https://orcid.org/0000-0002-2645-8154","observed_orcids":["https://orcid.org/0000-0002-2645-8154"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eli Gilboa","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA. egilboa@med.miami.edu","Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA. egilboa@med.miami.edu","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068892519"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":3.4895,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.93656887,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"3773","last_page":"3773"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.28439998626708984,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tap","display_name":"TAP","score":0.6660000085830688},{"id":"https://openalex.org/keywords/transporter-associated-with-antigen-processing","display_name":"transporter associated with antigen processing","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.5590000152587891},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.8830000162124634},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.9089999794960022},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/flt3-ligand","display_name":"Flt3 ligand","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cancer-vaccination","display_name":"cancer vaccination","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C2776525860","wikidata":"https://www.wikidata.org/wiki/Q18029887","display_name":"Nucleolin","level":4,"score":0.7775958776473999},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6880702376365662},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5822644233703613},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.5536768436431885},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5212200880050659},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4985947608947754},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4915808141231537},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4571949541568756},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.4394797682762146},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3839816451072693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36845386028289795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35097450017929077},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21871697902679443},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.16507446765899658},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0869777500629425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06523469090461731},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.0},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097796","descriptor_name":"Nucleolin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1038/s41467-019-11728-2","doi":"https://doi.org/10.1038/s41467-019-11728-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-11728-2","pdf_url":"https://www.nature.com/articles/s41467-019-11728-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5657032","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6704146","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31434881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31434881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6704146","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6704146/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_2986681","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/121315","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 10","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11728-2","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-019-11728-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:alma.31UKB_LEU:9940752580702711","doi":null,"is_oa":false,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/121315","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:771dbc87c952460b8105b735d85f6259","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/771dbc87c952460b8105b735d85f6259","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9412b6e3bd1140079d62c6a2a9c464d0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9412b6e3bd1140079d62c6a2a9c464d0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)","raw_type":"article"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/121315","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/121315","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"10","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2986681","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/121315","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1038/s41467-019-11728-2","doi":"https://doi.org/10.1038/s41467-019-11728-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-11728-2","pdf_url":"https://www.nature.com/articles/s41467-019-11728-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G169756849","display_name":null,"funder_award_id":"P30AI073961","funder_id":"https://openalex.org/F4320332582","funder_display_name":"Center for AIDS Research, University of Washington"},{"id":"https://openalex.org/G2630461588","display_name":null,"funder_award_id":"P30 AI073961","funder_id":"https://openalex.org/F4320332562","funder_display_name":"Miami Center for AIDS Research"},{"id":"https://openalex.org/G3138949240","display_name":null,"funder_award_id":"P30AI073961","funder_id":"https://openalex.org/F4320309249","funder_display_name":"University of Miami"},{"id":"https://openalex.org/G8968883607","display_name":null,"funder_award_id":"P30AI073961","funder_id":"https://openalex.org/F4320332699","funder_display_name":"Leonard M. Miller School of Medicine"},{"id":"https://openalex.org/G9000898192","display_name":"The Sylvester Cancer Center Support Grant","funder_award_id":"P30CA240139","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000913280","display_name":"Miami Center for AIDS Research","funder_award_id":"P30AI073961","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309249","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320318541","display_name":"Sylvester Comprehensive Cancer Center, University of Miami Health Systems","ror":"https://ror.org/0552r4b12"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332562","display_name":"Miami Center for AIDS Research","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332699","display_name":"Leonard M. Miller School of Medicine","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2969367127.pdf","grobid_xml":"https://content.openalex.org/works/W2969367127.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1668110919","https://openalex.org/W1970195561","https://openalex.org/W1975907310","https://openalex.org/W1986913819","https://openalex.org/W1990699051","https://openalex.org/W1998566813","https://openalex.org/W2006080840","https://openalex.org/W2006759360","https://openalex.org/W2024039709","https://openalex.org/W2025240311","https://openalex.org/W2026308063","https://openalex.org/W2030661519","https://openalex.org/W2031084812","https://openalex.org/W2033013069","https://openalex.org/W2037991649","https://openalex.org/W2049553585","https://openalex.org/W2052320971","https://openalex.org/W2066437073","https://openalex.org/W2074992368","https://openalex.org/W2080878900","https://openalex.org/W2081921422","https://openalex.org/W2088513299","https://openalex.org/W2109424535","https://openalex.org/W2111091957","https://openalex.org/W2132548815","https://openalex.org/W2155671268","https://openalex.org/W2157096456","https://openalex.org/W2159125933","https://openalex.org/W2160007096","https://openalex.org/W2168436899","https://openalex.org/W2181078902","https://openalex.org/W2251775966","https://openalex.org/W2291298003","https://openalex.org/W2313442613","https://openalex.org/W2404396229","https://openalex.org/W2463547628","https://openalex.org/W2512065543","https://openalex.org/W2514996992","https://openalex.org/W2560367415","https://openalex.org/W2564783191","https://openalex.org/W2573519355","https://openalex.org/W2590497374","https://openalex.org/W2622499649","https://openalex.org/W2736476343","https://openalex.org/W2748037493","https://openalex.org/W2759764620","https://openalex.org/W2761575992","https://openalex.org/W2766209631","https://openalex.org/W2770647635","https://openalex.org/W2774113098","https://openalex.org/W2787835497","https://openalex.org/W2795499450","https://openalex.org/W2802455484","https://openalex.org/W2808898302","https://openalex.org/W2885871434","https://openalex.org/W2897118246","https://openalex.org/W2904068706","https://openalex.org/W2996280338"],"related_works":["https://openalex.org/W2913132987","https://openalex.org/W2742012749","https://openalex.org/W2548960167","https://openalex.org/W2887878022","https://openalex.org/W2083053278","https://openalex.org/W3016447485","https://openalex.org/W3013222230","https://openalex.org/W2121035314","https://openalex.org/W1888008159","https://openalex.org/W3046325002"],"abstract_inverted_index":{"Neoantigen":[0],"burden":[1],"is":[2],"a":[3,45,75,114,130],"major":[4],"determinant":[5],"of":[6,21,48,61,70,103,113,137,145],"tumor":[7,54,81,85,119,138],"immunogenicity,":[8],"underscored":[9],"by":[10,58],"recent":[11],"clinical":[12],"experience":[13],"with":[14,65,122],"checkpoint":[15],"blockade":[16],"therapy.":[17,38],"Yet":[18],"the":[19,62,100,111,123,135,143],"majority":[20],"patients":[22],"do":[23],"not":[24],"express,":[25],"or":[26,106],"express":[27],"too":[28],"few,":[29],"neoantigens,":[30,98],"and":[31,109,140],"hence":[32],"are":[33,51],"less":[34],"responsive":[35],"to":[36,74,93,133],"immune":[37,146],"Here":[39],"we":[40],"describe":[41],"an":[42],"approach":[43,132],"whereby":[44],"common":[46],"set":[47],"new":[49],"antigens":[50],"induced":[52,110],"in":[53,56,83,117],"cells":[55],"situ":[57],"transient":[59],"downregulation":[60],"transporter":[63],"associated":[64],"antigen":[66],"processing":[67],"(TAP).":[68],"Administration":[69],"TAP":[71],"siRNA":[72,127],"conjugated":[73],"broad-range":[76],"tumor-targeting":[77],"nucleolin":[78,125],"aptamer":[79],"inhibited":[80],"growth":[82],"multiple":[84],"models":[86],"without":[87],"measurable":[88],"toxicity,":[89],"was":[90],"comparatively":[91],"effective":[92],"vaccination":[94],"against":[95],"prototypic":[96],"mutation-generated":[97],"potentiated":[99],"antitumor":[101],"effect":[102],"PD-1":[104],"antibody":[105],"Flt3":[107],"ligand,":[108],"presentation":[112],"TAP-independent":[115],"peptide":[116],"human":[118],"cells.":[120],"Treatment":[121],"chemically-synthesized":[124],"aptamer-TAP":[126],"conjugate":[128],"represents":[129],"broadly-applicable":[131],"increase":[134],"antigenicity":[136],"lesions":[139],"thereby":[141],"enhance":[142],"effectiveness":[144],"potentiating":[147],"therapies.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":12}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-08-29T00:00:00"}
