{"id":"https://openalex.org/W2969345688","doi":"https://doi.org/10.1002/art.41084","title":"Targeting Mechanistic Target of Rapamycin Complex 1 Restricts Proinflammatory T Cell Differentiation and Ameliorates Takayasu Arteritis","display_name":"Targeting Mechanistic Target of Rapamycin Complex 1 Restricts Proinflammatory T Cell Differentiation and Ameliorates Takayasu Arteritis","publication_year":2019,"publication_date":"2019-08-20","ids":{"openalex":"https://openalex.org/W2969345688","doi":"https://doi.org/10.1002/art.41084","mag":"2969345688","pmid":"https://pubmed.ncbi.nlm.nih.gov/31430047"},"language":"en","primary_location":{"id":"doi:10.1002/art.41084","doi":"https://doi.org/10.1002/art.41084","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.41084","pdf_url":null,"source":{"id":"https://openalex.org/S4210186158","display_name":"Arthritis & Rheumatology","issn_l":"2326-5191","issn":["2326-5191","2326-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100784039","display_name":"Jifeng Zhang","orcid":"https://orcid.org/0000-0001-5161-4705","observed_orcids":["https://orcid.org/0000-0001-5161-4705"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jifeng Zhang","raw_affiliation_strings":["Jilin University School of Pharmaceutical Sciences, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin University School of Pharmaceutical Sciences, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024081157","display_name":"Lei Zhao","orcid":"https://orcid.org/0000-0003-4322-6475","observed_orcids":["https://orcid.org/0000-0003-4322-6475"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhao","raw_affiliation_strings":["Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Changchun Central Hospital, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changchun Central Hospital, Changchun, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014722609","display_name":"Zhihua Cheng","orcid":"https://orcid.org/0000-0002-2294-9458","observed_orcids":["https://orcid.org/0000-0002-2294-9458"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihua Cheng","raw_affiliation_strings":["First Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101732731","display_name":"Mengyao Sun","orcid":"https://orcid.org/0009-0009-3848-0234","observed_orcids":["https://orcid.org/0009-0009-3848-0234"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyao Sun","raw_affiliation_strings":["First Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070480554","display_name":"Jiayi Zhao","orcid":"https://orcid.org/0000-0001-9975-9911","observed_orcids":["https://orcid.org/0000-0001-9975-9911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiayi Zhao","raw_affiliation_strings":["General Hospital of Jilin Chemical Group Corporation, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Hospital of Jilin Chemical Group Corporation, Jilin, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Liu","raw_affiliation_strings":["Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiyu Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiyu Liu","raw_affiliation_strings":["China-Japan Union Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China-Japan Union Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019375137","display_name":"Zhenke Wen","orcid":"https://orcid.org/0000-0003-0542-0349","observed_orcids":["https://orcid.org/0000-0003-0542-0349"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenke Wen","raw_affiliation_strings":["Soochow University, Suzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-0542-0349","affiliations":[{"raw_affiliation_string":"Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100630004","display_name":"Zhibo Li","orcid":"https://orcid.org/0000-0003-1278-735X","observed_orcids":["https://orcid.org/0000-0003-1278-735X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhibo Li","raw_affiliation_strings":["Second Hospital of Jilin University, Changchun, China"],"raw_orcid":"https://orcid.org/0000-0003-1278-735X","affiliations":[{"raw_affiliation_string":"Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019375137","https://openalex.org/A5100630004"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I3923682","https://openalex.org/I4210142484"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.7366,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.90242655,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"72","issue":"2","first_page":"303","last_page":"315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/takayasu-arteritis","display_name":"Takayasu arteritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":1.0},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mtorc1-inhibition","display_name":"mTORC1 inhibition","score":0.5910000205039978},{"id":"https://openalex.org/keywords/large-vessel-vasculitis","display_name":"large-vessel vasculitis","score":0.843999981880188},{"id":"https://openalex.org/keywords/ribosomal-protein-s6","display_name":"ribosomal protein S6","score":0.7590000033378601},{"id":"https://openalex.org/keywords/s6-kinase-1","display_name":"S6 kinase 1","score":0.7580000162124634},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8596905469894409},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.822328507900238},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5832933187484741},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4364822506904602},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39540430903434753},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.378527969121933},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36486661434173584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35322555899620056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3480093479156494},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2630072832107544},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24736371636390686},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1572217345237732}],"mesh":[{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013625","descriptor_name":"Takayasu Arteritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.41084","doi":"https://doi.org/10.1002/art.41084","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.41084","pdf_url":null,"source":{"id":"https://openalex.org/S4210186158","display_name":"Arthritis & Rheumatology","issn_l":"2326-5191","issn":["2326-5191","2326-5205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatology","raw_type":"journal-article"},{"id":"pmid:31430047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31430047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis & rheumatology (Hoboken, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2638000187","display_name":null,"funder_award_id":"31300722","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322300","display_name":"Jilin University","ror":"https://ror.org/00js3aw79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1749413658","https://openalex.org/W1847459770","https://openalex.org/W1964525131","https://openalex.org/W1974619073","https://openalex.org/W1986963456","https://openalex.org/W1990179644","https://openalex.org/W2038252445","https://openalex.org/W2063888187","https://openalex.org/W2073025161","https://openalex.org/W2078765043","https://openalex.org/W2084885786","https://openalex.org/W2091564445","https://openalex.org/W2105058874","https://openalex.org/W2130746744","https://openalex.org/W2151422820","https://openalex.org/W2153866915","https://openalex.org/W2155759076","https://openalex.org/W2238610105","https://openalex.org/W2301939152","https://openalex.org/W2438502441","https://openalex.org/W2535462468","https://openalex.org/W2563505684","https://openalex.org/W2580651357","https://openalex.org/W2592622405","https://openalex.org/W2617242388","https://openalex.org/W2625273780","https://openalex.org/W2735854936","https://openalex.org/W2736621442","https://openalex.org/W2738294709","https://openalex.org/W2740358108","https://openalex.org/W2753800489","https://openalex.org/W2765782630","https://openalex.org/W2766795566","https://openalex.org/W2768634894","https://openalex.org/W2773804470","https://openalex.org/W2789489602","https://openalex.org/W2791734424","https://openalex.org/W2795576082","https://openalex.org/W2811373638","https://openalex.org/W2884516890","https://openalex.org/W2886766341","https://openalex.org/W2898144712","https://openalex.org/W2901000859","https://openalex.org/W2903242390","https://openalex.org/W2912170595","https://openalex.org/W2912285780","https://openalex.org/W2913711207","https://openalex.org/W6643920457"],"related_works":["https://openalex.org/W4214716176","https://openalex.org/W4321748712","https://openalex.org/W2884516890","https://openalex.org/W2903291590","https://openalex.org/W2789489602","https://openalex.org/W1847459770","https://openalex.org/W2026879782","https://openalex.org/W4386407210","https://openalex.org/W4409516517","https://openalex.org/W2238610105"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Takayasu":[1],"arteritis":[2],"(TAK)":[3],"is":[4,181,210,227],"a":[5,18,211,228],"progressive":[6],"autoimmune":[7],"large":[8],"vessel":[9,55],"vasculitis":[10,166],"with":[11,17,49,53,71,150],"infiltration":[12],"of":[13,30,33,99,134,148,156,175,208,218],"proinflammatory":[14,37,135,185,219],"T":[15,38,67,129,136,186,220],"cells,":[16],"largely":[19],"unknown":[20],"etiology.":[21],"This":[22],"study":[23],"was":[24,82],"undertaken":[25],"to":[26,106,183],"explore":[27],"the":[28,154],"involvement":[29],"mechanistic":[31],"target":[32],"rapamycin":[34,151],"(mTOR)":[35],"in":[36,44,122,126,141,167,197,222],"cell":[39,187],"differentiation":[40],"and":[41,57,64,74,90,95,138,158,164,192],"disease":[42,123,140,195],"progression":[43,196],"TAK.":[45,233],"METHODS:":[46],"Ninety-five":[47],"patients":[48,52,143],"TAK,":[50],"26":[51],"small":[54],"vasculitis,":[56],"40":[58],"healthy":[59],"donors":[60],"were":[61,69,104,117],"enrolled.":[62],"Naive":[63],"memory":[65],"CD4+":[66,128],"cells":[68,130,137,160,221],"activated":[70],"anti-CD3/CD28":[72],"beads":[73],"analyzed":[75],"for":[76,119],"lineage":[77],"differentiation.":[78],"The":[79],"mTORC1":[80,108,121,149,176,209,226],"activity":[81],"determined":[83],"by":[84],"quantifying":[85],"intracellular":[86],"phospho-S6":[87,91],"kinase":[88],"1":[89],"ribosomal":[92],"protein.":[93],"Rapamycin":[94],"lentiviral":[96],"regulatory-associated":[97],"protein":[98],"mTOR":[100],"short":[101],"hairpin":[102],"RNA":[103,178],"used":[105],"block":[107],"activity.":[109],"Human":[110],"artery-NSG":[111],"mouse":[112],"chimeras":[113,170],"representing":[114],"human":[115],"TAK":[116,142,169,194,223],"established":[118],"targeting":[120],"treatment.":[124],"RESULTS:":[125],"circulating":[127],"predicted":[131],"elevated":[132],"frequencies":[133,188],"active":[139],"(P":[144,161,171,189,199],"<":[145,162,172,190,200],"0.001).":[146,173],"Blockade":[147],"efficiently":[152],"abrogated":[153],"maldifferentiation":[155,217],"Th1":[157],"Th17":[159],"0.01)":[163,191],"ameliorated":[165],"humanized":[168],"Inhibition":[174],"using":[177],"interference":[179],"technology":[180],"sufficient":[182],"reduce":[184],"restrict":[193],"vivo":[198],"0.01).":[201],"CONCLUSION:":[202],"Our":[203],"findings":[204],"indicate":[205],"that":[206],"hyperactivity":[207],"critical":[212],"cell-intrinsic":[213],"mechanism":[214],"underlying":[215],"spontaneous":[216],"patients.":[224],"Targeting":[225],"promising":[229],"therapeutic":[230],"strategy":[231],"against":[232]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-29T00:00:00"}
