{"id":"https://openalex.org/W2969324201","doi":"https://doi.org/10.1097/aci.0000000000000579","title":"Manufacturing and quality assessment of allergenic extracts for immunotherapy: state of the art","display_name":"Manufacturing and quality assessment of allergenic extracts for immunotherapy: state of the art","publication_year":2019,"publication_date":"2019-08-24","ids":{"openalex":"https://openalex.org/W2969324201","doi":"https://doi.org/10.1097/aci.0000000000000579","mag":"2969324201","pmid":"https://pubmed.ncbi.nlm.nih.gov/31449134"},"language":"en","primary_location":{"id":"doi:10.1097/aci.0000000000000579","doi":"https://doi.org/10.1097/aci.0000000000000579","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aci.0000000000000579","pdf_url":null,"source":{"id":"https://openalex.org/S13845130","display_name":"Current Opinion in Allergy and Clinical Immunology","issn_l":"1473-6322","issn":["1473-6322","1528-4050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Allergy &amp; Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089909883","display_name":"Andreas Bonertz","orcid":"https://orcid.org/0000-0002-6846-9265","observed_orcids":["https://orcid.org/0000-0002-6846-9265"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Bonertz","raw_affiliation_strings":["Paul Ehrlich Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul Ehrlich Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008135040","display_name":"Vera Mahler","orcid":"https://orcid.org/0000-0001-6471-1811","observed_orcids":["https://orcid.org/0000-0001-6471-1811"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vera Mahler","raw_affiliation_strings":["Paul Ehrlich Institut, Langen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul Ehrlich Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026230972","display_name":"Stefan Vieths","orcid":"https://orcid.org/0000-0003-3826-6704","observed_orcids":["https://orcid.org/0000-0003-3826-6704"]},"institutions":[{"id":"https://openalex.org/I884002606","display_name":"Paul Ehrlich Institut","ror":"https://ror.org/00yssnc44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I884002606"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan Vieths","raw_affiliation_strings":["Paul Ehrlich Institut, Langen, Germany","to Stefan Vieths, PhD, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany. Tel: +49 6103 77 2000; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","to Stefan Vieths, PhD, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany. Tel: +49 6103 77 2000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul Ehrlich Institut, Langen, Germany","institution_ids":["https://openalex.org/I884002606"]},{"raw_affiliation_string":"to Stefan Vieths, PhD, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany. Tel: +49 6103 77 2000; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I884002606"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"to Stefan Vieths, PhD, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany. Tel: +49 6103 77 2000","institution_ids":["https://openalex.org/I884002606"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026230972"],"corresponding_institution_ids":["https://openalex.org/I884002606"],"apc_list":null,"apc_paid":null,"fwci":2.2006,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.85814001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"6","first_page":"640","last_page":"645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergen-extracts","display_name":"allergen extracts","score":0.8270000219345093},{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/quality-control","display_name":"quality control","score":0.7020000219345093},{"id":"https://openalex.org/keywords/method-standardization","display_name":"method standardization","score":0.7540000081062317},{"id":"https://openalex.org/keywords/regulatory-requirements","display_name":"regulatory requirements","score":0.9290000200271606},{"id":"https://openalex.org/keywords/product-consistency","display_name":"product consistency","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C197947376","wikidata":"https://www.wikidata.org/wiki/Q5155608","display_name":"Comparability","level":2,"score":0.7524926662445068},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.692071795463562},{"id":"https://openalex.org/C188087704","wikidata":"https://www.wikidata.org/wiki/Q369577","display_name":"Standardization","level":2,"score":0.6305740475654602},{"id":"https://openalex.org/C3020001037","wikidata":"https://www.wikidata.org/wiki/Q836575","display_name":"Quality assessment","level":3,"score":0.5480688810348511},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.5442003607749939},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.5155046582221985},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.47988760471343994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4639548659324646},{"id":"https://openalex.org/C106436119","wikidata":"https://www.wikidata.org/wiki/Q836575","display_name":"Quality assurance","level":3,"score":0.43884485960006714},{"id":"https://openalex.org/C117671659","wikidata":"https://www.wikidata.org/wiki/Q11049265","display_name":"Manufacturing engineering","level":1,"score":0.3329014778137207},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27887070178985596},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.20187914371490479},{"id":"https://openalex.org/C2778618615","wikidata":"https://www.wikidata.org/wiki/Q4008393","display_name":"External quality assessment","level":2,"score":0.11755698919296265},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002457","descriptor_name":"Cell Extracts","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D003888","descriptor_name":"Desensitization, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011785","descriptor_name":"Quality Assurance, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/aci.0000000000000579","doi":"https://doi.org/10.1097/aci.0000000000000579","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aci.0000000000000579","pdf_url":null,"source":{"id":"https://openalex.org/S13845130","display_name":"Current Opinion in Allergy and Clinical Immunology","issn_l":"1473-6322","issn":["1473-6322","1528-4050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Allergy &amp; Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:31449134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31449134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in allergy and clinical immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W41228127","https://openalex.org/W2281797260","https://openalex.org/W2715716507","https://openalex.org/W2743814467","https://openalex.org/W2768805395","https://openalex.org/W2783713430","https://openalex.org/W2790089204","https://openalex.org/W2795753611","https://openalex.org/W2804327362","https://openalex.org/W2889056640","https://openalex.org/W2890721848","https://openalex.org/W2895398166","https://openalex.org/W2902001080","https://openalex.org/W2903408828","https://openalex.org/W2906191281","https://openalex.org/W2912866837","https://openalex.org/W2913816957","https://openalex.org/W2920659320","https://openalex.org/W2922267231","https://openalex.org/W2923156501","https://openalex.org/W2947397217","https://openalex.org/W6761225316"],"related_works":["https://openalex.org/W143309635","https://openalex.org/W2767946053","https://openalex.org/W7084389568","https://openalex.org/W2765397678","https://openalex.org/W2768805395","https://openalex.org/W7064811458","https://openalex.org/W2228101419","https://openalex.org/W2096911087","https://openalex.org/W2075575817","https://openalex.org/W1515889193"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"The":[3],"recent":[4],"developments":[5],"in":[6,15,44,87],"the":[7,45,96],"manufacturing":[8,113],"and":[9,59,71,115,122,129],"quality":[10,97,127],"assessment":[11,22,130],"of":[12,29,47,54,73,98,103,107,125],"allergenic":[13],"extracts":[14],"Europe":[16],"are":[17,85],"summarized.":[18],"RECENT":[19],"FINDINGS:":[20],"Quality":[21],"has":[23],"always":[24],"been":[25,37],"a":[26],"fundamental":[27],"part":[28],"allergen":[30,50,78,99],"product":[31,79,117],"evaluation.":[32],"New":[33,52],"analytical":[34,74],"methods":[35],"have":[36],"reported":[38],"that":[39],"fill":[40],"currently":[41],"existing":[42],"gaps":[43],"characterization":[46,118],"commonly":[48],"used":[49],"products.":[51],"types":[53],"products":[55,100,106],"require":[56],"innovative":[57],"considerations":[58],"concepts":[60,131],"for":[61,77],"their":[62],"assessment.":[63],"Advanced":[64],"standardization":[65],"efforts":[66],"aim":[67],"at":[68],"increasing":[69],"reliability":[70],"comparability":[72],"tools":[75],"applied":[76],"characterization.":[80],"In":[81],"consequence,":[82],"regulatory":[83],"requirements":[84],"updated":[86],"line":[88],"with":[89,112],"such":[90],"developments.":[91],"SUMMARY:":[92],"Current":[93],"demands":[94],"on":[95],"ensure":[101],"production":[102],"well":[104],"characterized":[105],"consistent":[108],"quality.":[109],"While":[110],"experience":[111],"processes":[114],"successful":[116],"approaches":[119],"increase,":[120],"accompanying":[121],"continuous":[123],"re-evaluation":[124],"underlying":[126],"control":[128],"is":[132],"being":[133],"performed.":[134]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-29T00:00:00"}
