{"id":"https://openalex.org/W2968665282","doi":"https://doi.org/10.3390/molecules24162940","title":"Complex of EGCG with Cu(II) Suppresses Amyloid Aggregation and Cu(II)-Induced Cytotoxicity of \u03b1-Synuclein","display_name":"Complex of EGCG with Cu(II) Suppresses Amyloid Aggregation and Cu(II)-Induced Cytotoxicity of \u03b1-Synuclein","publication_year":2019,"publication_date":"2019-08-14","ids":{"openalex":"https://openalex.org/W2968665282","doi":"https://doi.org/10.3390/molecules24162940","mag":"2968665282","pmid":"https://pubmed.ncbi.nlm.nih.gov/31416122","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6719089"},"language":"en","primary_location":{"id":"doi:10.3390/molecules24162940","doi":"https://doi.org/10.3390/molecules24162940","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules24162940","pdf_url":"https://www.mdpi.com/1420-3049/24/16/2940/pdf?version=1565755498","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/24/16/2940/pdf?version=1565755498","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020591042","display_name":"Yilong Teng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yilong Teng","raw_affiliation_strings":["State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107866041","display_name":"Juan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Zhao","raw_affiliation_strings":["State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035186907","display_name":"Lulu Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lulu Ding","raw_affiliation_strings":["Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058374925","display_name":"Yu Ding","orcid":"https://orcid.org/0000-0001-7772-6449","observed_orcids":["https://orcid.org/0000-0001-7772-6449"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Ding","raw_affiliation_strings":["Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China"],"raw_orcid":"https://orcid.org/0000-0001-7772-6449","affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045749448","display_name":"Ping Zhou","orcid":"https://orcid.org/0000-0002-5954-7655","observed_orcids":["https://orcid.org/0000-0002-5954-7655"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ping Zhou","raw_affiliation_strings":["State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045749448","https://openalex.org/A5058374925"],"corresponding_institution_ids":["https://openalex.org/I24943067"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":3.8332,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.94173636,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"24","issue":"16","first_page":"2940","last_page":"2940"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cu-ii-complexes","display_name":"copper(II) complexes","score":0.8289999961853027},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8830000162124634},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9539999961853027},{"id":"https://openalex.org/keywords/protein-fibrillation","display_name":"protein fibrillation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/beta-sheet-conformation","display_name":"\u03b2-sheet conformation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8180000185966492},{"id":"https://openalex.org/keywords/metal-chelation","display_name":"metal chelation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.828000009059906},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7573912143707275},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6270403861999512},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6137208938598633},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.598298192024231},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5332320332527161},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5229333639144897},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.5011465549468994},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4706425070762634},{"id":"https://openalex.org/C2777356233","wikidata":"https://www.wikidata.org/wiki/Q1001150","display_name":"Fibrillation","level":3,"score":0.46374520659446716},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4633261561393738},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.4261396825313568},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38334932923316956},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3625554144382477},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.351019024848938},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25595563650131226},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15309900045394897},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066263","descriptor_name":"Protein Aggregation, Pathological","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D066263","descriptor_name":"Protein Aggregation, Pathological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066329","descriptor_name":"Protein Aggregates","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules24162940","doi":"https://doi.org/10.3390/molecules24162940","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules24162940","pdf_url":"https://www.mdpi.com/1420-3049/24/16/2940/pdf?version=1565755498","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmid:31416122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31416122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6719089","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6719089/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b23ba389131f4bceab45a31c434ae022","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b23ba389131f4bceab45a31c434ae022","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 24, Iss 16, p 2940 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules24162940","doi":"https://doi.org/10.3390/molecules24162940","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules24162940","pdf_url":"https://www.mdpi.com/1420-3049/24/16/2940/pdf?version=1565755498","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G428082530","display_name":"\u96f7\u516c\u85e4\u7532\u7d20\u6291\u5236\u8840\u7ba1\u751f\u6210\u7684\u9776\u70b9\u9274\u5b9a\u53ca\u76f8\u5173\u4fe1\u53f7\u901a\u8def\u7814\u7a76","funder_award_id":"31470764","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4843107138","display_name":null,"funder_award_id":"81374032","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5075279141","display_name":null,"funder_award_id":"21374022","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2968665282.pdf","grobid_xml":"https://content.openalex.org/works/W2968665282.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W121642688","https://openalex.org/W1618236677","https://openalex.org/W1975143207","https://openalex.org/W1977682751","https://openalex.org/W1987722773","https://openalex.org/W1990004798","https://openalex.org/W1991960405","https://openalex.org/W2006510253","https://openalex.org/W2009526570","https://openalex.org/W2027783821","https://openalex.org/W2031229678","https://openalex.org/W2032545721","https://openalex.org/W2035879579","https://openalex.org/W2046287735","https://openalex.org/W2049516913","https://openalex.org/W2049728393","https://openalex.org/W2051098162","https://openalex.org/W2052335617","https://openalex.org/W2054636900","https://openalex.org/W2055377018","https://openalex.org/W2058827782","https://openalex.org/W2061678835","https://openalex.org/W2067970878","https://openalex.org/W2068118457","https://openalex.org/W2069856306","https://openalex.org/W2077044335","https://openalex.org/W2081412929","https://openalex.org/W2083500052","https://openalex.org/W2083977136","https://openalex.org/W2089518281","https://openalex.org/W2089522371","https://openalex.org/W2101190679","https://openalex.org/W2106059645","https://openalex.org/W2121696598","https://openalex.org/W2123913108","https://openalex.org/W2135642745","https://openalex.org/W2138397062","https://openalex.org/W2141483618","https://openalex.org/W2141880963","https://openalex.org/W2148225540","https://openalex.org/W2149949558","https://openalex.org/W2151912557","https://openalex.org/W2153742411","https://openalex.org/W2154010267","https://openalex.org/W2155875767","https://openalex.org/W2158901625","https://openalex.org/W2165186407","https://openalex.org/W2171322955","https://openalex.org/W2174711957","https://openalex.org/W2175179366","https://openalex.org/W2260246117","https://openalex.org/W2327641970","https://openalex.org/W2328668744","https://openalex.org/W2331603755","https://openalex.org/W2553421239","https://openalex.org/W2706226125","https://openalex.org/W2743312417","https://openalex.org/W2752479090","https://openalex.org/W2764058575","https://openalex.org/W2889197740","https://openalex.org/W2947696479","https://openalex.org/W3023013291"],"related_works":["https://openalex.org/W2752479090","https://openalex.org/W2706226125","https://openalex.org/W1135187864","https://openalex.org/W4313626984","https://openalex.org/W2771086331","https://openalex.org/W2475133359","https://openalex.org/W3003328308","https://openalex.org/W3103381479","https://openalex.org/W2993032525","https://openalex.org/W2067322652"],"abstract_inverted_index":{"Accumulation":[0],"of":[1,37,42,99,128,132,155,188],"\u03b1-synuclein":[2],"(\u03b1-Syn)":[3],"is":[4,15,45,89,140],"a":[5,17,110,121,141,160],"remarkable":[6],"pathology":[7],"for":[8,20],"Parkinson's":[9],"disease":[10],"(PD),":[11],"therefore":[12],"clearing":[13],"it":[14],"possibly":[16],"promising":[18],"strategy":[19],"treating":[21],"PD.":[22,43],"Aberrant":[23],"copper":[24],"(Cu(II))":[25],"homeostasis":[26],"and":[27,57,101,112,147,157,186,193],"oxidative":[28],"stress":[29],"play":[30],"critical":[31],"roles":[32],"in":[33,39,144,159,176,190],"the":[34,40,48,95,103,126,153,177,184,191,201],"abnormal":[35],"aggregation":[36],"\u03b1-Syn":[38,55,60,67,100,133,145,178,189],"progress":[41],"It":[44],"reported":[46,76],"that":[47,77,117,152,175],"polyphenol":[49],"(-)-epi-gallocatechin":[50],"gallate":[51],"(EGCG)":[52],"can":[53,79,92,119,167,182],"inhibit":[54,169,183],"fibrillation":[56,98,187],"aggregation,":[58],"disaggregate":[59],"mature":[61],"fibrils,":[62],"as":[63,65],"well":[64],"protect":[66,102],"overexpressed-PC12":[68],"cells":[69,202],"against":[70,203],"damage.":[71],"Also,":[72],"previous":[73],"studies":[74],"have":[75],"EGCG":[78,91,118,158,181],"chelate":[80],"many":[81],"divalent":[82],"metal":[83],"ions.":[84],"What":[85],"we":[86,115,150,173],"investigate":[87],"here":[88],"whether":[90],"interfere":[93],"with":[94],"Cu(II)":[96,156],"induced":[97],"cell":[104],"viability.":[105],"In":[106],"this":[107,170],"work,":[108],"on":[109],"molecular":[111],"cellulaire":[113],"basis,":[114],"demonstrated":[116,174],"form":[120],"Cu(II)/EGCG":[122],"complex,":[123],"leading":[124],"to":[125,137,165],"inhibition":[127],"Cu(II)-induced":[129,195],"conformation":[130],"transition":[131],"from":[134,163],"random":[135],"coil":[136],"\u03b2-sheet,":[138],"which":[139],"dominant":[142],"structure":[143],"fibrils":[146],"aggregates.":[148],"Moreover,":[149],"found":[151],"mixture":[154],"molar":[161],"ratio":[162],"0.5":[164],"2":[166],"efficiently":[168],"process.":[171],"Furthermore,":[172],"transduced-PC12":[179],"cells,":[180,192],"overexpression":[185],"reduce":[194],"reactive":[196],"oxygen":[197],"species":[198],"(ROS),":[199],"protecting":[200],"Cu(II)-mediated":[204],"toxicity.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-08-22T00:00:00"}