{"id":"https://openalex.org/W2968655262","doi":"https://doi.org/10.3389/fimmu.2019.02020","title":"MEK1/2 Inhibitors Unlock the Constrained Interferon Response in Macrophages Through IRF1 Signaling","display_name":"MEK1/2 Inhibitors Unlock the Constrained Interferon Response in Macrophages Through IRF1 Signaling","publication_year":2019,"publication_date":"2019-08-27","ids":{"openalex":"https://openalex.org/W2968655262","doi":"https://doi.org/10.3389/fimmu.2019.02020","mag":"2968655262","pmid":"https://pubmed.ncbi.nlm.nih.gov/31507609","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6718554"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2019.02020","doi":"https://doi.org/10.3389/fimmu.2019.02020","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.02020","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.02020/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.02020/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042018609","display_name":"Lei Yang","orcid":"https://orcid.org/0000-0003-1916-8519","observed_orcids":["https://orcid.org/0000-0003-1916-8519"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lei Yang","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016756488","display_name":"Jeak Ling Ding","orcid":"https://orcid.org/0000-0003-4578-370X","observed_orcids":["https://orcid.org/0000-0003-4578-370X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Jeak Ling Ding","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016756488"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.4985,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.59811446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"2020","last_page":"2020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.7372999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.7372999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.21629999577999115,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/irf-1","display_name":"IRF1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tlr7","display_name":"TLR7","score":0.781000018119812},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.8529999852180481},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.7229999899864197},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.8370000123977661},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9470000267028809},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.6290000081062317},{"id":"https://openalex.org/keywords/immunomodulatory-cytokines","display_name":"immunomodulatory cytokines","score":0.6769999861717224},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.6330000162124634},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C32300475","wikidata":"https://www.wikidata.org/wiki/Q18027992","display_name":"IRF1","level":4,"score":0.840839147567749},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.7028175592422485},{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.6903656721115112},{"id":"https://openalex.org/C9173399","wikidata":"https://www.wikidata.org/wiki/Q6046461","display_name":"Interferon regulatory factors","level":4,"score":0.5510851740837097},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5426110029220581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5417587757110596},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.5208335518836975},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5087164044380188},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5068536400794983},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49415162205696106},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48680970072746277},{"id":"https://openalex.org/C5858377","wikidata":"https://www.wikidata.org/wiki/Q986112","display_name":"CXCL10","level":4,"score":0.4790293276309967},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.3900442123413086},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38326725363731384},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.35541605949401855},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2719056010246277},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.1485414206981659},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08574086427688599},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0680866539478302}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048370","descriptor_name":"MAP Kinase Kinase 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050856","descriptor_name":"Interferon Regulatory Factor-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051199","descriptor_name":"Toll-Like Receptor 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3389/fimmu.2019.02020","doi":"https://doi.org/10.3389/fimmu.2019.02020","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.02020","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.02020/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6718554","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6718554","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:31507609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31507609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/193730","doi":null,"is_oa":false,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/193730","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Elements","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:6581717ef00f482694d7c4841c0653ba","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6581717ef00f482694d7c4841c0653ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 10 (2019)","raw_type":"article"},{"id":"mag:3182433006","doi":null,"is_oa":false,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/193730","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Elements","raw_type":null}],"best_oa_location":{"id":"doi:10.3389/fimmu.2019.02020","doi":"https://doi.org/10.3389/fimmu.2019.02020","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.02020","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.02020/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G211754572","display_name":null,"funder_award_id":"NMRC/CBRG/0055/2013","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"},{"id":"https://openalex.org/G2874234887","display_name":null,"funder_award_id":"R-154-000-A76-114","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"},{"id":"https://openalex.org/G4691797981","display_name":null,"funder_award_id":"/CBRG/0055/2013","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320325611","display_name":"Veterin\u00e4rmedizinische Universit\u00e4t Wien","ror":"https://ror.org/01w6qp003"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"},{"id":"https://openalex.org/F4320334739","display_name":"Faculty of Science, National University of Singapore","ror":"https://ror.org/01tgyzw49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2968655262.pdf","grobid_xml":"https://content.openalex.org/works/W2968655262.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1611944043","https://openalex.org/W1840371537","https://openalex.org/W1909680668","https://openalex.org/W1917777024","https://openalex.org/W1950829641","https://openalex.org/W1969072247","https://openalex.org/W1977957999","https://openalex.org/W1979920919","https://openalex.org/W1989114351","https://openalex.org/W1989773068","https://openalex.org/W1991401350","https://openalex.org/W2010298363","https://openalex.org/W2019277416","https://openalex.org/W2021951044","https://openalex.org/W2027425960","https://openalex.org/W2031051020","https://openalex.org/W2035422548","https://openalex.org/W2036606290","https://openalex.org/W2042433863","https://openalex.org/W2042732565","https://openalex.org/W2043823867","https://openalex.org/W2043948229","https://openalex.org/W2052615604","https://openalex.org/W2064665989","https://openalex.org/W2067575233","https://openalex.org/W2072564827","https://openalex.org/W2088599017","https://openalex.org/W2096173332","https://openalex.org/W2102376334","https://openalex.org/W2102776981","https://openalex.org/W2103017472","https://openalex.org/W2115403498","https://openalex.org/W2115617484","https://openalex.org/W2116386978","https://openalex.org/W2126544418","https://openalex.org/W2129400742","https://openalex.org/W2130014441","https://openalex.org/W2133402546","https://openalex.org/W2138085240","https://openalex.org/W2138651252","https://openalex.org/W2139154967","https://openalex.org/W2169988783","https://openalex.org/W2170287675","https://openalex.org/W2275249553","https://openalex.org/W2466811948","https://openalex.org/W2494587789","https://openalex.org/W2520601585","https://openalex.org/W2520970142","https://openalex.org/W2534772180","https://openalex.org/W2556485149","https://openalex.org/W2559271789","https://openalex.org/W2582686270","https://openalex.org/W2604808360","https://openalex.org/W2605233023","https://openalex.org/W2739154332","https://openalex.org/W2765615653","https://openalex.org/W2767281692","https://openalex.org/W2773164564","https://openalex.org/W2794323280","https://openalex.org/W2804669050","https://openalex.org/W2991525222"],"related_works":["https://openalex.org/W2940087831","https://openalex.org/W3143863654","https://openalex.org/W2765615653","https://openalex.org/W6999725860","https://openalex.org/W2012451630","https://openalex.org/W2034414999","https://openalex.org/W2765367127","https://openalex.org/W7099258942","https://openalex.org/W2057316023","https://openalex.org/W4364376987"],"abstract_inverted_index":{"Macrophages":[0],"are":[1],"immune":[2,9],"sentinels":[3],"essential":[4],"for":[5],"pathogen":[6],"recognition":[7],"and":[8,20,33,63,81,107,128,150,177,187],"defense.":[10],"Nucleic":[11],"acid-sensing":[12],"toll-like":[13],"receptors":[14],"like":[15],"TLR7":[16,29,126,188],"activate":[17],"tailored":[18],"proinflammatory":[19],"interferon":[21,38,76,97,105,151,172],"responses":[22],"in":[23,41,91,96,159,175],"macrophages.":[24],"Here":[25],"we":[26],"found":[27],"that":[28],"activation":[30],"constrained":[31,72],"itself":[32],"other":[34],"TLRs":[35],"from":[36],"inducing":[37],"response":[39,77,90,106,152,174],"genes":[40,153],"macrophages":[42,56,112],"through":[43],"MAPK":[44],"kinase":[45],"1/2":[46],"(MEK1/2)-dependent":[47],"IRF1":[48],"inhibition.":[49],"Downstream":[50],"of":[51,65,75,111,120,135,148,181],"the":[52,73,104,109,133,178],"MEK1/2-ERK":[53],"pathway,":[54],"TLR7-activated":[55],"induced":[57],"interleukin-10":[58],"(IL-10),":[59],"a":[60,118,125,143],"signal":[61],"transducer":[62],"activator":[64],"transcription":[66],"3":[67],"(STAT3)":[68],"signaling":[69],"axis,":[70],"which":[71],"expression":[74,147],"genes,":[78],"immunomodulatory":[79],"cytokines":[80],"chemokines.":[82],"Nevertheless,":[83],"MEK1/2":[84,129,168,185],"inhibitors":[85],"unlocked":[86],"an":[87,92,114],"IRF1-interferon":[88],"signature":[89,173],"NF-\uf06bB-dependent":[93],"manner.":[94],"Deficiency":[95],"regulatory":[98],"factor":[99],"1":[100],"(Irf1)":[101],"completely":[102],"abrogated":[103],"prevented":[108],"reprogramming":[110],"into":[113],"immunostimulatory":[115],"phenotype.":[116],"As":[117],"proof":[119],"concept,":[121],"combination":[122,182],"treatment":[123],"with":[124,155,161,184],"agonist":[127],"inhibitor":[130,169,186],"synergistically":[131],"extended":[132],"survival":[134],"wild-type":[136],"but":[137],"not":[138],"Irf1-deficient":[139],"melanoma-bearing":[140],"mice.":[141],"In":[142],"retrospective":[144],"study,":[145],"higher":[146],"Irf1":[149],"correlated":[154],"more":[156],"favorable":[157],"prognosis":[158],"patients":[160],"cutaneous":[162],"melanoma.":[163],"Our":[164],"findings":[165],"demonstrated":[166],"how":[167],"unlocks":[170],"IRF1-mediated":[171],"macrophages,":[176],"therapeutic":[179],"potentials":[180],"therapy":[183],"agonist.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-08-22T00:00:00"}