{"id":"https://openalex.org/W2968101488","doi":"https://doi.org/10.1093/ijnp/pyw041.307","title":"PM307. Untargeted Global Metabolomics Reveals Metabolites Associated with Acamprosate Treatment Outcome","display_name":"PM307. Untargeted Global Metabolomics Reveals Metabolites Associated with Acamprosate Treatment Outcome","publication_year":2016,"publication_date":"2016-05-27","ids":{"openalex":"https://openalex.org/W2968101488","doi":"https://doi.org/10.1093/ijnp/pyw041.307","mag":"2968101488"},"language":"en","primary_location":{"id":"doi:10.1093/ijnp/pyw041.307","doi":"https://doi.org/10.1093/ijnp/pyw041.307","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ijnp/pyw041.307","pdf_url":null,"source":{"id":"https://openalex.org/S199972112","display_name":"The International Journal of Neuropsychopharmacology","issn_l":"1461-1457","issn":["1461-1457","1469-5111"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neuropsychopharmacology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ijnp/pyw041.307","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042266009","display_name":"Ada Man\u2010Choi Ho","orcid":"https://orcid.org/0000-0003-4989-8782","observed_orcids":["https://orcid.org/0000-0003-4989-8782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ada Ho","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics","Department of Psychiatry and Psychology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry and Psychology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089948049","display_name":"David J. Hinton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Hinton","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics","Department of Psychiatry and Psychology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry and Psychology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077904075","display_name":"Victor M. Karpyak","orcid":"https://orcid.org/0000-0002-9552-6130","observed_orcids":["https://orcid.org/0000-0002-9552-6130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor Karpyak","raw_affiliation_strings":["Department of Psychiatry and Psychology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110482120","display_name":"Sun Kil Choi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sun Choi","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078158915","display_name":"Tumpa Dutta","orcid":"https://orcid.org/0000-0003-0400-209X","observed_orcids":["https://orcid.org/0000-0003-0400-209X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dutta Tumpa","raw_affiliation_strings":["Mayo Metabolomic Core, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Metabolomic Core, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029433360","display_name":"Mark A. Frye","orcid":"https://orcid.org/0000-0001-6997-4215","observed_orcids":["https://orcid.org/0000-0001-6997-4215"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Frye","raw_affiliation_strings":["Department of Psychiatry and Psychology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050515785","display_name":"Joanna M. Biernacka","orcid":"https://orcid.org/0000-0001-9350-4440","observed_orcids":["https://orcid.org/0000-0001-9350-4440"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna Biernacka","raw_affiliation_strings":["Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester MN 55901, USA","Department of Psychiatry and Psychology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester MN 55901, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Psychiatry and Psychology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083436505","display_name":"Doo\u2010Sup Choi","orcid":"https://orcid.org/0000-0002-6796-9938","observed_orcids":["https://orcid.org/0000-0002-6796-9938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Doo-Sup Choi","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics","Department of Psychiatry and Psychology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry and Psychology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2042,"currency":"GBP","value_usd":2693},"apc_paid":{"value":2042,"currency":"GBP","value_usd":2693},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"Suppl_1","first_page":"9","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.7387999892234802,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.7387999892234802,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.19099999964237213,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acamprosate","display_name":"acamprosate","score":1.0},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.9919999837875366},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/caffeine-metabolism","display_name":"caffeine metabolism","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ethanol-intake","display_name":"ethanol consumption","score":0.843999981880188},{"id":"https://openalex.org/keywords/abstinence","display_name":"abstinence","score":0.7099999785423279},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2779992327","wikidata":"https://www.wikidata.org/wiki/Q337668","display_name":"Acamprosate","level":5,"score":0.8967541456222534},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7157007455825806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40716028213500977},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37750011682510376},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2701495289802551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20448517799377441},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1728123128414154},{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.07421982288360596},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/ijnp/pyw041.307","doi":"https://doi.org/10.1093/ijnp/pyw041.307","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ijnp/pyw041.307","pdf_url":null,"source":{"id":"https://openalex.org/S199972112","display_name":"The International Journal of Neuropsychopharmacology","issn_l":"1461-1457","issn":["1461-1457","1469-5111"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neuropsychopharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5616243","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5616243","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Neuropsychopharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ijnp/pyw041.307","doi":"https://doi.org/10.1093/ijnp/pyw041.307","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ijnp/pyw041.307","pdf_url":null,"source":{"id":"https://openalex.org/S199972112","display_name":"The International Journal of Neuropsychopharmacology","issn_l":"1461-1457","issn":["1461-1457","1469-5111"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neuropsychopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3157932587","https://openalex.org/W2618884689","https://openalex.org/W2412889814","https://openalex.org/W4206730816","https://openalex.org/W2119536200","https://openalex.org/W2518822834","https://openalex.org/W4294308518","https://openalex.org/W4224986439","https://openalex.org/W4413284305","https://openalex.org/W17382911"],"abstract_inverted_index":{"Abstract":[0],"Using":[1],"acamprosate":[2,56,109,188,204,213,223],"as":[3,67],"a":[4,156,195],"probe":[5],"medication,":[6],"we":[7,82,215],"aim":[8],"to":[9,13,19,118,175],"discover":[10],"serum":[11,39,227],"biomarkers":[12,229],"predict":[14],"antidipsotropic":[15],"treatment":[16,57,76,205,224,236],"outcome":[17],"and":[18,51,98],"uncover":[20],"metabolic":[21],"pathways":[22],"associated":[23,202,221],"with":[24,33,145,203,222],"the":[25,75,114,153,168,184,234],"pharmacological":[26,185],"effect":[27,186],"of":[28,55,100,108,187,197,212],"these":[29,101],"medications":[30],"in":[31,86,124,132,140,152,159,172,189,237],"patients":[32],"alcohol":[34,43],"use":[35],"disorder.":[36],"We":[37,193],"analyzed":[38],"samples":[40],"from":[41],"84":[42],"dependent":[44],"subjects":[45],"collected":[46],"at":[47,113,167],"baseline":[48,198],"(before":[49],"treatment)":[50],"after":[52,105,209],"3":[53,106,210],"months":[54,107,211],"using":[58],"an":[59],"untargeted":[60],"global":[61],"metabolomics":[62],"approach.":[63],"Subjects":[64],"were":[65,92,137,149,165],"classified":[66],"responders":[68,120,173],"if":[69],"they":[70],"maintained":[71],"complete":[72],"abstinence":[73],"during":[74],"period.":[77],"Based":[78],"on":[79],"our":[80],"findings,":[81],"performed":[83],"functional":[84],"studies":[85,178],"mice.":[87],"At":[88],"baseline,":[89,119],"48":[90],"metabolites":[91,102,112,126,136,164,199,219],"significantly":[93],"different":[94,104],"between":[95],"response":[96],"groups":[97],"26":[99],"remained":[103],"treatment.":[110],"Comparing":[111],"3-month":[115,169],"time":[116,170],"point":[117,171],"showed":[121,130,179],"significant":[122,157],"changes":[123,131],"100":[125],"whereas":[127],"non-responders":[128],"only":[129],"16":[133],"metabolites.":[134],"Five":[135],"similarly":[138],"changed":[139,151],"both":[141],"groups.":[142],"Pathway":[143],"analysis":[144],"95":[146],"metabolites,":[147],"which":[148],"uniquely":[150],"responders,":[154],"identified":[155,194,216],"enrichment":[158],"caffeine":[160,163,181,218],"metabolism.":[161],"Specifically,":[162],"increased":[166],"compared":[174],"non-responders.":[176],"Animal":[177],"that":[180,200,217],"co-administration":[182],"improves":[183],"reducing":[190],"ethanol":[191],"intake.":[192],"panel":[196],"is":[201],"response.":[206],"In":[207],"addition,":[208],"treatment,":[214],"are":[220],"response,":[225],"indicating":[226],"metabolite":[228],"will":[230],"be":[231],"useful":[232],"for":[233],"personalized":[235],"alcoholism.":[238]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-08-22T00:00:00"}