{"id":"https://openalex.org/W2968097295","doi":"https://doi.org/10.1016/j.vaccine.2019.07.009","title":"Process intensification for Peste des Petites Ruminants Virus vaccine production","display_name":"Process intensification for Peste des Petites Ruminants Virus vaccine production","publication_year":2019,"publication_date":"2019-08-08","ids":{"openalex":"https://openalex.org/W2968097295","doi":"https://doi.org/10.1016/j.vaccine.2019.07.009","mag":"2968097295","pmid":"https://pubmed.ncbi.nlm.nih.gov/31402239"},"language":"en","primary_location":{"id":"doi:10.1016/j.vaccine.2019.07.009","doi":"https://doi.org/10.1016/j.vaccine.2019.07.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2019.07.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X19308874/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0264410X19308874/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054830737","display_name":"Marcos F. Q. Sousa","orcid":"https://orcid.org/0000-0003-3766-3900","observed_orcids":["https://orcid.org/0000-0003-3766-3900"]},"institutions":[{"id":"https://openalex.org/I4210159117","display_name":"Instituto de Biologia Experimental e Tecnol\u00f3gica","ror":"https://ror.org/0599z7n30","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210159117"]},{"id":"https://openalex.org/I4405278324","display_name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier","ror":"https://ror.org/05qd25g49","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Marcos Sousa","raw_affiliation_strings":["Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal; Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal","Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal","Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-3766-3900","affiliations":[{"raw_affiliation_string":"Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal; Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal","institution_ids":["https://openalex.org/I4210159117","https://openalex.org/I4405278324","https://openalex.org/I83558840"]},{"raw_affiliation_string":"Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal","institution_ids":["https://openalex.org/I4210159117"]},{"raw_affiliation_string":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal","institution_ids":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006698186","display_name":"Christel Fenge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117289","display_name":"Sartorius (Germany)","ror":"https://ror.org/01nvz9x61","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210117289"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christel Fenge","raw_affiliation_strings":["Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210117289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109918661","display_name":"Jens Rupprecht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117289","display_name":"Sartorius (Germany)","ror":"https://ror.org/01nvz9x61","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210117289"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens Rupprecht","raw_affiliation_strings":["Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210117289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110544624","display_name":"Alexander Tappe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117289","display_name":"Sartorius (Germany)","ror":"https://ror.org/01nvz9x61","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210117289"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Tappe","raw_affiliation_strings":["Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210117289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087267889","display_name":"Gerhard Greller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117289","display_name":"Sartorius (Germany)","ror":"https://ror.org/01nvz9x61","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210117289"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard Greller","raw_affiliation_strings":["Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210117289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041231390","display_name":"Paula M. Alves","orcid":"https://orcid.org/0000-0003-1445-3556","observed_orcids":["https://orcid.org/0000-0003-1445-3556"]},"institutions":[{"id":"https://openalex.org/I4210159117","display_name":"Instituto de Biologia Experimental e Tecnol\u00f3gica","ror":"https://ror.org/0599z7n30","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210159117"]},{"id":"https://openalex.org/I4405278324","display_name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier","ror":"https://ror.org/05qd25g49","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paula Alves","raw_affiliation_strings":["Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal; Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal","Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal","Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal; Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal","institution_ids":["https://openalex.org/I4210159117","https://openalex.org/I4405278324","https://openalex.org/I83558840"]},{"raw_affiliation_string":"Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal","institution_ids":["https://openalex.org/I4210159117"]},{"raw_affiliation_string":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal","institution_ids":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021060711","display_name":"Manuel J.T. Carrondo","orcid":"https://orcid.org/0000-0002-4550-4574","observed_orcids":["https://orcid.org/0000-0002-4550-4574"]},"institutions":[{"id":"https://openalex.org/I4210159117","display_name":"Instituto de Biologia Experimental e Tecnol\u00f3gica","ror":"https://ror.org/0599z7n30","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210159117"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Manuel Carrondo","raw_affiliation_strings":["Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal","institution_ids":["https://openalex.org/I4210159117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066601894","display_name":"Ant\u00f3nio Rold\u00e3o","orcid":"https://orcid.org/0000-0003-0414-4899","observed_orcids":["https://orcid.org/0000-0003-0414-4899"]},"institutions":[{"id":"https://openalex.org/I4210159117","display_name":"Instituto de Biologia Experimental e Tecnol\u00f3gica","ror":"https://ror.org/0599z7n30","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210159117"]},{"id":"https://openalex.org/I4405278324","display_name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier","ror":"https://ror.org/05qd25g49","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Ant\u00f3nio Rold\u00e3o","raw_affiliation_strings":["Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal; Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal. Electronic address: aroldao@ibet.pt","Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal","Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-0414-4899","affiliations":[{"raw_affiliation_string":"Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal; Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal. Electronic address: aroldao@ibet.pt","institution_ids":["https://openalex.org/I4210159117","https://openalex.org/I4405278324","https://openalex.org/I83558840"]},{"raw_affiliation_string":"Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras 2780-901, Portugal","institution_ids":["https://openalex.org/I4210159117"]},{"raw_affiliation_string":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal","institution_ids":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066601894"],"corresponding_institution_ids":["https://openalex.org/I4210159117","https://openalex.org/I4405278324","https://openalex.org/I83558840"],"apc_list":{"value":2450,"currency":"USD","value_usd":2450},"apc_paid":{"value":2450,"currency":"USD","value_usd":2450},"fwci":0.586,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.60555204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"37","issue":"47","first_page":"7041","last_page":"7051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/process-intensification","display_name":"process intensification","score":0.9010000228881836},{"id":"https://openalex.org/keywords/vero-cells","display_name":"Vero cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/serum-free-medium","display_name":"serum-free medium","score":0.902999997138977},{"id":"https://openalex.org/keywords/stirred-tank-bioreactor","display_name":"stirred tank bioreactor","score":0.8730000257492065},{"id":"https://openalex.org/keywords/scale-up","display_name":"scale-up","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C176999471","wikidata":"https://www.wikidata.org/wiki/Q6839314","display_name":"Microcarrier","level":3,"score":0.9200377464294434},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.891045331954956},{"id":"https://openalex.org/C4916135","wikidata":"https://www.wikidata.org/wiki/Q4119055","display_name":"Bioprocess","level":2,"score":0.5776591300964355},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5436586141586304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5261570811271667},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4820736050605774},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.4494006633758545},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.42527422308921814},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.33118122816085815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2751791775226593},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012418","descriptor_name":"Ruminants","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018107","descriptor_name":"Peste-des-petits-ruminants virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D029021","descriptor_name":"Peste-des-Petits-Ruminants","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.vaccine.2019.07.009","doi":"https://doi.org/10.1016/j.vaccine.2019.07.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2019.07.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X19308874/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},{"id":"pmid:31402239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31402239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.vaccine.2019.07.009","doi":"https://doi.org/10.1016/j.vaccine.2019.07.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2019.07.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X19308874/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6773999929428101,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"},{"score":0.6735000014305115,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"},{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1516346500","display_name":null,"funder_award_id":"01-0145","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2673245850","display_name":null,"funder_award_id":"PT2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3893482033","display_name":null,"funder_award_id":"LISBOA\u201001\u20100145\u2010FEDER\u2010007344","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6143387732","display_name":"Next Generation Seasonal Influenza Vaccines: Towards a VLP-based Production Platform","funder_award_id":"IF/01704/2014/CP1229/CT0001","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6504024958","display_name":null,"funder_award_id":"IF/01704/2014","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7123698595","display_name":null,"funder_award_id":"CT0001","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G946021960","display_name":null,"funder_award_id":"LISBOA-01-0145-FEDER","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320324228","display_name":"Centre de Coop\u00e9ration Internationale en Recherche Agronomique pour le D\u00e9veloppement","ror":"https://ror.org/05kpkpg04"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2968097295.pdf","grobid_xml":"https://content.openalex.org/works/W2968097295.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W24507448","https://openalex.org/W33636737","https://openalex.org/W62193260","https://openalex.org/W179362921","https://openalex.org/W849469014","https://openalex.org/W1021421801","https://openalex.org/W1050738719","https://openalex.org/W1452316399","https://openalex.org/W1511780372","https://openalex.org/W1545616820","https://openalex.org/W1546039099","https://openalex.org/W1590608194","https://openalex.org/W1696859219","https://openalex.org/W1938840020","https://openalex.org/W1970939201","https://openalex.org/W1971125791","https://openalex.org/W1972816511","https://openalex.org/W1980709271","https://openalex.org/W1987701748","https://openalex.org/W1995376869","https://openalex.org/W1995924547","https://openalex.org/W2001745898","https://openalex.org/W2007823749","https://openalex.org/W2012725345","https://openalex.org/W2038323479","https://openalex.org/W2054983931","https://openalex.org/W2057328561","https://openalex.org/W2057457796","https://openalex.org/W2059292696","https://openalex.org/W2066858026","https://openalex.org/W2077293277","https://openalex.org/W2078673114","https://openalex.org/W2080584920","https://openalex.org/W2084605980","https://openalex.org/W2086466918","https://openalex.org/W2092128952","https://openalex.org/W2092237558","https://openalex.org/W2098152450","https://openalex.org/W2102811382","https://openalex.org/W2106221695","https://openalex.org/W2119888383","https://openalex.org/W2139521806","https://openalex.org/W2141645094","https://openalex.org/W2159200529","https://openalex.org/W2164733956","https://openalex.org/W2167850151","https://openalex.org/W2168865373","https://openalex.org/W2342202594","https://openalex.org/W2409925039","https://openalex.org/W2580933284","https://openalex.org/W2607334636","https://openalex.org/W2769996555","https://openalex.org/W2793797393","https://openalex.org/W2800956912","https://openalex.org/W2803412611","https://openalex.org/W6806864091"],"related_works":["https://openalex.org/W2054983931","https://openalex.org/W2787116280","https://openalex.org/W3214080520","https://openalex.org/W4206679412","https://openalex.org/W3109153290","https://openalex.org/W4205569048","https://openalex.org/W2803412611","https://openalex.org/W3080525280","https://openalex.org/W2359871843","https://openalex.org/W2025073786"],"abstract_inverted_index":{"Process":[0],"intensification":[1],"for":[2,36,134,199,250],"Peste":[3,239],"des":[4,240],"Petites":[5,241],"Ruminants":[6,242],"Virus":[7],"(PPRV)":[8],"vaccine":[9,38,227],"production":[10,39,155,201,228],"in":[11,40,49,97,156,177,197,202,272],"anchorage":[12],"dependent":[13],"Vero":[14,41,60],"cells":[15,42,61],"is":[16],"challenging,":[17],"involving":[18],"substantial":[19],"amount":[20],"of":[21,31,150,217,263,268],"bioprocess":[22,35],"development.":[23],"In":[24],"this":[25],"study,":[26],"we":[27],"describe":[28],"the":[29,113,119,132,157,194,213,218,233,237],"implementation":[30],"a":[32,127,135,260,277],"new,":[33],"scalable":[34,226],"PPRV":[37,154,175,200],"using":[43,103,276],"serum-free":[44],"medium":[45],"(SFM),":[46],"microcarrier":[47],"technology":[48],"stirred-tank":[50],"bioreactors":[51],"(STB),":[52],"in-situ":[53,82,114],"cell":[54,83,99,115,151],"detachment":[55,84,116],"from":[56,126],"microcarriers":[57],"and":[58,142,153,160,166,188,204,215,225],"perfusion.":[59],"were":[62],"successfully":[63,87],"adapted":[64],"to":[65,72,94,107,121,235],"ProVero\u2122-1":[66],"SFM,":[67],"reaching":[68],"growth":[69,152],"rates":[70],"similar":[71],"serum-containing":[73],"cultures":[74],"(0.030":[75],"1/h":[76],"vs":[77],"0.026":[78],"1/h,":[79],"respectively).":[80],"An":[81],"method":[85,117],"was":[86,101,164],"implemented,":[88],"with":[89,112,259],"efficiencies":[90],"above":[91],"85%.":[92],"Up":[93],"2.5-fold":[95],"increase":[96],"maximum":[98],"concentration":[100],"obtained":[102],"perfusion":[104,111],"when":[105],"compared":[106],"batch":[108],"culture.":[109],"Combining":[110],"enabled":[118],"scale-up":[120],"20":[122,161,278],"L":[123,129,140,159,162,279],"STB":[124,163,203],"directly":[125],"2":[128,158],"STB,":[130],"surpassing":[131],"need":[133],"mid-scale":[136],"platform":[137,261],"(i.e.":[138],"5":[139,185],"STB)":[141],"thus":[143,211],"reducing":[144],"seed":[145,219],"train":[146,220],"duration.":[147],"Head-to-head":[148],"comparison":[149],"performed,":[165],"no":[167],"significant":[168],"differences":[169],"could":[170],"be":[171],"observed.":[172],"Estimated":[173],"infectious":[174],"titers":[176],"Tissue":[178],"Culture":[179],"Infection":[180],"Dose":[181],"(TCID50)":[182],"(TCID50/mL":[183],"=":[184,190],"\u00d7":[186],"106":[187],"TCID50/cell":[189],"5)":[191],"are":[192],"within":[193],"log-range":[195],"reported":[196],"literature":[198],"SFM":[205],"by":[206,248,252],"Silva":[207],"et":[208],"al.":[209],"(2008),":[210],"confirming":[212],"feasibility":[214],"scalability":[216],"designed":[221],"[1].":[222],"The":[223],"novel":[224],"process":[229],"herein":[230],"proposed":[231],"has":[232],"potential":[234],"assist":[236],"upcoming":[238],"(PPR)":[243],"Global":[244],"Eradication":[245],"Program":[246],"(targeted":[247],"FAAO":[249],"2030)":[251],"providing":[253],"African":[254],"local":[255],"and/or":[256],"regional":[257],"manufacturers":[258],"capable":[262],"generating":[264],"over":[265],"25,000":[266],"doses":[267],"Nigeria":[269],"75/1":[270],"strain":[271],"just":[273],"19":[274],"days":[275],"STB.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-22T00:00:00"}