{"id":"https://openalex.org/W2968097188","doi":"https://doi.org/10.1371/journal.pone.0220711","title":"Computational analysis of high-risk SNPs in human CHK2 gene responsible for hereditary breast cancer: A functional and structural impact","display_name":"Computational analysis of high-risk SNPs in human CHK2 gene responsible for hereditary breast cancer: A functional and structural impact","publication_year":2019,"publication_date":"2019-08-09","ids":{"openalex":"https://openalex.org/W2968097188","doi":"https://doi.org/10.1371/journal.pone.0220711","mag":"2968097188","pmid":"https://pubmed.ncbi.nlm.nih.gov/31398194","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6688789"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0220711","doi":"https://doi.org/10.1371/journal.pone.0220711","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0220711","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0220711&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0220711&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049827384","display_name":"Nutan V. Badgujar","orcid":"https://orcid.org/0000-0002-2408-6481","observed_orcids":["https://orcid.org/0000-0002-2408-6481"]},"institutions":[{"id":"https://openalex.org/I135230010","display_name":"Gujarat Cancer & Research Institute","ror":"https://ror.org/015bxyv30","country_code":"IN","type":"facility","lineage":["https://openalex.org/I135230010"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nutan V. Badgujar","raw_affiliation_strings":["Stem Cell Biology Lab, Department of Cancer Biology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Biology Lab, Department of Cancer Biology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India","institution_ids":["https://openalex.org/I135230010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012657341","display_name":"Bhoomi V. Tarapara","orcid":"https://orcid.org/0000-0001-9262-925X","observed_orcids":["https://orcid.org/0000-0001-9262-925X"]},"institutions":[{"id":"https://openalex.org/I135230010","display_name":"Gujarat Cancer & Research Institute","ror":"https://ror.org/015bxyv30","country_code":"IN","type":"facility","lineage":["https://openalex.org/I135230010"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bhoomi V. Tarapara","raw_affiliation_strings":["Stem Cell Biology Lab, Department of Cancer Biology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Biology Lab, Department of Cancer Biology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India","institution_ids":["https://openalex.org/I135230010"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038960798","display_name":"Franky Dhaval Shah","orcid":"https://orcid.org/0000-0002-7265-2839","observed_orcids":["https://orcid.org/0000-0002-7265-2839"]},"institutions":[{"id":"https://openalex.org/I135230010","display_name":"Gujarat Cancer & Research Institute","ror":"https://ror.org/015bxyv30","country_code":"IN","type":"facility","lineage":["https://openalex.org/I135230010"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Franky D. Shah","raw_affiliation_strings":["Stem Cell Biology Lab, Department of Cancer Biology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India"],"raw_orcid":"https://orcid.org/0000-0002-7265-2839","affiliations":[{"raw_affiliation_string":"Stem Cell Biology Lab, Department of Cancer Biology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India","institution_ids":["https://openalex.org/I135230010"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038960798"],"corresponding_institution_ids":["https://openalex.org/I135230010"],"apc_list":{"value":1595,"currency":"USD","value_usd":1595},"apc_paid":{"value":1595,"currency":"USD","value_usd":1595},"fwci":1.5309,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.80922928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"14","issue":"8","first_page":"e0220711","last_page":"e0220711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.13609999418258667,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonsynonymous-snps","display_name":"non-synonymous SNPs","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hereditary-breast-cancer","display_name":"hereditary breast cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.6880000233650208},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8159999847412109},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.46700000762939453},{"id":"https://openalex.org/keywords/functional-impact-of-mutations","display_name":"functional impact of mutations","score":0.5740000009536743},{"id":"https://openalex.org/keywords/fha-domain","display_name":"FHA domain","score":0.7799999713897705},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.36800000071525574},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6764988899230957},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6087435483932495},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5922855138778687},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5473525524139404},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.515168309211731},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.47008752822875977},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43418365716934204},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3975452482700348},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3632153272628784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13280653953552246},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08752048015594482},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0220711","doi":"https://doi.org/10.1371/journal.pone.0220711","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0220711","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0220711&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:31398194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31398194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6688789","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6688789/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:82790c2187274023ab0fecfaba8430de","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/82790c2187274023ab0fecfaba8430de","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 14, Iss 8, p e0220711 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0220711","doi":"https://doi.org/10.1371/journal.pone.0220711","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0220711","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0220711&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325506","display_name":"Gujarat Cancer and Research Institute","ror":"https://ror.org/015bxyv30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2968097188.pdf","grobid_xml":"https://content.openalex.org/works/W2968097188.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1480741751","https://openalex.org/W1545084887","https://openalex.org/W1567221268","https://openalex.org/W1571439191","https://openalex.org/W1972614331","https://openalex.org/W1988876917","https://openalex.org/W1991227314","https://openalex.org/W2000446586","https://openalex.org/W2008967059","https://openalex.org/W2012718299","https://openalex.org/W2028044172","https://openalex.org/W2034195376","https://openalex.org/W2039878336","https://openalex.org/W2058005740","https://openalex.org/W2063588256","https://openalex.org/W2063714349","https://openalex.org/W2069518838","https://openalex.org/W2069732046","https://openalex.org/W2074986801","https://openalex.org/W2089335658","https://openalex.org/W2099564671","https://openalex.org/W2102668767","https://openalex.org/W2109372707","https://openalex.org/W2111427849","https://openalex.org/W2116423958","https://openalex.org/W2117355601","https://openalex.org/W2120949690","https://openalex.org/W2121519777","https://openalex.org/W2124052876","https://openalex.org/W2126234813","https://openalex.org/W2132752562","https://openalex.org/W2134043317","https://openalex.org/W2135174775","https://openalex.org/W2137843575","https://openalex.org/W2139915497","https://openalex.org/W2140538197","https://openalex.org/W2143238378","https://openalex.org/W2146084306","https://openalex.org/W2149195137","https://openalex.org/W2153544371","https://openalex.org/W2166548889","https://openalex.org/W2167690210","https://openalex.org/W2168621448","https://openalex.org/W2169068990","https://openalex.org/W2170984483","https://openalex.org/W2171898962","https://openalex.org/W2266784506","https://openalex.org/W2340844837","https://openalex.org/W2400927555","https://openalex.org/W2401241322","https://openalex.org/W2406551390","https://openalex.org/W2502699228","https://openalex.org/W2513124755","https://openalex.org/W2521270390","https://openalex.org/W2557981253","https://openalex.org/W2562940941","https://openalex.org/W2604460686","https://openalex.org/W2612846717","https://openalex.org/W2736063065","https://openalex.org/W2905302488","https://openalex.org/W2921065824","https://openalex.org/W4235517641"],"related_works":["https://openalex.org/W7135618972","https://openalex.org/W2057659399","https://openalex.org/W4401607535","https://openalex.org/W2943736050","https://openalex.org/W2969674185","https://openalex.org/W4200093073","https://openalex.org/W2069732046","https://openalex.org/W170437174","https://openalex.org/W3136958391","https://openalex.org/W69903773"],"abstract_inverted_index":{"Nowadays":[0],"CHK2":[1,17,46,83,109,159,230,251,269],"mutation":[2,237,248],"is":[3,18,47,75,245,263],"studied":[4],"frequently":[5],"in":[6,13,30,41,123,194,204,216,227,249,275,292,300],"hereditary":[7],"breast":[8,66],"and":[9,39,151,175,186,200,224,290],"ovarian":[10],"cancer":[11],"patients":[12],"addition":[14],"to":[15,43,77,97,103,191,240,256,297],"BRCA1/BRCA2.":[16],"a":[19,25,48,246],"tumor":[20],"suppressor":[21],"gene":[22,52,60,270],"that":[23,53,111,236],"encodes":[24],"serine/threonine":[26],"kinase,":[27],"also":[28,291],"involved":[29,193],"pathways":[31],"such":[32],"as":[33],"DNA":[34,44],"repair,":[35],"cell":[36],"cycle":[37],"regulation":[38],"apoptosis":[40],"response":[42],"damage.":[45],"well-studied":[49],"moderate":[50],"penetrance":[51],"correlates":[54],"with":[55,61,181,231],"third":[56],"high":[57],"risk":[58,64],"susceptibility":[59],"an":[62],"increased":[63],"for":[65],"cancer.":[67],"Hence":[68],"before":[69],"planning":[70],"large":[71,287],"population":[72],"study,":[73,90,267],"it":[74,279],"better":[76],"scrutinize":[78],"putative":[79],"functional":[80],"SNPs":[81],"of":[82,108,154,157,184,218,221,229,238,282,303],"using":[84,274],"different":[85,122],"computational":[86,95],"tools.":[87],"In":[88],"this":[89,115],"we":[91],"have":[92],"used":[93],"various":[94],"approaches":[96],"identify":[98],"nsSNPs":[99,162],"which":[100,253],"are":[101,177,272],"deleterious":[102],"the":[104,264,301],"structure":[105],"and/or":[106],"function":[107],"protein":[110,252],"might":[112,225,254],"be":[113,192,281],"causing":[114,260],"disease.":[116,261],"Computational":[117],"analysis":[118],"was":[119],"performed":[120],"by":[121],"silico":[124,276],"tools":[125,277],"including":[126],"SIFT,":[127],"Align":[128],"GVGD,":[129],"SNAP-2,":[130],"PROVEAN,":[131],"Poly-Phen-2,":[132],"PANTHER,":[133],"PhD-SNP,":[134],"MUpro,":[135],"iPTREE-STAB,":[136],"Consurf,":[137],"InterPro,":[138],"NCBI":[139],"Conserved":[140],"Domain":[141],"Search":[142],"tool,":[143],"ModPred,":[144],"SPARKS-X,":[145],"RAMPAGE,":[146],"Verify-3D,":[147],"FT":[148],"Site,":[149],"COACH":[150],"PyMol.":[152],"Out":[153],"78":[155],"nsSNP":[156,188],"human":[158],"gene,":[160],"seven":[161,171],"were":[163,189],"predicted":[164,190],"functionally":[165],"most":[166],"significant":[167],"SNPs.":[168],"Among":[169],"these":[170,298],"nsSNP,":[172],"p.Arg160Gly,":[173],"p.Gly210Arg":[174,201],"p.Ser415Phe":[176,213],"highly":[178],"conserved":[179,210],"residues":[180],"conservation":[182],"score":[183],"9":[185],"three":[187],"post":[195],"translational":[196],"modification.":[197],"The":[198,212,233],"p.Arg160Gly":[199],"may":[202,214],"interfere":[203,215,226],"phosphopeptide":[205],"binding":[206],"site":[207],"on":[208],"FHA":[209],"domain.":[211],"formation":[217],"activation":[219],"loop":[220],"protein-kinase":[222],"domain":[223],"interactions":[228],"ligand.":[232],"study":[234],"concludes":[235],"serine":[239],"phenylalanine":[241],"at":[242],"position":[243],"415":[244],"major":[247],"native":[250],"contribute":[255],"its":[257],"malfunction,":[258],"ultimately":[259],"This":[262],"first":[265],"comprehensive":[266],"where":[268],"variants":[271],"analyzed":[273],"hence":[278],"will":[280],"great":[283],"help":[284],"while":[285],"considering":[286],"scale":[288],"studies":[289],"developing":[293],"precision":[294],"medicines":[295],"related":[296],"polymorphisms":[299],"era":[302],"personalized":[304],"medicine.":[305]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-08-22T00:00:00"}