{"id":"https://openalex.org/W2968065037","doi":"https://doi.org/10.1111/ejn.14547","title":"Neurobiology of resilience in depression: immune and vascular insights from human and animal studies","display_name":"Neurobiology of resilience in depression: immune and vascular insights from human and animal studies","publication_year":2019,"publication_date":"2019-08-17","ids":{"openalex":"https://openalex.org/W2968065037","doi":"https://doi.org/10.1111/ejn.14547","mag":"2968065037","pmid":"https://pubmed.ncbi.nlm.nih.gov/31421056","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7891571"},"language":"en","primary_location":{"id":"doi:10.1111/ejn.14547","doi":"https://doi.org/10.1111/ejn.14547","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ejn.14547","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1111/ejn.14547","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054985515","display_name":"Katarzyna Dudek","orcid":"https://orcid.org/0000-0003-4894-5268","observed_orcids":["https://orcid.org/0000-0003-4894-5268"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405287202","display_name":"Centre de recherche CERVO","ror":"https://ror.org/04d9mwe30","country_code":"CA","type":"facility","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4392738268","https://openalex.org/I4405279980","https://openalex.org/I4405287202"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Katarzyna A. Dudek","raw_affiliation_strings":["Department of Psychiatry and Neuroscience Faculty of Medicine and CERVO Brain Research Center Universit\u00e9 Laval Quebec City QC Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neuroscience Faculty of Medicine and CERVO Brain Research Center Universit\u00e9 Laval Quebec City QC Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405287202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013551361","display_name":"Laurence Dion\u2010Albert","orcid":"https://orcid.org/0000-0002-7051-6390","observed_orcids":["https://orcid.org/0000-0002-7051-6390"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405287202","display_name":"Centre de recherche CERVO","ror":"https://ror.org/04d9mwe30","country_code":"CA","type":"facility","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4392738268","https://openalex.org/I4405279980","https://openalex.org/I4405287202"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Laurence Dion\u2010Albert","raw_affiliation_strings":["Department of Psychiatry and Neuroscience Faculty of Medicine and CERVO Brain Research Center Universit\u00e9 Laval Quebec City QC Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neuroscience Faculty of Medicine and CERVO Brain Research Center Universit\u00e9 Laval Quebec City QC Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405287202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058413813","display_name":"Fernanda Neutzling Kaufmann","orcid":"https://orcid.org/0000-0002-8175-8600","observed_orcids":["https://orcid.org/0000-0002-8175-8600"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405287202","display_name":"Centre de recherche CERVO","ror":"https://ror.org/04d9mwe30","country_code":"CA","type":"facility","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4392738268","https://openalex.org/I4405279980","https://openalex.org/I4405287202"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fernanda Neutzling Kaufmann","raw_affiliation_strings":["Department of Psychiatry and Neuroscience Faculty of Medicine and CERVO Brain Research Center Universit\u00e9 Laval Quebec City QC Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neuroscience Faculty of Medicine and CERVO Brain Research Center Universit\u00e9 Laval Quebec City QC Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405287202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009998083","display_name":"Ellen Tuck","orcid":"https://orcid.org/0000-0001-6997-8056","observed_orcids":["https://orcid.org/0000-0001-6997-8056"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Ellen Tuck","raw_affiliation_strings":["Smurfit Institute of Genetics, Trinity College, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Smurfit Institute of Genetics, Trinity College, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087528342","display_name":"Manon Lebel","orcid":"https://orcid.org/0000-0003-1649-1214","observed_orcids":["https://orcid.org/0000-0003-1649-1214"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405287202","display_name":"Centre de recherche CERVO","ror":"https://ror.org/04d9mwe30","country_code":"CA","type":"facility","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4392738268","https://openalex.org/I4405279980","https://openalex.org/I4405287202"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Manon Lebel","raw_affiliation_strings":["Department of Psychiatry and Neuroscience Faculty of Medicine and CERVO Brain Research Center Universit\u00e9 Laval Quebec City QC Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neuroscience Faculty of Medicine and CERVO Brain Research Center Universit\u00e9 Laval Quebec City QC Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405287202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062929009","display_name":"Caroline M\u00e9nard","orcid":"https://orcid.org/0000-0001-8202-7378","observed_orcids":["https://orcid.org/0000-0001-8202-7378"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405287202","display_name":"Centre de recherche CERVO","ror":"https://ror.org/04d9mwe30","country_code":"CA","type":"facility","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4392738268","https://openalex.org/I4405279980","https://openalex.org/I4405287202"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Caroline Menard","raw_affiliation_strings":["Department of Psychiatry and Neuroscience Faculty of Medicine and CERVO Brain Research Center Universit\u00e9 Laval Quebec City QC Canada"],"raw_orcid":"https://orcid.org/0000-0001-8202-7378","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neuroscience Faculty of Medicine and CERVO Brain Research Center Universit\u00e9 Laval Quebec City QC Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405287202"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062929009"],"corresponding_institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405287202"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.2685,"has_fulltext":false,"cited_by_count":168,"citation_normalized_percentile":{"value":0.77419355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"53","issue":"1","first_page":"183","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.7710000276565552,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.7710000276565552,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.17990000545978546,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9369999766349792},{"id":"https://openalex.org/keywords/resilience","display_name":"resilience","score":0.6119999885559082},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.8330000042915344},{"id":"https://openalex.org/keywords/stress-vulnerability","display_name":"stress vulnerability","score":0.7609999775886536},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.5090000033378601},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.871999979019165},{"id":"https://openalex.org/keywords/cardiovascular-comorbidity","display_name":"cardiovascular comorbidity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/antidepressant-resistance","display_name":"antidepressant resistance","score":0.7319999933242798},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6729999780654907},{"id":"https://openalex.org/keywords/rodent-models-of-depression","display_name":"rodent models of depression","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hormonal-response","display_name":"endocrine response","score":0.7160000205039978},{"id":"https://openalex.org/keywords/vascular-changes","display_name":"vascular changes","score":0.4129999876022339},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6556121110916138},{"id":"https://openalex.org/C2779585090","wikidata":"https://www.wikidata.org/wiki/Q3457762","display_name":"Resilience (materials science)","level":2,"score":0.6381962299346924},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6253507137298584},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5753089189529419},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5486897826194763},{"id":"https://openalex.org/C2778875871","wikidata":"https://www.wikidata.org/wiki/Q4764954","display_name":"Animal models of depression","level":4,"score":0.49627023935317993},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.44378378987312317},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.42709916830062866},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.36367249488830566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25636810064315796},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25262415409088135},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17253994941711426},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.12417629361152649},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07568404078483582},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000223","descriptor_name":"Adaptation, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009446","descriptor_name":"Neurobiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/ejn.14547","doi":"https://doi.org/10.1111/ejn.14547","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ejn.14547","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7891571","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7891571","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur J Neurosci","raw_type":"Text"},{"id":"pmid:31421056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31421056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:corpus.ulaval.ca:20.500.11794/39978","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11794/39978","pdf_url":null,"source":{"id":"https://openalex.org/S4306400293","display_name":"Corpus Universit\u00e9 Laval (Universit\u00e9 Laval)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43406934","host_organization_name":"Universit\u00e9 Laval","host_organization_lineage":["https://openalex.org/I43406934"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article de recherche"}],"best_oa_location":{"id":"doi:10.1111/ejn.14547","doi":"https://doi.org/10.1111/ejn.14547","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ejn.14547","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306147","display_name":"Brain and Behavior Research Foundation","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320326644","display_name":"Canada First Research Excellence Fund","ror":"https://ror.org/01ktx4s83"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":427,"referenced_works":["https://openalex.org/W70778864","https://openalex.org/W71703336","https://openalex.org/W91600810","https://openalex.org/W105790761","https://openalex.org/W188961659","https://openalex.org/W972583108","https://openalex.org/W1480729244","https://openalex.org/W1487848522","https://openalex.org/W1489136175","https://openalex.org/W1506045573","https://openalex.org/W1513845930","https://openalex.org/W1514423159","https://openalex.org/W1518423770","https://openalex.org/W1553712313","https://openalex.org/W1554042779","https://openalex.org/W1567691403","https://openalex.org/W1570428653","https://openalex.org/W1574222693","https://openalex.org/W1576427485","https://openalex.org/W1588685142","https://openalex.org/W1601899128","https://openalex.org/W1625833818","https://openalex.org/W1654634226","https://openalex.org/W1697553032","https://openalex.org/W1806368578","https://openalex.org/W1828600263","https://openalex.org/W1830916283","https://openalex.org/W1878942803","https://openalex.org/W1897972863","https://openalex.org/W1916200225","https://openalex.org/W1941997998","https://openalex.org/W1954315312","https://openalex.org/W1958676502","https://openalex.org/W1962480635","https://openalex.org/W1963708297","https://openalex.org/W1963713864","https://openalex.org/W1964744961","https://openalex.org/W1964798550","https://openalex.org/W1967214620","https://openalex.org/W1968713831","https://openalex.org/W1969909017","https://openalex.org/W1972886613","https://openalex.org/W1973125755","https://openalex.org/W1973477241","https://openalex.org/W1973810774","https://openalex.org/W1973916547","https://openalex.org/W1973994559","https://openalex.org/W1974253960","https://openalex.org/W1975110303","https://openalex.org/W1975676699","https://openalex.org/W1976597647","https://openalex.org/W1976738806","https://openalex.org/W1977430165","https://openalex.org/W1977593923","https://openalex.org/W1979180489","https://openalex.org/W1979785761","https://openalex.org/W1979924329","https://openalex.org/W1981020037","https://openalex.org/W1981352649","https://openalex.org/W1981466881","https://openalex.org/W1981755144","https://openalex.org/W1981907384","https://openalex.org/W1981984722","https://openalex.org/W1982085687","https://openalex.org/W1983166842","https://openalex.org/W1983242089","https://openalex.org/W1984103995","https://openalex.org/W1984427714","https://openalex.org/W1984572077","https://openalex.org/W1984981155","https://openalex.org/W1985438873","https://openalex.org/W1987836975","https://openalex.org/W1989580462","https://openalex.org/W1990814941","https://openalex.org/W1990985572","https://openalex.org/W1991156200","https://openalex.org/W1992636747","https://openalex.org/W1992874462","https://openalex.org/W1993537924","https://openalex.org/W1993856151","https://openalex.org/W1995596015","https://openalex.org/W1995767136","https://openalex.org/W1996454121","https://openalex.org/W1998509935","https://openalex.org/W1998821779","https://openalex.org/W1999419270","https://openalex.org/W1999744197","https://openalex.org/W2000351290","https://openalex.org/W2000829001","https://openalex.org/W2000956334","https://openalex.org/W2003641508","https://openalex.org/W2003982930","https://openalex.org/W2004181696","https://openalex.org/W2004665610","https://openalex.org/W2004702938","https://openalex.org/W2005471473","https://openalex.org/W2005474456","https://openalex.org/W2006693696","https://openalex.org/W2007266882","https://openalex.org/W2007816528","https://openalex.org/W2007905997","https://openalex.org/W2008225034","https://openalex.org/W2008810019","https://openalex.org/W2009792683","https://openalex.org/W2010359731","https://openalex.org/W2011334992","https://openalex.org/W2011684192","https://openalex.org/W2011710037","https://openalex.org/W2012520574","https://openalex.org/W2012741273","https://openalex.org/W2013245174","https://openalex.org/W2013586266","https://openalex.org/W2013704890","https://openalex.org/W2014498328","https://openalex.org/W2014570372","https://openalex.org/W2016495291","https://openalex.org/W2017752268","https://openalex.org/W2019027336","https://openalex.org/W2019203176","https://openalex.org/W2020977183","https://openalex.org/W2022987442","https://openalex.org/W2023299675","https://openalex.org/W2023560341","https://openalex.org/W2023631628","https://openalex.org/W2025373842","https://openalex.org/W2026113561","https://openalex.org/W2028417725","https://openalex.org/W2028756918","https://openalex.org/W2029334700","https://openalex.org/W2030588597","https://openalex.org/W2030804316","https://openalex.org/W2031558203","https://openalex.org/W2033032062","https://openalex.org/W2033289727","https://openalex.org/W2034041324","https://openalex.org/W2034154165","https://openalex.org/W2034189826","https://openalex.org/W2035025683","https://openalex.org/W2037806725","https://openalex.org/W2039902359","https://openalex.org/W2040518110","https://openalex.org/W2040645020","https://openalex.org/W2040924241","https://openalex.org/W2041352084","https://openalex.org/W2041439089","https://openalex.org/W2041591201","https://openalex.org/W2042430137","https://openalex.org/W2043139614","https://openalex.org/W2043299701","https://openalex.org/W2043553185","https://openalex.org/W2043961643","https://openalex.org/W2044364684","https://openalex.org/W2045322458","https://openalex.org/W2046186483","https://openalex.org/W2046456432","https://openalex.org/W2046597351","https://openalex.org/W2046737138","https://openalex.org/W2046960533","https://openalex.org/W2047318763","https://openalex.org/W2048418520","https://openalex.org/W2048595403","https://openalex.org/W2048734836","https://openalex.org/W2050581082","https://openalex.org/W2052445727","https://openalex.org/W2054155432","https://openalex.org/W2054179832","https://openalex.org/W2054931962","https://openalex.org/W2055408622","https://openalex.org/W2055620105","https://openalex.org/W2056487354","https://openalex.org/W2056784169","https://openalex.org/W2057017838","https://openalex.org/W2057119181","https://openalex.org/W2057615104","https://openalex.org/W2058978987","https://openalex.org/W2059150405","https://openalex.org/W2059658263","https://openalex.org/W2060203137","https://openalex.org/W2060345189","https://openalex.org/W2061929866","https://openalex.org/W2062354466","https://openalex.org/W2062392962","https://openalex.org/W2063026836","https://openalex.org/W2063393311","https://openalex.org/W2063920673","https://openalex.org/W2066760376","https://openalex.org/W2067085553","https://openalex.org/W2067632849","https://openalex.org/W2068080380","https://openalex.org/W2068400560","https://openalex.org/W2068671283","https://openalex.org/W2069353795","https://openalex.org/W2069588969","https://openalex.org/W2069961551","https://openalex.org/W2070447896","https://openalex.org/W2070772124","https://openalex.org/W2071525132","https://openalex.org/W2071721757","https://openalex.org/W2071887266","https://openalex.org/W2072865274","https://openalex.org/W2072874329","https://openalex.org/W2073015829","https://openalex.org/W2073269192","https://openalex.org/W2073704076","https://openalex.org/W2074661552","https://openalex.org/W2074782157","https://openalex.org/W2074802748","https://openalex.org/W2075175167","https://openalex.org/W2075688573","https://openalex.org/W2077129553","https://openalex.org/W2077310230","https://openalex.org/W2078181370","https://openalex.org/W2079320514","https://openalex.org/W2079342201","https://openalex.org/W2080795205","https://openalex.org/W2081596482","https://openalex.org/W2081621134","https://openalex.org/W2082347869","https://openalex.org/W2083221115","https://openalex.org/W2083256590","https://openalex.org/W2083739539","https://openalex.org/W2084079665","https://openalex.org/W2084123893","https://openalex.org/W2084194797","https://openalex.org/W2084333656","https://openalex.org/W2085099489","https://openalex.org/W2086050354","https://openalex.org/W2086158333","https://openalex.org/W2087146795","https://openalex.org/W2087162420","https://openalex.org/W2087356761","https://openalex.org/W2087627032","https://openalex.org/W2087704532","https://openalex.org/W2088450404","https://openalex.org/W2089521828","https://openalex.org/W2090439142","https://openalex.org/W2092605566","https://openalex.org/W2092630217","https://openalex.org/W2093685381","https://openalex.org/W2093850082","https://openalex.org/W2094134187","https://openalex.org/W2094284063","https://openalex.org/W2094660330","https://openalex.org/W2094788265","https://openalex.org/W2095296355","https://openalex.org/W2095361011","https://openalex.org/W2095827218","https://openalex.org/W2096709697","https://openalex.org/W2096751702","https://openalex.org/W2096856326","https://openalex.org/W2097086441","https://openalex.org/W2097533850","https://openalex.org/W2097573610","https://openalex.org/W2097818544","https://openalex.org/W2098082628","https://openalex.org/W2099516158","https://openalex.org/W2103719975","https://openalex.org/W2105973012","https://openalex.org/W2106623141","https://openalex.org/W2108569388","https://openalex.org/W2109290881","https://openalex.org/W2109452045","https://openalex.org/W2109759840","https://openalex.org/W2110508899","https://openalex.org/W2110921107","https://openalex.org/W2111038577","https://openalex.org/W2114678113","https://openalex.org/W2117309811","https://openalex.org/W2119531941","https://openalex.org/W2119810088","https://openalex.org/W2119914329","https://openalex.org/W2119994447","https://openalex.org/W2120226638","https://openalex.org/W2120306544","https://openalex.org/W2120334173","https://openalex.org/W2120987567","https://openalex.org/W2121588628","https://openalex.org/W2122341732","https://openalex.org/W2123011060","https://openalex.org/W2123367689","https://openalex.org/W2123670954","https://openalex.org/W2124949756","https://openalex.org/W2125838820","https://openalex.org/W2126755143","https://openalex.org/W2126795224","https://openalex.org/W2127192021","https://openalex.org/W2131643987","https://openalex.org/W2131830842","https://openalex.org/W2132924600","https://openalex.org/W2134549690","https://openalex.org/W2134702933","https://openalex.org/W2135562556","https://openalex.org/W2136581644","https://openalex.org/W2136765547","https://openalex.org/W2136869363","https://openalex.org/W2137329623","https://openalex.org/W2137996543","https://openalex.org/W2139023977","https://openalex.org/W2139463883","https://openalex.org/W2140454795","https://openalex.org/W2142349354","https://openalex.org/W2144903567","https://openalex.org/W2144903977","https://openalex.org/W2145803099","https://openalex.org/W2145865543","https://openalex.org/W2145890122","https://openalex.org/W2146122014","https://openalex.org/W2146291241","https://openalex.org/W2146758523","https://openalex.org/W2148992136","https://openalex.org/W2150734066","https://openalex.org/W2150896891","https://openalex.org/W2152934881","https://openalex.org/W2154340809","https://openalex.org/W2155686640","https://openalex.org/W2159009152","https://openalex.org/W2159178030","https://openalex.org/W2159443316","https://openalex.org/W2159816974","https://openalex.org/W2159821105","https://openalex.org/W2160935383","https://openalex.org/W2167216405","https://openalex.org/W2167739272","https://openalex.org/W2169695492","https://openalex.org/W2170202759","https://openalex.org/W2170684975","https://openalex.org/W2170724437","https://openalex.org/W2171030454","https://openalex.org/W2171848652","https://openalex.org/W2171912692","https://openalex.org/W2172467955","https://openalex.org/W2175927969","https://openalex.org/W2192342554","https://openalex.org/W2194524147","https://openalex.org/W2199203598","https://openalex.org/W2201607793","https://openalex.org/W2206933179","https://openalex.org/W2235724087","https://openalex.org/W2245537484","https://openalex.org/W2248379178","https://openalex.org/W2258507793","https://openalex.org/W2273021913","https://openalex.org/W2276165451","https://openalex.org/W2284813719","https://openalex.org/W2291292537","https://openalex.org/W2298433114","https://openalex.org/W2308164839","https://openalex.org/W2315187051","https://openalex.org/W2323040745","https://openalex.org/W2325341530","https://openalex.org/W2333510934","https://openalex.org/W2334702670","https://openalex.org/W2346213377","https://openalex.org/W2372521931","https://openalex.org/W2397426560","https://openalex.org/W2403852705","https://openalex.org/W2407849915","https://openalex.org/W2413515606","https://openalex.org/W2443768325","https://openalex.org/W2473407108","https://openalex.org/W2477580207","https://openalex.org/W2518536270","https://openalex.org/W2549439587","https://openalex.org/W2550356572","https://openalex.org/W2555294804","https://openalex.org/W2556483487","https://openalex.org/W2582903515","https://openalex.org/W2591605663","https://openalex.org/W2592677663","https://openalex.org/W2596323490","https://openalex.org/W2601585445","https://openalex.org/W2605062075","https://openalex.org/W2608545681","https://openalex.org/W2617360094","https://openalex.org/W2618472850","https://openalex.org/W2625350969","https://openalex.org/W2626018769","https://openalex.org/W2626448348","https://openalex.org/W2656568860","https://openalex.org/W2727163725","https://openalex.org/W2739173143","https://openalex.org/W2743887053","https://openalex.org/W2761181514","https://openalex.org/W2762868429","https://openalex.org/W2765474597","https://openalex.org/W2766051881","https://openalex.org/W2766343543","https://openalex.org/W2766821888","https://openalex.org/W2767047170","https://openalex.org/W2767440265","https://openalex.org/W2777976393","https://openalex.org/W2787781459","https://openalex.org/W2789582745","https://openalex.org/W2793970618","https://openalex.org/W2794098750","https://openalex.org/W2795360338","https://openalex.org/W2797528967","https://openalex.org/W2798136647","https://openalex.org/W2808196202","https://openalex.org/W2808882111","https://openalex.org/W2853214301","https://openalex.org/W2884814715","https://openalex.org/W2896061350","https://openalex.org/W2898314619","https://openalex.org/W2898482130","https://openalex.org/W2902125411","https://openalex.org/W2903766786","https://openalex.org/W2907856418","https://openalex.org/W2911080281","https://openalex.org/W2911572355","https://openalex.org/W2912060693","https://openalex.org/W2913403297","https://openalex.org/W2913595316","https://openalex.org/W2913872344","https://openalex.org/W2914018423","https://openalex.org/W2923833103","https://openalex.org/W2926139416","https://openalex.org/W2928956234","https://openalex.org/W2943092371","https://openalex.org/W2943823496","https://openalex.org/W2944105566","https://openalex.org/W2945968921","https://openalex.org/W3149326883","https://openalex.org/W4205522576","https://openalex.org/W4206443588","https://openalex.org/W4247665917","https://openalex.org/W4414130677"],"related_works":["https://openalex.org/W4388680952","https://openalex.org/W4307705776","https://openalex.org/W2911611581","https://openalex.org/W2606878819","https://openalex.org/W2443768325","https://openalex.org/W2946082442","https://openalex.org/W4293242526","https://openalex.org/W2608555252","https://openalex.org/W4409657199","https://openalex.org/W2055457894"],"abstract_inverted_index":{"Major":[0],"depressive":[1],"disorder":[2],"(MDD)":[3],"is":[4,41,57,133,176],"a":[5,92,111,120],"chronic":[6,58],"and":[7,17,47,60,119,135,143,149,157,181,190,200,211,231],"recurrent":[8],"psychiatric":[9],"condition":[10],"characterized":[11],"by":[12],"depressed":[13,32,155],"mood,":[14],"social":[15],"isolation":[16],"anhedonia.":[18],"It":[19],"will":[20],"affect":[21],"20%":[22],"of":[23,31,65,84,98,113,122,131,141,173,197,217,234],"individuals":[24,33,156],"with":[25,186,204],"considerable":[26],"economic":[27],"impacts.":[28],"Unfortunately,":[29],"30-50%":[30],"are":[34,50,152,184],"resistant":[35],"to":[36,80,102,126,167,242],"current":[37],"antidepressant":[38],"treatments.":[39],"MDD":[40,132,179],"twice":[42],"as":[43],"prevalent":[44],"in":[45,67,154,178,209,214],"women":[46,61],"associated":[48,185,203],"symptoms":[49],"different.":[51],"Depression's":[52],"main":[53],"environmental":[54],"risk":[55],"factor":[56],"stress,":[59],"report":[62],"higher":[63,171],"levels":[64],"stress":[66,85,127,205],"daily":[68],"life.":[69],"However,":[70],"not":[71,225],"every":[72],"stressed":[73],"individual":[74],"becomes":[75],"depressed,":[76],"highlighting":[77],"the":[78,104],"need":[79],"identify":[81],"biological":[82,123,229],"determinants":[83],"vulnerability":[86,206],"but":[87],"also":[88],"resilience.":[89,109,128],"Based":[90],"on":[91],"reverse":[93],"translational":[94],"approach,":[95],"rodent":[96],"models":[97],"depression":[99],"were":[100],"developed":[101],"study":[103],"mechanisms":[105,118],"underlying":[106],"susceptibility":[107],"vs":[108],"Indeed,":[110],"subpopulation":[112],"animals":[114],"can":[115],"display":[116],"coping":[117],"set":[121],"alterations":[124],"leading":[125],"The":[129],"aetiology":[130],"multifactorial":[134],"involves":[136],"several":[137],"physiological":[138],"systems.":[139],"Exacerbation":[140],"endocrine":[142],"immune":[144,199],"responses":[145],"from":[146],"both":[147],"innate":[148],"adaptive":[150],"systems":[151],"observed":[153],"mice":[158],"exhibiting":[159],"depression-like":[160],"behaviours.":[161],"Increasing":[162],"attention":[163],"has":[164],"been":[165],"given":[166],"neurovascular":[168],"health":[169],"since":[170],"prevalence":[172],"cardiovascular":[174],"diseases":[175],"found":[177],"patients":[180],"inflammatory":[182],"conditions":[183],"depression,":[187],"treatment":[188,218],"resistance":[189],"relapse.":[191],"Here,":[192],"we":[193],"provide":[194],"an":[195],"overview":[196],"endocrine,":[198],"vascular":[201],"changes":[202],"vs.":[207],"resilience":[208],"rodents":[210],"when":[212],"available,":[213],"humans.":[215],"Lack":[216],"efficacy":[219],"suggests":[220],"that":[221],"neuron-centric":[222],"treatments":[223],"do":[224],"address":[226],"important":[227],"causal":[228],"factors":[230],"better":[232],"understanding":[233],"stress-induced":[235],"adaptations,":[236],"including":[237,247],"sex":[238],"differences,":[239],"could":[240],"contribute":[241],"develop":[243],"novel":[244],"therapeutic":[245],"strategies":[246],"personalized":[248],"medicine":[249],"approaches.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":11},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-08-22T00:00:00"}
