{"id":"https://openalex.org/W2967976783","doi":null,"title":"Development of a serum-based immunoassay for prostate cancer detection.","display_name":"Development of a serum-based immunoassay for prostate cancer detection.","publication_year":2006,"publication_date":"2006-04-15","ids":{"openalex":"https://openalex.org/W2967976783","mag":"2967976783"},"language":"en","primary_location":{"id":"mag:2967976783","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/66/8_Supplement/1240.3","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061878884","display_name":"Christine Chavany","orcid":"https://orcid.org/0009-0006-8354-9112","observed_orcids":["https://orcid.org/0009-0006-8354-9112"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I4210158883","display_name":"Milagen (United States)","ror":"https://ror.org/05h2ydr55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Chavany","raw_affiliation_strings":["Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259","https://openalex.org/I4210158883"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steven S. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I4210158883","display_name":"Milagen (United States)","ror":"https://ror.org/05h2ydr55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven S. Chen","raw_affiliation_strings":["Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259","https://openalex.org/I4210158883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059353711","display_name":"Stephen R. Schramm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I4210158883","display_name":"Milagen (United States)","ror":"https://ror.org/05h2ydr55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R. Schramm","raw_affiliation_strings":["Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259","https://openalex.org/I4210158883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068672350","display_name":"Rosaura P.C. Valle","orcid":"https://orcid.org/0009-0005-8993-8226","observed_orcids":["https://orcid.org/0009-0005-8993-8226"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I4210158883","display_name":"Milagen (United States)","ror":"https://ror.org/05h2ydr55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosaura P.C. Valle","raw_affiliation_strings":["Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259","https://openalex.org/I4210158883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089470479","display_name":"Gunjan Malik","orcid":"https://orcid.org/0009-0003-6705-5858","observed_orcids":["https://orcid.org/0009-0003-6705-5858"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I4210158883","display_name":"Milagen (United States)","ror":"https://ror.org/05h2ydr55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gunjan Malik","raw_affiliation_strings":["Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":"https://orcid.org/0009-0003-6705-5858","affiliations":[{"raw_affiliation_string":"Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259","https://openalex.org/I4210158883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070937942","display_name":"John O. Semmes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I4210158883","display_name":"Milagen (United States)","ror":"https://ror.org/05h2ydr55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Semmes","raw_affiliation_strings":["Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259","https://openalex.org/I4210158883"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113196135","display_name":"Moncef Jendoubi","orcid":"https://orcid.org/0009-0001-5287-1268","observed_orcids":["https://orcid.org/0009-0001-5287-1268"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I4210158883","display_name":"Milagen (United States)","ror":"https://ror.org/05h2ydr55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210158883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moncef Jendoubi","raw_affiliation_strings":["Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Milagen, Inc, Emeryville, CA and Eastern Virginia Medical School, Norfolk, VA","institution_ids":["https://openalex.org/I156802259","https://openalex.org/I4210158883"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44201437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":null,"first_page":"1240","last_page":"1240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.6967999935150146,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.6967999935150146,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.18960000574588776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.051899999380111694,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8920000195503235},{"id":"https://openalex.org/keywords/prostate-cancer-screening","display_name":"prostate cancer screening","score":0.7260000109672546},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.9240000247955322},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.906000018119812},{"id":"https://openalex.org/keywords/multiplex-immunoassay","display_name":"multiplex immunoassay","score":0.7059999704360962},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.4880000054836273},{"id":"https://openalex.org/keywords/early-stage-prostate-cancer","display_name":"early-stage prostate cancer","score":0.5540000200271606},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.5989999771118164},{"id":"https://openalex.org/keywords/chemiluminescence-immunoassay","display_name":"chemiluminescence immunoassay","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7586468458175659},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6823825836181641},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.6668826937675476},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6532623767852783},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.597887396812439},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5224615335464478},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.4996602535247803},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4550318717956543},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44753551483154297},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4085659384727478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34425872564315796},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2227117419242859},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.21782943606376648},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12063431739807129},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2967976783","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/66/8_Supplement/1240.3","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2605285020","https://openalex.org/W1605522383","https://openalex.org/W2156219307","https://openalex.org/W2042919028","https://openalex.org/W2033690284","https://openalex.org/W2046278656","https://openalex.org/W2885770817","https://openalex.org/W4306179296","https://openalex.org/W2013989151","https://openalex.org/W1978949532"],"abstract_inverted_index":{"5290":[0],"Prostate":[2],"cancer":[3,35,285,294],"(PC)":[4],"screening":[5,122,135],"is":[6,18,30,52,305],"currently":[7],"based":[8],"on":[9,159,229],"evaluation":[10],"of":[11,47,97,117,136,143,177,189,198,201,212,233,330,341,358],"prostate":[12,32,102],"specific":[13,33,80,276,362],"antigen":[14],"(PSA),":[15],"however":[16],"there":[17],"insufficient":[19],"evidence":[20],"to":[21,53,111,183,316,333],"recommend":[22],"that":[23,89,203,278,291],"average-risk":[24],"men":[25],"undergo":[26],"regular":[27],"screening.":[28],"PSA":[29,39],"more":[31,77],"than":[34],"specific,":[36],"and":[37,63,79,85,94,113,153,163,174,209,223,252,256,258,286,289,296,302,325,344,355,370],"elevated":[38,281],"can":[40],"also":[41],"be":[42],"found":[43,274],"in":[44,207,218,282,352],"benign":[45,95,101,154],"conditions":[46,96],"the":[48,98,134,190,196],"prostate.":[49],"Our":[50],"aim":[51],"develop":[54,334],"improved":[55],"non-invasive":[56],"serum-based":[57,336],"immunodiagnostic":[58,337],"assays":[59],"for":[60,82,339],"PC":[61,83,213,221,368],"detection":[62,340],"disease":[64,356],"management.":[65],"To":[66],"this":[67],"end,":[68],"we":[69],"have":[70,106,350],"focused":[71],"our":[72,108],"efforts":[73],"on:":[74],"i)":[75],"developing":[76,87],"sensitive":[78],"biomarkers":[81,88,118,202,277,290,348],"screening,":[84],"ii)":[86],"allow":[90],"discrimination":[91],"between":[92],"malignant":[93],"prostate,":[99],"including":[100,235],"hyperplasia":[103],"(BPH).":[104],"We":[105,273,319],"applied":[107,182],"proprietary":[109],"technologies":[110],"discover":[112],"validate":[114],"a":[115,120,140,160,178,199,230,327,335],"panel":[116,200],"using":[119,267],"multiplex":[121],"platform":[123],"known":[124],"as":[125],"Matrix":[126],"Protein":[127],"Array":[128],"Technology":[129],"(MPAT).":[130],"The":[131],"MPAT":[132],"involves":[133],"clinical":[137],"samples":[138,156,222],"with":[139,165],"large":[141,231,328],"collection":[142],"70,000":[144],"distinct":[145],"polyclonal":[146],"antibodies.":[147,167],"Total":[148],"proteome":[149],"from":[150,262,307],"normal,":[151],"cancer,":[152],"serum":[155,237],"was":[157,170,181],"printed":[158],"solid":[161],"support,":[162],"reacted":[164],"individual":[166],"Antibody-sample":[168],"reaction":[169],"detected":[171],"by":[172],"chemiluminescence,":[173],"computer":[175],"analysis":[176,188],"CCD-acquired":[179],"image":[180],"quantify":[184],"each":[185],"spot.":[186],"Statistical":[187],"data":[191],"points":[192],"thus":[193],"generated":[194],"enabled":[195],"selection":[197],"are":[204,313,320],"differentially":[205],"expressed":[206],"early":[208,343,353],"advanced":[210,345],"stage":[211,243,248,298],"versus":[214,220,284,300],"normal":[215,224,254,287,301],"controls,":[216,255],"or":[217],"BPH":[219,275,283,361],"controls.":[225],"Biomarkers":[226,312],"were":[227,260,279],"validated":[228],"number":[232],"samples,":[234,288],"242":[236],"specimens":[238],"comprising":[239],"73":[240],"T1/T2":[241],"(early":[242,295],"PC),":[244,249],"69":[245],"T3/T4":[246],"(advanced":[247],"50":[250,253],"BPH,":[251,342],"sensitivity":[257],"specificity":[259],"determined":[261],"receiver":[263],"operating":[264],"curves":[265],"(ROC)":[266],"statistical":[268],"package":[269],"GB-STAT":[270],"(Dynamic":[271],"microsystem).":[272],"significantly":[280,292],"discriminate":[293],"late":[297],"respectively)":[299],"benign.":[303],"Sensitivity":[304],"ranging":[306],"70-80%":[308],"at":[309],"80%":[310],"specificity.":[311],"being":[314],"combined":[315],"optimize":[317],"sensitivity.":[318],"fully":[321],"characterizing":[322],"these":[323],"biomarkers,":[324],"producing":[326],"supply":[329],"monospecific":[331],"antibodies":[332],"assay":[338],"PC.":[346,359],"These":[347],"may":[349],"application":[351],"detection,":[354,369],"management":[357],"A":[360],"diagnostic":[363],"test":[364],"would":[365],"improve":[366],"accurate":[367],"reduce":[371],"unnecessary":[372],"biopsies.":[373]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-08-22T00:00:00"}
