{"id":"https://openalex.org/W29678825","doi":null,"title":"Emerging therapeutics for rheumatoid arthritis.","display_name":"Emerging therapeutics for rheumatoid arthritis.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W29678825","mag":"29678825","pmid":"https://pubmed.ncbi.nlm.nih.gov/18937634"},"language":"en","primary_location":{"id":"pmid:18937634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18937634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the NYU hospital for joint diseases","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104520389","display_name":"Clifton O. Bingham","orcid":"https://orcid.org/0000-0002-4752-5029","observed_orcids":["https://orcid.org/0000-0002-4752-5029"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clifton O Bingham","raw_affiliation_strings":["John Hopkins University, Baltimore, MD, USA. clifton.bingham@jhmi.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Hopkins University, Baltimore, MD, USA. clifton.bingham@jhmi.edu","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5104520389"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":6.2581,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.96615119,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"66","issue":"3","first_page":"210","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/biological-agents","display_name":"biological agents","score":0.7509999871253967},{"id":"https://openalex.org/keywords/tnf-antagonists","display_name":"TNF antagonists","score":0.9160000085830688},{"id":"https://openalex.org/keywords/il-1-inhibitors","display_name":"IL-1 inhibitors","score":0.7720000147819519},{"id":"https://openalex.org/keywords/abatacept","display_name":"abatacept","score":0.8799999952316284},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9950000047683716},{"id":"https://openalex.org/keywords/certolizumab-pegol","display_name":"certolizumab pegol","score":0.9810000061988831},{"id":"https://openalex.org/keywords/golimumab","display_name":"golimumab","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":0.9399999976158142},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6660000085830688},{"id":"https://openalex.org/keywords/belimumab","display_name":"belimumab","score":0.8840000033378601},{"id":"https://openalex.org/keywords/april","display_name":"APRIL","score":0.7680000066757202},{"id":"https://openalex.org/keywords/b-lymphocyte-stimulator","display_name":"B lymphocyte stimulator","score":0.7419999837875366},{"id":"https://openalex.org/keywords/syk-inhibitors","display_name":"SYK inhibitors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/small-molecule-drugs","display_name":"small molecule drugs","score":0.8100000023841858},{"id":"https://openalex.org/keywords/clinical-trial-efficacy","display_name":"clinical trial efficacy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9418189525604248},{"id":"https://openalex.org/C2779605438","wikidata":"https://www.wikidata.org/wiki/Q2697833","display_name":"Abatacept","level":4,"score":0.7865179181098938},{"id":"https://openalex.org/C2781290027","wikidata":"https://www.wikidata.org/wiki/Q413879","display_name":"Golimumab","level":4,"score":0.7762190103530884},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.7548117637634277},{"id":"https://openalex.org/C2777226972","wikidata":"https://www.wikidata.org/wiki/Q415343","display_name":"Etanercept","level":3,"score":0.7274028062820435},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.6738566160202026},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6343469023704529},{"id":"https://openalex.org/C2781228260","wikidata":"https://www.wikidata.org/wiki/Q415411","display_name":"Anakinra","level":3,"score":0.5734875798225403},{"id":"https://openalex.org/C2778714382","wikidata":"https://www.wikidata.org/wiki/Q410656","display_name":"Ofatumumab","level":4,"score":0.5683423280715942},{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.5460056662559509},{"id":"https://openalex.org/C2776215756","wikidata":"https://www.wikidata.org/wiki/Q412909","display_name":"Certolizumab pegol","level":4,"score":0.5214314460754395},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.5175537467002869},{"id":"https://openalex.org/C2778843634","wikidata":"https://www.wikidata.org/wiki/Q2013780","display_name":"Ocrelizumab","level":4,"score":0.4635559618473053},{"id":"https://openalex.org/C2781205201","wikidata":"https://www.wikidata.org/wiki/Q1996249","display_name":"Belimumab","level":5,"score":0.44961729645729065},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44656071066856384},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4264657497406006},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.3535957932472229},{"id":"https://openalex.org/C170286685","wikidata":"https://www.wikidata.org/wiki/Q409346","display_name":"B-cell activating factor","level":4,"score":0.342009037733078},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26293885707855225},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.15794730186462402},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.15371793508529663},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015507","descriptor_name":"Drugs, Investigational","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18937634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18937634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the NYU hospital for joint diseases","raw_type":"Journal Article"},{"id":"mag:29678825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18937634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1968416967","https://openalex.org/W2008925400","https://openalex.org/W2085684863","https://openalex.org/W2095013915","https://openalex.org/W2100791409","https://openalex.org/W2101583195","https://openalex.org/W2118176175","https://openalex.org/W2134229958","https://openalex.org/W2198961923"],"related_works":["https://openalex.org/W2068359337","https://openalex.org/W2131477449","https://openalex.org/W2046764800","https://openalex.org/W2131657597","https://openalex.org/W2088691921","https://openalex.org/W2117210866","https://openalex.org/W2116271726","https://openalex.org/W2318113264","https://openalex.org/W2965253443","https://openalex.org/W2091435876"],"abstract_inverted_index":{"Therapeutics":[0],"options":[1],"for":[2],"rheumatoid":[3],"arthritis":[4],"(RA)":[5],"have":[6,27,76,87,152],"increased":[7],"tremendously":[8],"in":[9,19,90,118,177],"the":[10,14,39,91],"past":[11],"decade":[12],"with":[13,30,104],"introduction":[15],"of":[16,56,65,95,171],"biological":[17],"agents":[18,86,101,112,121],"1999.":[20],"Several":[21],"different":[22],"cellular":[23],"and":[24,61,111,131,144,163,181],"cytokine":[25,126],"targets":[26,75],"been":[28,77,88,153],"identified,":[29],"specific":[31],"inhibitors":[32,107],"now":[33],"approved":[34],"to":[35,100,141],"treat":[36],"RA,":[37,178],"including":[38,128,161],"tumor":[40],"necrosis":[41],"factor":[42],"(TNF)":[43],"antagonists":[44],"(adalimumab,":[45],"etanercept,":[46],"infliximab),":[47],"an":[48,54],"interleukin":[49],"1":[50],"(IL1)":[51],"antagonist":[52],"(anakinra),":[53],"inhibitor":[55],"T":[57],"cell":[58],"co-stimulation":[59],"(abatacept),":[60],"a":[62,168],"selective":[63],"depleter":[64],"B":[66],"cells":[67],"(rituximab).":[68],"As":[69],"research":[70],"has":[71],"progressed,":[72],"additional":[73,105],"promising":[74],"identified.":[78],"Results":[79],"from":[80,173],"RA":[81],"studies":[82],"using":[83],"several":[84],"new":[85,125],"reported":[89],"last":[92],"year.":[93],"Some":[94],"these":[96],"compounds":[97],"are":[98,122,156],"similar":[99],"already":[102],"available,":[103],"TNF":[106],"(certolizumab":[108],"pegol,":[109],"golimumab)":[110],"targeting":[113],"CD20":[114],"(ocrelizumab,":[115],"ofatumumab,":[116],"TRU-015)":[117],"development.":[119],"Other":[120],"directed":[123,157],"toward":[124],"targets,":[127,140],"IL-6":[129],"(tocilizumab),":[130],"lymphotoxin":[132],"pathways":[133],"(briobacept),":[134],"as":[135,137],"well":[136],"other":[138],"B-cell":[139],"include":[142],"BLyS":[143],"APRIL":[145],"(belimumab,":[146],"atacicept).":[147],"Additional":[148],"small":[149],"molecule":[150],"therapies":[151],"studied":[154],"that":[155],"against":[158],"intracellular":[159],"kinases,":[160],"JAK-3":[162],"Syk.":[164],"This":[165],"article":[166],"provides":[167],"brief":[169],"update":[170],"data":[172],"selected":[174],"clinical":[175],"trials":[176],"highlighting":[179],"efficacy,":[180],"mechanism-based":[182],"safety":[183],"concerns.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}