{"id":"https://openalex.org/W2967712794","doi":"https://doi.org/10.21451/1984-3143-ar2019-0053","title":"Reproductive physiology of the heat-stressed dairy cow: implications for fertility and assisted reproduction","display_name":"Reproductive physiology of the heat-stressed dairy cow: implications for fertility and assisted reproduction","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2967712794","doi":"https://doi.org/10.21451/1984-3143-ar2019-0053","mag":"2967712794","pmid":"https://pubmed.ncbi.nlm.nih.gov/32435293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7234026"},"language":"en","primary_location":{"id":"doi:10.21451/1984-3143-ar2019-0053","doi":"https://doi.org/10.21451/1984-3143-ar2019-0053","is_oa":true,"landing_page_url":"https://doi.org/10.21451/1984-3143-ar2019-0053","pdf_url":null,"source":{"id":"https://openalex.org/S2764819964","display_name":"Animal Reproduction","issn_l":"1806-9614","issn":["1806-9614","1984-3143"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-40","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312017","host_organization_name":"Col\u00e9gio Brasileiro de Patologia Animal (CBPA)","host_organization_lineage":["https://openalex.org/P4310312017"],"host_organization_lineage_names":["Col\u00e9gio Brasileiro de Patologia Animal (CBPA)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.21451/1984-3143-ar2019-0053","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028606515","display_name":"Peter James Hansen","orcid":"https://orcid.org/0000-0003-3061-9333","observed_orcids":["https://orcid.org/0000-0003-3061-9333"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter J. Hansen","raw_affiliation_strings":["Department of Animal Sciences, D. H. Barron Reproductive and Perinatal Biology Research Program and Genetics Institute, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, D. H. Barron Reproductive and Perinatal Biology Research Program and Genetics Institute, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028606515"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":450,"currency":"USD","value_usd":450},"apc_paid":{"value":450,"currency":"USD","value_usd":450},"fwci":12.8971,"has_fulltext":true,"cited_by_count":129,"citation_normalized_percentile":{"value":0.9948857,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"16","issue":"3","first_page":"497","last_page":"507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12365","display_name":"Effects of Environmental Stressors on Livestock","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12365","display_name":"Effects of Environmental Stressors on Livestock","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.48969998955726624,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/dairy-cows","display_name":"dairy cattle","score":0.8679999709129333},{"id":"https://openalex.org/keywords/reproductive-physiology","display_name":"reproductive physiology","score":0.949999988079071},{"id":"https://openalex.org/keywords/fertility","display_name":"fertility","score":0.9229999780654907},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.9620000123977661},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.7070000171661377},{"id":"https://openalex.org/keywords/embryonic-survival","display_name":"embryo survival","score":0.7139999866485596},{"id":"https://openalex.org/keywords/fertilization-rate","display_name":"fertilization rate","score":0.7620000243186951},{"id":"https://openalex.org/keywords/oocytes","display_name":"oocytes","score":0.6650000214576721},{"id":"https://openalex.org/keywords/embryo-transfer","display_name":"embryo transfer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.949999988079071},{"id":"https://openalex.org/keywords/hormone-regulation","display_name":"hormonal regulation","score":0.875},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6202678680419922},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.5849217176437378},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5461170077323914},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5273326635360718},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.4991891384124756},{"id":"https://openalex.org/C2777542035","wikidata":"https://www.wikidata.org/wiki/Q17001806","display_name":"Embryo quality","level":4,"score":0.4835391044616699},{"id":"https://openalex.org/C5512455","wikidata":"https://www.wikidata.org/wiki/Q2142940","display_name":"Folliculogenesis","level":4,"score":0.481876939535141},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40926992893218994},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.39067378640174866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36710432171821594},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2917470335960388},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16734579205513}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21451/1984-3143-ar2019-0053","doi":"https://doi.org/10.21451/1984-3143-ar2019-0053","is_oa":true,"landing_page_url":"https://doi.org/10.21451/1984-3143-ar2019-0053","pdf_url":null,"source":{"id":"https://openalex.org/S2764819964","display_name":"Animal Reproduction","issn_l":"1806-9614","issn":["1806-9614","1984-3143"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-40","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312017","host_organization_name":"Col\u00e9gio Brasileiro de Patologia Animal (CBPA)","host_organization_lineage":["https://openalex.org/P4310312017"],"host_organization_lineage_names":["Col\u00e9gio Brasileiro de Patologia Animal (CBPA)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Reproduction","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7234026","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7234026","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anim Reprod","raw_type":"Text"},{"id":"pmid:32435293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32435293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal reproduction","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21451/1984-3143-ar2019-0053","doi":"https://doi.org/10.21451/1984-3143-ar2019-0053","is_oa":true,"landing_page_url":"https://doi.org/10.21451/1984-3143-ar2019-0053","pdf_url":null,"source":{"id":"https://openalex.org/S2764819964","display_name":"Animal Reproduction","issn_l":"1806-9614","issn":["1806-9614","1984-3143"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-40","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312017","host_organization_name":"Col\u00e9gio Brasileiro de Patologia Animal (CBPA)","host_organization_lineage":["https://openalex.org/P4310312017"],"host_organization_lineage_names":["Col\u00e9gio Brasileiro de Patologia Animal (CBPA)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.9208999872207642}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W582451431","https://openalex.org/W1101994455","https://openalex.org/W1964205497","https://openalex.org/W1965479136","https://openalex.org/W1965493090","https://openalex.org/W1972772190","https://openalex.org/W1974254507","https://openalex.org/W1980017043","https://openalex.org/W1985749966","https://openalex.org/W1987315512","https://openalex.org/W1991600111","https://openalex.org/W1992343350","https://openalex.org/W1992447380","https://openalex.org/W2011713837","https://openalex.org/W2012626071","https://openalex.org/W2014754770","https://openalex.org/W2015018451","https://openalex.org/W2020771103","https://openalex.org/W2021754603","https://openalex.org/W2022176169","https://openalex.org/W2025333329","https://openalex.org/W2034259083","https://openalex.org/W2036192894","https://openalex.org/W2039400788","https://openalex.org/W2041267697","https://openalex.org/W2042600161","https://openalex.org/W2045894564","https://openalex.org/W2048268931","https://openalex.org/W2050162228","https://openalex.org/W2050203587","https://openalex.org/W2053899724","https://openalex.org/W2063200496","https://openalex.org/W2063882006","https://openalex.org/W2066400647","https://openalex.org/W2067117349","https://openalex.org/W2068822754","https://openalex.org/W2069496120","https://openalex.org/W2072587187","https://openalex.org/W2080876273","https://openalex.org/W2085612998","https://openalex.org/W2087410098","https://openalex.org/W2090947157","https://openalex.org/W2091860547","https://openalex.org/W2092159409","https://openalex.org/W2092822425","https://openalex.org/W2093571877","https://openalex.org/W2098145889","https://openalex.org/W2099332883","https://openalex.org/W2105044270","https://openalex.org/W2107919199","https://openalex.org/W2109440406","https://openalex.org/W2116841595","https://openalex.org/W2116963152","https://openalex.org/W2117204353","https://openalex.org/W2119497253","https://openalex.org/W2124026841","https://openalex.org/W2125720158","https://openalex.org/W2125877891","https://openalex.org/W2129594712","https://openalex.org/W2133143602","https://openalex.org/W2142093633","https://openalex.org/W2142601669","https://openalex.org/W2162756794","https://openalex.org/W2169037505","https://openalex.org/W2170226435","https://openalex.org/W2170561924","https://openalex.org/W2172252154","https://openalex.org/W2181475953","https://openalex.org/W2322784232","https://openalex.org/W2410095193","https://openalex.org/W2413270598","https://openalex.org/W2461032673","https://openalex.org/W2509496999","https://openalex.org/W2530716369","https://openalex.org/W2563811852","https://openalex.org/W2568880064","https://openalex.org/W2588046987","https://openalex.org/W2624625296","https://openalex.org/W2734623036","https://openalex.org/W2775823442","https://openalex.org/W2786381155","https://openalex.org/W2791331029","https://openalex.org/W2794481651","https://openalex.org/W2794826279","https://openalex.org/W2893254196","https://openalex.org/W2901918794","https://openalex.org/W2902256622","https://openalex.org/W2908645596","https://openalex.org/W2913468432","https://openalex.org/W2922677351","https://openalex.org/W2949872692","https://openalex.org/W4239964333","https://openalex.org/W4244200550","https://openalex.org/W4409122463"],"related_works":["https://openalex.org/W2112241375","https://openalex.org/W2181475953","https://openalex.org/W4252141110","https://openalex.org/W1563889499","https://openalex.org/W3033293723","https://openalex.org/W7165001058","https://openalex.org/W4239770482","https://openalex.org/W2016705041","https://openalex.org/W7163010975","https://openalex.org/W2552242594"],"abstract_inverted_index":{".":[0],"Heat":[1],"stress":[2,37,85,123,152],"can":[3,173],"also":[4],"compromise":[5],"fertilization":[6],"rate.":[7],"The":[8,143],"first":[9],"seven":[10,25],"days":[11],"of":[12,55,83,110,121,132,150,159],"embryonic":[13,71],"development":[14],"are":[15,61,103],"very":[16,40],"susceptible":[17],"to":[18,35,43,46,63,80,94,118,141,147,155,161],"disruption":[19],"by":[20,74,124,179],"heat":[21,36,75,84,122,151,162],"stress.":[22,76,163],"During":[23],"these":[24],"days,":[26],"the":[27,50,59,87,96,129,133,148],"embryo":[28,60,92,99],"undergoes":[29],"a":[30],"rapid":[31],"change":[32],"in":[33,70],"sensitivity":[34],"from":[38,176],"being":[39],"sensitive":[41],"(2-":[42],"4-cell":[44],"stage)":[45],"largely":[47],"resistant":[48],"(by":[49],"morulae":[51],"stage).":[52],"Direct":[53],"actions":[54],"elevated":[56],"temperature":[57],"on":[58,86],"likely":[62],"be":[64,115,154,174],"an":[65],"important":[66],"mechanism":[67],"for":[68],"reduction":[69],"survival":[72],"caused":[73],"An":[77],"effective":[78],"way":[79],"avoid":[81],"effects":[82,97,120],"oocyte,":[88],"fertilization,":[89],"and":[90,170],"early":[91],"is":[93],"bypass":[95],"through":[98],"transfer":[100],"because":[101],"embryos":[102],"typically":[104],"transferred":[105],"into":[106],"females":[107],"after":[108],"acquisition":[109],"thermal":[111],"resistance.":[112],"There":[113],"may":[114,153],"some":[116],"opportunity":[117],"mitigate":[119],"feeding":[125],"antioxidants":[126],"or":[127,182],"regulating":[128],"endocrine":[130],"environment":[131],"cow":[134],"but":[135],"neither":[136],"approach":[137],"has":[138],"been":[139],"reduced":[140],"practice.":[142],"best":[144],"long-term":[145],"solution":[146],"problem":[149],"increase":[156],"genetic":[157],"resistance":[158],"cows":[160],"Thermotolerance":[164],"genes":[165,172],"exist":[166],"within":[167],"dairy":[168],"breeds":[169,178],"additional":[171],"introgressed":[175],"other":[177],"traditional":[180],"means":[181],"gene":[183],"editing.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-08-22T00:00:00"}