{"id":"https://openalex.org/W2967643164","doi":"https://doi.org/10.1186/s12968-019-0555-2","title":"Genetic variants of HIF1\u03b1 are associated with right ventricular fibrotic load in repaired tetralogy of Fallot patients: a cardiovascular magnetic resonance study","display_name":"Genetic variants of HIF1\u03b1 are associated with right ventricular fibrotic load in repaired tetralogy of Fallot patients: a cardiovascular magnetic resonance study","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2967643164","doi":"https://doi.org/10.1186/s12968-019-0555-2","mag":"2967643164","pmid":"https://pubmed.ncbi.nlm.nih.gov/31422771","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6699069"},"language":"en","primary_location":{"id":"doi:10.1186/s12968-019-0555-2","doi":"https://doi.org/10.1186/s12968-019-0555-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12968-019-0555-2","pdf_url":"https://jcmr-online.biomedcentral.com/track/pdf/10.1186/s12968-019-0555-2","source":{"id":"https://openalex.org/S144688638","display_name":"Journal of Cardiovascular Magnetic Resonance","issn_l":"1097-6647","issn":["1097-6647","1532-429X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Magnetic Resonance","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jcmr-online.biomedcentral.com/track/pdf/10.1186/s12968-019-0555-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079096533","display_name":"Thanh T. Hoang","orcid":"https://orcid.org/0000-0002-8498-0020","observed_orcids":["https://orcid.org/0000-0002-8498-0020"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thanh T. Hoang","raw_affiliation_strings":["Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070330077","display_name":"Paulo Henrique Manso","orcid":"https://orcid.org/0000-0003-1165-9786","observed_orcids":["https://orcid.org/0000-0003-1165-9786"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo Henrique Manso","raw_affiliation_strings":["Department of Pediatrics, Ribeiro Preto Medical School USP, Ribeirao Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Ribeiro Preto Medical School USP, Ribeirao Preto, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026877818","display_name":"Sharon Edman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Edman","raw_affiliation_strings":["Division of Cardiology, Children's Hospital of Philadelphia, Abramson Research Center 702A, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Children's Hospital of Philadelphia, Abramson Research Center 702A, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108780167","display_name":"Laura Mercer\u2010Rosa","orcid":"https://orcid.org/0000-0003-2170-5942","observed_orcids":["https://orcid.org/0000-0003-2170-5942"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Mercer-Rosa","raw_affiliation_strings":["Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","Division of Cardiology, Children's Hospital of Philadelphia, Abramson Research Center 702A, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Cardiology, Children's Hospital of Philadelphia, Abramson Research Center 702A, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080204637","display_name":"Laura E. Mitchell","orcid":"https://orcid.org/0000-0003-1151-5096","observed_orcids":["https://orcid.org/0000-0003-1151-5096"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura E. Mitchell","raw_affiliation_strings":["Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027005283","display_name":"Anshuman Sewda","orcid":"https://orcid.org/0000-0002-2272-5382","observed_orcids":["https://orcid.org/0000-0002-2272-5382"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anshuman Sewda","raw_affiliation_strings":["Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087463136","display_name":"Michael D. Swartz","orcid":"https://orcid.org/0000-0003-3953-8775","observed_orcids":["https://orcid.org/0000-0003-3953-8775"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Swartz","raw_affiliation_strings":["Department of Biostatistics and Data Science, UTHealth School of Public Health, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Data Science, UTHealth School of Public Health, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042777838","display_name":"Mark A. Fogel","orcid":"https://orcid.org/0000-0001-7490-3702","observed_orcids":["https://orcid.org/0000-0001-7490-3702"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Fogel","raw_affiliation_strings":["Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","Division of Cardiology, Children's Hospital of Philadelphia, Abramson Research Center 702A, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Cardiology, Children's Hospital of Philadelphia, Abramson Research Center 702A, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055407649","display_name":"A. J. Agopian","orcid":"https://orcid.org/0000-0002-5874-4155","observed_orcids":["https://orcid.org/0000-0002-5874-4155"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.J. Agopian","raw_affiliation_strings":["Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027871977","display_name":"Elizabeth Goldmuntz","orcid":"https://orcid.org/0000-0003-2936-4396","observed_orcids":["https://orcid.org/0000-0003-2936-4396"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth Goldmuntz","raw_affiliation_strings":["Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. goldmuntz@email.chop.edu","Division of Cardiology, Children's Hospital of Philadelphia, Abramson Research Center 702A, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA. goldmuntz@email.chop.edu","Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2936-4396","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. goldmuntz@email.chop.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Cardiology, Children's Hospital of Philadelphia, Abramson Research Center 702A, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA. goldmuntz@email.chop.edu","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5027871977"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.7609,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71916659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"21","issue":"1","first_page":"51","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetralogy-of-fallot","display_name":"tetralogy of Fallot","score":0.9190000295639038},{"id":"https://openalex.org/keywords/right-ventricular-fibrosis","display_name":"right ventricular fibrosis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.8119999766349792},{"id":"https://openalex.org/keywords/right-ventricular-remodeling","display_name":"right ventricular remodeling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/right-ventricular-ejection-fraction","display_name":"right ventricular ejection fraction","score":0.8270000219345093},{"id":"https://openalex.org/keywords/right-ventricular-end-diastolic-volume","display_name":"right ventricular end-diastolic volume","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.7310000061988831},{"id":"https://openalex.org/keywords/repaired-congenital-heart-disease","display_name":"repaired congenital heart disease","score":0.8180000185966492},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.5339999794960022},{"id":"https://openalex.org/keywords/late-gadolinium-enhancement","display_name":"late gadolinium enhancement","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2778646171","wikidata":"https://www.wikidata.org/wiki/Q445307","display_name":"Tetralogy of Fallot","level":3,"score":0.9528453350067139},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8907288312911987},{"id":"https://openalex.org/C555175668","wikidata":"https://www.wikidata.org/wiki/Q539690","display_name":"Angiology","level":2,"score":0.8841890692710876},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.707180380821228},{"id":"https://openalex.org/C2987145844","wikidata":"https://www.wikidata.org/wiki/Q5038325","display_name":"Cardiac magnetic resonance","level":3,"score":0.6970610022544861},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6773022413253784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6466934084892273},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3299112319946289},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.19094255566596985}],"mesh":[{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006348","descriptor_name":"Cardiac Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013771","descriptor_name":"Tetralogy of Fallot","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D013771","descriptor_name":"Tetralogy of Fallot","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013771","descriptor_name":"Tetralogy of Fallot","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013771","descriptor_name":"Tetralogy of Fallot","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D016278","descriptor_name":"Ventricular Function, Right","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019028","descriptor_name":"Magnetic Resonance Imaging, Cine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12968-019-0555-2","doi":"https://doi.org/10.1186/s12968-019-0555-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12968-019-0555-2","pdf_url":"https://jcmr-online.biomedcentral.com/track/pdf/10.1186/s12968-019-0555-2","source":{"id":"https://openalex.org/S144688638","display_name":"Journal of Cardiovascular Magnetic Resonance","issn_l":"1097-6647","issn":["1097-6647","1532-429X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Magnetic Resonance","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6699069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6699069","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cardiovasc Magn Reson","raw_type":"Text"},{"id":"pmid:31422771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31422771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:332f7a2ac8004734b36b89f90eb6cda8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/332f7a2ac8004734b36b89f90eb6cda8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cardiovascular Magnetic Resonance, Vol 21, Iss 1, Pp 1-10 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12968-019-0555-2","doi":"https://doi.org/10.1186/s12968-019-0555-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12968-019-0555-2","pdf_url":"https://jcmr-online.biomedcentral.com/track/pdf/10.1186/s12968-019-0555-2","source":{"id":"https://openalex.org/S144688638","display_name":"Journal of Cardiovascular Magnetic Resonance","issn_l":"1097-6647","issn":["1097-6647","1532-429X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Magnetic Resonance","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7099999785423279,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2214717506","display_name":"Hypertension genotypes in mothers and risk for congenital heart defects in offspring","funder_award_id":"16GRNT29660001","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G3572101131","display_name":null,"funder_award_id":"2014/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G5157295700","display_name":"Genetic Mechanisms in Pediatric Heart Disease","funder_award_id":"P50HL074731","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7683699529","display_name":"Institutional Clinical and Translational Science Award","funder_award_id":"UL1TR000003","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000040984","display_name":null,"funder_award_id":"HL74731","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000872398","display_name":"Training in Molecular Therapeutics for Pediatric Cardiology","funder_award_id":"T32HL007915","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2967643164.pdf","grobid_xml":"https://content.openalex.org/works/W2967643164.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1556853917","https://openalex.org/W1572147296","https://openalex.org/W1676600749","https://openalex.org/W1972647812","https://openalex.org/W1973838758","https://openalex.org/W1980719288","https://openalex.org/W1985934488","https://openalex.org/W2002132361","https://openalex.org/W2012001635","https://openalex.org/W2018189081","https://openalex.org/W2040339824","https://openalex.org/W2046092155","https://openalex.org/W2063439326","https://openalex.org/W2069263823","https://openalex.org/W2089500519","https://openalex.org/W2090453116","https://openalex.org/W2099805722","https://openalex.org/W2107955352","https://openalex.org/W2110065044","https://openalex.org/W2132401137","https://openalex.org/W2142372892","https://openalex.org/W2148112190","https://openalex.org/W2153784828","https://openalex.org/W2155014420","https://openalex.org/W2160995259","https://openalex.org/W2161788311","https://openalex.org/W2161918376","https://openalex.org/W2163013660","https://openalex.org/W2164901837","https://openalex.org/W2166320441","https://openalex.org/W2190427377","https://openalex.org/W2216745296","https://openalex.org/W2299099463","https://openalex.org/W2376010025","https://openalex.org/W2514336737","https://openalex.org/W2538144873","https://openalex.org/W2539412725","https://openalex.org/W2603875937","https://openalex.org/W2898011297"],"related_works":["https://openalex.org/W6977332520","https://openalex.org/W4386661474","https://openalex.org/W4205937206","https://openalex.org/W2046092155","https://openalex.org/W2785017357","https://openalex.org/W2142372892","https://openalex.org/W4415794024","https://openalex.org/W2770311808","https://openalex.org/W4247129071","https://openalex.org/W4415535696"],"abstract_inverted_index":{"BACKGROUND:":[0],"Studies":[1],"suggest":[2],"that":[3,43,218],"right":[4],"ventricular":[5],"(RV)":[6],"fibrosis":[7,51],"is":[8],"associated":[9,170,189,199],"with":[10,18,129,138,171,190,200],"RV":[11,50,53,59,66,103],"remodeling":[12,104],"and":[13,33,52,58,61,65,81,100,109,133,146,157,166,214],"long-term":[14],"outcomes":[15],"in":[16,118,225],"patients":[17],"tetralogy":[19],"of":[20,28,102,179,194,210],"Fallot":[21],"(TOF).":[22],"Pre-operative":[23],"hypoxia":[24,29],"may":[25,220],"increase":[26],"expression":[27],"inducible":[30],"factor-1-alpha":[31],"(HIF1\u03b1)":[32],"promote":[34],"transforming":[35],"growth":[36],"factor":[37],"\u03b21":[38],"(TGF\u03b21)-mediated":[39],"fibrosis.":[40],"We":[41,73],"hypothesized":[42],"there":[44],"would":[45],"be":[46],"associations":[47],"between:":[48],"(1)":[49],"function,":[54],"(2)":[55],"HIF1\u03b1":[56,63,182,196,212,219],"variants":[57,64],"fibrosis,":[60],"(3)":[62],"function":[67],"among":[68],"post-surgical":[69,76],"TOF":[70,86],"cases.":[71,120],"METHODS:":[72],"retrospectively":[74],"measured":[75],"fibrotic":[77,82,144,147,164,191,202,215,223],"load":[78],"(indexed":[79],"volume":[80,111,145,165],"score)":[83],"from":[84],"237":[85],"cases":[87],"who":[88],"had":[89],"existing":[90],"cardiovascular":[91],"magnetic":[92],"resonance":[93],"imaging":[94],"using":[95,124],"late":[96],"gadolinium":[97],"enhancement":[98],"(LGE),":[99],"indicators":[101],"(i.e.,":[105],"ejection":[106],"fraction":[107],"[RVEF]":[108],"end-diastolic":[110],"indexed":[112,201],"[RVEDVI]).":[113],"Genetic":[114],"data":[115],"were":[116,122,168,188,198],"available":[117],"125":[119],"Analyses":[121],"conducted":[123],"multivariable":[125,134],"linear":[126],"mixed-effects":[127],"regression":[128,137],"a":[130,139],"random":[131,140],"intercept":[132],"generalized":[135],"Poisson":[136],"intercept.":[141],"RESULTS:":[142],"Indexed":[143,163],"score":[148,167,216],"significantly":[149],"decreased":[150],"RVEF":[151],"by":[152],"1.6%":[153],"(p":[154,159],"=":[155,160],"0.04)":[156],"0.9%":[158],"0.03),":[161],"respectively.":[162],"not":[169],"RVEDVI.":[172],"After":[173],"adjusting":[174],"for":[175],"multiple":[176],"comparisons,":[177],"6":[178],"the":[180,195,222],"48":[181],"polymorphisms":[183,197,213],"(representing":[184],"two":[185],"unique":[186],"signals)":[187],"score.":[192],"None":[193],"volume,":[203],"RVEDVI,":[204],"or":[205],"RVEF.":[206],"CONCLUSION:":[207],"The":[208],"association":[209],"some":[211],"suggests":[217],"modulate":[221],"response":[224],"TOF.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-08-22T00:00:00"}