{"id":"https://openalex.org/W2967584098","doi":"https://doi.org/10.1200/po.19.00029","title":"21-Gene Recurrence Score Adds Significant Value for Grade 3 Breast Cancers: Results From a National Cohort","display_name":"21-Gene Recurrence Score Adds Significant Value for Grade 3 Breast Cancers: Results From a National Cohort","publication_year":2019,"publication_date":"2019-08-14","ids":{"openalex":"https://openalex.org/W2967584098","doi":"https://doi.org/10.1200/po.19.00029","mag":"2967584098","pmid":"https://pubmed.ncbi.nlm.nih.gov/32457931","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7250459"},"language":"en","primary_location":{"id":"doi:10.1200/po.19.00029","doi":"https://doi.org/10.1200/po.19.00029","is_oa":false,"landing_page_url":"https://doi.org/10.1200/po.19.00029","pdf_url":null,"source":{"id":"https://openalex.org/S4210227748","display_name":"JCO Precision Oncology","issn_l":"2473-4284","issn":["2473-4284"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precision Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7250459","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064933173","display_name":"Julian Bryan Iorgulescu","orcid":"https://orcid.org/0000-0003-1405-3667","observed_orcids":["https://orcid.org/0000-0003-1405-3667"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Bryan Iorgulescu","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA","Dana-Farber Cancer Institute, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080530218","display_name":"Rachel A. Freedman","orcid":"https://orcid.org/0000-0003-0460-674X","observed_orcids":["https://orcid.org/0000-0003-0460-674X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel A. Freedman","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015440359","display_name":"Susan C. Lester","orcid":"https://orcid.org/0000-0002-6345-1664","observed_orcids":["https://orcid.org/0000-0002-6345-1664"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan C. Lester","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029062544","display_name":"Elizabeth Ann Mittendorf","orcid":"https://orcid.org/0000-0002-9762-8536","observed_orcids":["https://orcid.org/0000-0002-9762-8536"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Mittendorf","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103889267","display_name":"Jane E. Brock","orcid":"https://orcid.org/0000-0003-3358-0534","observed_orcids":["https://orcid.org/0000-0003-3358-0534"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane E. Brock","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4747,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.51623265,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"3","first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncotype-dx","display_name":"Oncotype DX","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.8560000061988831},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.8659999966621399},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9589999914169312},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6010000109672546},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.781000018119812},{"id":"https://openalex.org/keywords/national-cancer-database","display_name":"National Cancer Database","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8424735069274902},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7108457088470459},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7024190425872803},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7013936042785645},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5491488575935364},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.534991443157196},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5227927565574646},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5104126334190369},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.49878430366516113},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4531850516796112},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.331023246049881},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1200/po.19.00029","doi":"https://doi.org/10.1200/po.19.00029","is_oa":false,"landing_page_url":"https://doi.org/10.1200/po.19.00029","pdf_url":null,"source":{"id":"https://openalex.org/S4210227748","display_name":"JCO Precision Oncology","issn_l":"2473-4284","issn":["2473-4284"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precision Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7250459","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7250459","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precis Oncol","raw_type":"Text"},{"id":"pmid:32457931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32457931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO precision oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7250459","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7250459","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precis Oncol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1826970265","display_name":"Vascular, Pulmonary and Renal Injury","funder_award_id":"T32HL007627","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W140268124","https://openalex.org/W2061643898","https://openalex.org/W2105882193","https://openalex.org/W2113344831","https://openalex.org/W2129168200","https://openalex.org/W2130639106","https://openalex.org/W2160377567","https://openalex.org/W2190954851","https://openalex.org/W2267844613","https://openalex.org/W2289933199","https://openalex.org/W2517421365","https://openalex.org/W2592783575","https://openalex.org/W2592904882","https://openalex.org/W2593162010","https://openalex.org/W2603868227","https://openalex.org/W2784452011","https://openalex.org/W2805734855","https://openalex.org/W2870583179","https://openalex.org/W4386946325"],"related_works":["https://openalex.org/W7220657720","https://openalex.org/W3014042534","https://openalex.org/W7162001855","https://openalex.org/W3109605696","https://openalex.org/W2938876221","https://openalex.org/W2947613448","https://openalex.org/W3190653893","https://openalex.org/W2225477806","https://openalex.org/W2744921522","https://openalex.org/W2890017934"],"abstract_inverted_index":{"PURPOSE":[0],"The":[1,180],"21-gene":[2],"recurrence":[3],"score":[4],"(RS)":[5],"is":[6],"used":[7],"to":[8,25,75,78,95,107,149,153,253,291,294],"identify":[9],"patients":[10,186,260,281],"with":[11,33,73,127,159,164,167,187,198,261,282],"hormone":[12],"receptor\u2013positive":[13],"early-stage":[14],"breast":[15,91],"cancer":[16],"who":[17,267],"may":[18,40,52,251],"benefit":[19,54,274],"from":[20,55,93],"the":[21,67,156,162],"addition":[22],"of":[23,45,48,63,249],"chemotherapy":[24,43,199],"endocrine":[26],"therapy.":[27],"We":[28],"hypothesized":[29],"that":[30,235],"many":[31],"women":[32,65,158],"poor":[34],"prognostic":[35],"histopathologic":[36],"grade":[37,80,139,262],"3":[38,81,140,263],"disease":[39,166,264],"be":[41,277],"offered":[42],"irrespective":[44],"RS":[46,97,117,136,168,207,220,250],"results,":[47],"whom":[49],"a":[50,188],"subset":[51],"not":[53,192,271],"adjuvant":[56],"chemotherapy.":[57],"PATIENTS":[58],"AND":[59],"METHODS":[60],"A":[61],"total":[62],"30,864":[64],"in":[66,138,238,279],"National":[68],"Cancer":[69],"Database":[70],"were":[71,236],"diagnosed":[72],"pT1c":[74],"pT2,":[76],"pN0":[77,160,208,221],"pN1,":[79,151],"estrogen":[82,283],"receptor\u2013positive,":[83],"human":[84],"epidermal":[85,285],"growth":[86,286],"factor":[87,287],"receptor":[88,288],"2\u2013negative":[89,289],"invasive":[90],"carcinoma":[92],"2010":[94,144],"2015.":[96],"was":[98,118,195],"stratified":[99],"as":[100],"low":[101,175,193,219],"(less":[102,177],"than":[103,178],"18),":[104],"intermediate":[105],"(18":[106],"30),":[108],"and":[109,123,132,145,161,171,211,227,269,275],"high":[110,189,206],"(31":[111],"or":[112],"more).":[113],"Overall":[114],"survival":[115,183,273],"by":[116,120,243,258],"evaluated":[119],"Kaplan-Meier,":[121],"log-rank,":[122],"multivariable":[124,239],"proportional":[125],"hazards,":[126],"adjustment":[128],"for":[129,185],"relevant":[130],"clinical":[131],"demographic":[133],"variables.":[134],"RESULTS":[135],"testing":[137],"cancers":[141],"increased":[142],"between":[143],"2015":[146],"(pN0,":[147],"53%":[148],"72%;":[150],"16%":[152],"36%).":[154],"Among":[155],"13,558":[157],"2,840":[163],"pN1":[165,212,228],"testing,":[169],"27.1%":[170],"30.0%,":[172],"respectively,":[173],"had":[174],"scores":[176],"18).":[179],"5-year":[181],"overall":[182],"rate":[184],"RS,":[190,194],"but":[191],"significantly":[196],"higher":[197],"(":[200],"v":[201],"no":[202],"chemotherapy;":[203],"absolute":[204],"differences:":[205],"=":[209,213,222,225,229,232],"12.2%":[210],"25.5%,":[214],"both":[215],"P":[216,224,231],"<":[217],".001;":[218],"2.5%,":[223],".07;":[226],"1.0%,":[230],".27),":[233],"findings":[234],"reinforced":[237],"analyses":[240],"risk":[241],"adjusted":[242],"clinicopathologic":[244],"characteristics.":[245],"CONCLUSION":[246],"Increased":[247],"use":[248],"help":[252],"better":[254],"tailor":[255],"treatment":[256],"recommendations":[257],"stratifying":[259],"into":[265],"those":[266],"will":[268,270],"derive":[272],"should":[276],"considered":[278],"all":[280],"receptor\u2013positive/human":[284],"T1c":[290],"T2,":[292],"N0":[293],"N1":[295],"disease.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-08-22T00:00:00"}