{"id":"https://openalex.org/W2967580993","doi":"https://doi.org/10.3389/fmicb.2019.01981","title":"Raltegravir-Induced Adaptations of the HIV-1 Integrase: Analysis of Structure, Variability, and Mutation Co-occurrence","display_name":"Raltegravir-Induced Adaptations of the HIV-1 Integrase: Analysis of Structure, Variability, and Mutation Co-occurrence","publication_year":2019,"publication_date":"2019-09-03","ids":{"openalex":"https://openalex.org/W2967580993","doi":"https://doi.org/10.3389/fmicb.2019.01981","mag":"2967580993","pmid":"https://pubmed.ncbi.nlm.nih.gov/31551948","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6733956"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2019.01981","doi":"https://doi.org/10.3389/fmicb.2019.01981","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2019.01981","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.01981/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.01981/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035682634","display_name":"Lucas de Almeida Machado","orcid":"https://orcid.org/0000-0002-6575-1687","observed_orcids":["https://orcid.org/0000-0002-6575-1687"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Lucas de Almeida Machado","raw_affiliation_strings":["Laboratory for Functional Genomics and Bioinformatics, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Functional Genomics and Bioinformatics, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002055143","display_name":"Marcelo Ferreira da Costa Gomes","orcid":"https://orcid.org/0000-0003-4693-5402","observed_orcids":["https://orcid.org/0000-0003-4693-5402"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo Ferreira da Costa Gomes","raw_affiliation_strings":["Scientific Computing Program, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Computing Program, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019125482","display_name":"Ana Carolina Ramos Guimar\u00e3es","orcid":"https://orcid.org/0000-0003-1260-543X","observed_orcids":["https://orcid.org/0000-0003-1260-543X"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Carolina Ramos Guimar\u00e3es","raw_affiliation_strings":["Laboratory for Functional Genomics and Bioinformatics, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Functional Genomics and Bioinformatics, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035682634"],"corresponding_institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.5441,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80313832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":null,"first_page":"1981","last_page":"1981"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-integrase","display_name":"HIV-1 integrase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/raltegravir","display_name":"raltegravir","score":0.9919999837875366},{"id":"https://openalex.org/keywords/integrase-inhibitors","display_name":"integrase inhibitors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/drug-resistance-mutations","display_name":"drug resistance mutations","score":0.7950000166893005},{"id":"https://openalex.org/keywords/shannon-entropy","display_name":"Shannon entropy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/intasome","display_name":"intasome","score":0.5049999952316284},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.722000002861023},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.6579999923706055},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2780404665","wikidata":"https://www.wikidata.org/wiki/Q421552","display_name":"Raltegravir","level":5,"score":0.9802862405776978},{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.941275417804718},{"id":"https://openalex.org/C2777068322","wikidata":"https://www.wikidata.org/wiki/Q2740966","display_name":"Elvitegravir","level":5,"score":0.9187283515930176},{"id":"https://openalex.org/C2779502633","wikidata":"https://www.wikidata.org/wiki/Q937224","display_name":"Dolutegravir","level":5,"score":0.6945264339447021},{"id":"https://openalex.org/C2777302000","wikidata":"https://www.wikidata.org/wiki/Q412251","display_name":"Integrase inhibitor","level":5,"score":0.6829314827919006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5984414219856262},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5794227123260498},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5320307612419128},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.49762943387031555},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.46336930990219116},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42737874388694763},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.33266493678092957},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.28948408365249634},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.24329409003257751},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.16280215978622437}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmicb.2019.01981","doi":"https://doi.org/10.3389/fmicb.2019.01981","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2019.01981","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.01981/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmid:31551948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31551948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6733956","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6733956/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c494d827c66740c49d2889215958fbdd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c494d827c66740c49d2889215958fbdd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 10 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2019.01981","doi":"https://doi.org/10.3389/fmicb.2019.01981","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2019.01981","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.01981/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G29316538","display_name":null,"funder_award_id":"(Code 001)","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2967580993.pdf","grobid_xml":"https://content.openalex.org/works/W2967580993.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W35389034","https://openalex.org/W322329514","https://openalex.org/W1489859663","https://openalex.org/W1967284000","https://openalex.org/W1977016360","https://openalex.org/W1983837630","https://openalex.org/W1986191025","https://openalex.org/W1994342377","https://openalex.org/W1995875735","https://openalex.org/W2007825562","https://openalex.org/W2012627860","https://openalex.org/W2013498624","https://openalex.org/W2017402153","https://openalex.org/W2025952824","https://openalex.org/W2026059788","https://openalex.org/W2030429605","https://openalex.org/W2030854058","https://openalex.org/W2041921162","https://openalex.org/W2043638353","https://openalex.org/W2044660041","https://openalex.org/W2052287045","https://openalex.org/W2056360005","https://openalex.org/W2057925552","https://openalex.org/W2060696966","https://openalex.org/W2076696614","https://openalex.org/W2078975498","https://openalex.org/W2085992210","https://openalex.org/W2091480648","https://openalex.org/W2095751322","https://openalex.org/W2099607690","https://openalex.org/W2101998560","https://openalex.org/W2104029568","https://openalex.org/W2109360985","https://openalex.org/W2112581675","https://openalex.org/W2112713806","https://openalex.org/W2114822477","https://openalex.org/W2117072114","https://openalex.org/W2122026430","https://openalex.org/W2124211547","https://openalex.org/W2124600882","https://openalex.org/W2132585743","https://openalex.org/W2132926880","https://openalex.org/W2133024144","https://openalex.org/W2135430194","https://openalex.org/W2137154596","https://openalex.org/W2139876724","https://openalex.org/W2152880150","https://openalex.org/W2154190260","https://openalex.org/W2155676461","https://openalex.org/W2164978656","https://openalex.org/W2166557397","https://openalex.org/W2169790816","https://openalex.org/W2286136427","https://openalex.org/W2337619770","https://openalex.org/W2342896458","https://openalex.org/W2407247987","https://openalex.org/W2474869173","https://openalex.org/W2523305619","https://openalex.org/W2568171404","https://openalex.org/W2784124240","https://openalex.org/W2794472562","https://openalex.org/W2887207364","https://openalex.org/W4238876492","https://openalex.org/W6629400895","https://openalex.org/W6682978103"],"related_works":["https://openalex.org/W7214412920","https://openalex.org/W1489859663","https://openalex.org/W2148234993","https://openalex.org/W1969106027","https://openalex.org/W2080562393","https://openalex.org/W2089098812","https://openalex.org/W2006513862","https://openalex.org/W3146675191","https://openalex.org/W2139876724","https://openalex.org/W4225323283"],"abstract_inverted_index":{"The":[0,181,237,282,313],"human":[1],"immunodeficiency":[2],"virus":[3],"type":[4],"1":[5],"(HIV-1)":[6],"has":[7,90],"several":[8],"proteins":[9,27],"of":[10,14,37,55,82,103,106,114,144,164,207,336],"therapeutic":[11,348],"importance,":[12],"many":[13],"which":[15,31,319],"are":[16,65,169,220],"currently":[17,66],"used":[18,67],"as":[19,68,342,344],"drug":[20,338],"targets":[21],"in":[22,58,111,134,184,193,221,233,279,305,339],"antiretroviral":[23,72],"therapy.":[24,326],"Among":[25],"these":[26,88],"is":[28,32,269],"the":[29,35,38,42,53,59,79,101,107,145,151,165,178,185,194,198,208,213,224,234,242,257,263,266,285,290,293,320,334,337,340],"integrase,":[30],"responsible":[33],"for":[34,49,71,303],"integration":[36],"viral":[39],"DNA":[40,311],"into":[41,273,276],"host":[43,225],"genome":[44],"-":[45],"a":[46,92,299],"crucial":[47],"step":[48],"HIV-1":[50,108,146,321],"replication.":[51],"Given":[52],"importance":[54],"this":[56,97,260],"protein":[57],"replication":[60],"process,":[61],"three":[62,186],"integrase":[63,109,147,209,322],"inhibitors":[64],"an":[69],"option":[70],"therapy:":[73],"Raltegravir,":[74],"Elvitegravir,":[75],"and":[76,116,156,175,218,227,247,284],"Dolutegravir.":[77],"However,":[78],"crescent":[80],"emergence":[81],"mutations":[83,132,189,251,304],"that":[84,160,212,241,265,292],"cause":[85],"resistance":[86,167,244],"to":[87,129,203,301,309,332],"drugs":[89],"become":[91],"worldwide":[93],"health":[94],"problem.":[95],"In":[96],"study,":[98],"we":[99,149],"compared":[100],"variability":[102],"each":[104,253],"position":[105],"sequence":[110],"clinical":[112],"isolates":[113],"Raltegravir-treated":[115],"drug-na\u00efve":[117],"patients":[118,135,174],"by":[119,140,318],"calculating":[120],"their":[121,204,228],"Shannon":[122],"entropies.":[123,205],"A":[124],"co-occurrence":[125,238],"network":[126,239,283],"was":[127],"created":[128],"explore":[130],"how":[131],"co-occur":[133],"treated":[136,179],"with":[137,223,252,256],"Raltegravir.":[138],"Then,":[139],"building":[141],"tridimensional":[142],"models":[143],"intasomes,":[148],"investigated":[150],"relationship":[152],"between":[153],"variability,":[154],"architecture,":[155],"co-occurrence.":[157],"We":[158],"observed":[159],"positions":[161,199],"bearing":[162],"some":[163],"major":[166,243],"pathways":[168,245],"highly":[170],"conserved":[171],"among":[172,177],"non-treated":[173],"variable":[176],"ones.":[180],"residues":[182,215,308],"involved":[183],"main":[187],"resistance-related":[188,294],"could":[190],"be":[191,298,330],"identified":[192],"same":[195],"group":[196],"when":[197],"were":[200],"clustered":[201],"according":[202],"Analysis":[206],"architecture":[210],"showed":[211],"high-entropy":[214],"S119,":[216],"T124,":[217],"T125,":[219],"contact":[222],"DNA,":[226],"variations":[229],"may":[230,297],"have":[231],"impacts":[232,335],"protein-DNA":[235],"recognition.":[236],"revealed":[240],"N155H":[246,267],"Q148HR":[248],"share":[249],"more":[250],"other":[254],"than":[255,275],"Y143R":[258],"pathway,":[259],"observation":[261],"corroborates":[262],"fact":[264],"pathway":[268,278],"most":[270],"commonly":[271],"converted":[272],"Q148HRK":[274],"Y143RCH":[277],"patients'":[280],"isolates.":[281],"structure":[286],"analysis":[287],"also":[288],"support":[289],"hypothesis":[291],"E138K":[295],"mutation":[296],"mechanism":[300],"compensate":[302],"neighbor":[306],"lysine":[307],"maintain":[310],"binding.":[312],"present":[314],"study":[315],"reveals":[316],"patterns":[317],"adapts":[323],"during":[324],"Raltegravir":[325],"This":[327],"information":[328],"can":[329],"useful":[331],"comprehend":[333],"enzyme,":[341],"well":[343],"help":[345],"planning":[346],"new":[347],"approaches.":[349]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-08-22T00:00:00"}