{"id":"https://openalex.org/W2967537587","doi":"https://doi.org/10.1080/13543776.2019.1655542","title":"Protein tyrosine phosphatase 1B (PTP1B) inhibitors as potential anti-diabetes agents: patent review (2015-2018)","display_name":"Protein tyrosine phosphatase 1B (PTP1B) inhibitors as potential anti-diabetes agents: patent review (2015-2018)","publication_year":2019,"publication_date":"2019-08-10","ids":{"openalex":"https://openalex.org/W2967537587","doi":"https://doi.org/10.1080/13543776.2019.1655542","mag":"2967537587","pmid":"https://pubmed.ncbi.nlm.nih.gov/31402706"},"language":"en","primary_location":{"id":"doi:10.1080/13543776.2019.1655542","doi":"https://doi.org/10.1080/13543776.2019.1655542","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13543776.2019.1655542","pdf_url":null,"source":{"id":"https://openalex.org/S3784663","display_name":"Expert Opinion on Therapeutic Patents","issn_l":"1354-3776","issn":["1354-3776","1744-7674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Patents","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072783254","display_name":"Hidayat Hussain","orcid":"https://orcid.org/0000-0002-8654-8127","observed_orcids":["https://orcid.org/0000-0002-8654-8127"]},"institutions":[{"id":"https://openalex.org/I4210110463","display_name":"Leibniz Institute of Plant Biochemistry","ror":"https://ror.org/01mzk5576","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210110463"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hidayat Hussain","raw_affiliation_strings":["Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210110463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026804109","display_name":"Ivan R. Green","orcid":"https://orcid.org/0000-0002-9158-670X","observed_orcids":["https://orcid.org/0000-0002-9158-670X"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Ivan R Green","raw_affiliation_strings":["Department of Chemistry and Polymer Science, University of Stellenbosch, Matieland, Stellenbosch, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Polymer Science, University of Stellenbosch, Matieland, Stellenbosch, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102894593","display_name":"Ghulam Abbas","orcid":"https://orcid.org/0000-0003-4352-7964","observed_orcids":["https://orcid.org/0000-0003-4352-7964"]},"institutions":[{"id":"https://openalex.org/I209803261","display_name":"University of Nizwa","ror":"https://ror.org/01pxe3r04","country_code":"OM","type":"education","lineage":["https://openalex.org/I209803261"]}],"countries":["OM"],"is_corresponding":false,"raw_author_name":"Ghulam Abbas","raw_affiliation_strings":["Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Nizwa, Sultanate of Oman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Nizwa, Sultanate of Oman","institution_ids":["https://openalex.org/I209803261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006256037","display_name":"Sergazy Mynzhasarovich Adekenov","orcid":"https://orcid.org/0000-0001-7588-6174","observed_orcids":["https://orcid.org/0000-0001-7588-6174"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergazy M Adekenov","raw_affiliation_strings":["JSC International Research and Production Holding \u201cPhytochemistry\u201d, Karaganda, Republic of Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JSC International Research and Production Holding \u201cPhytochemistry\u201d, Karaganda, Republic of Kazakhstan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115592589","display_name":"Wahid Hussain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wahid Hussain","raw_affiliation_strings":["Department of Botany, GPGC Parachinar Kurram Agency Pakistan, Parachinar, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany, GPGC Parachinar Kurram Agency Pakistan, Parachinar, Pakistan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045158817","display_name":"Iftikhar Ali","orcid":"https://orcid.org/0000-0002-5817-8800","observed_orcids":["https://orcid.org/0000-0002-5817-8800"]},"institutions":[{"id":"https://openalex.org/I236232284","display_name":"Karakoram International University","ror":"https://ror.org/0324r4e56","country_code":"PK","type":"education","lineage":["https://openalex.org/I236232284"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Iftikhar Ali","raw_affiliation_strings":["Department of Chemistry, Karakoram International University,Gilgit, Pakistan","Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Jinan, Shandong Province, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Karakoram International University,Gilgit, Pakistan","institution_ids":["https://openalex.org/I236232284"]},{"raw_affiliation_string":"Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Jinan, Shandong Province, P.R. China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5072783254"],"corresponding_institution_ids":["https://openalex.org/I4210110463"],"apc_list":null,"apc_paid":null,"fwci":1.0493,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.74103547,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"29","issue":"9","first_page":"689","last_page":"702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ptp1b","display_name":"PTP1B","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ptp1b-inhibitors","display_name":"PTP1B inhibitors","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9670000076293945},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.906000018119812},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.7910000085830688},{"id":"https://openalex.org/keywords/antidiabetic-drug-discovery","display_name":"antidiabetic drug discovery","score":0.8140000104904175},{"id":"https://openalex.org/keywords/heterocyclic-scaffolds","display_name":"heterocyclic scaffolds","score":0.7929999828338623},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.5979999899864197},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pharmaceutical-patents","display_name":"pharmaceutical patents","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5867117643356323},{"id":"https://openalex.org/C3020580240","wikidata":"https://www.wikidata.org/wiki/Q663272","display_name":"Expert opinion","level":2,"score":0.5521803498268127},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5277398824691772},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.49393874406814575},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49266964197158813},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.4856954514980316},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42900437116622925},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.42308810353279114},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4188951551914215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36286842823028564},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.34786415100097656},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33978164196014404},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30311623215675354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2963467240333557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23422715067863464},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22177308797836304},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.16858863830566406},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010330","descriptor_name":"Patents as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054562","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054562","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/13543776.2019.1655542","doi":"https://doi.org/10.1080/13543776.2019.1655542","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13543776.2019.1655542","pdf_url":null,"source":{"id":"https://openalex.org/S3784663","display_name":"Expert Opinion on Therapeutic Patents","issn_l":"1354-3776","issn":["1354-3776","1744-7674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Patents","raw_type":"journal-article"},{"id":"pmid:31402706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31402706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on therapeutic patents","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308269","display_name":"Alexander von Humboldt-Stiftung","ror":"https://ror.org/012kf4317"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W388296777","https://openalex.org/W1751392371","https://openalex.org/W1984150764","https://openalex.org/W1991632919","https://openalex.org/W2002547501","https://openalex.org/W2008135270","https://openalex.org/W2013948951","https://openalex.org/W2029816065","https://openalex.org/W2030211802","https://openalex.org/W2033768383","https://openalex.org/W2036748337","https://openalex.org/W2045171296","https://openalex.org/W2055204515","https://openalex.org/W2057986476","https://openalex.org/W2070582535","https://openalex.org/W2075992939","https://openalex.org/W2077895077","https://openalex.org/W2083475858","https://openalex.org/W2087482176","https://openalex.org/W2088642752","https://openalex.org/W2095581714","https://openalex.org/W2100628831","https://openalex.org/W2109420135","https://openalex.org/W2148457238","https://openalex.org/W2154102997","https://openalex.org/W2156683062","https://openalex.org/W2160478996","https://openalex.org/W2167043041","https://openalex.org/W2194863767","https://openalex.org/W2293723534","https://openalex.org/W2335887725","https://openalex.org/W2395593463","https://openalex.org/W2412155027","https://openalex.org/W2418293022","https://openalex.org/W2430425153","https://openalex.org/W2443864270","https://openalex.org/W2515429636","https://openalex.org/W2535265582","https://openalex.org/W2536270858","https://openalex.org/W2566536860","https://openalex.org/W2738838688","https://openalex.org/W2766884506","https://openalex.org/W2774743973","https://openalex.org/W2800371601","https://openalex.org/W2911899178","https://openalex.org/W2916286683","https://openalex.org/W4212810717","https://openalex.org/W4251966062"],"related_works":["https://openalex.org/W7125425096","https://openalex.org/W2095581714","https://openalex.org/W104024032","https://openalex.org/W4384926822","https://openalex.org/W4378349212","https://openalex.org/W2096653160","https://openalex.org/W3083157961","https://openalex.org/W2469324777","https://openalex.org/W4410641521","https://openalex.org/W7169715143"],"abstract_inverted_index":{"Introduction:":[0],"Protein":[1],"tyrosine":[2],"phosphatase":[3],"1B":[4],"(PTP1B)":[5],"inhibition":[6],"has":[7],"been":[8,113],"recommended":[9],"as":[10,73,101,188,190],"a":[11],"crucial":[12],"strategy":[13,171],"to":[14,43,61,89,104,137,154],"enhance":[15],"insulin":[16,37,45],"sensitivity":[17,34],"in":[18,115,122,182],"various":[19],"cells":[20],"and":[21,39,64,163,176,184,192],"this":[22],"fact":[23],"is":[24,55,152],"supported":[25],"by":[26],"human":[27],"genetic":[28],"data.":[29],"PTP1B":[30,53,68,99,116,143,157,186],"inhibitors":[31,54,69,100,158,187],"improve":[32],"the":[33,36,41,49,95,139,160],"of":[35,67,83,97,142,172],"receptor":[38],"have":[40,112],"ability":[42],"cure":[44],"resistance-related":[46],"diseases.":[47],"In":[48],"latter":[50],"years,":[51],"targeting":[52],"being":[56,71,135],"considered":[57],"an":[58,81,169],"attractive":[59],"target":[60],"treat":[62,105],"T2DM":[63],"therefore":[65],"libraries":[66],"are":[70,134],"suggested":[72],"potent":[74,98,183],"antidiabetic":[75],"drugs.Areas":[76],"covered:":[77],"This":[78],"review":[79,93],"provides":[80],"overview":[82],"published":[84],"patents":[85],"from":[86],"January":[87],"2015":[88],"December":[90],"2018.":[91],"The":[92],"describes":[94,120],"effectiveness":[96],"pharmaceutical":[102],"agents":[103],"type":[106],"2":[107],"diabetes.Expert":[108],"opinion:":[109],"Enormous":[110],"developments":[111],"made":[114],"drug":[117],"discovery":[118],"which":[119],"progress":[121],"natural":[123],"products,":[124],"synthetic":[125],"heterocyclic":[126,129],"scaffolds":[127],"or":[128],"hybrid":[130],"compounds.":[131],"Various":[132],"protocols":[133],"followed":[136],"boost":[138],"pharmacological":[140],"effects":[141],"inhibitors.":[144],"Moreover":[145],"these":[146],"new":[147],"advancements":[148],"suggest":[149],"that":[150],"it":[151],"possible":[153],"get":[155],"small-molecule":[156],"with":[159],"required":[161],"potency":[162],"selectivity.":[164],"Furthermore,":[165],"future":[166],"endevours":[167],"via":[168],"integrated":[170],"using":[173],"medicinal":[174],"chemistry":[175],"structural":[177],"biology":[178],"will":[179],"hopefully":[180],"result":[181],"selective":[185],"well":[189],"safer":[191],"more":[193],"effective":[194],"orally":[195],"available":[196],"drugs.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2019-08-22T00:00:00"}