{"id":"https://openalex.org/W2967526536","doi":"https://doi.org/10.1134/s0006297919080108","title":"Role of TGF-\u03b21 and C-Kit Mutations in the Development of Hepatocellular Carcinoma in Hepatitis C Virus-Infected Patients: in vitro Study","display_name":"Role of TGF-\u03b21 and C-Kit Mutations in the Development of Hepatocellular Carcinoma in Hepatitis C Virus-Infected Patients: in vitro Study","publication_year":2019,"publication_date":"2019-08-01","ids":{"openalex":"https://openalex.org/W2967526536","doi":"https://doi.org/10.1134/s0006297919080108","mag":"2967526536","pmid":"https://pubmed.ncbi.nlm.nih.gov/31522676"},"language":"en","primary_location":{"id":"doi:10.1134/s0006297919080108","doi":"https://doi.org/10.1134/s0006297919080108","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0006297919080108","pdf_url":null,"source":{"id":"https://openalex.org/S71215691","display_name":"Biochemistry (Moscow)","issn_l":"0006-2979","issn":["0006-2979","0320-9725","1608-3040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046837602","display_name":"Motawa E. El-Houseini","orcid":"https://orcid.org/0000-0003-4873-8429","observed_orcids":["https://orcid.org/0000-0003-4873-8429"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"M. E. El-Houseini","raw_affiliation_strings":["Cairo University, National Cancer Institute, Department of Cancer Biology, Cairo, 11796, Egypt","Cairo University, National Cancer Institute, Department of Cancer Biology, 11796, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cairo University, National Cancer Institute, Department of Cancer Biology, Cairo, 11796, Egypt","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Cairo University, National Cancer Institute, Department of Cancer Biology, 11796, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067042274","display_name":"Ahmed Hamed Ismail","orcid":"https://orcid.org/0009-0000-9429-0739","observed_orcids":["https://orcid.org/0009-0000-9429-0739"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"A. Ismail","raw_affiliation_strings":["Ain Shams University, Faculty of Medicine, Department of Surgery, Cairo, 11566, Egypt","Ain Shams University, Faculty of Medicine, Department of Surgery, 11566, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ain Shams University, Faculty of Medicine, Department of Surgery, Cairo, 11566, Egypt","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Ain Shams University, Faculty of Medicine, Department of Surgery, 11566, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103902614","display_name":"A A Abdelaal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"A. A. Abdelaal","raw_affiliation_strings":["Ain Shams University, Faculty of Medicine, Department of Surgery, Cairo, 11566, Egypt","Ain Shams University, Faculty of Medicine, Department of Surgery, 11566, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ain Shams University, Faculty of Medicine, Department of Surgery, Cairo, 11566, Egypt","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Ain Shams University, Faculty of Medicine, Department of Surgery, 11566, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049945362","display_name":"AHMED H. EL-HABASHY","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"A. H. El-Habashy","raw_affiliation_strings":["Cairo University, National Cancer Institute, Department of Pathology, Cairo, 11796, Egypt","Cairo University, National Cancer Institute, Department of Pathology, 11796, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cairo University, National Cancer Institute, Department of Pathology, Cairo, 11796, Egypt","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Cairo University, National Cancer Institute, Department of Pathology, 11796, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057113034","display_name":"Zeinab Fathy Abdallah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Z. F. Abdallah","raw_affiliation_strings":["Cairo University, National Cancer Institute, Department of Cancer Biology, Cairo, 11796, Egypt","Cairo University, National Cancer Institute, Department of Cancer Biology, 11796, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cairo University, National Cancer Institute, Department of Cancer Biology, Cairo, 11796, Egypt","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Cairo University, National Cancer Institute, Department of Cancer Biology, 11796, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Z. Mohamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150722","display_name":"Egyptian Government","ror":"https://ror.org/05csgyk98","country_code":"EG","type":"government","lineage":["https://openalex.org/I4210150722"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"M. Z. Mohamed","raw_affiliation_strings":["Medical Center of Egyptian Railways, Department of Medical Laboratory, Cairo, 11669, Egypt","Medical Center of Egyptian Railways, Department of Medical Laboratory, 11669, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Center of Egyptian Railways, Department of Medical Laboratory, Cairo, 11669, Egypt","institution_ids":[]},{"raw_affiliation_string":"Medical Center of Egyptian Railways, Department of Medical Laboratory, 11669, Cairo, Egypt","institution_ids":["https://openalex.org/I4210150722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069484090","display_name":"Mohamed S. El-Hadidi","orcid":"https://orcid.org/0000-0002-0360-3654","observed_orcids":["https://orcid.org/0000-0002-0360-3654"]},"institutions":[{"id":"https://openalex.org/I57629906","display_name":"Nile University","ror":"https://ror.org/03cg7cp61","country_code":"EG","type":"education","lineage":["https://openalex.org/I57629906"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"M. El-Hadidi","raw_affiliation_strings":["Nile University, Center of Informatics Science, Giza, 12525, Egypt","Nile University, Center of Informatics Science, 12525, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nile University, Center of Informatics Science, Giza, 12525, Egypt","institution_ids":["https://openalex.org/I57629906"]},{"raw_affiliation_string":"Nile University, Center of Informatics Science, 12525, Giza, Egypt","institution_ids":["https://openalex.org/I57629906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049313911","display_name":"William Chi Shing Cho","orcid":"https://orcid.org/0000-0003-4174-4586","observed_orcids":["https://orcid.org/0000-0003-4174-4586"]},"institutions":[{"id":"https://openalex.org/I4210166598","display_name":"Queen Elizabeth Hospital","ror":"https://ror.org/05ee2qy47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210166598"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W. C. S. Cho","raw_affiliation_strings":["Queen Elizabeth Hospital, Department of Clinical Oncology, Kowloon, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen Elizabeth Hospital, Department of Clinical Oncology, Kowloon, Hong Kong, China","institution_ids":["https://openalex.org/I4210166598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058993620","display_name":"Hany M. Ahmed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Ahmed","raw_affiliation_strings":["GlycoMantra, Inc., Baltimore, MD 21227, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlycoMantra, Inc., Baltimore, MD 21227, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082779838","display_name":"Tamer A. Al\u2010Shafie","orcid":"https://orcid.org/0000-0001-9179-697X","observed_orcids":["https://orcid.org/0000-0001-9179-697X"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I146977602","display_name":"Pharos University in Alexandria","ror":"https://ror.org/04cgmbd24","country_code":"EG","type":"education","lineage":["https://openalex.org/I146977602"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"T. A. Al-Shafie","raw_affiliation_strings":["Cairo University, National Cancer Institute, Department of Cancer Biology, Cairo, 11796, Egypt. tamer.alshafie@pua.edu.eg","Pharos University in Alexandria, Faculty of Pharmacy and Drug Manufacturing, Department of Pharmacology and Therapeutics, Alexandria, 21311, Egypt","Pharos University in Alexandria, Faculty of Pharmacy and Drug Manufacturing, Department of Pharmacology and Therapeutics, 21311, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cairo University, National Cancer Institute, Department of Cancer Biology, Cairo, 11796, Egypt. tamer.alshafie@pua.edu.eg","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Pharos University in Alexandria, Faculty of Pharmacy and Drug Manufacturing, Department of Pharmacology and Therapeutics, Alexandria, 21311, Egypt","institution_ids":["https://openalex.org/I146977602"]},{"raw_affiliation_string":"Pharos University in Alexandria, Faculty of Pharmacy and Drug Manufacturing, Department of Pharmacology and Therapeutics, 21311, Alexandria, Egypt","institution_ids":["https://openalex.org/I146977602"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5082779838"],"corresponding_institution_ids":["https://openalex.org/I145487455","https://openalex.org/I146977602"],"apc_list":null,"apc_paid":null,"fwci":1.1254,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.76816927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"84","issue":"8","first_page":"941","last_page":"953"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.10130000114440918,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.09290000051259995,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9269999861717224},{"id":"https://openalex.org/keywords/kit-mutations","display_name":"KIT mutations","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.878000020980835},{"id":"https://openalex.org/keywords/liver-stem-cells","display_name":"liver stem cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4950000047683716},{"id":"https://openalex.org/keywords/hcv-viremia","display_name":"HCV viremia","score":0.7429999709129333},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.6959999799728394},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.5149999856948853},{"id":"https://openalex.org/keywords/stem-cell-proliferation","display_name":"stem cell proliferation","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6254528164863586},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5970844030380249},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.5172496438026428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4569126069545746},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4382012188434601},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43793874979019165},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4333113729953766},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.4173605442047119},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4105437099933624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39111998677253723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25084400177001953},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19751909375190735},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.19619661569595337},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.18851271271705627},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16294336318969727},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018800","descriptor_name":"Thy-1 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024921","descriptor_name":"Drug Resistance, Multiple, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1134/s0006297919080108","doi":"https://doi.org/10.1134/s0006297919080108","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0006297919080108","pdf_url":null,"source":{"id":"https://openalex.org/S71215691","display_name":"Biochemistry (Moscow)","issn_l":"0006-2979","issn":["0006-2979","0320-9725","1608-3040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow)","raw_type":"journal-article"},{"id":"pmid:31522676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31522676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry. Biokhimiia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W146587884","https://openalex.org/W797867439","https://openalex.org/W1173698717","https://openalex.org/W1483247593","https://openalex.org/W1760363395","https://openalex.org/W1975914304","https://openalex.org/W1980740976","https://openalex.org/W1986058579","https://openalex.org/W1998993573","https://openalex.org/W2001532608","https://openalex.org/W2017002193","https://openalex.org/W2032448653","https://openalex.org/W2043587965","https://openalex.org/W2044636213","https://openalex.org/W2050962497","https://openalex.org/W2050962565","https://openalex.org/W2051935450","https://openalex.org/W2055043387","https://openalex.org/W2057088392","https://openalex.org/W2058170540","https://openalex.org/W2058812508","https://openalex.org/W2074692967","https://openalex.org/W2086250583","https://openalex.org/W2087493023","https://openalex.org/W2101291993","https://openalex.org/W2104193042","https://openalex.org/W2106787323","https://openalex.org/W2108894953","https://openalex.org/W2120054052","https://openalex.org/W2131674072","https://openalex.org/W2137503836","https://openalex.org/W2138198379","https://openalex.org/W2148468786","https://openalex.org/W2166076504","https://openalex.org/W2167583762","https://openalex.org/W2181400744","https://openalex.org/W2411765633","https://openalex.org/W2506963569","https://openalex.org/W2509538085","https://openalex.org/W2557496587","https://openalex.org/W2731417772","https://openalex.org/W2738171429","https://openalex.org/W2771131584"],"related_works":["https://openalex.org/W4367593425","https://openalex.org/W2167583762","https://openalex.org/W2386300787","https://openalex.org/W2610944712","https://openalex.org/W2052181632","https://openalex.org/W2563371803","https://openalex.org/W2137672147","https://openalex.org/W248531125","https://openalex.org/W2411765633","https://openalex.org/W4403416860"],"abstract_inverted_index":{"Transforming":[0],"growth":[1,146],"factor":[2],"beta":[3],"(TGF-\u03b2)":[4],"acts":[5],"as":[6],"a":[7,34],"tumor-suppressing":[8],"cytokine":[9],"in":[10,17,37,60,90,106,158,163,172,177,180,186,189,202,207,243,247,269],"healthy":[11],"tissues":[12,96],"and":[13,41,55,57,86,92,132,154,194,199,218,266,277],"non-malignant":[14,94,119,133,165],"tumors.":[15],"Yet,":[16],"malignancy,":[18],"TGF-\u03b2":[19,54],"can":[20,26],"exert":[21],"the":[22,51,61,70,118,145,187,190,227,238,244,258,263],"opposite":[23],"effects":[24],"that":[25,241],"promote":[27],"proliferation":[28,128],"of":[29,63,72,75,104,126,129,147,168,196,220,262],"cancer":[30],"cells.":[31],"C-Kit":[32,56,87,151,169,245,267],"plays":[33],"prominent":[35],"role":[36,59],"stem":[38,83],"cell":[39],"activation":[40],"liver":[42,82,95,183,204],"regeneration":[43],"after":[44],"injury.":[45],"However,":[46],"little":[47],"is":[48,237],"known":[49],"about":[50],"cross-talk":[52],"between":[53],"its":[58],"progression":[62],"hepatocellular":[64],"carcinoma":[65],"(HCC).":[66],"Here,":[67],"we":[68],"studied":[69],"effect":[71],"increasing":[73,124],"doses":[74,125],"TGF-\u03b21":[76,140,228,264],"on":[77],"CD44":[78],"+":[79,81],"CD90":[80],"cells":[84,184],"(LSCs)":[85],"gene":[88,246],"expression":[89,219],"malignant":[91,107,131,148,159,182,203],"adjacent":[93],"excised":[97],"from":[98,117],"32":[99],"HCC":[100,248,275],"patients.":[101],"The":[102],"percentage":[103],"LSCs":[105,134],"tumors":[108],"was":[109,135,223],"two":[110],"times":[111],"higher":[112],"compared":[113],"to":[114,143],"their":[115,164],"counterparts":[116],"tissues.":[120],"When":[121],"treated":[122],"with":[123,212,252,271],"TGF-\u03b21,":[127],"both":[130],"progressively":[136],"suppressed,":[137],"but":[138,161],"low":[139],"dose":[141],"failed":[142],"suppress":[144],"LSCs.":[149],"Moreover,":[150],"exons":[152],"9":[153,174,209],"11":[155],"were":[156,210],"expressed":[157],"LSCs,":[160],"not":[162,176,224],"counterparts.":[166],"Analysis":[167],"detected":[170],"mutations":[171,206,242,268],"exon":[173,178,208,222],"(but":[175],"11)":[179],"some":[181],"resulting":[185],"changes":[188],"amino":[191],"acid":[192],"sequence":[193],"dysregulation":[195],"protein":[197],"structure":[198],"function.":[200],"Interestingly,":[201],"cells,":[205],"associated":[211,251],"high-viremia":[213,253],"hepatitis":[214],"C":[215],"virus":[216],"(HCV),":[217],"this":[221,236],"suppressed":[225],"by":[226],"treatment":[229],"at":[230],"all":[231],"doses.":[232],"To":[233],"our":[234],"knowledge,":[235],"first":[239],"report":[240],"patients":[249,270],"are":[250],"HCV.":[254],"Our":[255],"study":[256],"emphasizes":[257],"need":[259],"for":[260,274],"investigation":[261],"level":[265],"chronic":[272],"HCV":[273],"prevention":[276],"better":[278],"therapy":[279],"management.":[280]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-22T00:00:00"}
