{"id":"https://openalex.org/W2967413643","doi":"https://doi.org/10.1136/bmjgast-2019-000315","title":"High potency multistrain probiotic improves liver histology in non-alcoholic fatty liver disease (NAFLD): a randomised, double-blind, proof of concept study","display_name":"High potency multistrain probiotic improves liver histology in non-alcoholic fatty liver disease (NAFLD): a randomised, double-blind, proof of concept study","publication_year":2019,"publication_date":"2019-08-01","ids":{"openalex":"https://openalex.org/W2967413643","doi":"https://doi.org/10.1136/bmjgast-2019-000315","mag":"2967413643","pmid":"https://pubmed.ncbi.nlm.nih.gov/31423319","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6688701"},"language":"en","primary_location":{"id":"doi:10.1136/bmjgast-2019-000315","doi":"https://doi.org/10.1136/bmjgast-2019-000315","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjgast-2019-000315","pdf_url":"https://bmjopengastro.bmj.com/content/bmjgast/6/1/e000315.full.pdf","source":{"id":"https://openalex.org/S2764956485","display_name":"BMJ Open Gastroenterology","issn_l":"2054-4774","issn":["2054-4774"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopengastro.bmj.com/content/bmjgast/6/1/e000315.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090656568","display_name":"Ajay Kumar. Duseja","orcid":"https://orcid.org/0000-0003-3590-2664","observed_orcids":["https://orcid.org/0000-0003-3590-2664"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ajay Duseja","raw_affiliation_strings":["Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"],"raw_orcid":"https://orcid.org/0000-0003-3590-2664","affiliations":[{"raw_affiliation_string":"Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108107038","display_name":"Subrat Kumar Acharya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Subrat K Acharya","raw_affiliation_strings":["Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108570287","display_name":"Manu Mehta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manu Mehta","raw_affiliation_strings":["Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shruti Chhabra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shruti Chhabra","raw_affiliation_strings":["Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shalimar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]},{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shalimar","raw_affiliation_strings":["Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India","Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]},{"raw_affiliation_string":"Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112839642","display_name":"Satyavati V. Rana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Satyavati Rana","raw_affiliation_strings":["Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100600065","display_name":"Ashim Das","orcid":"https://orcid.org/0000-0002-2031-7000","observed_orcids":["https://orcid.org/0000-0002-2031-7000"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]},{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashim Das","raw_affiliation_strings":["Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]},{"raw_affiliation_string":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108107417","display_name":"Siddhartha DATTAGUPTA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]},{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Siddhartha Dattagupta","raw_affiliation_strings":["Department of Pathology, All India Institute of Medical Sciences, New Delhi, India","Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]},{"raw_affiliation_string":"Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048552465","display_name":"Radha Krishan Dhiman","orcid":"https://orcid.org/0000-0002-4107-8512","observed_orcids":["https://orcid.org/0000-0002-4107-8512"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Radha K Dhiman","raw_affiliation_strings":["Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102946788","display_name":"Yogesh Kumar Chawla","orcid":"https://orcid.org/0000-0002-1543-4034","observed_orcids":["https://orcid.org/0000-0002-1543-4034"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yogesh K Chawla","raw_affiliation_strings":["Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090656568","https://openalex.org/A5108107038"],"corresponding_institution_ids":["https://openalex.org/I45294948","https://openalex.org/I63739035"],"apc_list":{"value":1700,"currency":"GBP","value_usd":2085},"apc_paid":{"value":1700,"currency":"GBP","value_usd":2085},"fwci":9.0034,"has_fulltext":true,"cited_by_count":145,"citation_normalized_percentile":{"value":0.98630277,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"6","issue":"1","first_page":"e000315","last_page":"e000315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.1273999959230423,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/multi-strain-probiotics","display_name":"multi-strain probiotics","score":0.9309999942779541},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.777999997138977},{"id":"https://openalex.org/keywords/nafld-activity-score","display_name":"NAFLD activity score","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hepatocyte-ballooning","display_name":"hepatocyte ballooning","score":0.9340000152587891},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/lobular-inflammation","display_name":"lobular inflammation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.7039999961853027},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.972000002861023},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/lifestyle-modification","display_name":"lifestyle modification","score":0.9169999957084656},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5059999823570251},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.628000020980835},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cytokine-profile","display_name":"cytokine profile","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8484145402908325},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7355377674102783},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7096701264381409},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6849138736724854},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.6038531064987183},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5949925780296326},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.5459191203117371},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.5037636160850525},{"id":"https://openalex.org/C2780567839","wikidata":"https://www.wikidata.org/wiki/Q2448873","display_name":"Elevated transaminases","level":2,"score":0.44916799664497375},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.4481401741504669},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.26993656158447266},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.26522982120513916},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.24499467015266418},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1987590193748474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1136/bmjgast-2019-000315","doi":"https://doi.org/10.1136/bmjgast-2019-000315","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjgast-2019-000315","pdf_url":"https://bmjopengastro.bmj.com/content/bmjgast/6/1/e000315.full.pdf","source":{"id":"https://openalex.org/S2764956485","display_name":"BMJ Open Gastroenterology","issn_l":"2054-4774","issn":["2054-4774"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5645267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6688701","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6688701","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6688701","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Gastroenterol","raw_type":"Text"},{"id":"pmid:31423319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31423319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:402c369816764047a102f395e59618dd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/402c369816764047a102f395e59618dd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open Gastroenterology, Vol 6, Iss 1 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/bmjgast-2019-000315","doi":"https://doi.org/10.1136/bmjgast-2019-000315","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjgast-2019-000315","pdf_url":"https://bmjopengastro.bmj.com/content/bmjgast/6/1/e000315.full.pdf","source":{"id":"https://openalex.org/S2764956485","display_name":"BMJ Open Gastroenterology","issn_l":"2054-4774","issn":["2054-4774"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2967413643.pdf","grobid_xml":"https://content.openalex.org/works/W2967413643.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W90736706","https://openalex.org/W94311971","https://openalex.org/W1892559326","https://openalex.org/W1967972402","https://openalex.org/W2004177180","https://openalex.org/W2006933971","https://openalex.org/W2018539892","https://openalex.org/W2029945723","https://openalex.org/W2034604842","https://openalex.org/W2046775810","https://openalex.org/W2052266489","https://openalex.org/W2060089767","https://openalex.org/W2061654362","https://openalex.org/W2068894782","https://openalex.org/W2069354135","https://openalex.org/W2088366586","https://openalex.org/W2098972213","https://openalex.org/W2106768039","https://openalex.org/W2107883335","https://openalex.org/W2114602866","https://openalex.org/W2115895723","https://openalex.org/W2145051098","https://openalex.org/W2156116850","https://openalex.org/W2170666048","https://openalex.org/W2204688218","https://openalex.org/W2253420963","https://openalex.org/W2415314033","https://openalex.org/W2471964074","https://openalex.org/W2477872031","https://openalex.org/W2530171514","https://openalex.org/W2605173654","https://openalex.org/W2732221304","https://openalex.org/W2734724639","https://openalex.org/W2746863374","https://openalex.org/W2754550313","https://openalex.org/W2762994022","https://openalex.org/W2888443845","https://openalex.org/W2908673496","https://openalex.org/W3143409077","https://openalex.org/W4230870013"],"related_works":["https://openalex.org/W2989514645","https://openalex.org/W2351168105","https://openalex.org/W3047447831","https://openalex.org/W4403203769","https://openalex.org/W3199381301","https://openalex.org/W4404353418","https://openalex.org/W2302089850","https://openalex.org/W3174947742","https://openalex.org/W4288693098","https://openalex.org/W4223631864"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Pharmacological":[1],"treatment":[2,17],"of":[3,34,88,105,136,147,226],"non-alcoholic":[4],"fatty":[5],"liver":[6,47,151,274],"disease":[7],"(NAFLD)":[8],"is":[9,285],"still":[10],"evolving.":[11],"Probiotics":[12],"could":[13,156],"be":[14,24,157],"a":[15,35,55],"promising":[16],"option,":[18],"but":[19],"their":[20],"effectiveness":[21],"needs":[22],"to":[23,30,58,175,245],"established.":[25],"The":[26,282],"present":[27],"study":[28,107,143],"aimed":[29],"evaluate":[31],"the":[32,106,109,142,193,200,206,257],"efficacy":[33],"high":[36],"potency":[37],"multistrain":[38,65,268],"probiotic":[39,66,164,194,207,241,269],"in":[40,54,97,112,125,159,163,170,192,205,213,224,240,243,256,273],"adult":[41],"patients":[42,49,138,161,168],"with":[43,50,99,139,144,198,211,261,264,287],"NAFLD.":[44],"METHODS:":[45],"Thirty-nine":[46],"biopsy-proven":[48],"NAFLD":[51,113,140,262],"were":[52,123,254],"randomised":[53],"double-blind":[56],"fashion":[57],"either":[59],"lifestyle":[60,265],"modifications":[61,80,266],"plus":[62],"an":[63],"oral":[64],"(675":[67],"billion":[68],"bacteria":[69],"daily,":[70],"n=19)":[71],"or":[72],"identical":[73],"placebo":[74,171,246],"(n=20)":[75],"for":[76,84],"1":[77,145,154,190,248],"year.":[78,249],"Lifestyle":[79],"included":[81],"regular":[82],"exercise":[83],"all":[85],"and":[86,95,117,120,129,166,183,217,235,267,277],"control":[87],"overweight/obesity":[89],"(with":[90],"additional":[91],"dietary":[92],"restrictions),":[93],"hypertension":[94],"hyperlipidaemia":[96],"those":[98],"these":[100],"risk":[101],"factors.":[102],"Primary":[103],"objective":[104],"was":[108,238],"histological":[110],"improvement":[111,124,223,272],"activity":[114],"score":[115,185,202],"(NAS)":[116],"its":[118],"components":[119],"secondary":[121],"objectives":[122],"alanine":[126],"transaminase":[127],"(ALT)":[128],"cytokine":[130],"profile.":[131],"RESULTS:":[132],"Thirty":[133],"(76.9%)":[134],"out":[135],"39":[137],"completed":[141],"year":[146,155,191],"follow-up.":[148],"A":[149,221],"repeat":[150],"biopsy":[152],"at":[153,189,247],"done":[158],"10":[160],"(52.6%)":[162],"group":[165,208,242],"five":[167],"(25%)":[169],"group.":[172,195],"In":[173],"comparison":[174,244],"baseline,":[176],"hepatocyte":[177,214],"ballooning":[178,215],"(p=0.036),":[179],"lobular":[180],"inflammation":[181],"(p=0.003)":[182],"NAS":[184,201],"(p=0.007)":[186],"improved":[187,203],"significantly":[188,204],"When":[196],"compared":[197],"placebo,":[199],"(p=0.004),":[209],"along":[210],"improvements":[212],"(p=0.05)":[216],"hepatic":[218],"fibrosis":[219],"(p=0.018).":[220],"significant":[222,251,271],"levels":[225],"ALT":[227,276],"(p=0.046),":[228],"leptin":[229],"(p=0.006),":[230],"tumour":[231],"necrosis":[232],"factor-\u03b1":[233],"(p=0.016)":[234],"endotoxins":[236],"(p=0.017)":[237],"observed":[239],"No":[250],"adverse":[252],"events":[253],"reported":[255],"study.":[258],"CONCLUSION:":[259],"Patients":[260],"managed":[263],"showed":[270],"histology,":[275],"cytokines.":[278],"TRIAL":[279,289],"REGISTRATION":[280],"NUMBER:":[281],"clinical":[283],"trial":[284],"registered":[286],"CLINICAL":[288],"REGISTRYINDIA":[290],"(CTRI);":[291],"http://ctri.nic.in,":[292],"No.":[293],"CTRI/2008/091/000074.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":29},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-08-22T00:00:00"}