{"id":"https://openalex.org/W2967328563","doi":"https://doi.org/10.1093/nutrit/nuz037","title":"Effect of vitamin D supplementation on serum lipid profiles: a systematic review and meta-analysis","display_name":"Effect of vitamin D supplementation on serum lipid profiles: a systematic review and meta-analysis","publication_year":2019,"publication_date":"2019-05-06","ids":{"openalex":"https://openalex.org/W2967328563","doi":"https://doi.org/10.1093/nutrit/nuz037","mag":"2967328563","pmid":"https://pubmed.ncbi.nlm.nih.gov/31407792"},"language":"en","primary_location":{"id":"doi:10.1093/nutrit/nuz037","doi":"https://doi.org/10.1093/nutrit/nuz037","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nutrit/nuz037","pdf_url":null,"source":{"id":"https://openalex.org/S38078933","display_name":"Nutrition Reviews","issn_l":"0029-6643","issn":["0029-6643","1753-4887"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044510931","display_name":"Daniel Tefera Dibaba","orcid":"https://orcid.org/0000-0002-5734-8804","observed_orcids":["https://orcid.org/0000-0002-5734-8804"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel T Dibaba","raw_affiliation_strings":["TN-Clinical and Translational Science Institute, University of Tennessee, Health Science Center, Memphis, Tennessee, USA; and the Department of Epidemiology, College of Public Health, and the Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA","TN-Clinical and Translational Science Institute, University of Tennessee, Health Science Center, Memphis, Tennessee, USA"],"raw_orcid":"https://orcid.org/0000-0002-5734-8804","affiliations":[{"raw_affiliation_string":"TN-Clinical and Translational Science Institute, University of Tennessee, Health Science Center, Memphis, Tennessee, USA; and the Department of Epidemiology, College of Public Health, and the Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I160606119"]},{"raw_affiliation_string":"TN-Clinical and Translational Science Institute, University of Tennessee, Health Science Center, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044510931"],"corresponding_institution_ids":["https://openalex.org/I143302722","https://openalex.org/I160606119"],"apc_list":{"value":4981,"currency":"USD","value_usd":4981},"apc_paid":null,"fwci":2.5717,"has_fulltext":false,"cited_by_count":196,"citation_normalized_percentile":{"value":0.91996362,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"77","issue":"12","first_page":"890","last_page":"902"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":1.0},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.8320000171661377},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.8769999742507935},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-health","display_name":"cardiovascular health","score":0.8109999895095825},{"id":"https://openalex.org/keywords/lipid-lowering-effect","display_name":"hypolipidemic effect","score":0.6200000047683716},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.3490000069141388},{"id":"https://openalex.org/keywords/vitamin-d2","display_name":"vitamin D2","score":0.9070000052452087},{"id":"https://openalex.org/keywords/fat-intake","display_name":"dietary fat intake","score":0.35600000619888306},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.652999997138977},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.34599998593330383},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.30799999833106995},{"id":"https://openalex.org/keywords/statin-sparing-therapy","display_name":"statin-sparing therapy","score":0.3930000066757202},{"id":"https://openalex.org/keywords/statin-intolerance","display_name":"statin intolerance","score":0.34700000286102295},{"id":"https://openalex.org/keywords/statin-safety","display_name":"statin safety","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7633967399597168},{"id":"https://openalex.org/C82605166","wikidata":"https://www.wikidata.org/wiki/Q967190","display_name":"Funnel plot","level":4,"score":0.7164854407310486},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7070665955543518},{"id":"https://openalex.org/C2780439572","wikidata":"https://www.wikidata.org/wiki/Q919364","display_name":"Publication bias","level":3,"score":0.6895145177841187},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.653960645198822},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6111682653427124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5776395797729492},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.5659887790679932},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5566067099571228},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4890035390853882},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4545024335384369},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.40647587180137634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12955975532531738},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07878142595291138},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06237402558326721},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/nutrit/nuz037","doi":"https://doi.org/10.1093/nutrit/nuz037","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nutrit/nuz037","pdf_url":null,"source":{"id":"https://openalex.org/S38078933","display_name":"Nutrition Reviews","issn_l":"0029-6643","issn":["0029-6643","1753-4887"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition Reviews","raw_type":"journal-article"},{"id":"pmid:31407792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31407792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W145616655","https://openalex.org/W1485794018","https://openalex.org/W1586129212","https://openalex.org/W1783110207","https://openalex.org/W1905909645","https://openalex.org/W1964435302","https://openalex.org/W1964979997","https://openalex.org/W1965871015","https://openalex.org/W1978853678","https://openalex.org/W1979488098","https://openalex.org/W1984073072","https://openalex.org/W1984741094","https://openalex.org/W1986215651","https://openalex.org/W1998298665","https://openalex.org/W2001675277","https://openalex.org/W2004404485","https://openalex.org/W2004890880","https://openalex.org/W2005403837","https://openalex.org/W2023491817","https://openalex.org/W2024277698","https://openalex.org/W2029379656","https://openalex.org/W2033451677","https://openalex.org/W2033585778","https://openalex.org/W2035139971","https://openalex.org/W2038070668","https://openalex.org/W2040219214","https://openalex.org/W2046235222","https://openalex.org/W2048986874","https://openalex.org/W2051747259","https://openalex.org/W2053868913","https://openalex.org/W2064870470","https://openalex.org/W2080287910","https://openalex.org/W2081845767","https://openalex.org/W2097354177","https://openalex.org/W2099433041","https://openalex.org/W2099479777","https://openalex.org/W2106647095","https://openalex.org/W2107328434","https://openalex.org/W2113666749","https://openalex.org/W2117977362","https://openalex.org/W2123457747","https://openalex.org/W2124831262","https://openalex.org/W2127976042","https://openalex.org/W2132827404","https://openalex.org/W2135994897","https://openalex.org/W2136001038","https://openalex.org/W2137189607","https://openalex.org/W2146153059","https://openalex.org/W2157222729","https://openalex.org/W2159984532","https://openalex.org/W2160985613","https://openalex.org/W2163760677","https://openalex.org/W2167888452","https://openalex.org/W2171987230","https://openalex.org/W2259565892","https://openalex.org/W2281690647","https://openalex.org/W2299400929","https://openalex.org/W2523188657","https://openalex.org/W2581417314","https://openalex.org/W2582885575","https://openalex.org/W2583984806","https://openalex.org/W2612745733","https://openalex.org/W2621128658","https://openalex.org/W2696457852","https://openalex.org/W2738995924","https://openalex.org/W2741417031","https://openalex.org/W2744309703","https://openalex.org/W2756482546","https://openalex.org/W2760512984","https://openalex.org/W2762371553","https://openalex.org/W2883733158","https://openalex.org/W6605896810","https://openalex.org/W6684539604","https://openalex.org/W6695066654"],"related_works":["https://openalex.org/W2099479777","https://openalex.org/W4220840277","https://openalex.org/W4386295401","https://openalex.org/W7215493157","https://openalex.org/W6925089897","https://openalex.org/W7154095912","https://openalex.org/W7084680855","https://openalex.org/W4399355948","https://openalex.org/W4210601002","https://openalex.org/W1968174416"],"abstract_inverted_index":{"CONTEXT:":[0],"Vitamin":[1,364,388],"D":[2,15,44,62,105,199,272,361,365,389,399],"deficiency":[3],"is":[4],"highly":[5],"prevalent":[6],"across":[7],"the":[8,40,58,114,153,156,197,207,215,234,242,263,270,276,321,324,327],"world.":[9],"The":[10,29,251,346],"existing":[11],"evidence":[12],"suggests":[13],"vitamin":[14,43,61,104,198,271,360,398],"may":[16,391],"have":[17,369],"beneficial":[18,371],"effects":[19,126],"on":[20,46,64,94,320,373],"serum":[21,47,65,375],"lipid":[22,48,66],"profiles":[23,67],"and":[24,35,68,83,107,128,150,155,169,171,181,202,212,256,275,303,336,351,380],"thus":[25],"cardiovascular":[26,407],"health.":[27],"OBJECTIVE:":[28],"objective":[30],"of":[31,42,60,88,100,103,109,159,187,219,233,248,323,406],"this":[32],"systematic":[33,121],"review":[34],"meta-analysis":[36],"was":[37,174,316,331,341],"to":[38,134,267,288,295,301,309,334,344,368],"examine":[39],"effect":[41,59,97,325,372],"supplementation":[45,63,200,273,366,390],"profiles.":[49],"DATA":[50,91,116],"SOURCE:":[51],"Original":[52],"randomized":[53],"controlled":[54],"trials":[55,235],"(RCTs)":[56],"examining":[57],"published":[69],"before":[70],"July":[71],"2018":[72],"were":[73,111,123,132,164,210,222,280,353],"identified":[74,211],"by":[75,113],"searching":[76],"online":[77],"databases,":[78],"including":[79],"PubMed,":[80],"Google":[81],"Scholar,":[82],"ScienceDirect,":[84],"using":[85,166,176],"a":[86,313,370],"combination":[87],"relevant":[89],"keywords.":[90],"EXTRACTION:":[92],"Data":[93],"study":[95,220],"characteristics,":[96],"size,":[98,326],"measure":[99],"variation,":[101],"type":[102],"supplementation,":[106],"duration":[108,238,247],"follow-up":[110,237,246,268],"extracted":[112],"author.":[115],"ANALYSIS:":[117],"PRISMA":[118],"guidelines":[119],"for":[120,261,329,338],"reviews":[122],"followed.":[124],"Random":[125],"(DerSimonian":[127],"Laird":[129],"[D-V)]":[130],"models":[131],"used":[133],"pool":[135],"standardized":[136,252],"mean":[137,253],"differences":[138,254],"in":[139,196,206,214,348,356,394],"total":[140,186,283,349,376],"cholesterol,":[141,145,149,377,379],"low-density":[142],"lipoprotein":[143,147],"(LDL)":[144],"high-density":[146],"(HDL)":[148],"triglycerides":[151,297,330,352],"between":[152,269],"active":[154],"placebo":[157,208,277],"arms":[158],"RCT":[160],"studies.":[161],"Between-study":[162],"heterogeneities":[163],"assessed":[165,175],"Cochrane":[167],"Q":[168],"I2,":[170],"publication":[172],"bias":[173],"Begg's":[177],"test,":[178,180],"Egger's":[179],"funnel":[182],"plot.":[183],"RESULTS:":[184],"A":[185],"41":[188],"RCTs":[189],"comprising":[190],"3434":[191],"participants":[192,221,357],"(n":[193],"=":[194,204,285,292,298,306],"1699":[195],"arm":[201,274,279],"n":[203],"1735":[205],"arm)":[209],"included":[213],"meta-analysis.":[216],"Approximately":[217,231],"63.4%":[218],"women,":[223],"with":[224,358,397],"14":[225],"studies":[226],"conducted":[227],"entirely":[228],"among":[229],"women.":[230],"24%":[232],"had":[236,245],">6":[239],"months,":[240],"whereas":[241],"remaining":[243],"76%":[244],"<6":[249],"months.":[250],"(SMDs)":[255],"95%":[257],"confidence":[258],"intervals":[259],"(CIs)":[260],"comparing":[262],"change":[264],"from":[265],"baseline":[266,359],"(control)":[278],"as":[281],"follows:":[282],"cholesterol":[284,291,305,340,350,386],"-0.17":[286],"(-0.28":[287,343],"-0.06);":[289],"LDL":[290,378],"-0.12":[293,299],"(-0.23":[294],"-0.01);":[296],"(-0.25":[300],"0.01);":[302],"HDL":[304,339,385],"-0.19":[307],"(-0.44":[308],"0.06).":[310],"After":[311],"removing":[312],"trial":[314],"that":[315,337],"an":[317],"outlier":[318],"based":[319],"magnitude":[322],"SMD":[328],"-0.15":[332],"(-0.24":[333],"-0.06)":[335],"-0.10":[342],"0.09).":[345],"improvements":[347],"more":[354],"pronounced":[355],"deficiency.":[362],"CONCLUSIONS:":[363],"appeared":[367],"reducing":[374],"triglyceride":[381],"levels":[382],"but":[383],"not":[384],"levels.":[387],"be":[392],"useful":[393],"hypercholesterolemia":[395],"patients":[396],"insufficiency":[400],"who":[401],"are":[402],"at":[403],"high":[404],"risk":[405],"diseases.":[408]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":44},{"year":2023,"cited_by_count":37},{"year":2022,"cited_by_count":39},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-22T00:00:00"}