{"id":"https://openalex.org/W2967319941","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.178.7","title":"Targeting debris\u2010stimulated angiogenesis and primary tumor growth by resolvin mediated clearance","display_name":"Targeting debris\u2010stimulated angiogenesis and primary tumor growth by resolvin mediated clearance","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2967319941","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.178.7","mag":"2967319941"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.31.1_supplement.178.7","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.178.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.178.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053011061","display_name":"Jaimie Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaimie Chang","raw_affiliation_strings":["Pathology, Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074925782","display_name":"Molly M. Gilligan","orcid":"https://orcid.org/0000-0002-7342-9858","observed_orcids":["https://orcid.org/0000-0002-7342-9858"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly Gilligan","raw_affiliation_strings":["Pathology, Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087810115","display_name":"Megan L. Sulciner","orcid":"https://orcid.org/0000-0003-0137-6467","observed_orcids":["https://orcid.org/0000-0003-0137-6467"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Sulciner","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019206785","display_name":"Sui Huang","orcid":"https://orcid.org/0000-0002-3545-4665","observed_orcids":["https://orcid.org/0000-0002-3545-4665"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sui Huang","raw_affiliation_strings":["Institute of Systems Biology, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Systems Biology, Seattle, WA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060208068","display_name":"Mark W. Kieran","orcid":"https://orcid.org/0000-0003-2184-7692","observed_orcids":["https://orcid.org/0000-0003-2184-7692"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Kieran","raw_affiliation_strings":["Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029525374","display_name":"Charles Nicholas Serhan","orcid":"https://orcid.org/0000-0003-4627-8545","observed_orcids":["https://orcid.org/0000-0003-4627-8545"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Serhan","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108417438","display_name":"Dipak Panigrahy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipak Panigrahy","raw_affiliation_strings":["Pathology, Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2292134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.36399999260902405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.36399999260902405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.29269999265670776,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.10300000011920929,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/resolvins","display_name":"resolvins","score":0.9580000042915344},{"id":"https://openalex.org/keywords/specialized-pro-resolving-mediators","display_name":"specialized pro-resolving mediators","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chemotherapy-induced-inflammation","display_name":"chemotherapy-induced inflammation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mip-1alpha","display_name":"MIP-1\u03b1","score":0.7609999775886536},{"id":"https://openalex.org/keywords/serpine1","display_name":"SERPINE1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.656000018119812},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.6620000004768372},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6769999861717224},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7170000076293945},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8205786943435669},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6438589096069336},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.589396059513092},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5324094891548157},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4849879741668701},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4190680980682373},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3184986114501953},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.13058200478553772}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.31.1_supplement.178.7","doi":"https://doi.org/10.1096/fasebj.31.1_supplement.178.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.31.1_supplement.178.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2771932310","https://openalex.org/W3017210831","https://openalex.org/W4253033012","https://openalex.org/W2810338268","https://openalex.org/W1810690762","https://openalex.org/W4389018554","https://openalex.org/W4285008905","https://openalex.org/W1026909922","https://openalex.org/W3206659842","https://openalex.org/W4405761160"],"abstract_inverted_index":{"Background":[0],"Standard":[1],"cancer":[2,25,111],"therapy":[3,26],"reduces":[4],"tumor":[5,9,14,22,33,46,49,94,115,123,140,151,173,181,190,203,212,279,310,318,322,326,332,346,352],"burden":[6],"by":[7,68,126,233,300,350],"killing":[8],"cells,":[10,204],"yet":[11],"simultaneously":[12],"creates":[13],"cell":[15,73,152,182,222,311,319,333],"debris":[16,74,124,153,187,223,245,320,334],"and":[17,75,79,86,257,324,348],"associated":[18],"inflammation":[19,67],"in":[20,93,142,209,226,265],"the":[21,40,64,89,127,169,251,266,329],"microenvironment.":[23],"Thus,":[24,102],"is":[27,35],"inherently":[28],"a":[29,106,143,176,210,227,341],"double\u2010edged":[30],"sword.":[31],"Since":[32],"growth":[34,47,141,191,288,347],"angiogenesis\u2010dependent,":[36],"we":[37,119,167],"hypothesize":[38],"that":[39,121,316],"accumulation":[41],"of":[42,66,72,91,114,171,179,186,196,236,250,268,284,289,309,331],"chemotherapy\u2010generated":[43,317],"debris,":[44],"stimulates":[45,321],"via":[48,240,294,335],"angiogenesis.":[50,116,353],"\u03c9\u20103":[51],"fatty":[52],"acid\u2010derived":[53],"lipid":[54],"autacoids":[55],"termed":[56],"\u2018Specialized":[57],"pro\u2010resolving":[58],"mediators\u2019":[59],"(SPMs),":[60],"including":[61],"resolvins,":[62,339],"stimulate":[63],"resolution":[65],"activating":[69],"macrophage":[70,248,307],"clearance":[71,330],"promote":[76],"wound":[77],"healing":[78],"regeneration.":[80],"While":[81],"SPMs":[82,92],"inhibit":[83],"VEGFA\u2010mediated":[84],"corneal":[85],"retinal":[87],"neovascularization,":[88],"role":[90],"angiogenesis":[95,225,323],"had":[96],"not":[97,156,207],"been":[98],"studied":[99],"to":[100,110,147,175,274,344],"date.":[101],"resolvins":[103,285],"may":[104],"represent":[105],"novel":[107,342],"therapeutic":[108],"approach":[109,343],"through":[112],"inhibition":[113],"Results":[117],"Here,":[118],"show":[120,315],"co\u2010injecting":[122],"generated":[125],"chemotherapeutic":[128],"agent":[129],"5\u2010Fluorouracil":[130],"(5\u2010FU),":[131],"with":[132,277],"living":[133,172,202,278],"murine":[134],"colon":[135,291],"carcinoma":[136],"(CT26)":[137],"cells":[138,174,239,280],"stimulated":[139,224,247,306],"dose\u2010dependent":[144],"manner":[145],"up":[146],"100\u2010fold.":[148],"In":[149],"contrast,":[150],"alone":[154],"did":[155],"produce":[157],"any":[158],"visible":[159,211],"tumors,":[160],"even":[161,192,216],"at":[162,193,217],"100":[163],"days":[164,219],"post\u2010injection.":[165,220],"Next,":[166],"titrated":[168],"number":[170],"fixed":[177],"quantity":[178],"5\u2010FU\u2010generated":[180,244],"debris.":[183,312],"The":[184],"presence":[185],"promoted":[188],"CT26":[189],"an":[194],"inoculum":[195],"1\u00d710":[197,200],"2":[198],"or":[199,355],"3":[201],"which":[205],"do":[206],"result":[208],"when":[213],"injected":[214,276],"alone,":[215],"150":[218],"Tumor":[221],"matrigel":[228],"plug":[229],"assay":[230],"as":[231,338],"measured":[232,299],"increased":[234,262],"infiltration":[235],"CD31+":[237,301],"endothelial":[238,302],"flow":[241],"cytometry":[242],"analysis.":[243],"also":[246,260,305],"production":[249],"pro\u2010angiogenic":[252],"factors,":[253],"MIP\u20101\u03b1,":[254],"serpin":[255],"E1,":[256],"osteopontin.":[258],"We":[259,314],"detected":[261],"osteopontin":[263],"levels":[264],"plasma":[267],"mice":[269,275],"bearing":[270],"debris\u2010stimulated":[271],"tumors":[272],"compared":[273],"alone.":[281],"Systemic":[282],"administration":[283],"inhibited":[286],"primary":[287,325],"human":[290],"xenografts":[292],"(CCL\u2010188)":[293],"reduced":[295],"microvessel":[296],"density":[297],"(as":[298],"cells).":[303],"Resolvins":[304],"phagocytosis":[308],"Conclusions":[313],"growth.":[327],"Stimulating":[328],"SPMs,":[336],"such":[337],"represents":[340],"preventing":[345],"progression":[349],"inhibiting":[351],"Support":[354],"Funding":[356],"Information":[357],"R01\u2010170549":[358]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-08-22T00:00:00"}