{"id":"https://openalex.org/W2967215356","doi":null,"title":"Validation of citrate and derivatives in expressed prostatic secretions to predict prostate cancer: High-resolution 1H-NMR study","display_name":"Validation of citrate and derivatives in expressed prostatic secretions to predict prostate cancer: High-resolution 1H-NMR study","publication_year":2006,"publication_date":"2006-04-15","ids":{"openalex":"https://openalex.org/W2967215356","mag":"2967215356"},"language":"en","primary_location":{"id":"mag:2967215356","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/66/8_Supplement/155.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025904775","display_name":"Natalie Julie Serkova","orcid":"https://orcid.org/0000-0002-4573-3895","observed_orcids":["https://orcid.org/0000-0002-4573-3895"]},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie J. Serkova","raw_affiliation_strings":["University of Colorado Cancer Center, Denver, CO"],"raw_orcid":"https://orcid.org/0000-0002-4573-3895","affiliations":[{"raw_affiliation_string":"University of Colorado Cancer Center, Denver, CO","institution_ids":["https://openalex.org/I4210134151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033597680","display_name":"Eduard J. Gamito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduard J. Gamito","raw_affiliation_strings":["University of Colorado Cancer Center, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Cancer Center, Denver, CO","institution_ids":["https://openalex.org/I4210134151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088742899","display_name":"Richard H. Jones","orcid":"https://orcid.org/0000-0002-7570-2141","observed_orcids":["https://orcid.org/0000-0002-7570-2141"]},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard H. Jones","raw_affiliation_strings":["University of Colorado Cancer Center, Denver, CO"],"raw_orcid":"https://orcid.org/0000-0002-7570-2141","affiliations":[{"raw_affiliation_string":"University of Colorado Cancer Center, Denver, CO","institution_ids":["https://openalex.org/I4210134151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111476998","display_name":"Colin I. O\u2019Donnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin O\u2019Donnell","raw_affiliation_strings":["University of Colorado Cancer Center, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Cancer Center, Denver, CO","institution_ids":["https://openalex.org/I4210134151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021616410","display_name":"Elward David Crawford","orcid":"https://orcid.org/0000-0002-5009-1655","observed_orcids":["https://orcid.org/0000-0002-5009-1655"]},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. David Crawford","raw_affiliation_strings":["University of Colorado Cancer Center, Denver, CO"],"raw_orcid":"https://orcid.org/0000-0002-5009-1655","affiliations":[{"raw_affiliation_string":"University of Colorado Cancer Center, Denver, CO","institution_ids":["https://openalex.org/I4210134151"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210134151"],"apc_list":null,"apc_paid":null,"fwci":0.135,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.51482878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"66","issue":null,"first_page":"155","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.03970000147819519,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/expressed-prostatic-secretions","display_name":"expressed prostatic secretions","score":0.9139999747276306},{"id":"https://openalex.org/keywords/citrate","display_name":"citrate","score":0.9829999804496765},{"id":"https://openalex.org/keywords/spermine","display_name":"spermine","score":0.6819999814033508},{"id":"https://openalex.org/keywords/myo-inositol","display_name":"myo-inositol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.7250000238418579},{"id":"https://openalex.org/keywords/endogenous-metabolites","display_name":"endogenous metabolites","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7609999775886536},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.7689999938011169},{"id":"https://openalex.org/keywords/1h-nmr-metabolomics","display_name":"1H NMR metabolomics","score":0.7820000052452087},{"id":"https://openalex.org/keywords/logistic-regression-prediction-model","display_name":"logistic regression prediction model","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6440078020095825},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.574617862701416},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5669857859611511},{"id":"https://openalex.org/C2776923060","wikidata":"https://www.wikidata.org/wiki/Q576895","display_name":"Phosphocholine","level":5,"score":0.564711332321167},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4761122167110443},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.45432227849960327},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.44840314984321594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32114720344543457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2571083903312683},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20619434118270874},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.18569961190223694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15981870889663696},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.088137686252594},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2967215356","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/66/8_Supplement/155.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2341102283","https://openalex.org/W2007780414","https://openalex.org/W1527552132","https://openalex.org/W2068216768","https://openalex.org/W2995087063","https://openalex.org/W7147353144","https://openalex.org/W2161232700","https://openalex.org/W2026361718","https://openalex.org/W2071096005","https://openalex.org/W2946999006"],"abstract_inverted_index":{"651":[0],"Reliable":[2],"markers":[3],"for":[4,182],"early":[5],"detection":[6],"of":[7,18,27,109,123,156,162,169,208],"prostatic":[8,62],"cancer":[9,69],"which":[10],"sensitivity/":[11],"specificity":[12],"will":[13],"be":[14],"higher":[15],"than":[16],"those":[17],"PSA":[19],"(prostatic":[20],"specific":[21],"antigen)":[22],"are":[23],"desirable.":[24],"High":[25],"concentrations":[26,122],"citrate":[28],"have":[29],"been":[30],"reported":[31],"in":[32,34,60],"vivo":[33],"the":[35,154,160,163,170,183],"healthy":[36,73],"prostate":[37,68],"gland.":[38],"Quantitative":[39],"proton":[40],"nuclear":[41],"magnetic":[42],"resonance":[43],"spectroscopy":[44,93],"(1H-NMR)":[45],"along":[46],"with":[47,67,83,102,118,185],"a":[48,95,103],"novel":[49],"statistical":[50],"method":[51],"were":[52,88,135,204],"utilized":[53],"to":[54,152],"analyze":[55],"and":[56,71,85,202],"validate":[57],"endogenous":[58,124],"metabolites":[59,125],"expressed":[61],"secretions":[63],"(EPS)":[64],"from":[65,72,79],"men":[66,81,184],"(PCa)":[70],"controls.":[74],"Flash":[75],"frozen":[76],"EPS":[77,171],"samples":[78],"66":[80],"(40":[82],"PCa":[84,157,186,209],"26":[86],"controls)":[87],"analyzed":[89],"by":[90],"high-resolution":[91],"1H-NMR":[92,114],"using":[94,137],"Bruker":[96],"500":[97],"MHz":[98],"DRX":[99],"NMR":[100],"spectrometer":[101],"1-mm":[104],"microprobe.":[105],"The":[106,166,178,191],"total":[107],"number":[108],"scans":[110],"per":[111],"fully":[112],"relaxed":[113],"spectrum":[115],"was":[116,150,173,187],"n=40":[117],"water":[119],"suppression.":[120],"Absolute":[121],"(citrate,":[126],"spermine,":[127,199],"myo-inositol,":[128],"lactate,":[129],"alanine,":[130],"phosphocholine,":[131],"glutamate,":[132],"acetate,":[133],"hydroxybutyrate)":[134],"quantified":[136],"trimethylsilyl-propionic":[138],"acid":[139],"as":[140],"an":[141],"external":[142],"standard":[143],"reference.":[144],"Stepwise":[145],"multivariable":[146],"logistic":[147],"regression":[148],"(LR)":[149],"used":[151],"model":[153],"risk":[155],"based":[158],"upon":[159],"levels":[161],"measured":[164],"metabolites.":[165],"average":[167],"age":[168],"donors":[172],"54.7":[174],"\u00b1":[175],"9.8":[176],"years.":[177],"median":[179],"Gleason":[180],"score":[181],"6":[188],"(range":[189],"5-9).":[190],"Wilcoxon":[192],"rank":[193],"sum":[194],"test":[195],"indicated":[196],"that":[197],"citrate,":[198],"inositol,":[200],"citrate/spermine,":[201],"citrate/lactate":[203],"all":[205],"significant":[206],"predictors":[207],"(p":[210]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-08-22T00:00:00"}