{"id":"https://openalex.org/W2966730488","doi":"https://doi.org/10.1038/s42255-019-0105-0","title":"Oxygen and mammalian cell culture: are we repeating the experiment of Dr. Ox?","display_name":"Oxygen and mammalian cell culture: are we repeating the experiment of Dr. Ox?","publication_year":2019,"publication_date":"2019-08-05","ids":{"openalex":"https://openalex.org/W2966730488","doi":"https://doi.org/10.1038/s42255-019-0105-0","mag":"2966730488","pmid":"https://pubmed.ncbi.nlm.nih.gov/32694740"},"language":"en","primary_location":{"id":"doi:10.1038/s42255-019-0105-0","doi":"https://doi.org/10.1038/s42255-019-0105-0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42255-019-0105-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210232714","display_name":"Nature Metabolism","issn_l":"2522-5812","issn":["2522-5812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034669172","display_name":"Tslil Ast","orcid":"https://orcid.org/0000-0002-6927-6238","observed_orcids":["https://orcid.org/0000-0002-6927-6238"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tslil Ast","raw_affiliation_strings":["Broad Institute, Cambridge, MA, USA","Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA","Harvard Medical School, Boston, MA, USA","Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068971521","display_name":"Vamsi K. Mootha","orcid":"https://orcid.org/0000-0001-9924-642X","observed_orcids":["https://orcid.org/0000-0001-9924-642X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vamsi K. Mootha","raw_affiliation_strings":["Broad Institute, Cambridge, MA, USA. vamsi@hms.harvard.edu","Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. vamsi@hms.harvard.edu","Harvard Medical School, Boston, MA, USA. vamsi@hms.harvard.edu","Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA, USA. vamsi@hms.harvard.edu","Broad Institute, Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9924-642X","affiliations":[{"raw_affiliation_string":"Broad Institute, Cambridge, MA, USA. vamsi@hms.harvard.edu","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. vamsi@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA. vamsi@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA, USA. vamsi@hms.harvard.edu","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Broad Institute, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068971521"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":4.441,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.97017491,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"1","issue":"9","first_page":"858","last_page":"860"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6840999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6840999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.12729999423027039,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.10620000213384628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxygen","display_name":"oxygen","score":0.8180000185966492},{"id":"https://openalex.org/keywords/mammalian-cell-culture","display_name":"mammalian cell culture","score":0.9909999966621399},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7459999918937683},{"id":"https://openalex.org/keywords/experimental-interpretation","display_name":"experimental interpretation","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2780616401","wikidata":"https://www.wikidata.org/wiki/Q1133673","display_name":"Cornerstone","level":2,"score":0.7925095558166504},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5779099464416504},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.539404034614563},{"id":"https://openalex.org/C527412718","wikidata":"https://www.wikidata.org/wiki/Q855395","display_name":"Interpretation (philosophy)","level":2,"score":0.44091659784317017},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4168722331523895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3927277624607086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3553101420402527},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.1892108917236328},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.1489696204662323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08547383546829224},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/s42255-019-0105-0","doi":"https://doi.org/10.1038/s42255-019-0105-0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42255-019-0105-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210232714","display_name":"Nature Metabolism","issn_l":"2522-5812","issn":["2522-5812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Metabolism","raw_type":"journal-article"},{"id":"pmid:32694740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32694740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6200041939","display_name":null,"funder_award_id":"R35GM122455","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8517036629","display_name":"Mitochondrial Parts, Pathways, and Pathogenesis","funder_award_id":"R35GM122455","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1232758273","https://openalex.org/W1547863599","https://openalex.org/W1595202381","https://openalex.org/W1986241637","https://openalex.org/W1990120691","https://openalex.org/W1991874179","https://openalex.org/W2009948917","https://openalex.org/W2012822303","https://openalex.org/W2015012139","https://openalex.org/W2018722597","https://openalex.org/W2087377825","https://openalex.org/W2093173456","https://openalex.org/W2099379562","https://openalex.org/W2147295203","https://openalex.org/W2278345709","https://openalex.org/W2804335534","https://openalex.org/W2910314537","https://openalex.org/W2922176925","https://openalex.org/W2922376589","https://openalex.org/W2941023745"],"related_works":["https://openalex.org/W2896573442","https://openalex.org/W4220876135","https://openalex.org/W3127097062","https://openalex.org/W4213198383","https://openalex.org/W4411594708","https://openalex.org/W4411257917","https://openalex.org/W3092412138","https://openalex.org/W2762502468","https://openalex.org/W1264055872","https://openalex.org/W2291131180"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-08-13T00:00:00"}
