{"id":"https://openalex.org/W2966463673","doi":null,"title":"Overexpression of Catalase in Mitochondria Mitigates the Effects of Simulated Microgravity and Social Isolation on Cytokine Expression in Mouse Hippocampus","display_name":"Overexpression of Catalase in Mitochondria Mitigates the Effects of Simulated Microgravity and Social Isolation on Cytokine Expression in Mouse Hippocampus","publication_year":2019,"publication_date":"2019-04-06","ids":{"openalex":"https://openalex.org/W2966463673","mag":"2966463673"},"language":"en","primary_location":{"id":"mag:2966463673","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/api/citations/20190002784/downloads/20190002784.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Experimental biology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078532102","display_name":"Linda Guttmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1329765538","display_name":"Universities Space Research Association","ror":"https://ror.org/043pgqy52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1329765538"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Guttmann","raw_affiliation_strings":["Universities Space Research Association (USRA) Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universities Space Research Association (USRA) Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1329765538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062582492","display_name":"Ruth K. Globus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth K. Globus","raw_affiliation_strings":["NASA Ames Research Center Moffett field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NASA Ames Research Center Moffett field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064276499","display_name":"Candice Ginn T. Tahimic","orcid":"https://orcid.org/0000-0001-5862-2652","observed_orcids":["https://orcid.org/0000-0001-5862-2652"]},"institutions":[{"id":"https://openalex.org/I144472018","display_name":"Wyle (United States)","ror":"https://ror.org/02zeryz43","country_code":"US","type":"company","lineage":["https://openalex.org/I144472018","https://openalex.org/I153156064"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Candice Tahimic","raw_affiliation_strings":["Wyle Labs., Inc. Moffett Field, CA, United States"],"raw_orcid":"https://orcid.org/0000-0001-5862-2652","affiliations":[{"raw_affiliation_string":"Wyle Labs., Inc. Moffett Field, CA, United States","institution_ids":["https://openalex.org/I144472018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029373657","display_name":"Ann\u2010Sofie Schreurs","orcid":"https://orcid.org/0000-0002-9503-032X","observed_orcids":["https://orcid.org/0000-0002-9503-032X"]},"institutions":[{"id":"https://openalex.org/I144472018","display_name":"Wyle (United States)","ror":"https://ror.org/02zeryz43","country_code":"US","type":"company","lineage":["https://openalex.org/I144472018","https://openalex.org/I153156064"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne-Sofie Schreurs","raw_affiliation_strings":["Wyle Labs., Inc. Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyle Labs., Inc. Moffett Field, CA, United States","institution_ids":["https://openalex.org/I144472018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055870646","display_name":"Moniece G. Lowe","orcid":"https://orcid.org/0000-0002-0230-8928","observed_orcids":["https://orcid.org/0000-0002-0230-8928"]},"institutions":[{"id":"https://openalex.org/I4210144256","display_name":"Blue Marble Space","ror":"https://ror.org/03dewsa74","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210144256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moniece Lowe","raw_affiliation_strings":["Blue Marble Space Seattle, WA, United States"],"raw_orcid":"https://orcid.org/0000-0002-0230-8928","affiliations":[{"raw_affiliation_string":"Blue Marble Space Seattle, WA, United States","institution_ids":["https://openalex.org/I4210144256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019483678","display_name":"Sonette Steczina","orcid":"https://orcid.org/0000-0002-5415-828X","observed_orcids":["https://orcid.org/0000-0002-5415-828X"]},"institutions":[{"id":"https://openalex.org/I4210144256","display_name":"Blue Marble Space","ror":"https://ror.org/03dewsa74","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210144256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonette Stecczina","raw_affiliation_strings":["Blue Marble Space Seattle, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blue Marble Space Seattle, WA, United States","institution_ids":["https://openalex.org/I4210144256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11325816,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catalase-overexpression","display_name":"catalase overexpression","score":0.8370000123977661},{"id":"https://openalex.org/keywords/simulated-microgravity","display_name":"simulated microgravity","score":0.875},{"id":"https://openalex.org/keywords/hindlimb-unloading","display_name":"hindlimb unloading","score":0.9700000286102295},{"id":"https://openalex.org/keywords/social-isolation","display_name":"social isolation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8130000233650208},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9100000262260437},{"id":"https://openalex.org/keywords/4-hydroxynonenal","display_name":"4-hydroxynonenal","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dj-1","display_name":"DJ-1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.8519999980926514},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/spaceflight","display_name":"spaceflight","score":0.6600000262260437},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8080000281333923},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6780665516853333},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.554973840713501},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.49819016456604004},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.49553239345550537},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.487505167722702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4695815443992615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44613415002822876},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.41754770278930664},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3276344835758209},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3218649625778198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24456080794334412}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2966463673","doi":null,"is_oa":false,"landing_page_url":"https://ntrs.nasa.gov/api/citations/20190002784/downloads/20190002784.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402118","display_name":"NASA Technical Reports Server (NASA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Experimental biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3139222698","https://openalex.org/W3180933675","https://openalex.org/W3169200644","https://openalex.org/W4308772154","https://openalex.org/W2806432873","https://openalex.org/W4221018588","https://openalex.org/W2278563013","https://openalex.org/W2106791134","https://openalex.org/W2128321922","https://openalex.org/W2004254712"],"abstract_inverted_index":{"Space":[0],"flight":[1],"missions":[2,17],"are":[3],"becoming":[4],"longer":[5],"and":[6,9,26,45,57,79,137,141,161,199,239,315,343,352],"more":[7,197,201],"common":[8],"evidence":[10],"points":[11],"to":[12,41,65,93,106,169,205,225,285,298,308,376],"the":[13,16,20,42,66,84,88,158,184,187,293,299,312,350,377],"physiological":[14],"toll":[15],"have":[18,28],"on":[19,32],"human":[21,131],"body.":[22],"Aging,":[23],"sedentary":[24],"lifestyle,":[25],"spaceflight":[27],"similar":[29],"degenerative":[30,81],"effects":[31,236,318],"almost":[33],"every":[34],"part":[35],"of":[36,110,130,134,143,176,186,222,231,237,244,248,254,289,328],"our":[37,336],"body;":[38],"both":[39,340],"exposure":[40,64],"space":[43,67],"environment":[44,68],"aging":[46],"result":[47],"in":[48,77,83,114,122,163,220,241,250,261,268,278,292,311,332,349,373],"cardiovascular":[49],"deconditioning,":[50],"bone":[51],"loss,":[52],"muscle":[53],"atrophy,":[54],"brain":[55],"changes,":[56],"immune":[58,226],"response":[59],"impairment.":[60],"We":[61,86,302],"hypothesize":[62],"that":[63,190,339],"generates":[69],"excessive":[70],"Reactive":[71],"Oxygen":[72],"Species":[73],"(ROS),":[74],"which":[75,123,329],"results":[76,211,337],"neuroinflammation":[78],"aging-like":[80],"symptoms":[82],"brain.":[85],"used":[87],"hindlimb":[89],"unloading":[90],"(HU)":[91],"model":[92],"mimic":[94],"microgravity":[95,214,342],"with":[96],"either":[97],"paired":[98],"or":[99,116],"single":[100],"housed":[101],"animals":[102],"(social":[103],"isolation).":[104],"Responses":[105],"30d":[107],"(30":[108],"days)":[109],"HU":[111,192,238,260],"were":[112,146,196,319,330,355],"compared":[113,204],"wildtype":[115],"transgenic":[117],"MCAT":[118,191,269,333,353],"(Mitochondrial-targeted":[119],"CATalase)":[120],"mice,":[121,270],"mitochondrial":[124,275,371],"ROS":[125,276,372],"is":[126],"quenched":[127],"by":[128,148,167,259,380],"over-expression":[129],"catalase.":[132],"Expression":[133],"4-Hydroxynonenal":[135],"(4HNE)":[136],"Park7":[138],"(redox-sensitive":[139],"chaperone":[140],"sensor":[142],"oxidative":[144,171],"stress)":[145],"measured":[147,166],"ELISA":[149,168],"(Enzyme-Linked":[150],"ImmunoSorbent":[151],"Assay),":[152],"a":[153,272,366],"protein":[154],"array":[155],"quantified":[156],"from":[157,180,360],"hippocampal":[159],"cytokines":[160,223,246,258,291],"8-hydroxy-2'-deoxyguanosine":[162],"serum":[164],"was":[165,266],"assess":[170],"DNA":[172],"damage.":[173],"Preliminary":[174],"analysis":[175],"cage":[177],"behavior":[178],"patterns":[179],"video":[181],"collected":[182],"at":[183,356],"end":[185],"study":[188],"showed":[189,212,338],"mice":[193,265,354],"(socially":[194],"housed)":[195],"active":[198],"conducted":[200],"exploratory":[202],"activities":[203],"NL":[206],"(Normally":[207],"Loaded).":[208],"Our":[209],"biochemical":[210],"simulated":[213,341],"and/or":[215],"social":[216,309,344],"isolation":[217,310,345],"caused":[218],"changes":[219],"levels":[221,243,348],"related":[224],"responses.":[227],"Two-way":[228],"ANOVA":[229],"(Analysis":[230],"Variance)":[232],"revealed":[233],"significant":[234,320],"interaction":[235,317],"genotype":[240,316],"expression":[242],"five":[245],"(out":[247],"35)":[249],"socially-housed":[251],"animals.":[252],"Elevation":[253],"these":[255,290,361],"generally":[256],"pro-inflammatory":[257],"WT":[262],"(Wild":[263],"Type)":[264],"mitigated":[267,331],"suggesting":[271],"role":[273,369],"for":[274,324,370],"signaling":[277],"inflammatory":[279],"CNS":[280,374],"(Central":[281],"Nervous":[282],"System)":[283],"responses":[284,307,375],"microgravity.":[286],"Interestingly,":[287],"some":[288],"hippocampus":[294,351],"displayed":[295],"strong":[296],"correlations":[297],"4HNE":[300],"levels.":[301],"also":[303],"found":[304],"substantive":[305],"cytokine":[306,347],"hippocampus;":[313],"housing":[314],"(by":[321],"2-Factor":[322],"ANOVA)":[323],"15":[325],"cytokines,":[326],"most":[327],"mice.Taken":[334],"together,":[335],"influenced":[346],"least":[357],"partially":[358],"protected":[359],"changes.":[362],"These":[363],"findings":[364],"implicate":[365],"potentially":[367],"important":[368],"challenges":[378],"posed":[379],"long":[381],"duration":[382],"spaceflight.":[383]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-13T00:00:00"}
