{"id":"https://openalex.org/W2966450571","doi":"https://doi.org/10.3390/vaccines7030080","title":"Proteomic Analysis of Antigen 60 Complex of M. bovis Bacillus Calmette-Gu\u00e9rin Reveals Presence of Extracellular Vesicle Proteins and Predicted Functional Interactions","display_name":"Proteomic Analysis of Antigen 60 Complex of M. bovis Bacillus Calmette-Gu\u00e9rin Reveals Presence of Extracellular Vesicle Proteins and Predicted Functional Interactions","publication_year":2019,"publication_date":"2019-08-02","ids":{"openalex":"https://openalex.org/W2966450571","doi":"https://doi.org/10.3390/vaccines7030080","mag":"2966450571","pmid":"https://pubmed.ncbi.nlm.nih.gov/31382538","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6789874"},"language":"en","primary_location":{"id":"doi:10.3390/vaccines7030080","doi":"https://doi.org/10.3390/vaccines7030080","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/vaccines7030080","pdf_url":"https://www.mdpi.com/2076-393X/7/3/80/pdf?version=1565353574","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-393X/7/3/80/pdf?version=1565353574","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010029153","display_name":"Khayriyyah Mohd Hanafiah","orcid":"https://orcid.org/0000-0003-2976-1965","observed_orcids":["https://orcid.org/0000-0003-2976-1965"]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]},{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]}],"countries":["AU","MY"],"is_corresponding":true,"raw_author_name":"Khayriyyah Mohd Hanafiah","raw_affiliation_strings":["Life Sciences, Macfarlane Burnet Institute, Melbourne, VIC 3004, Australia","School of Biological Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia"],"raw_orcid":"https://orcid.org/0000-0003-2976-1965","affiliations":[{"raw_affiliation_string":"Life Sciences, Macfarlane Burnet Institute, Melbourne, VIC 3004, Australia","institution_ids":["https://openalex.org/I145902186"]},{"raw_affiliation_string":"School of Biological Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074264244","display_name":"Norsyahida Arifin","orcid":"https://orcid.org/0000-0003-2729-8866","observed_orcids":["https://orcid.org/0000-0003-2729-8866"]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Norsyahida Arifin","raw_affiliation_strings":["Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang 11800, Malaysia"],"raw_orcid":"https://orcid.org/0000-0003-2729-8866","affiliations":[{"raw_affiliation_string":"Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang 11800, Malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079810919","display_name":"Paul R. Sanders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul R. Sanders","raw_affiliation_strings":["Life Sciences, Macfarlane Burnet Institute, Melbourne, VIC 3004, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences, Macfarlane Burnet Institute, Melbourne, VIC 3004, Australia","institution_ids":["https://openalex.org/I145902186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033928106","display_name":"Nurulhasanah Othman","orcid":"https://orcid.org/0000-0003-1105-4509","observed_orcids":["https://orcid.org/0000-0003-1105-4509"]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Nurulhasanah Othman","raw_affiliation_strings":["Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang 11800, Malaysia"],"raw_orcid":"https://orcid.org/0000-0003-1105-4509","affiliations":[{"raw_affiliation_string":"Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang 11800, Malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067574422","display_name":"Mary L. Garcia","orcid":"https://orcid.org/0009-0008-9031-4965","observed_orcids":["https://orcid.org/0009-0008-9031-4965"]},"institutions":[{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mary L. Garcia","raw_affiliation_strings":["Life Sciences, Macfarlane Burnet Institute, Melbourne, VIC 3004, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences, Macfarlane Burnet Institute, Melbourne, VIC 3004, Australia","institution_ids":["https://openalex.org/I145902186"]}]},{"author_position":"last","author":{"id":null,"display_name":"David A. Anderson","orcid":"https://orcid.org/0000-0001-9528-1340","observed_orcids":["https://orcid.org/0000-0001-9528-1340"]},"institutions":[{"id":"https://openalex.org/I145902186","display_name":"Burnet Institute","ror":"https://ror.org/05ktbsm52","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I145902186"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David A. Anderson","raw_affiliation_strings":["Life Sciences, Macfarlane Burnet Institute, Melbourne, VIC 3004, Australia"],"raw_orcid":"https://orcid.org/0000-0001-9528-1340","affiliations":[{"raw_affiliation_string":"Life Sciences, Macfarlane Burnet Institute, Melbourne, VIC 3004, Australia","institution_ids":["https://openalex.org/I145902186"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010029153"],"corresponding_institution_ids":["https://openalex.org/I139322472","https://openalex.org/I145902186"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1418},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1418},"fwci":0.5828,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.67037171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"7","issue":"3","first_page":"80","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-bovis-bcg","display_name":"Mycobacterium bovis BCG","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.515999972820282},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8809999823570251},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9729999899864197},{"id":"https://openalex.org/keywords/chaperonin","display_name":"chaperonin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/groel","display_name":"GroEL","score":0.8769999742507935},{"id":"https://openalex.org/keywords/serological-diagnosis","display_name":"serological diagnosis","score":0.6230000257492065},{"id":"https://openalex.org/keywords/tuberculosis-vaccine","display_name":"tuberculosis vaccine","score":0.7070000171661377},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7229999899864197},{"id":"https://openalex.org/keywords/antigenicity","display_name":"antigenicity","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6279304623603821},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6135811805725098},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.6131777167320251},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6048441529273987},{"id":"https://openalex.org/C2778497218","wikidata":"https://www.wikidata.org/wiki/Q133447","display_name":"Mycobacterium bovis","level":4,"score":0.582936704158783},{"id":"https://openalex.org/C2779078216","wikidata":"https://www.wikidata.org/wiki/Q7850848","display_name":"Tuberculosis vaccines","level":4,"score":0.547181248664856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49210113286972046},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.47420600056648254},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44458386301994324},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.4362680912017822},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.41824227571487427},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4005437195301056},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3826919198036194},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19198471307754517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16517725586891174},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12704795598983765},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/vaccines7030080","doi":"https://doi.org/10.3390/vaccines7030080","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/vaccines7030080","pdf_url":"https://www.mdpi.com/2076-393X/7/3/80/pdf?version=1565353574","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5751967","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6789874","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6789874","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6789874","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines (Basel)","raw_type":"Text"},{"id":"pmid:31382538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31382538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cf62994051e34924b836aec10569da42","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cf62994051e34924b836aec10569da42","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines, Vol 7, Iss 3, p 80 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/vaccines7030080","doi":"https://doi.org/10.3390/vaccines7030080","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/vaccines7030080","pdf_url":"https://www.mdpi.com/2076-393X/7/3/80/pdf?version=1565353574","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2966450571.pdf","grobid_xml":"https://content.openalex.org/works/W2966450571.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W88784396","https://openalex.org/W868436125","https://openalex.org/W1270356811","https://openalex.org/W1489360290","https://openalex.org/W1626392937","https://openalex.org/W1706985097","https://openalex.org/W1746756181","https://openalex.org/W1975793467","https://openalex.org/W1993375177","https://openalex.org/W1997846955","https://openalex.org/W2004727493","https://openalex.org/W2006165959","https://openalex.org/W2008808919","https://openalex.org/W2012955884","https://openalex.org/W2017120466","https://openalex.org/W2019627612","https://openalex.org/W2020532093","https://openalex.org/W2036218860","https://openalex.org/W2046864525","https://openalex.org/W2057995877","https://openalex.org/W2060112412","https://openalex.org/W2081502785","https://openalex.org/W2084098587","https://openalex.org/W2085318854","https://openalex.org/W2090443926","https://openalex.org/W2098363863","https://openalex.org/W2102319933","https://openalex.org/W2104486115","https://openalex.org/W2104714277","https://openalex.org/W2129997700","https://openalex.org/W2130599605","https://openalex.org/W2145989523","https://openalex.org/W2150059429","https://openalex.org/W2153996257","https://openalex.org/W2166973430","https://openalex.org/W2233241933","https://openalex.org/W2253044406","https://openalex.org/W2275974181","https://openalex.org/W2460507950","https://openalex.org/W2514444028","https://openalex.org/W2580295475","https://openalex.org/W2592137826","https://openalex.org/W2604758646","https://openalex.org/W2715480331","https://openalex.org/W2756158128","https://openalex.org/W2774421588","https://openalex.org/W2774638123","https://openalex.org/W2794843970","https://openalex.org/W2795899725","https://openalex.org/W2808319530","https://openalex.org/W2834181619","https://openalex.org/W2891040617","https://openalex.org/W2898938484","https://openalex.org/W2899508700","https://openalex.org/W2900569176","https://openalex.org/W2935646388","https://openalex.org/W3020814773","https://openalex.org/W6637745438","https://openalex.org/W6694839545"],"related_works":["https://openalex.org/W2166973430","https://openalex.org/W2019627612","https://openalex.org/W1706985097","https://openalex.org/W2918135090","https://openalex.org/W2543566430","https://openalex.org/W2597335832","https://openalex.org/W2092471876","https://openalex.org/W4404203760","https://openalex.org/W2016768498","https://openalex.org/W7096896904"],"abstract_inverted_index":{"Tuberculosis":[0],"(TB)":[1],"is":[2,26],"ranked":[3],"among":[4],"the":[5],"top":[6],"10":[7],"causes":[8],"of":[9,140],"death":[10],"worldwide.":[11],"New":[12],"biomarker-based":[13],"serodiagnostics":[14],"and":[15,45,77,90,97,123,143,157,163,170,184,208],"vaccines":[16],"are":[17],"unmet":[18],"needs":[19],"stalling":[20],"disease":[21],"control.":[22],"Antigen":[23],"60":[24],"(A60)":[25],"a":[27],"thermostable":[28],"mycobacterial":[29,128],"complex":[30],"typically":[31],"purified":[32],"from":[33],"Bacillus":[34],"Calmette-Gu\u00e9rin":[35],"(BCG)":[36],"vaccine.":[37],"A60":[38,55,64,114,191],"was":[39,65],"historically":[40],"evaluated":[41],"for":[42,153,159],"TB":[43,169],"serodiagnostic":[44],"vaccine":[46,209],"potential":[47],"with":[48,93,151,198],"variable":[49],"findings.":[50],"Despite":[51],"containing":[52],"immunogenic":[53],"proteins,":[54,156,180,194,197],"has":[56],"yet":[57],"to":[58,86,105],"be":[59],"proteomically":[60],"characterized.":[61],"Here,":[62],"commercial":[63],"(1)":[66],"trypsin-digested":[67],"in-solution,":[68],"analyzed":[69,83],"by":[70],"LC-MS/MS,":[71],"searched":[72],"against":[73,177],"M.":[74,141],"tuberculosis":[75],"H37Rv":[76],"M.bovis":[78],"BCG":[79],"Uniprot":[80],"databases;":[81],"(2)":[82],"using":[84],"STRING":[85],"predict":[87],"protein\u2013protein":[88,149],"interactions;":[89],"(3)":[91],"probed":[92],"anti-TB":[94],"monoclonal":[95],"antibodies":[96],"patient":[98],"immunoglobulin":[99],"G":[100],"(IgG)":[101],"on":[102,206],"Western":[103,166],"blot":[104],"evaluate":[106],"antigenicity.":[107],"We":[108],"detected":[109],"778":[110],"proteins":[111,117,146,158],"in":[112,127,138],"two":[113],"samples":[115,174],"(440":[116],"shared),":[118],"including":[119,195],"DnaK,":[120],"LprG,":[121],"LpqH,":[122,182],"GroEL1/2,":[124],"reportedly":[125],"present":[126],"extracellular":[129],"vesicles":[130],"(EV).":[131],"Of":[132],"these,":[133],"107":[134],"were":[135,186],"also":[136],"reported":[137],"EVs":[139],"tuberculosis,":[142],"27":[144],"key":[145],"had":[147,175],"significant":[148],"interaction,":[150],"clustering":[152],"chaperonins,":[154],"ribosomal":[155],"ligand":[160],"transport":[161],"(LpqH":[162],"LprG).":[164],"On":[165],"blot,":[167],"7/8":[168],"1/8":[171],"non-TB":[172],"sera":[173],"reactivity":[176],"37\u201350":[178],"kDa":[179],"while":[181],"GroEL2,":[183],"PstS1":[185],"strongly":[187],"detected.":[188],"In":[189],"conclusion,":[190],"comprises":[192],"numerous":[193],"EV":[196],"predicted":[199],"biological":[200],"interactions,":[201],"which":[202],"may":[203],"have":[204],"implications":[205],"biomarker":[207],"development.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-08-13T00:00:00"}