{"id":"https://openalex.org/W2966412929","doi":"https://doi.org/10.1080/15321819.2019.1649695","title":"Elevated levels of inflammatory markers in women with rheumatoid arthritis","display_name":"Elevated levels of inflammatory markers in women with rheumatoid arthritis","publication_year":2019,"publication_date":"2019-07-31","ids":{"openalex":"https://openalex.org/W2966412929","doi":"https://doi.org/10.1080/15321819.2019.1649695","mag":"2966412929","pmid":"https://pubmed.ncbi.nlm.nih.gov/31366272"},"language":"en","primary_location":{"id":"doi:10.1080/15321819.2019.1649695","doi":"https://doi.org/10.1080/15321819.2019.1649695","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15321819.2019.1649695","pdf_url":null,"source":{"id":"https://openalex.org/S59718605","display_name":"Journal of Immunoassay and Immunochemistry","issn_l":"1532-1819","issn":["1532-1819","1532-4230"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunoassay and Immunochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081929926","display_name":"Camila Medeiros Costa","orcid":"https://orcid.org/0000-0002-5952-1703","observed_orcids":["https://orcid.org/0000-0002-5952-1703"]},"institutions":[{"id":"https://openalex.org/I4210139486","display_name":"Centro Universit\u00e1rio de Formiga","ror":"https://ror.org/043eemy38","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210139486"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Camila Medeiros Costa","raw_affiliation_strings":["Department of Physiotherapy, Centro Universit\u00e1rio de Formiga UNIFOR-MG, Minas Gerais, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-5952-1703","affiliations":[{"raw_affiliation_string":"Department of Physiotherapy, Centro Universit\u00e1rio de Formiga UNIFOR-MG, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4210139486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040331975","display_name":"M. A. T. Santos","orcid":"https://orcid.org/0000-0002-2328-788X","observed_orcids":["https://orcid.org/0000-0002-2328-788X"]},"institutions":[{"id":"https://openalex.org/I4210139486","display_name":"Centro Universit\u00e1rio de Formiga","ror":"https://ror.org/043eemy38","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210139486"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Matheus Augusto Teixeira Dos Santos","raw_affiliation_strings":["Department of Physiotherapy, Centro Universit\u00e1rio de Formiga UNIFOR-MG, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiotherapy, Centro Universit\u00e1rio de Formiga UNIFOR-MG, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4210139486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000408812","display_name":"Andrei Pereira Pernambuco","orcid":"https://orcid.org/0000-0002-5673-8165","observed_orcids":["https://orcid.org/0000-0002-5673-8165"]},"institutions":[{"id":"https://openalex.org/I4210139486","display_name":"Centro Universit\u00e1rio de Formiga","ror":"https://ror.org/043eemy38","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210139486"]},{"id":"https://openalex.org/I67266860","display_name":"Universidade de Ita\u00fana","ror":"https://ror.org/05sw4bn05","country_code":"BR","type":"education","lineage":["https://openalex.org/I67266860"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Andrei Pereira Pernambuco","raw_affiliation_strings":["Department of Physiotherapy, Centro Universit\u00e1rio de Formiga UNIFOR-MG, Minas Gerais, Brazil","Department of Physiotherapy, Universidade de Ita\u00fana (UIT), Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiotherapy, Centro Universit\u00e1rio de Formiga UNIFOR-MG, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4210139486"]},{"raw_affiliation_string":"Department of Physiotherapy, Universidade de Ita\u00fana (UIT), Minas Gerais, Brazil","institution_ids":["https://openalex.org/I67266860"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000408812"],"corresponding_institution_ids":["https://openalex.org/I4210139486","https://openalex.org/I67266860"],"apc_list":null,"apc_paid":null,"fwci":0.8449,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.71891716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"40","issue":"5","first_page":"540","last_page":"554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5799999833106995},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.996999979019165},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.8600000143051147},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.925000011920929},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/das28","display_name":"DAS28","score":0.9940000176429749},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8919991254806519},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.762856125831604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.663119912147522},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6502701044082642},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5869154930114746},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5003364086151123},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48789119720458984},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4663611650466919},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.44133955240249634},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.43942877650260925},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.4392140805721283},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4268653690814972},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42397966980934143},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.41820237040519714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0656760036945343},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/15321819.2019.1649695","doi":"https://doi.org/10.1080/15321819.2019.1649695","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15321819.2019.1649695","pdf_url":null,"source":{"id":"https://openalex.org/S59718605","display_name":"Journal of Immunoassay and Immunochemistry","issn_l":"1532-1819","issn":["1532-1819","1532-4230"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunoassay and Immunochemistry","raw_type":"journal-article"},{"id":"pmid:31366272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31366272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunoassay & immunochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W876448828","https://openalex.org/W1209106218","https://openalex.org/W1488771302","https://openalex.org/W1540671408","https://openalex.org/W1581202634","https://openalex.org/W1704268624","https://openalex.org/W1980327861","https://openalex.org/W1996375401","https://openalex.org/W2000011073","https://openalex.org/W2004007605","https://openalex.org/W2012566528","https://openalex.org/W2037607807","https://openalex.org/W2040474392","https://openalex.org/W2052829600","https://openalex.org/W2055853265","https://openalex.org/W2058076949","https://openalex.org/W2087530820","https://openalex.org/W2089180934","https://openalex.org/W2093120748","https://openalex.org/W2093825845","https://openalex.org/W2094521397","https://openalex.org/W2095611904","https://openalex.org/W2115421980","https://openalex.org/W2121771810","https://openalex.org/W2136639832","https://openalex.org/W2141655217","https://openalex.org/W2153049551","https://openalex.org/W2156022583","https://openalex.org/W2179904263","https://openalex.org/W2188734691","https://openalex.org/W2196374892","https://openalex.org/W2200509731","https://openalex.org/W2270670296","https://openalex.org/W2339002589","https://openalex.org/W2403058566","https://openalex.org/W2410260085","https://openalex.org/W2503297794","https://openalex.org/W2511485166","https://openalex.org/W2516458668","https://openalex.org/W2523119278","https://openalex.org/W2523423592","https://openalex.org/W2545081205","https://openalex.org/W2580050890","https://openalex.org/W2580645593","https://openalex.org/W2623617647","https://openalex.org/W2693593900","https://openalex.org/W2744297581","https://openalex.org/W2750085851","https://openalex.org/W2790990555","https://openalex.org/W2793241324","https://openalex.org/W2795146667","https://openalex.org/W2799521902","https://openalex.org/W2800589908","https://openalex.org/W2803276548","https://openalex.org/W2804125180","https://openalex.org/W2886638259","https://openalex.org/W2907478620","https://openalex.org/W4211111012"],"related_works":["https://openalex.org/W1671039664","https://openalex.org/W4323534782","https://openalex.org/W7117547151","https://openalex.org/W2025222181","https://openalex.org/W2920995565","https://openalex.org/W2214657673","https://openalex.org/W7154186843","https://openalex.org/W2035120102","https://openalex.org/W2392170263","https://openalex.org/W2029628188"],"abstract_inverted_index":{"Rheumatoid":[0],"arthritis":[1],"(RA)":[2],"is":[3],"an":[4],"autoimmune":[5],"and":[6,31,43,51,71,134,159,200],"progressive":[7],"disease.":[8,211],"Evidence":[9],"indicates":[10],"that":[11,149,192,201],"inflammatory":[12],"mediators":[13],"may":[14,195],"contribute":[15,205],"to":[16,29,58,206],"the":[17,26,33,60,64,99,103,110,181,184,207,210],"genesis":[18],"and/or":[19],"evolution":[20],"of":[21,36,78,118,125,183,189,209],"this":[22],"clinical":[23],"condition.":[24],"Thus,":[25],"objective":[27],"was":[28,106,112,120],"evaluate":[30,59],"compare":[32],"plasma":[34,123],"levels":[35,77,124,167,194,204],"Interleukin-17":[37],"(IL-17),":[38],"Tumor":[39],"Necrosis":[40],"Factor-Alpha":[41],"(TNF-\u03b1)":[42],"Complement":[44],"3":[45],"(C3)":[46],"in":[47,109,141,168,187],"women":[48,68,100,142,169],"with":[49,63,69,89,101,143,165,170],"RA":[50,70,171],"healthy":[52],"controls":[53],"(HC),":[54],"as":[55,57],"well":[56],"association":[61],"them":[62],"disease":[65],"activity.":[66],"25":[67],"15":[72],"HC":[73],"were":[74,80,87,139],"recruited.":[75],"Plasma":[76],"biomarkers":[79],"measured":[81],"by":[82],"ELISA.":[83],"All":[84],"statistical":[85],"analyzes":[86],"performed":[88],"a":[90,153,197],"significance":[91],"level":[92],"set":[93],"at":[94],"\u03b1":[95,151],"=":[96,128,173],"0.05.":[97],"In":[98],"RA,":[102,190],"median":[104,116],"age":[105],"55":[107],"and,":[108],"HC,":[111],"50":[113],"years.":[114],"The":[115,122,145],"value":[117],"DAS-28":[119,161],"3.79.":[121],"IL-17":[126,158],"(p":[127,131,136],".03),":[129],"TNF-\u03b1":[130,193],"\u2264":[132,137],"0.01)":[133,138],"C3":[135,166,203],"higher":[140,154],"RA.":[144],"ROC":[146],"curve":[147],"showed":[148],"TNF-":[150],"has":[152],"discriminating":[155],"ability":[156],"than":[157],"C3.":[160],"score":[162],"correlated":[163],"significantly":[164],"(r":[172],"0.91;":[174],"p":[175],"<":[176],".01).":[177],"These":[178],"findings":[179],"reaffirm":[180],"participation":[182],"immune":[185],"system":[186],"pathophysiology":[188],"suggest":[191],"be":[196],"good":[198],"biomarker":[199],"elevated":[202],"worsening":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-08-13T00:00:00"}