{"id":"https://openalex.org/W2966332995","doi":null,"title":"Modulation of immune responses by Fasciola hepatica-derived products","display_name":"Modulation of immune responses by Fasciola hepatica-derived products","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2966332995","mag":"2966332995"},"language":"en","primary_location":{"id":"pmh:http://www.rian.ie/168259/","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2262/88799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"WALSH, ROBERT JAMES, Modulation of immune responses by Fasciola hepatica-derived products, Trinity College Dublin.School of Biochemistry & Immunology, 2019","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Robert Walsh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Robert Walsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fasciola-hepatica","display_name":"Fasciola hepatica","score":0.9980000257492065},{"id":"https://openalex.org/keywords/excretory-secretory-products","display_name":"excretory-secretory products","score":0.8679999709129333},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8539999723434448},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/trained-immunity","display_name":"trained immunity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/alternative-macrophage-activation","display_name":"alternative macrophage activation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.9369999766349792},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.8489999771118164},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9769999980926514},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.7450000047683716},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/regulatory-immune-response","display_name":"regulatory immune response","score":0.6169999837875366},{"id":"https://openalex.org/keywords/autoimmune-disease-treatment","display_name":"autoimmune disease therapy","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2777856171","wikidata":"https://www.wikidata.org/wiki/Q334149","display_name":"Fasciola hepatica","level":3,"score":0.9172351360321045},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.7508343458175659},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6523376703262329},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.5530598163604736},{"id":"https://openalex.org/C2777228834","wikidata":"https://www.wikidata.org/wiki/Q157505","display_name":"Hepatica","level":4,"score":0.4991486072540283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38465815782546997},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3196883797645569},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.20026487112045288},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19829073548316956},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.05617731809616089}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:http://www.rian.ie/168259/","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2262/88799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"WALSH, ROBERT JAMES, Modulation of immune responses by Fasciola hepatica-derived products, Trinity College Dublin.School of Biochemistry & Immunology, 2019","raw_type":"Doctoral thesis"},{"id":"pmh:oai:tara.tcd.ie:2262/88799","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2262/88799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400387","display_name":"Trinity's Access to Research Output (TARA) (Trinity College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205274468","host_organization_name":"Trinity College Dublin","host_organization_lineage":["https://openalex.org/I205274468"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2966332995","doi":null,"is_oa":false,"landing_page_url":"http://www.tara.tcd.ie/handle/2262/88799","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":346,"referenced_works":["https://openalex.org/W36896502","https://openalex.org/W40765902","https://openalex.org/W605348340","https://openalex.org/W1101992567","https://openalex.org/W1499870879","https://openalex.org/W1500518582","https://openalex.org/W1505833426","https://openalex.org/W1506067117","https://openalex.org/W1508752722","https://openalex.org/W1512693074","https://openalex.org/W1513095566","https://openalex.org/W1514064771","https://openalex.org/W1516197123","https://openalex.org/W1538802759","https://openalex.org/W1559873248","https://openalex.org/W1577642131","https://openalex.org/W1579102917","https://openalex.org/W1586763903","https://openalex.org/W1603126127","https://openalex.org/W1615963452","https://openalex.org/W1630060072","https://openalex.org/W1639310471","https://openalex.org/W1762620449","https://openalex.org/W1763258797","https://openalex.org/W1767934134","https://openalex.org/W1771440738","https://openalex.org/W1782561717","https://openalex.org/W1823625017","https://openalex.org/W1828576284","https://openalex.org/W1850539057","https://openalex.org/W1892542831","https://openalex.org/W1919714885","https://openalex.org/W1942668068","https://openalex.org/W1957267795","https://openalex.org/W1957737980","https://openalex.org/W1965639641","https://openalex.org/W1965734808","https://openalex.org/W1966826140","https://openalex.org/W1967261754","https://openalex.org/W1967994686","https://openalex.org/W1968552851","https://openalex.org/W1968728160","https://openalex.org/W1968801556","https://openalex.org/W1971562865","https://openalex.org/W1972849553","https://openalex.org/W1975015556","https://openalex.org/W1975711421","https://openalex.org/W1976381808","https://openalex.org/W1977536320","https://openalex.org/W1977692564","https://openalex.org/W1978790143","https://openalex.org/W1978798501","https://openalex.org/W1980005248","https://openalex.org/W1981671042","https://openalex.org/W1982237578","https://openalex.org/W1982500490","https://openalex.org/W1984079725","https://openalex.org/W1984390733","https://openalex.org/W1985205191","https://openalex.org/W1985585453","https://openalex.org/W1986736465","https://openalex.org/W1987313116","https://openalex.org/W1987628377","https://openalex.org/W1987989908","https://openalex.org/W1988128973","https://openalex.org/W1988272962","https://openalex.org/W1988639136","https://openalex.org/W1989111278","https://openalex.org/W1990571858","https://openalex.org/W1993026721","https://openalex.org/W1994315436","https://openalex.org/W1995853066","https://openalex.org/W1996120942","https://openalex.org/W1996396767","https://openalex.org/W1996417096","https://openalex.org/W1996787721","https://openalex.org/W1998047654","https://openalex.org/W1999768705","https://openalex.org/W2000076863","https://openalex.org/W2002144356","https://openalex.org/W2002186586","https://openalex.org/W2003652884","https://openalex.org/W2004482801","https://openalex.org/W2005066469","https://openalex.org/W2005225316","https://openalex.org/W2005654301","https://openalex.org/W2006249161","https://openalex.org/W2007937714","https://openalex.org/W2009016013","https://openalex.org/W2009495078","https://openalex.org/W2009800174","https://openalex.org/W2010484682","https://openalex.org/W2010593999","https://openalex.org/W2011671647","https://openalex.org/W2011848880","https://openalex.org/W2013645766","https://openalex.org/W2014556622","https://openalex.org/W2015305713","https://openalex.org/W2016193783","https://openalex.org/W2016278466","https://openalex.org/W2016414250","https://openalex.org/W2017092296","https://openalex.org/W2017653795","https://openalex.org/W2018173725","https://openalex.org/W2018473648","https://openalex.org/W2019870550","https://openalex.org/W2021454776","https://openalex.org/W2023429621","https://openalex.org/W2023552484","https://openalex.org/W2023914369","https://openalex.org/W2024864921","https://openalex.org/W2028190708","https://openalex.org/W2029437196","https://openalex.org/W2029836713","https://openalex.org/W2031084334","https://openalex.org/W2031613673","https://openalex.org/W2031721046","https://openalex.org/W2032879966","https://openalex.org/W2033023829","https://openalex.org/W2033279572","https://openalex.org/W2033289727","https://openalex.org/W2033946555","https://openalex.org/W2035831689","https://openalex.org/W2036500213","https://openalex.org/W2038461328","https://openalex.org/W2038944440","https://openalex.org/W2040572245","https://openalex.org/W2041659749","https://openalex.org/W2041896789","https://openalex.org/W2042433863","https://openalex.org/W2042810911","https://openalex.org/W2042851093","https://openalex.org/W2042964255","https://openalex.org/W2043416239","https://openalex.org/W2044098624","https://openalex.org/W2046649749","https://openalex.org/W2046999139","https://openalex.org/W2047882259","https://openalex.org/W2048073154","https://openalex.org/W2049204549","https://openalex.org/W2049310795","https://openalex.org/W2049952530","https://openalex.org/W2050209022","https://openalex.org/W2050604953","https://openalex.org/W2051403769","https://openalex.org/W2053523260","https://openalex.org/W2053923770","https://openalex.org/W2055620105","https://openalex.org/W2055909669","https://openalex.org/W2058065781","https://openalex.org/W2058856567","https://openalex.org/W2059418183","https://openalex.org/W2059422010","https://openalex.org/W2060389791","https://openalex.org/W2061677370","https://openalex.org/W2064662152","https://openalex.org/W2065210647","https://openalex.org/W2065278135","https://openalex.org/W2065897299","https://openalex.org/W2065927080","https://openalex.org/W2066031247","https://openalex.org/W2066300055","https://openalex.org/W2066432115","https://openalex.org/W2066738380","https://openalex.org/W2067031028","https://openalex.org/W2067742268","https://openalex.org/W2067761476","https://openalex.org/W2068005505","https://openalex.org/W2069286887","https://openalex.org/W2069526125","https://openalex.org/W2072186231","https://openalex.org/W2072322888","https://openalex.org/W2072450186","https://openalex.org/W2073293928","https://openalex.org/W2073654249","https://openalex.org/W2073666097","https://openalex.org/W2073959171","https://openalex.org/W2074229539","https://openalex.org/W2075942844","https://openalex.org/W2076889715","https://openalex.org/W2077301497","https://openalex.org/W2077672203","https://openalex.org/W2078724513","https://openalex.org/W2079492782","https://openalex.org/W2079683161","https://openalex.org/W2080172203","https://openalex.org/W2080879611","https://openalex.org/W2084575069","https://openalex.org/W2084825289","https://openalex.org/W2084990572","https://openalex.org/W2086037306","https://openalex.org/W2086068975","https://openalex.org/W2086331830","https://openalex.org/W2087778794","https://openalex.org/W2087888043","https://openalex.org/W2088102919","https://openalex.org/W2088165913","https://openalex.org/W2088839160","https://openalex.org/W2089262366","https://openalex.org/W2089385363","https://openalex.org/W2089934054","https://openalex.org/W2090640877","https://openalex.org/W2090704292","https://openalex.org/W2091487793","https://openalex.org/W2093396768","https://openalex.org/W2093626188","https://openalex.org/W2093816226","https://openalex.org/W2093949724","https://openalex.org/W2096558846","https://openalex.org/W2097147259","https://openalex.org/W2097761110","https://openalex.org/W2097811455","https://openalex.org/W2098750651","https://openalex.org/W2099019634","https://openalex.org/W2099334193","https://openalex.org/W2099371266","https://openalex.org/W2099520023","https://openalex.org/W2100067495","https://openalex.org/W2100379211","https://openalex.org/W2100386453","https://openalex.org/W2102212852","https://openalex.org/W2102235987","https://openalex.org/W2103125300","https://openalex.org/W2103904373","https://openalex.org/W2104934425","https://openalex.org/W2105772739","https://openalex.org/W2106068114","https://openalex.org/W2106248075","https://openalex.org/W2106684817","https://openalex.org/W2107235439","https://openalex.org/W2107237641","https://openalex.org/W2107370389","https://openalex.org/W2109357160","https://openalex.org/W2109684132","https://openalex.org/W2110201516","https://openalex.org/W2110745501","https://openalex.org/W2111691492","https://openalex.org/W2112174079","https://openalex.org/W2113148160","https://openalex.org/W2113697701","https://openalex.org/W2114737175","https://openalex.org/W2115954882","https://openalex.org/W2117047064","https://openalex.org/W2117384446","https://openalex.org/W2118706017","https://openalex.org/W2118967240","https://openalex.org/W2119532085","https://openalex.org/W2120010406","https://openalex.org/W2120131335","https://openalex.org/W2121135409","https://openalex.org/W2123761806","https://openalex.org/W2124103660","https://openalex.org/W2125198788","https://openalex.org/W2127379971","https://openalex.org/W2128627731","https://openalex.org/W2130298480","https://openalex.org/W2130924672","https://openalex.org/W2131227412","https://openalex.org/W2131678280","https://openalex.org/W2132247162","https://openalex.org/W2136105491","https://openalex.org/W2136861118","https://openalex.org/W2137425057","https://openalex.org/W2138281334","https://openalex.org/W2138947021","https://openalex.org/W2139593344","https://openalex.org/W2140206763","https://openalex.org/W2140288892","https://openalex.org/W2140380746","https://openalex.org/W2140637559","https://openalex.org/W2141701917","https://openalex.org/W2143481612","https://openalex.org/W2144008452","https://openalex.org/W2146074801","https://openalex.org/W2146358032","https://openalex.org/W2147326548","https://openalex.org/W2148198599","https://openalex.org/W2149566497","https://openalex.org/W2149671708","https://openalex.org/W2149717051","https://openalex.org/W2150464681","https://openalex.org/W2152039403","https://openalex.org/W2153318621","https://openalex.org/W2154057864","https://openalex.org/W2155013311","https://openalex.org/W2157069655","https://openalex.org/W2159277875","https://openalex.org/W2159402147","https://openalex.org/W2159560463","https://openalex.org/W2160016892","https://openalex.org/W2160980347","https://openalex.org/W2161045611","https://openalex.org/W2161697288","https://openalex.org/W2162819001","https://openalex.org/W2163175900","https://openalex.org/W2164903177","https://openalex.org/W2165246875","https://openalex.org/W2165578318","https://openalex.org/W2165604127","https://openalex.org/W2165728924","https://openalex.org/W2166189303","https://openalex.org/W2168028214","https://openalex.org/W2170114979","https://openalex.org/W2171362737","https://openalex.org/W2175702062","https://openalex.org/W2176750505","https://openalex.org/W2196799556","https://openalex.org/W2209250550","https://openalex.org/W2211754517","https://openalex.org/W2270215994","https://openalex.org/W2278771771","https://openalex.org/W2285621780","https://openalex.org/W2298512893","https://openalex.org/W2300366124","https://openalex.org/W2336656712","https://openalex.org/W2342031861","https://openalex.org/W2346402282","https://openalex.org/W2417702689","https://openalex.org/W2443873000","https://openalex.org/W2506892818","https://openalex.org/W2511168089","https://openalex.org/W2520017917","https://openalex.org/W2522054313","https://openalex.org/W2529143558","https://openalex.org/W2541194853","https://openalex.org/W2548862806","https://openalex.org/W2554106971","https://openalex.org/W2578266761","https://openalex.org/W2582904441","https://openalex.org/W2596984373","https://openalex.org/W2604936735","https://openalex.org/W2605760195","https://openalex.org/W2693379865","https://openalex.org/W2735574704","https://openalex.org/W2753029449","https://openalex.org/W2755753624","https://openalex.org/W2755765772","https://openalex.org/W2765470992","https://openalex.org/W2767008024","https://openalex.org/W2770927276","https://openalex.org/W2783711120","https://openalex.org/W2794623172","https://openalex.org/W2796983933","https://openalex.org/W2890925318","https://openalex.org/W2900735818","https://openalex.org/W2951070274"],"related_works":["https://openalex.org/W8666339","https://openalex.org/W2197904459","https://openalex.org/W1996817217","https://openalex.org/W3081617644","https://openalex.org/W2897234265","https://openalex.org/W4390035559","https://openalex.org/W2327074544","https://openalex.org/W2731095606","https://openalex.org/W2990938907","https://openalex.org/W4409703877"],"abstract_inverted_index":{"Helminths":[0],"are":[1,17,66],"successful":[2],"pathogens":[3],"that":[4,16,25,38,98,290,306],"infect":[5],"25%":[6],"of":[7,49,61,110,118,184,193,205,221,232,271,282,301,323,329],"the":[8,76,99,108,127,139,197,214,219,230,238,272,279,298,321,327],"world":[9],"s":[10],"population.":[11],"They":[12],"cause":[13],"chronic":[14],"infections":[15,51],"associated":[18,57,225],"with":[19,58,201,226],"type-2":[20,128],"and":[21,78,126,131,160,172,174,186,190,235,259,266,276,278,310,316],"regulatory":[22,77,293,313],"immune":[23,29,36,314],"responses":[24,37,315],"suppress":[26],"host":[27],"anti-parasite":[28],"responses.":[30],"However,":[31,75],"helminths":[32,65],"can":[33,106],"also":[34],"inhibit":[35],"mediate":[39],"inflammatory":[40,331],"pathology":[41],"in":[42,52,229,254,284,295,320],"autoimmune":[43,62,112],"diseases.":[44,63,74,332],"Indeed,":[45],"a":[46,87,115,227,255],"high":[47],"prevalence":[48],"helminth":[50,100],"certain":[53],"regions":[54],"has":[55,84,96],"been":[56],"low":[59],"incidences":[60],"Consequently,":[64],"being":[67],"trialed":[68],"as":[69],"potential":[70],"therapies":[71],"for":[72,89,141,162,326],"immune-mediated":[73],"practical":[79],"concerns":[80],"around":[81],"their":[82],"use":[83],"led":[85],"to":[86,218,242],"search":[88],"specific":[90],"helminth-derived":[91],"immunoregulatory":[92],"molecules.":[93,145],"Our":[94],"laboratory":[95],"demonstrated":[97,289],"Fasciola":[101],"hepatica":[102,248,308],"excretory-secretory":[103],"products":[104],"(FHES)":[105],"attenuate":[107],"development":[109],"experimental":[111],"encephalomyelitis":[113],"(EAE),":[114],"mouse":[116],"model":[117],"multiple":[119],"sclerosis.":[120],"Protection":[121],"was":[122,224,260],"mediated":[123],"by":[124,157,170],"eosinophils":[125,173,185],"cytokines":[129,274],"IL-33":[130],"IL-5.":[132],"FHES":[133,156],"is":[134],"heterogeneous":[135],"preparation":[136],"but":[137],"provides":[138],"basis":[140],"identifying":[142],"individual":[143,244],"immunomodulatory":[144,163,245],"In":[146,240],"this":[147],"project,":[148],"small":[149],"extracellular":[150],"vesicles":[151],"(exosomes)":[152],"were":[153],"isolated":[154],"from":[155],"sequential":[158],"centrifugation":[159],"examined":[161],"activity.":[164],"FH":[165,206],"exosomes":[166,207,309],"induced":[167,208],"IL-1RA":[168,275],"production":[169,270],"macrophages":[171,283],"when":[175],"injected":[176],"intraperitoneally":[177],"into":[178,196,237,263],"mice":[179,215],"promoted":[180,269],"recruitment":[181],"or":[182],"expansion":[183],"alternatively":[187],"activated":[188],"macrophages,":[189],"suppressed":[191],"infiltration":[192,231],"pro-inflammatory":[194],"cells":[195],"peritoneal":[198],"cavity.":[199],"Treatment":[200],"two":[202],"single":[203],"injections":[204],"anti-inflammatory":[209,273],"trained":[210],"immunity,":[211],"which":[212],"rendered":[213],"less":[216],"susceptible":[217],"induction":[220],"EAE.":[222,302],"This":[223],"reduction":[228],"pathogenic":[233],"Th1":[234],"Th17":[236],"CNS.":[239],"order":[241],"distinguish":[243],"proteins,":[246],"F.":[247,307],"Kunitz":[249],"Type":[250],"Molecule":[251],"(FHKTM),":[252],"identified":[253],"mass":[256],"spectrometry":[257],"screen":[258],"cloned,":[261],"transformed":[262],"yeast,":[264],"expressed,":[265],"purified.":[267],"FHKTM":[268,291,311],"IL-10":[277],"alternative":[280],"activation":[281],"vitro.":[285],"Finally,":[286],"functional":[287],"studies":[288],"had":[292],"activity":[294],"vivo,":[296],"attenuating":[297],"clinical":[299],"severity":[300],"The":[303],"findings":[304],"demonstrate":[305],"promote":[312],"may":[317],"be":[318],"useful":[319],"design":[322],"new":[324],"approaches":[325],"treatment":[328],"human":[330]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2019-08-13T00:00:00"}