{"id":"https://openalex.org/W2966315232","doi":"https://doi.org/10.1002/stem.3067","title":"A Phenotypic Switch of Differentiated Glial Cells to Dedifferentiated Cells Is Regulated by Folate Receptor \u03b1","display_name":"A Phenotypic Switch of Differentiated Glial Cells to Dedifferentiated Cells Is Regulated by Folate Receptor \u03b1","publication_year":2019,"publication_date":"2019-08-05","ids":{"openalex":"https://openalex.org/W2966315232","doi":"https://doi.org/10.1002/stem.3067","mag":"2966315232","pmid":"https://pubmed.ncbi.nlm.nih.gov/31381815","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6899875"},"language":"en","primary_location":{"id":"doi:10.1002/stem.3067","doi":"https://doi.org/10.1002/stem.3067","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.3067","pdf_url":"https://academic.oup.com/stmcls/article-pdf/37/11/1441/42612278/stmcls_37_11_1441.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/stmcls/article-pdf/37/11/1441/42612278/stmcls_37_11_1441.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045094548","display_name":"Sarah Elizabeth Monick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Monick","raw_affiliation_strings":["a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108663921","display_name":"Vineet Mohanty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vineet Mohanty","raw_affiliation_strings":["a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073008799","display_name":"Mariam M. Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariam Khan","raw_affiliation_strings":["a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018340970","display_name":"Gowtham Yerneni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gowtham Yerneni","raw_affiliation_strings":["a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078492523","display_name":"Praveen Kumar","orcid":"https://orcid.org/0000-0001-6596-9283","observed_orcids":["https://orcid.org/0000-0001-6596-9283"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raj Kumar","raw_affiliation_strings":["b Institute of Advanced Sciences, Dartmouth, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Institute of Advanced Sciences, Dartmouth, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066640943","display_name":"Jorge A. Cant\u00fa","orcid":"https://orcid.org/0000-0002-8881-2649","observed_orcids":["https://orcid.org/0000-0002-8881-2649"]},"institutions":[{"id":"https://openalex.org/I27639287","display_name":"Northeastern Illinois University","ror":"https://ror.org/04edns687","country_code":"US","type":"education","lineage":["https://openalex.org/I27639287"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Cantu","raw_affiliation_strings":["c Department of Biology, Northeastern Illinois University, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c Department of Biology, Northeastern Illinois University, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I27639287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081030548","display_name":"Shunsuke Ichi","orcid":"https://orcid.org/0000-0003-2533-5918","observed_orcids":["https://orcid.org/0000-0003-2533-5918"]},"institutions":[{"id":"https://openalex.org/I4210104057","display_name":"Japanese Red Cross Medical Center","ror":"https://ror.org/01gezbc84","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke Ichi","raw_affiliation_strings":["d Department of Neurosurgery, Japanese Red Cross Medical Center, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"d Department of Neurosurgery, Japanese Red Cross Medical Center, Tokyo, Japan","institution_ids":["https://openalex.org/I4210104057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037916968","display_name":"Guifa Xi","orcid":"https://orcid.org/0000-0001-9080-3277","observed_orcids":["https://orcid.org/0000-0001-9080-3277"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guifa Xi","raw_affiliation_strings":["a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":"https://orcid.org/0000-0001-9080-3277","affiliations":[{"raw_affiliation_string":"a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083903249","display_name":"Bal Ram Singh","orcid":"https://orcid.org/0000-0002-9069-1487","observed_orcids":["https://orcid.org/0000-0002-9069-1487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bal Ram Singh","raw_affiliation_strings":["b Institute of Advanced Sciences, Dartmouth, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Institute of Advanced Sciences, Dartmouth, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101994930","display_name":"Tadanori Tomita","orcid":"https://orcid.org/0000-0001-5281-5170","observed_orcids":["https://orcid.org/0000-0001-5281-5170"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tadanori Tomita","raw_affiliation_strings":["a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047571117","display_name":"Chandra Shekhar K. Mayanil","orcid":"https://orcid.org/0000-0001-9475-0483","observed_orcids":["https://orcid.org/0000-0001-9475-0483"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chandra Shekhar Mayanil","raw_affiliation_strings":["a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","b Institute of Advanced Sciences, Dartmouth, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0001-9475-0483","affiliations":[{"raw_affiliation_string":"a Developmental Biology Program, Stanley Manne Children's Research Institute, Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]},{"raw_affiliation_string":"b Institute of Advanced Sciences, Dartmouth, Massachusetts, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5047571117"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.3718,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.51966419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"37","issue":"11","first_page":"1441","last_page":"1454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.17810000479221344,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.07329999655485153,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folate-receptor-alpha","display_name":"folate receptor alpha","score":0.9760000109672546},{"id":"https://openalex.org/keywords/phenotypic-switching","display_name":"phenotypic switching","score":0.7680000066757202},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/protein-acetylation","display_name":"protein acetylation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.8669999837875366},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.6499999761581421},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/klf4","display_name":"KLF4","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pluripotency-genes","display_name":"pluripotency genes","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ocimum-sanctum","display_name":"Ocimum sanctum","score":0.8309999704360962},{"id":"https://openalex.org/keywords/redifferentiation","display_name":"redifferentiation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/caf-1","display_name":"CAF-1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8866711258888245},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.6403668522834778},{"id":"https://openalex.org/C2778265714","wikidata":"https://www.wikidata.org/wiki/Q18033993","display_name":"KLF4","level":5,"score":0.6338443756103516},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6047358512878418},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.47038164734840393},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4691575765609741},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4673754572868347},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4596512019634247},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.43529918789863586},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.4348496198654175},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4038357138633728},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.20891055464744568},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16822880506515503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1327558159828186}],"mesh":[{"descriptor_ui":"D000070004","descriptor_name":"Ocimum sanctum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000090062","descriptor_name":"Kruppel-Like Factor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053652","descriptor_name":"Nuclear Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058975","descriptor_name":"Folate Receptor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058975","descriptor_name":"Folate Receptor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/stem.3067","doi":"https://doi.org/10.1002/stem.3067","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.3067","pdf_url":"https://academic.oup.com/stmcls/article-pdf/37/11/1441/42612278/stmcls_37_11_1441.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5872110","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6899875","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6899875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6899875","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"Text"},{"id":"pmid:31381815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31381815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/stem.3067","doi":"https://doi.org/10.1002/stem.3067","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.3067","pdf_url":"https://academic.oup.com/stmcls/article-pdf/37/11/1441/42612278/stmcls_37_11_1441.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307622","display_name":"Kiwanis Rockford","ror":"https://ror.org/005t7ny15"},{"id":"https://openalex.org/F4320308907","display_name":"Spina Bifida Association","ror":"https://ror.org/05ddz3y46"},{"id":"https://openalex.org/F4320309578","display_name":"Bunning Food Allergy Institute, Ann and Robert H. Lurie Children's Hospital of Chicago","ror":"https://ror.org/03a6zw892"},{"id":"https://openalex.org/F4320312687","display_name":"Children\u2019s Hospital of Wisconsin Research Institute","ror":"https://ror.org/058g1h315"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2966315232.pdf","grobid_xml":"https://content.openalex.org/works/W2966315232.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1626483287","https://openalex.org/W1675907882","https://openalex.org/W1766248388","https://openalex.org/W1894510757","https://openalex.org/W1926527672","https://openalex.org/W1968627984","https://openalex.org/W1969494283","https://openalex.org/W1975692560","https://openalex.org/W1978279515","https://openalex.org/W1979039549","https://openalex.org/W1980151353","https://openalex.org/W1981718275","https://openalex.org/W1984632430","https://openalex.org/W1984667291","https://openalex.org/W1987480112","https://openalex.org/W1988492454","https://openalex.org/W1989763558","https://openalex.org/W1997519086","https://openalex.org/W2000924275","https://openalex.org/W2005564022","https://openalex.org/W2009193838","https://openalex.org/W2031645957","https://openalex.org/W2034614265","https://openalex.org/W2046467348","https://openalex.org/W2047278958","https://openalex.org/W2068294387","https://openalex.org/W2081226161","https://openalex.org/W2084758863","https://openalex.org/W2103050800","https://openalex.org/W2109399507","https://openalex.org/W2110128697","https://openalex.org/W2134595672","https://openalex.org/W2134600606","https://openalex.org/W2149814027","https://openalex.org/W2161004204","https://openalex.org/W2170552323","https://openalex.org/W2191924043","https://openalex.org/W2252719885","https://openalex.org/W2279907724","https://openalex.org/W2297627723","https://openalex.org/W2340525378","https://openalex.org/W2397198015","https://openalex.org/W2435325303","https://openalex.org/W2513822374","https://openalex.org/W2724942720","https://openalex.org/W2769459381","https://openalex.org/W2774566612","https://openalex.org/W2789603043","https://openalex.org/W2792102298","https://openalex.org/W2796281433","https://openalex.org/W2801975197","https://openalex.org/W2884741354","https://openalex.org/W2888904059","https://openalex.org/W2900682402"],"related_works":["https://openalex.org/W2570657665","https://openalex.org/W2435325303","https://openalex.org/W7140281544","https://openalex.org/W4237592641","https://openalex.org/W2022883506","https://openalex.org/W2053865406","https://openalex.org/W2081191664","https://openalex.org/W6977257296","https://openalex.org/W2036306750","https://openalex.org/W2001488371"],"abstract_inverted_index":{"In":[0],"a":[1,18,53],"previous":[2],"study,":[3],"we":[4,33],"showed":[5],"that":[6,35],"folate":[7,49,87],"receptor-\u03b1":[8],"(FR\u03b1)":[9],"translocates":[10],"to":[11,60,70],"the":[12,46,72,86,104],"nucleus":[13],"where":[14],"it":[15],"acts":[16],"as":[17],"transcription":[19],"factor":[20],"and":[21,26,37,50,111],"upregulates":[22],"Hes1,":[23],"Oct4,":[24],"Sox2,":[25],"Klf4":[27],"genes":[28],"responsible":[29],"for":[30],"pluripotency.":[31],"Here,":[32],"show":[34],"acetylation":[36],"phosphorylation":[38],"of":[39,48,66,74,90,97,107],"FR\u03b1":[40,67,75,110],"favor":[41],"its":[42],"nuclear":[43,105],"translocation":[44,106],"in":[45,76],"presence":[47],"can":[51],"cause":[52],"phenotypic":[54],"switch":[55],"from":[56],"differentiated":[57],"glial":[58,91,99],"cells":[59,92],"dedifferentiated":[61,98],"cells.":[62],"shRNA-FR\u03b1":[63],"mediated":[64,88],"knockdown":[65],"was":[68],"used":[69],"confirm":[71],"role":[73],"dedifferentiation.":[77],"Ocimum":[78],"sanctum":[79],"hydrophilic":[80],"fraction-1":[81],"treatment":[82],"not":[83],"only":[84],"blocks":[85],"dedifferentiation":[89],"but":[93],"also":[94],"promotes":[95],"redifferentiation":[96],"cells,":[100],"possibly":[101],"by":[102],"reducing":[103],"~38":[108],"kDa":[109],"subsequent":[112],"interaction":[113],"with":[114],"chromatin":[115],"assembly":[116],"factor-1.":[117],"Stem":[118],"Cells":[119],"2019;37:1441-1454.":[120]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-13T00:00:00"}
