{"id":"https://openalex.org/W2966296191","doi":null,"title":"Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1\u03b1 during the progression of insulin resistance and type 2 diabetes mellitus in rodent models","display_name":"Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1\u03b1 during the progression of insulin resistance and type 2 diabetes mellitus in rodent models","publication_year":2019,"publication_date":"2019-07-31","ids":{"openalex":"https://openalex.org/W2966296191","mag":"2966296191"},"language":"en","primary_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/92592","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/92592","pdf_url":"http://hdl.handle.net/10919/92592","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10919/92592","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080619565","display_name":"Sarah R. Donnelly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sarah R. Donnelly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080619565"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7730000019073486},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mitochondrial-dna-copy-number","display_name":"mitochondrial DNA copy number","score":0.9169999957084656},{"id":"https://openalex.org/keywords/promoter","display_name":"promoter","score":0.5049999952316284},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.7940000295639038},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9279999732971191},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.8460000157356262},{"id":"https://openalex.org/keywords/homa-beta","display_name":"HOMA-\u03b2","score":0.8420000076293945},{"id":"https://openalex.org/keywords/quantitative-insulin-sensitivity-check-index","display_name":"QUICKI","score":0.9950000047683716},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.7702972888946533},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7692866325378418},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7406293153762817},{"id":"https://openalex.org/C2778914748","wikidata":"https://www.wikidata.org/wiki/Q10850","display_name":"Rodent","level":2,"score":0.6681029200553894},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5995998382568359},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5312521457672119},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.49974513053894043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4745272696018219},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.46988609433174133},{"id":"https://openalex.org/C2992558993","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Rodent model","level":2,"score":0.4691024720668793},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41157248616218567},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36514270305633545},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.36464256048202515},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3535681366920471},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.351546049118042},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24860313534736633},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11768239736557007},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/92592","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/92592","pdf_url":"http://hdl.handle.net/10919/92592","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2966296191","doi":null,"is_oa":false,"landing_page_url":"https://vtechworks.lib.vt.edu/handle/10919/92592","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/92592","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/92592","pdf_url":"http://hdl.handle.net/10919/92592","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2966296191.pdf","grobid_xml":"https://content.openalex.org/works/W2966296191.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3168692312","https://openalex.org/W2408414184","https://openalex.org/W1985280131","https://openalex.org/W2182071468","https://openalex.org/W2476708960","https://openalex.org/W2172208093","https://openalex.org/W2961379506","https://openalex.org/W2812008925","https://openalex.org/W7155506825","https://openalex.org/W3091064733"],"abstract_inverted_index":{"Type":[0],"2":[1],"Diabetes":[2],"Mellitus":[3],"(T2DM),":[4],"a":[5,42,104,114],"metabolic":[6],"disorder":[7],"denoted":[8],"by":[9,142],"elevated":[10],"blood":[11],"glucose":[12],"levels":[13],"and":[14,33,58,75,124,165,197,204],"insufficient":[15],"insulin":[16,40,62,153],"action,":[17],"is":[18],"growing":[19,208],"in":[20,84,90,130,187],"prevalence":[21],"worldwide":[22],".":[23],"Barriers":[24],"to":[25,46,185,206,213],"improving":[26],"disease":[27,73,138,202],"outcome":[28],"resolve":[29],"primarily":[30],"around":[31],"identifying":[32],"intervening":[34],"during":[35],"the":[36,85,91,111,148,156,166,193,198,207,215],"preliminary":[37],"stages":[38],"of":[39,68,87,94,107,113,195,200,210],"resistance,":[41,63],"state":[43],"clinically":[44,143],"referred":[45],"as":[47,140,180],"pre-diabetes.":[48],"Emerging":[49],"evidence":[50],"suggests":[51],"that":[52,65,175],"mitochondrial":[53,69,108],"dysfunction":[54,70,162],"may":[55,178],"underlie":[56],",":[57],"potentially":[59],"precede,":[60],"progressive":[61],"suggesting":[64],"biomarkers":[66],"indicative":[67],"could":[71],"predict":[72],"risk":[74],"status.":[76],"In":[77],"this":[78],"study,":[79],"we":[80,118],"examined":[81],"epigenetic":[82],"modifications,":[83],"form":[86],"DNA":[88],"methylation,":[89],"promoter":[92],"region":[93],"peroxisome":[95],"proliferator":[96],"activated":[97],"receptor":[98],"gamma":[99],"coactivator":[100],"1":[101],"alpha":[102],"(PGC-1\u03b1),":[103],"known":[105],"regulator":[106],"biogenesis.":[109],"Following":[110],"initiation":[112],"high":[115],"fat":[116],"diet,":[117],"observed":[119],"significant":[120],"genotypic":[121],"(DNA":[122],"methylation)":[123],"phenotypic":[125],"(mitochondrial":[126],"copy":[127],"number)":[128],"alterations":[129],"C57/BL6":[131],"rodent":[132],"models.":[133],"These":[134],"changes":[135],"preceded":[136],"overt":[137],"onset,":[139],"classified":[141],"utilized":[144],"indices,":[145],"which":[146],"included":[147],"homeostatic":[149,157],"model":[150,158],"assessment":[151,159,199],"for":[152,160,192],"resistance":[154],"(HOMA-IR),":[155],"\u03b2-cell":[161],"(HOMA-":[163],"\u03b2),":[164],"quantitative":[167],"insulin-sensitivity":[168],"check":[169],"index":[170],"(QUICKI).":[171],"Our":[172],"data":[173],"indicate":[174],"methylation":[176],"analysis":[177],"serve":[179],"an":[181],"effective":[182],"clinical":[183],"parameter":[184],"use":[186],"conjunction":[188],"with":[189],"physiological":[190],"criterion":[191],"diagnosis":[194],"pre-diabetes":[196],"T2DM":[201],"risk,":[203],"adds":[205],"body":[209],"work":[211],"seeking":[212],"elucidate":[214],"role.":[216]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2019-08-13T00:00:00"}