{"id":"https://openalex.org/W2966254173","doi":"https://doi.org/10.3389/fnins.2019.00863","title":"MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex \u2013 A 6-Months Multimodal Imaging Follow-Up Study","display_name":"MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex \u2013 A 6-Months Multimodal Imaging Follow-Up Study","publication_year":2019,"publication_date":"2019-08-16","ids":{"openalex":"https://openalex.org/W2966254173","doi":"https://doi.org/10.3389/fnins.2019.00863","mag":"2966254173","pmid":"https://pubmed.ncbi.nlm.nih.gov/31474824","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6707062"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2019.00863","doi":"https://doi.org/10.3389/fnins.2019.00863","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2019.00863","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.00863/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.00863/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087070702","display_name":"Amna Yasmin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Amna Yasmin","raw_affiliation_strings":["A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091914497","display_name":"Asla Pitk\u00e4nen","orcid":"https://orcid.org/0000-0002-8163-5416","observed_orcids":["https://orcid.org/0000-0002-8163-5416"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Asla Pitk\u00e4nen","raw_affiliation_strings":["A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002202144","display_name":"Kimmo T. Jokivarsi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kimmo Jokivarsi","raw_affiliation_strings":["A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029444240","display_name":"Pekka Poutiainen","orcid":"https://orcid.org/0000-0001-8148-9909","observed_orcids":["https://orcid.org/0000-0001-8148-9909"]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pekka Poutiainen","raw_affiliation_strings":["Center of Diagnostic Imaging, Department of Cyclotron and Radiopharmacy, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Diagnostic Imaging, Department of Cyclotron and Radiopharmacy, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065702208","display_name":"Olli H.J. Gr\u00f6hn","orcid":"https://orcid.org/0000-0003-1372-1651","observed_orcids":["https://orcid.org/0000-0003-1372-1651"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Olli Gr\u00f6hn","raw_affiliation_strings":["A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059253514","display_name":"Riikka J. Immonen","orcid":"https://orcid.org/0000-0002-9855-7098","observed_orcids":["https://orcid.org/0000-0002-9855-7098"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Riikka Immonen","raw_affiliation_strings":["A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059253514"],"corresponding_institution_ids":["https://openalex.org/I175532246"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2673,"currency":"EUR","value_usd":2882},"fwci":2.007,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.85421613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"863","last_page":"863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.05270000174641609,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9480000138282776},{"id":"https://openalex.org/keywords/perilesional-cortex","display_name":"perilesional cortex","score":0.8989999890327454},{"id":"https://openalex.org/keywords/fluid-percussion-injury","display_name":"fluid percussion injury","score":0.8659999966621399},{"id":"https://openalex.org/keywords/myo-inositol","display_name":"myo-inositol","score":0.8949999809265137},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8980000019073486},{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.9700000286102295},{"id":"https://openalex.org/keywords/translocator-protein-tspo","display_name":"translocator protein (TSPO)","score":0.7829999923706055},{"id":"https://openalex.org/keywords/18f-feppa","display_name":"[18F]FEPPA","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tspo-pet","display_name":"TSPO PET","score":0.6209999918937683},{"id":"https://openalex.org/keywords/reactive-microgliosis","display_name":"reactive microgliosis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/glial-scar","display_name":"glial scar","score":0.7379999756813049},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/lesion-expansion","display_name":"lesion expansion","score":0.7770000100135803},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5929999947547913},{"id":"https://openalex.org/keywords/iron","display_name":"iron","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5427395105361938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5023553371429443},{"id":"https://openalex.org/C4441509","wikidata":"https://www.wikidata.org/wiki/Q6418787","display_name":"Multimodal therapy","level":2,"score":0.4451877176761627},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.42958056926727295},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3827444314956665},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.381431519985199},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3291870057582855},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.176395446062088},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1419878602027893}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fnins.2019.00863","doi":"https://doi.org/10.3389/fnins.2019.00863","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2019.00863","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.00863/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5673632","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6707062","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6707062","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6707062","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:31474824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31474824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d0d4ede9c10c4f9d8850be7875e3e27c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d0d4ede9c10c4f9d8850be7875e3e27c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 13 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2019.00863","doi":"https://doi.org/10.3389/fnins.2019.00863","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2019.00863","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.00863/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1093531541","display_name":null,"funder_award_id":"FP7/20072013","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2301236513","display_name":null,"funder_award_id":"272249","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2312555274","display_name":null,"funder_award_id":"298007","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G265847165","display_name":null,"funder_award_id":"FP7/2007\u20102013","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3186328506","display_name":null,"funder_award_id":"602102","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3334912529","display_name":null,"funder_award_id":"273909","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4128198342","display_name":null,"funder_award_id":"602102","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G496129201","display_name":null,"funder_award_id":"2007 \u2013 2013","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5752653382","display_name":null,"funder_award_id":"602102","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G592840682","display_name":null,"funder_award_id":"298007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G617688596","display_name":"Targets and biomarkers for antiepileptogenesis","funder_award_id":"602102","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6346781760","display_name":null,"funder_award_id":"273909","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6517766667","display_name":null,"funder_award_id":"272249","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G672513272","display_name":null,"funder_award_id":"A71429","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G6757901252","display_name":null,"funder_award_id":"273909","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G7150708786","display_name":null,"funder_award_id":"272249","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320328164","display_name":"Epilepsiatutkimuss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/03dj0ma68"},{"id":"https://openalex.org/F4320333065","display_name":"Seventh Framework Programme","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320335026","display_name":"Pohjois-Savon Rahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2966254173.pdf","grobid_xml":"https://content.openalex.org/works/W2966254173.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W1511399835","https://openalex.org/W1571044946","https://openalex.org/W1730237872","https://openalex.org/W1883523450","https://openalex.org/W1978229508","https://openalex.org/W1979728517","https://openalex.org/W1980539857","https://openalex.org/W1983635597","https://openalex.org/W1984652659","https://openalex.org/W1988527761","https://openalex.org/W1993318673","https://openalex.org/W1997256835","https://openalex.org/W1998332829","https://openalex.org/W1999934730","https://openalex.org/W2001560315","https://openalex.org/W2001949804","https://openalex.org/W2002841942","https://openalex.org/W2004732659","https://openalex.org/W2008576363","https://openalex.org/W2014808209","https://openalex.org/W2015551349","https://openalex.org/W2015850772","https://openalex.org/W2017553581","https://openalex.org/W2018316883","https://openalex.org/W2019544787","https://openalex.org/W2020945534","https://openalex.org/W2022693408","https://openalex.org/W2026844934","https://openalex.org/W2031668099","https://openalex.org/W2048165706","https://openalex.org/W2051600991","https://openalex.org/W2063570824","https://openalex.org/W2072171721","https://openalex.org/W2074661552","https://openalex.org/W2083480033","https://openalex.org/W2085314887","https://openalex.org/W2090969222","https://openalex.org/W2091965543","https://openalex.org/W2092013624","https://openalex.org/W2096019298","https://openalex.org/W2104234844","https://openalex.org/W2109195157","https://openalex.org/W2112158347","https://openalex.org/W2124873634","https://openalex.org/W2126394784","https://openalex.org/W2129151648","https://openalex.org/W2137368645","https://openalex.org/W2150484897","https://openalex.org/W2156180278","https://openalex.org/W2161521452","https://openalex.org/W2166326266","https://openalex.org/W2169076855","https://openalex.org/W2178869124","https://openalex.org/W2344918478","https://openalex.org/W2346003458","https://openalex.org/W2346481935","https://openalex.org/W2410316204","https://openalex.org/W2469143669","https://openalex.org/W2477083732","https://openalex.org/W2542741729","https://openalex.org/W2548765116","https://openalex.org/W2550033698","https://openalex.org/W2566981795","https://openalex.org/W2587869366","https://openalex.org/W2598412837","https://openalex.org/W2607249543","https://openalex.org/W2619641984","https://openalex.org/W2735103158","https://openalex.org/W2736002996","https://openalex.org/W2745047077","https://openalex.org/W2797989008","https://openalex.org/W2803742210","https://openalex.org/W2805062984","https://openalex.org/W2807107128","https://openalex.org/W2882972034","https://openalex.org/W2883345188","https://openalex.org/W2886359603","https://openalex.org/W2887251520","https://openalex.org/W2896353795"],"related_works":["https://openalex.org/W2166326266","https://openalex.org/W2894714620","https://openalex.org/W2965952275","https://openalex.org/W2072171721","https://openalex.org/W2882972034","https://openalex.org/W4292448869","https://openalex.org/W2022693408","https://openalex.org/W2002841942","https://openalex.org/W3084293409","https://openalex.org/W4385625389"],"abstract_inverted_index":{"Sustained":[0],"inflammation":[1,48,135,188,297],"in":[2,52,174,216,243,256,281,298,304],"the":[3,30,44,62,137,143,171,175,190,197,202,206,224,239,253,282],"injured":[4],"cortex":[5,145,178,192,259],"is":[6,152],"a":[7,114,213,274],"promising":[8],"therapeutic":[9],"target":[10],"for":[11,90,94,99,157,160,165],"disease-modification":[12],"after":[13],"traumatic":[14],"brain":[15],"injury":[16,55],"(TBI).":[17],"However,":[18,271],"its":[19],"extent":[20],"and":[21,32,71,82,96,132,163,232,235,307,316,323],"dynamics":[22],"of":[23,34,46,142,205,223,314,325],"expansion":[24,51,204],"are":[25],"incompletely":[26],"understood":[27],"which":[28],"challenges":[29],"timing":[31,324],"placement":[33],"therapeutics":[35],"to":[36,42,103,320],"lesioned":[37],"area.":[38],"Our":[39],"aim":[40],"was":[41,111,146,209,241],"characterize":[43],"evolution":[45],"chronic":[47,134,295],"during":[49],"lesion":[50,130,138,199,208],"lateral":[53],"fluid-percussion":[54],"(FPI)":[56],"rat":[57],"model":[58],"with":[59,113],"focus":[60],"on":[61],"MRI-negative":[63,147,299],"perilesional":[64,105,177,258,300],"cortex.":[65,301],"T2-weighted":[66],"MR":[67],"imaging":[68],"(T2w":[69],"MRI)":[70],"localized":[72],"magnetic":[73],"resonance":[74],"spectroscopy":[75],"(MRS)":[76],"were":[77,101,168],"performed":[78],"at":[79,267,285],"1,":[80],"3,":[81],"6":[83],"months":[84,219,269,287],"post-injury.":[85,270],"End-point":[86],"histology,":[87],"including":[88],"Nissl":[89],"neuronal":[91],"death,":[92],"GFAP":[93],"astrogliosis,":[95],"Prussian":[97],"Blue":[98],"iron":[100],"used":[102],"assess":[104],"histopathology.":[106],"An":[107],"additional":[108],"animal":[109],"cohort":[110],"imaged":[112],"positron":[115],"emission":[116],"tomography":[117],"(PET)":[118],"using":[119],"translocator":[120],"protein":[121],"18":[122],"kDa":[123],"(TSPO)":[124],"radiotracer":[125],"[18F]-FEPPA.":[126],"T2w":[127,217],"MRI":[128,306],"assessed":[129,266],"growth":[131],"detected":[133],"along":[136,262],"border":[139],"while":[140],"rest":[141],"ipsilateral":[144,191,283],"(MRI-).":[148],"Instead,":[149,201],"myoinositol":[150],"that":[151,292],"an":[153],"inflammatory":[154,318],"MRS":[155,183,254,293],"marker":[156],"gliosis,":[158],"glutathione":[159],"oxidative":[161],"stress,":[162],"choline":[164],"membrane":[166],"turnover":[167],"elevated":[169],"throughout":[170],"6-months":[172],"follow-up":[173],"MRI-":[176,257],"(all":[179],"p":[180],"<":[181],"0.05).":[182],"markers":[184],"revealed":[185],"chronically":[186],"sustained":[187],"across":[189],"but":[193],"did":[194],"not":[195],"indicate":[196],"upcoming":[198],"expansion.":[200],"rostral":[203],"cortical":[207,249],"systematically":[210],"preceded":[211],"by":[212],"hyperintense":[214],"band":[215,240],"images":[218],"earlier.":[220],"Histologic":[221],"analysis":[222],"hyperintensity":[225],"indicated":[226],"scattered":[227],"astrocytes,":[228],"incomplete":[229],"glial":[230,263],"scar,":[231],"intracellularly":[233],"packed":[234],"free":[236],"iron.":[237],"Yet,":[238],"negative":[242],"[18F]-FEPPA-PET.":[244],"[18F]-FEPPA":[245,272],"also":[246],"showed":[247,273],"no":[248],"TSPO":[250],"expression":[251],"within":[252],"voxel":[255],"or":[260],"anywhere":[261],"scar":[264],"when":[265],"2":[268,286],"robust":[275],"signal":[276],"increase,":[277],"indicating":[278],"reactive":[279],"microgliosis":[280],"thalamus":[284],"post-TBI.":[288],"We":[289],"present":[290],"evidence":[291],"reveals":[294],"posttraumatic":[296],"The":[302],"mismatch":[303],"MRS,":[305],"PET":[308],"measures":[309],"may":[310],"allow":[311],"noninvasive":[312],"endophenotyping":[313],"beneficial":[315],"detrimental":[317],"processes":[319],"aid":[321],"targeting":[322],"anti-inflammatory":[326],"therapeutics.":[327]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-13T00:00:00"}