{"id":"https://openalex.org/W2965791679","doi":"https://doi.org/10.1002/cncr.32425","title":"Reply to Natural history of thyroid cancer suggests beginning of the overdiagnosis of juvenile thyroid cancer in the United States and Harm of overdiagnosis or extremely early diagnosis behind trends in pediatric thyroid cancer","display_name":"Reply to Natural history of thyroid cancer suggests beginning of the overdiagnosis of juvenile thyroid cancer in the United States and Harm of overdiagnosis or extremely early diagnosis behind trends in pediatric thyroid cancer","publication_year":2019,"publication_date":"2019-07-29","ids":{"openalex":"https://openalex.org/W2965791679","doi":"https://doi.org/10.1002/cncr.32425","mag":"2965791679","pmid":"https://pubmed.ncbi.nlm.nih.gov/31355913","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13455760"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.32425","doi":"https://doi.org/10.1002/cncr.32425","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.32425","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.32425","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.32425","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022857670","display_name":"Marie\u2010Odile Bernier","orcid":"https://orcid.org/0000-0001-5807-4596","observed_orcids":["https://orcid.org/0000-0001-5807-4596"]},"institutions":[{"id":"https://openalex.org/I1293448361","display_name":"Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire","ror":"https://ror.org/01ha22c77","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I1293448361","https://openalex.org/I4405256652"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Marie\u2010Odile Bernier","raw_affiliation_strings":["Laboratory of Epidemiology, Radioprotection and Nuclear Safety Institute, Fontenay aux Roses, France","Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":"https://orcid.org/0000-0001-5807-4596","affiliations":[{"raw_affiliation_string":"Laboratory of Epidemiology, Radioprotection and Nuclear Safety Institute, Fontenay aux Roses, France","institution_ids":["https://openalex.org/I1293448361"]},{"raw_affiliation_string":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037704614","display_name":"Cari Meinhold Kitahara","orcid":"https://orcid.org/0000-0001-6416-4432","observed_orcids":["https://orcid.org/0000-0001-6416-4432","https://orcid.org/0000-0003-1147-2575"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cari M. Kitahara","raw_affiliation_strings":["Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041592688","display_name":"Meredith S. Shiels","orcid":"https://orcid.org/0000-0001-8390-6091","observed_orcids":["https://orcid.org/0000-0001-8390-6091"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meredith S. Shiels","raw_affiliation_strings":["Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":"https://orcid.org/0000-0001-8390-6091","affiliations":[{"raw_affiliation_string":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"125","issue":"22","first_page":"4109","last_page":"4110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-thyroid-cancer","display_name":"pediatric thyroid cancer","score":0.984000027179718},{"id":"https://openalex.org/keywords/overdiagnosis","display_name":"overdiagnosis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/incidence-trends","display_name":"incidence trends","score":0.7350000143051147},{"id":"https://openalex.org/keywords/differentiated-thyroid-cancer","display_name":"differentiated thyroid cancer","score":0.6880000233650208},{"id":"https://openalex.org/keywords/pediatric-cancer-survivors","display_name":"childhood cancer survivors","score":0.828000009059906},{"id":"https://openalex.org/keywords/health-behavior","display_name":"health behavior","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2779377019","wikidata":"https://www.wikidata.org/wiki/Q956131","display_name":"Overdiagnosis","level":2,"score":0.9867373704910278},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9277187585830688},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.8104866743087769},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6318877935409546},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5823416709899902},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5789852738380432},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4400749206542969},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36955857276916504},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3200458884239197},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069342","descriptor_name":"Medical Overuse","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/cncr.32425","doi":"https://doi.org/10.1002/cncr.32425","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.32425","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.32425","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:31355913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31355913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Letter"},{"id":"pmh:oai:pubmedcentral.nih.gov:13455760","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13455760/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-02982039v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-02982039","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer, 2019, 125 (22), pp.4109-4110. ⟨10.1002/cncr.32425⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/cncr.32425","doi":"https://doi.org/10.1002/cncr.32425","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.32425","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.32425","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000857328","display_name":"Descriptive Studies and Record Linkage","funder_award_id":"ZIACP010183","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2965791679.pdf","grobid_xml":"https://content.openalex.org/works/W2965791679.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2048252958","https://openalex.org/W2314815360","https://openalex.org/W2515945943","https://openalex.org/W2941761603","https://openalex.org/W6725982939"],"related_works":["https://openalex.org/W2966083905","https://openalex.org/W7024596161","https://openalex.org/W2964564890","https://openalex.org/W3153964654","https://openalex.org/W2972523645","https://openalex.org/W4252787645","https://openalex.org/W3026900255","https://openalex.org/W4409766400","https://openalex.org/W2941761603","https://openalex.org/W2098206569"],"abstract_inverted_index":{"Trends":[0],"in":[1,24,31,91,121],"Pediatric":[2],"Thyroid":[3],"CancerMidorikawa":[4],"et":[5],"al":[6],"and":[7,14,37,59,83,125],"Takano":[8],"expressed":[9],"concerns":[10],"about":[11],"our":[12,19],"interpretation":[13],"the":[15,32,43,52,62,75,79,87,96,116,136],"broader":[16],"implications":[17],"of":[18,45,64,67,81,98,130,135],"study,":[20],"which":[21],"described":[22],"trends":[23,120],"pediatric":[25],"differentiated":[26,46],"thyroid":[27,47,76],"cancer":[28,48],"incidence":[29,44,92],"rates":[30],"United":[33],"States":[34],"between":[35],"1998":[36],"2013.":[38],"1":[39],"We":[40],"found":[41,70],"that":[42,100],"increased":[49],"rapidly":[50],"over":[51,93,110],"study":[53],"period":[54],"for":[55,86],"all":[56],"tumor":[57],"stages":[58],"sizes":[60],"at":[61,78],"time":[63,80],"diagnosis.The":[65],"majority":[66],"cases":[68],"were":[69],"to":[71,74],"be":[72],"localized":[73,122],"gland":[77],"diagnosis,":[82],"these":[84],"accounted":[85],"largest":[88],"absolute":[89],"increase":[90],"time.Overdiagnosis,":[94],"or":[95,106],"diagnosis":[97],"cancers":[99],"never":[101],"would":[102],"have":[103],"become":[104],"symptomatic":[105],"caused":[107],"health":[108,126],"problems":[109],"a":[111],"lifetime,":[112],"has":[113],"likely":[114],"had":[115],"greatest":[117],"influence":[118],"on":[119],"tumors.More":[123],"intensive":[124],"behaviors":[127],"among":[128],"survivors":[129],"childhood":[131],"cancer:":[132],"current":[133],"state":[134],"literature.":[137]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-08-13T00:00:00"}