{"id":"https://openalex.org/W2965729454","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e19064","title":"EGFR mutation testing, from bench to practice: A single Irish institute experience.","display_name":"EGFR mutation testing, from bench to practice: A single Irish institute experience.","publication_year":2013,"publication_date":"2013-05-20","ids":{"openalex":"https://openalex.org/W2965729454","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e19064","mag":"2965729454"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2013.31.15_suppl.e19064","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e19064","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.e19064","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004098677","display_name":"Hassan Shikhrakab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Hassan Shikhrakab","raw_affiliation_strings":["St James's Hospital,Dublin,ireland., Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St James's Hospital,Dublin,ireland., Dublin, Ireland","institution_ids":["https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039986459","display_name":"Cathal P. O\u2019Brien","orcid":"https://orcid.org/0000-0001-9099-7462","observed_orcids":["https://orcid.org/0000-0001-9099-7462"]},"institutions":[{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Cathal O'Brien","raw_affiliation_strings":["St James's Hospital Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St James's Hospital Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082273060","display_name":"Nemer Osman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Nemer Osman","raw_affiliation_strings":["St. James's Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. James's Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210154619"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033519199","display_name":"Kenneth John O'Byrne","orcid":"https://orcid.org/0000-0002-6754-5633","observed_orcids":["https://orcid.org/0000-0002-6754-5633"]},"institutions":[{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Kenneth John O'Byrne","raw_affiliation_strings":["Department of Medical Oncology, St. James's Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, St. James's Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210154619"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210154619"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"15_suppl","first_page":"e19064","last_page":"e19064"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.625},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/exon-19-deletion","display_name":"exon 19 deletion","score":0.9480000138282776},{"id":"https://openalex.org/keywords/exon-21-l858r","display_name":"exon 21 L858R","score":0.9089999794960022},{"id":"https://openalex.org/keywords/exon-20-insertion","display_name":"exon 20 insertion","score":0.9350000023841858},{"id":"https://openalex.org/keywords/irish-patients","display_name":"Irish patients","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.8479628562927246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.793850302696228},{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.7643947601318359},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5332115888595581},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.510434091091156},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5056309700012207},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49430394172668457},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4795339107513428},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4180348515510559},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38104164600372314},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2828913927078247},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24615657329559326},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2297973930835724},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.2238301932811737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16594961285591125},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2013.31.15_suppl.e19064","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.e19064","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.e19064","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W319497155","https://openalex.org/W3008564975","https://openalex.org/W2914978038","https://openalex.org/W2771169290","https://openalex.org/W2051479010","https://openalex.org/W2981596962","https://openalex.org/W2101569260","https://openalex.org/W2366356213","https://openalex.org/W4226148278","https://openalex.org/W7037169015"],"abstract_inverted_index":{"e19064":[0],"Background:":[1],"Epidermal":[2],"growth":[3],"factor":[4],"receptor":[5],"(EGFR)":[6],"gene":[7,97],"mutations":[8,29,40,53,86,153,214,327],"determine":[9],"the":[10,25,36,42,63,95,152,236,303],"treatment":[11,83,131],"and":[12,19,92,129,184,188,207],"prognosis":[13],"in":[14,41,73,87,100,217,220,312,316,318,328],"lung":[15,140],"adenocarcinoma.":[16],"Exon":[17],"19":[18,161],"exon":[20,160,168,176,185,189],"21":[21,93,169],"(L858R)":[22],"deletions":[23],"represent":[24,302],"most":[26],"common":[27],"recognised":[28],"detected.":[30],"To":[31],"date,":[32],"no":[33],"figures":[34],"regarding":[35],"prevalence":[37,50],"of":[38,51,65,80,94,127,136,213,223,300,306,325],"EGFR":[39,52,66,85,96,145,227,278,310,326,357],"Irish":[43,76,102],"population":[44,331],"have":[45],"been":[46],"published.":[47],"Methods:":[48],"The":[49,78,211,245,323,338],"was":[54,98,157,215,239,250,256,341],"retrospectively":[55],"analysed":[56,111],"for":[57,258,277,309],"all":[58],"patient":[59,330],"samples":[60,109,262],"tested":[61,99,142,202,263,308],"since":[62],"introduction":[64],"testing":[67,249],"routinely":[68],"(Mar":[69],"to":[70,291,334,354],"Dec":[71],"2012)":[72],"a":[74,113,313],"single":[75,314],"institute.":[77],"presence":[79],"41":[81],"known":[82],"linked":[84],"exons":[88],"18,":[89],"19,":[90],"20":[91,177,190],"209":[101,137],"patients.":[103],"Resection,":[104],"core":[105],"biopsy":[106],"or":[107,270],"FNA":[108],"were":[110,123,204,229,264],"using":[112],"commercially":[114],"available":[115],"CE-IVD":[116],"marked":[117],"multiplex":[118],"real-time":[119],"PCR":[120],"assay.":[121],"Samples":[122],"included":[124],"from":[125,287],"patients":[126,138,201,301,307,348],"curative":[128],"palliative":[130],"intent.":[132],"Results:":[133],"30":[134],"out":[135],"with":[139,225,346],"adenocarcinoma":[141],"had":[143],"an":[144,226,356],"mutation":[146,228,279,311],"(13%,":[147],"95%":[148,165,173,181,196,232,242],"CI":[149,166,174,182,197,233,243],"8.4-17.6%).":[150],"Of":[151,199],"detected":[154],"relative":[155],"frequency":[156],"as":[158,352],"follows:":[159],"deletion":[162],"63.3%":[163,222],"(n=19,":[164,231],"46.1-80.6%),":[167],"(p.L858R)":[170],"16.7%":[171],"(n=5,":[172],"3.3-30.0%),":[175],"insertions":[178],"13.3%":[179],"(n=4,":[180],"1.2-25.5%)":[183],"18":[186],"(p.G719X)":[187],"(p.T790M)":[191],"both":[192],"at":[193,248],"3.3%":[194],"(n=1,":[195],"0-9.8%).":[198],"those":[200,224,344],"51.2%":[203],"male":[205,237],"(n=107)":[206],"48.8%":[208],"(n=102)":[209],"female.":[210],"incidence":[212,324],"higher":[216],"females":[218],"than":[219,293,320],"males;":[221],"female":[230,347],"46.1-80.6%).":[234],"Reciprocally,":[235],"percentage":[238],"36.7%":[240],"(n=11,":[241],"19.4-53.9).":[244],"mean":[246],"age":[247],"67":[251],"years.":[252],"Complete":[253],"smoking":[254],"data":[255],"unavailable":[257],"this":[259,329],"study.":[260],"All":[261],"formalin":[265],"fixed":[266],"paraffin":[267],"embedded":[268],"tissue":[269],"cell":[271],"preparations.":[272],"Turn":[273],"around":[274],"time":[275],"(TAT)":[276],"processing":[280],"substantially":[281],"improved":[282],"over":[283,288],"ten":[284],"month":[285],"period,":[286],"five":[289],"weeks":[290],"less":[292,319],"four":[294],"working":[295],"days.":[296],"Conclusions:":[297],"This":[298],"group":[299],"largest":[304],"cohort":[305],"institute":[315],"Ireland":[317],"12":[321],"months.":[322],"is":[332],"comparable":[333],"current":[335],"European":[336],"estimates.":[337],"gender":[339],"bias":[340],"notable":[342],"amongst":[343],"tested,":[345],"being":[349],"nearly":[350],"twice":[351],"likely":[353],"harbour":[355],"mutation.":[358]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-08-13T00:00:00"}
