{"id":"https://openalex.org/W2965654579","doi":"https://doi.org/10.1053/j.ajkd.2019.05.017","title":"Cognitive Impairment in CKD: Pathophysiology, Management, and Prevention","display_name":"Cognitive Impairment in CKD: Pathophysiology, Management, and Prevention","publication_year":2019,"publication_date":"2019-08-01","ids":{"openalex":"https://openalex.org/W2965654579","doi":"https://doi.org/10.1053/j.ajkd.2019.05.017","mag":"2965654579","pmid":"https://pubmed.ncbi.nlm.nih.gov/31378643","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7038648"},"language":"en","primary_location":{"id":"doi:10.1053/j.ajkd.2019.05.017","doi":"https://doi.org/10.1053/j.ajkd.2019.05.017","is_oa":false,"landing_page_url":"https://doi.org/10.1053/j.ajkd.2019.05.017","pdf_url":null,"source":{"id":"https://openalex.org/S18197459","display_name":"American Journal of Kidney Diseases","issn_l":"0272-6386","issn":["0272-6386","1523-6838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Kidney Diseases","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7038648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029956148","display_name":"David A. Drew","orcid":"https://orcid.org/0000-0003-0377-723X","observed_orcids":["https://orcid.org/0000-0003-0377-723X","https://orcid.org/0000-0002-8813-0816"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Drew","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018409007","display_name":"Daniel E. Weiner","orcid":"https://orcid.org/0000-0002-8775-394X","observed_orcids":["https://orcid.org/0000-0002-8775-394X"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel E. Weiner","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076361487","display_name":"Mark J. Sarnak","orcid":"https://orcid.org/0000-0002-2457-6368","observed_orcids":["https://orcid.org/0000-0002-2457-6368","https://orcid.org/0000-0003-4927-6609"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark J. Sarnak","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA. Electronic address: msarnak@tuftsmedicalcenter.org","Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA. Electronic address: msarnak@tuftsmedicalcenter.org","institution_ids":["https://openalex.org/I1290900354"]},{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076361487"],"corresponding_institution_ids":["https://openalex.org/I1290900354"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":4.305,"has_fulltext":false,"cited_by_count":459,"citation_normalized_percentile":{"value":0.97270306,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"74","issue":"6","first_page":"782","last_page":"790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7567999958992004,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7567999958992004,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.18799999356269836,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.996999979019165},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.7229999899864197},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.7979999780654907},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9649999737739563},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6899999976158142},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.9559999704360962},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":1.0},{"id":"https://openalex.org/keywords/dialysis","display_name":"dialysis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cognitive-decline-prevention","display_name":"cognitive decline prevention","score":0.6349999904632568},{"id":"https://openalex.org/keywords/advance-directives","display_name":"advance directives","score":0.7089999914169312},{"id":"https://openalex.org/keywords/shared-decision-making","display_name":"shared decision-making","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8536804914474487},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6995649933815002},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.610749363899231},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5871582627296448},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.5867795348167419},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.5839326977729797},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.5369278192520142},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.48976635932922363},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.4483373463153839},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4388429820537567},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4363346993923187},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4349740743637085},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.416337251663208},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.19623136520385742},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1053/j.ajkd.2019.05.017","doi":"https://doi.org/10.1053/j.ajkd.2019.05.017","is_oa":false,"landing_page_url":"https://doi.org/10.1053/j.ajkd.2019.05.017","pdf_url":null,"source":{"id":"https://openalex.org/S18197459","display_name":"American Journal of Kidney Diseases","issn_l":"0272-6386","issn":["0272-6386","1523-6838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Kidney Diseases","raw_type":"journal-article"},{"id":"pmid:31378643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31378643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of kidney diseases : the official journal of the National Kidney Foundation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7038648","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7038648","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Kidney Dis","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7038648","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7038648","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Kidney Dis","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7810496945","display_name":"The association of FGF-23 and Klotho with cognitive impairment and cerebrovascular disease in chronic kidney disease","funder_award_id":"K23DK105327","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1586213696","https://openalex.org/W1608403684","https://openalex.org/W1608677747","https://openalex.org/W1738168289","https://openalex.org/W1869735969","https://openalex.org/W1895139732","https://openalex.org/W1958566319","https://openalex.org/W1968364422","https://openalex.org/W1969370205","https://openalex.org/W1976448779","https://openalex.org/W1982949195","https://openalex.org/W1986133045","https://openalex.org/W2004848147","https://openalex.org/W2011862587","https://openalex.org/W2018280736","https://openalex.org/W2025771431","https://openalex.org/W2028573321","https://openalex.org/W2028786992","https://openalex.org/W2030235211","https://openalex.org/W2033803279","https://openalex.org/W2039354600","https://openalex.org/W2040029744","https://openalex.org/W2049800117","https://openalex.org/W2053509355","https://openalex.org/W2053789158","https://openalex.org/W2062571325","https://openalex.org/W2075761537","https://openalex.org/W2076393535","https://openalex.org/W2077510921","https://openalex.org/W2080953412","https://openalex.org/W2086095427","https://openalex.org/W2087814263","https://openalex.org/W2088479654","https://openalex.org/W2093141843","https://openalex.org/W2093576686","https://openalex.org/W2097269110","https://openalex.org/W2099899980","https://openalex.org/W2105986361","https://openalex.org/W2109527205","https://openalex.org/W2110423779","https://openalex.org/W2110601215","https://openalex.org/W2119509205","https://openalex.org/W2120391152","https://openalex.org/W2122846703","https://openalex.org/W2124097908","https://openalex.org/W2126496919","https://openalex.org/W2127784448","https://openalex.org/W2137802963","https://openalex.org/W2145365721","https://openalex.org/W2149753059","https://openalex.org/W2152289383","https://openalex.org/W2156896668","https://openalex.org/W2160663184","https://openalex.org/W2161923453","https://openalex.org/W2162430779","https://openalex.org/W2163899013","https://openalex.org/W2164996214","https://openalex.org/W2165733730","https://openalex.org/W2165758561","https://openalex.org/W2263685477","https://openalex.org/W2274989284","https://openalex.org/W2336678555","https://openalex.org/W2483224146","https://openalex.org/W2532210012","https://openalex.org/W2580166460","https://openalex.org/W2586334933","https://openalex.org/W2593218034","https://openalex.org/W2623951247","https://openalex.org/W2762968405","https://openalex.org/W2790580647","https://openalex.org/W2903750553","https://openalex.org/W2912533302","https://openalex.org/W2912696654","https://openalex.org/W4245435298"],"related_works":["https://openalex.org/W3095681972","https://openalex.org/W4400976406","https://openalex.org/W2113896733","https://openalex.org/W4315852350","https://openalex.org/W1975682575","https://openalex.org/W1789531012","https://openalex.org/W4414551170","https://openalex.org/W2965021653","https://openalex.org/W2733329884","https://openalex.org/W2061920037"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":68},{"year":2025,"cited_by_count":82},{"year":2024,"cited_by_count":120},{"year":2023,"cited_by_count":84},{"year":2022,"cited_by_count":53},{"year":2021,"cited_by_count":35},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-13T00:00:00"}