{"id":"https://openalex.org/W2965528385","doi":"https://doi.org/10.1093/rheumatology/kez291","title":"Efficacy and safety of tocilizumab in a real-life observational cohort of patients with polyarticular juvenile idiopathic arthritis","display_name":"Efficacy and safety of tocilizumab in a real-life observational cohort of patients with polyarticular juvenile idiopathic arthritis","publication_year":2019,"publication_date":"2019-06-27","ids":{"openalex":"https://openalex.org/W2965528385","doi":"https://doi.org/10.1093/rheumatology/kez291","mag":"2965528385","pmid":"https://pubmed.ncbi.nlm.nih.gov/31359057"},"language":"en","primary_location":{"id":"doi:10.1093/rheumatology/kez291","doi":"https://doi.org/10.1093/rheumatology/kez291","is_oa":false,"landing_page_url":"https://doi.org/10.1093/rheumatology/kez291","pdf_url":null,"source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110161425","display_name":"Minna\u2010Maija Gr\u00f6nlund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Minna-Maija Gr\u00f6nlund","raw_affiliation_strings":["Department of Pediatrics, Turku University Hospital, Turku"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Turku University Hospital, Turku","institution_ids":["https://openalex.org/I2801970007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056716664","display_name":"Terhi Remes\u2010Pakarinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Terhi Remes-Pakarinen","raw_affiliation_strings":["Department of Pediatrics, Kuopio University Hospital, Kuopio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kuopio University Hospital, Kuopio","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080193129","display_name":"Liisa M. Kr\u00f6ger","orcid":"https://orcid.org/0000-0002-2707-0178","observed_orcids":["https://orcid.org/0000-0002-2707-0178"]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Liisa Kr\u00f6ger","raw_affiliation_strings":["Department of Pediatrics, Kuopio University Hospital, Kuopio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Kuopio University Hospital, Kuopio","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039988207","display_name":"Kati Markula\u2010Patjas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kati Markula-Patjas","raw_affiliation_strings":["Department of Paediatrics, Tampere University Hospital, Tampere","University of Tampere, Tampere"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Tampere University Hospital, Tampere","institution_ids":["https://openalex.org/I4210126318"]},{"raw_affiliation_string":"University of Tampere, Tampere","institution_ids":["https://openalex.org/I4387153886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002675011","display_name":"Maria Christina Backstr\u00f6m","orcid":"https://orcid.org/0000-0002-8632-8634","observed_orcids":["https://orcid.org/0000-0002-8632-8634"]},"institutions":[{"id":"https://openalex.org/I4210103236","display_name":"Vaasa Central Hospital","ror":"https://ror.org/019xaj585","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210103236"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Maria Backstr\u00f6m","raw_affiliation_strings":["Department of Pediatrics, Vaasa Central Hospital, Vaasa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Vaasa Central Hospital, Vaasa","institution_ids":["https://openalex.org/I4210103236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081796517","display_name":"Anne Putto\u2010Laurila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Anne Putto-Laurila","raw_affiliation_strings":["Department of Pediatrics, Turku University Hospital, Turku"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Turku University Hospital, Turku","institution_ids":["https://openalex.org/I2801970007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035781724","display_name":"Kristiina T Aalto","orcid":"https://orcid.org/0000-0002-5285-0424","observed_orcids":["https://orcid.org/0000-0002-5285-0424"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kristiina Aalto","raw_affiliation_strings":["Department of Children and Adolescents, Helsinki University Hospital, Helsinki","Pediatric Research Center, University of Helsinki, Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Children and Adolescents, Helsinki University Hospital, Helsinki","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Pediatric Research Center, University of Helsinki, Helsinki","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077144329","display_name":"Paula V\u00e4h\u00e4salo","orcid":"https://orcid.org/0000-0002-2712-3903","observed_orcids":["https://orcid.org/0000-0002-2712-3903"]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Paula V\u00e4h\u00e4salo","raw_affiliation_strings":["Department of Children and Adolescents, Oulu University Hospital, Oulu","Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu","PEDEGO Research Unit, University of Oulu, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Children and Adolescents, Oulu University Hospital, Oulu","institution_ids":["https://openalex.org/I2799272722"]},{"raw_affiliation_string":"Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]},{"raw_affiliation_string":"PEDEGO Research Unit, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5110161425"],"corresponding_institution_ids":["https://openalex.org/I2801970007"],"apc_list":{"value":3486,"currency":"GBP","value_usd":4597},"apc_paid":null,"fwci":2.1913,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.88218409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"59","issue":"4","first_page":"732","last_page":"741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":1.0},{"id":"https://openalex.org/keywords/polyarticular-juvenile-idiopathic-arthritis","display_name":"polyarticular juvenile idiopathic arthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/il-6-receptor-inhibitor","display_name":"IL-6 receptor inhibitor","score":0.6430000066757202},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6399999856948853},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.765999972820282},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9409999847412109},{"id":"https://openalex.org/keywords/low-disease-activity","display_name":"low disease activity","score":0.796999990940094},{"id":"https://openalex.org/keywords/inactive-disease","display_name":"inactive disease","score":0.7009999752044678},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.4790000021457672},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.9746983051300049},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9640602469444275},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7281755805015564},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6844912171363831},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.6716495752334595},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5703173279762268},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.46749722957611084},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4564395844936371},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3215750455856323},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30629801750183105}],"mesh":[{"descriptor_ui":"D000077339","descriptor_name":"Leflunomide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001171","descriptor_name":"Arthritis, Juvenile","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001171","descriptor_name":"Arthritis, Juvenile","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055118","descriptor_name":"Medication Adherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/rheumatology/kez291","doi":"https://doi.org/10.1093/rheumatology/kez291","is_oa":false,"landing_page_url":"https://doi.org/10.1093/rheumatology/kez291","pdf_url":null,"source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},{"id":"pmid:31359057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31359057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1768609978","https://openalex.org/W1845856549","https://openalex.org/W1963703758","https://openalex.org/W1968864783","https://openalex.org/W1973827444","https://openalex.org/W1978638948","https://openalex.org/W1996629445","https://openalex.org/W2017213437","https://openalex.org/W2024714476","https://openalex.org/W2028698702","https://openalex.org/W2108546319","https://openalex.org/W2110217426","https://openalex.org/W2127359359","https://openalex.org/W2130128947","https://openalex.org/W2134389576","https://openalex.org/W2135974703","https://openalex.org/W2144824470","https://openalex.org/W2162065782","https://openalex.org/W2166909692","https://openalex.org/W2221264044","https://openalex.org/W2284895135","https://openalex.org/W2308906418","https://openalex.org/W2501691319","https://openalex.org/W2550731897","https://openalex.org/W2606053878","https://openalex.org/W2614732086","https://openalex.org/W2619315233","https://openalex.org/W2768081556","https://openalex.org/W2782847795","https://openalex.org/W2791780074","https://openalex.org/W2796761111","https://openalex.org/W2797862713","https://openalex.org/W2889865287","https://openalex.org/W2897242708","https://openalex.org/W2905915579","https://openalex.org/W2920685979","https://openalex.org/W6688631880"],"related_works":["https://openalex.org/W3087556346","https://openalex.org/W4246196046","https://openalex.org/W2950512293","https://openalex.org/W2951871520","https://openalex.org/W2743409171","https://openalex.org/W3174064184","https://openalex.org/W2999795883","https://openalex.org/W4254808903","https://openalex.org/W3009264907","https://openalex.org/W2110217426"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"evaluate":[2],"the":[3,203,239],"patterns":[4],"of":[5,10,19,41,47,59,71,104,179,186,194,202,211,224,242],"usage,":[6],"efficacy":[7],"and":[8,30,46,58,69,117,139,154,166,168,174,185,198,226],"safety":[9],"tocilizumab":[11,38,82,195],"in":[12,130,137,142,149,155,164,172,232,238],"polyarticular":[13,22],"JIA.":[14],"METHODS:":[15],"An":[16],"observational":[17],"study":[18,241],"56":[20],"consecutive":[21],"JIA":[23,32],"patients":[24,205],"was":[25,35,86,147,181,196],"conducted":[26],"using":[27],"patient":[28,183,190],"charts":[29],"electronic":[31],"databases.":[33],"Efficacy":[34,68],"assessed":[36],"by":[37,50],"survival,":[39],"rates":[40,111,223],"low":[42],"disease":[43,49,62,102,161,171],"activity":[44],"(LDA)":[45],"inactive":[48,61,160,170],"10-joint":[51],"Juvenile":[52],"Arthritis":[53],"Disease":[54],"Activity":[55],"Score":[56],"(JADAS-10),":[57],"clinically":[60,169],"according":[63],"to":[64,97,217],"Wallace's":[65],"preliminary":[66],"criteria.":[67],"rate":[70,178,215],"adverse":[72],"events":[73],"(AEs)":[74],"were":[75,112,126,229],"evaluated":[76],"during":[77],"a":[78,100,199],"24-month":[79],"period":[80],"after":[81],"commencement.":[83],"RESULTS:":[84],"Tocilizumab":[85],"started":[87],"on":[88],"average":[89],"as":[90],"third-line":[91],"biological":[92],"agent":[93],"(median,":[94],"range":[95,108],"first-":[96],"fourth-line)":[98],"at":[99,114,119,151,157,208],"median":[101],"duration":[103],"5.2":[105],"years":[106,184],"(interquartile":[107],"3.0-7.7).":[109],"Survival":[110,193],"82%":[113],"12":[115,152,209],"months":[116,153,210],"64%":[118],"24":[120,158,220],"months.":[121,221],"The":[122,177,213,222],"reasons":[123],"for":[124],"discontinuation":[125],"inadequate":[127,134],"treatment":[128,135],"effect":[129,136],"50%,":[131],"AE":[132,140],"plus":[133],"37.5%":[138],"alone":[141],"12.5%.":[143],"LDA":[144,207,214],"(JADAS-10":[145,162],"\u2a7d3.9)":[146],"reached":[148,206],"58%":[150],"84%":[156],"months,":[159],"\u2a7d0.7)":[163],"19%":[165],"44%,":[167],"28%":[173],"46%,":[175],"respectively.":[176],"AEs":[180,188,225,228],"200.9/100":[182],"serious":[187,227],"12.9/100":[189],"years.":[191],"CONCLUSION:":[192],"high":[197],"large":[200],"proportion":[201],"treatment-resistant":[204],"treatment.":[212],"continued":[216],"increase":[218],"throughout":[219],"higher":[230],"than":[231,237],"register":[233],"studies":[234],"but":[235],"lower":[236],"originator":[240],"tocilizumab.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-08-13T00:00:00"}