{"id":"https://openalex.org/W2965513851","doi":"https://doi.org/10.1002/cam4.2402","title":"In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma","display_name":"In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma","publication_year":2019,"publication_date":"2019-07-30","ids":{"openalex":"https://openalex.org/W2965513851","doi":"https://doi.org/10.1002/cam4.2402","mag":"2965513851","pmid":"https://pubmed.ncbi.nlm.nih.gov/31361072","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6745825"},"language":"en","primary_location":{"id":"doi:10.1002/cam4.2402","doi":"https://doi.org/10.1002/cam4.2402","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.2402","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2402","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2402","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101843729","display_name":"Man Gil Yang","orcid":"https://orcid.org/0000-0002-1473-6575","observed_orcids":["https://orcid.org/0000-0002-1473-6575"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Man Yang","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota","Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083557433","display_name":"Ryan A. Hlady","orcid":"https://orcid.org/0000-0002-2829-4237","observed_orcids":["https://orcid.org/0000-0002-2829-4237"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan A. Hlady","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624946","display_name":"Dan Zhou","orcid":"https://orcid.org/0000-0002-2306-3456","observed_orcids":["https://orcid.org/0000-0002-2306-3456"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Zhou","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058650905","display_name":"Thai H. Ho","orcid":"https://orcid.org/0000-0003-0023-2939","observed_orcids":["https://orcid.org/0000-0003-0023-2939"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thai H. Ho","raw_affiliation_strings":["Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona"],"raw_orcid":"https://orcid.org/0000-0003-0023-2939","affiliations":[{"raw_affiliation_string":"Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, Arizona","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077746203","display_name":"Keith D. Robertson","orcid":"https://orcid.org/0000-0002-7508-3328","observed_orcids":["https://orcid.org/0000-0002-7508-3328"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Keith D. Robertson","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0002-7508-3328","affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5077746203","https://openalex.org/A5101843729"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I183067930","https://openalex.org/I4210135742"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":{"value":2750,"currency":"USD","value_usd":2750},"fwci":0.4544,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.6446967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"12","first_page":"5760","last_page":"5768"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.63919997215271,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.63919997215271,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.2565999925136566,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-papillary-renal-cell-carcinoma","display_name":"type 2 papillary renal cell carcinoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ptk7","display_name":"PTK7","score":0.8009999990463257},{"id":"https://openalex.org/keywords/copy-number-gain","display_name":"copy number gain","score":0.9129999876022339},{"id":"https://openalex.org/keywords/disease-staging","display_name":"disease staging","score":0.6859999895095825},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7929999828338623},{"id":"https://openalex.org/keywords/treatment-goals","display_name":"treatment goals","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2776531350","wikidata":"https://www.wikidata.org/wiki/Q16877679","display_name":"Papillary renal cell carcinomas","level":3,"score":0.8478822708129883},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6994701623916626},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6243387460708618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5413051247596741},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.5405958294868469},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.5396115779876709},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5278458595275879},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.4587569236755371},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.38209348917007446},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.377942830324173},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.320041298866272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26423561573028564},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.175814688205719},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14421898126602173},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14232879877090454},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cam4.2402","doi":"https://doi.org/10.1002/cam4.2402","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.2402","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2402","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6745825","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6745825","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Med","raw_type":"Text"},{"id":"pmid:31361072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31361072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b15879f620204bc092cfdc8e3b685316","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b15879f620204bc092cfdc8e3b685316","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Medicine, Vol 8, Iss 12, Pp 5760-5768 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/cam4.2402","doi":"https://doi.org/10.1002/cam4.2402","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.2402","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2402","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6150091399","display_name":"Deciphering the interplay between H3K36 and DNA methylation in renal cancer","funder_award_id":"R01CA224917","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2965513851.pdf","grobid_xml":"https://content.openalex.org/works/W2965513851.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1501275336","https://openalex.org/W1582871569","https://openalex.org/W1879274824","https://openalex.org/W1975807698","https://openalex.org/W1987180785","https://openalex.org/W1987617101","https://openalex.org/W1993265232","https://openalex.org/W2006617902","https://openalex.org/W2008966194","https://openalex.org/W2028904305","https://openalex.org/W2039663245","https://openalex.org/W2065751798","https://openalex.org/W2067473404","https://openalex.org/W2075484250","https://openalex.org/W2077153806","https://openalex.org/W2100743480","https://openalex.org/W2101748824","https://openalex.org/W2103441967","https://openalex.org/W2111867681","https://openalex.org/W2114104545","https://openalex.org/W2116401585","https://openalex.org/W2128320141","https://openalex.org/W2141444851","https://openalex.org/W2345744951","https://openalex.org/W2574836938","https://openalex.org/W2589099231","https://openalex.org/W2751273694","https://openalex.org/W2771286954","https://openalex.org/W2791723837","https://openalex.org/W2805196515","https://openalex.org/W2890464284","https://openalex.org/W2898434771","https://openalex.org/W4255387133"],"related_works":["https://openalex.org/W3012464768","https://openalex.org/W4254676171","https://openalex.org/W3035264515","https://openalex.org/W3118727142","https://openalex.org/W4327685944","https://openalex.org/W2909959109","https://openalex.org/W3111211037","https://openalex.org/W2271328669","https://openalex.org/W2946228256","https://openalex.org/W2128320141"],"abstract_inverted_index":{"There":[0],"are":[1,49,69,104,115,155],"currently":[2],"no":[3],"effective":[4],"treatments":[5],"for":[6,28,71,119,217,231],"advanced-stage":[7,29,45,100,124,140,187,208,232],"papillary":[8,60],"renal":[9,59],"cell":[10,61,196],"carcinoma":[11,62],"(PRCC).":[12],"The":[13],"goal":[14],"of":[15,82,135],"this":[16],"study":[17],"is":[18,86,181,192],"to":[19,44,99,168,173,186,194],"define":[20],"potential":[21,228],"DNA":[22,34,200],"methylation-based":[23],"markers":[24,118,202,216],"and":[25,37,75,111,123,150,191,207,239],"treatment":[26,229],"targets":[27],"type":[30,46,101,125,141,188,209,233],"2":[31,47,102,126,142,189,210,234],"PRCC.":[32,127,143,235],"Progressive":[33,91],"methylation":[35,53,92,148,201,237],"changes":[36,93,149,238],"copy":[38,133,152,165,176,224,240],"number":[39,129,153,177,241],"variation":[40],"(CNV)":[41],"from":[42,97,184],"localized":[43,98,122,185,206],"PRCC":[48,103,190,211,249],"analyzed":[50],"by":[51,56,88],"using":[52],"data":[54],"generated":[55],"TCGA's":[57],"kidney":[58],"(TCGA-KIRP,":[63],"450k":[64],"array)":[65],"project.":[66],"Survival":[67],"analyses":[68],"performed":[70],"the":[72,83,145],"identified":[73,116],"biomarkers":[74],"genes":[76,85],"with":[77,157,245],"CNV.":[78],"In":[79,198],"addition,":[80],"expression":[81,171],"corresponding":[84],"investigated":[87],"RNA-seq":[89,160],"analysis.":[90],"in":[94,113,139,248],"several":[95],"CpGs":[96,107],"observed.":[105],"Four":[106],"(cg00489401,":[108],"cg27649239,":[109],"cg20555674,":[110],"cg07196505)":[112],"particular":[114],"as":[117,214],"differentiating":[120],"between":[121,205],"Copy":[128],"analysis":[130,161],"reveals":[131],"that":[132,163,203],"gain":[134,154,166,225,242],"PTK7":[136,151,164,170,180,223],"mostly":[137],"occurs":[138],"Both":[144],"four":[146],"CpG":[147],"associated":[156],"patient":[158],"survival.":[159],"demonstrates":[162],"leads":[167],"higher":[169],"relative":[172],"tumors":[174],"without":[175],"gain.":[178],"Moreover,":[179],"significantly":[182],"upregulated":[183],"linked":[193],"cancer":[195],"invasion.":[197],"conclusion,":[199],"differentiate":[204],"may":[212],"serve":[213],"useful":[215],"disease":[218,246],"staging":[219],"or":[220],"outcome,":[221],"while":[222],"represents":[226],"a":[227],"target":[230],"Stepwise":[236],"also":[243],"associate":[244],"stage":[247],"patients.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-08-13T00:00:00"}