{"id":"https://openalex.org/W2965357362","doi":null,"title":"Do Molecular Subtypes of Breast Cancer Affect Outcomes Following Hypofractionation or Conventional Fractionation Radiation Therapy","display_name":"Do Molecular Subtypes of Breast Cancer Affect Outcomes Following Hypofractionation or Conventional Fractionation Radiation Therapy","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2965357362","mag":"2965357362"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.unmc.edu:coph_slce-1076","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unmc.edu/coph_slce/77","pdf_url":"https://digitalcommons.unmc.edu/coph_slce/77","source":{"id":"https://openalex.org/S7407097584","display_name":"DigitalCommons@UNMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59130452","host_organization_name":"University of Nebraska Medical Center","host_organization_lineage":["https://openalex.org/I59130452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Capstone Experience: Master of Public Health","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.unmc.edu/coph_slce/77","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058086823","display_name":"Richard L. Sleightholm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Richard Sleightholm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058086823"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06135387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hypofractionated-radiotherapy","display_name":"hypofractionated radiotherapy","score":0.8820000290870667},{"id":"https://openalex.org/keywords/conventional-fractionation","display_name":"conventional fractionation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.902999997138977},{"id":"https://openalex.org/keywords/mastectomy","display_name":"mastectomy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/locoregional-recurrence","display_name":"locoregional recurrence","score":0.9660000205039978},{"id":"https://openalex.org/keywords/distant-recurrence","display_name":"distant recurrence","score":0.9649999737739563},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8610000014305115},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6880874633789062},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6530812978744507},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6219872236251831},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6086535453796387},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.5530588626861572},{"id":"https://openalex.org/C155806632","wikidata":"https://www.wikidata.org/wiki/Q5299253","display_name":"Dose fractionation","level":3,"score":0.4751443862915039},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47179192304611206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.451121062040329},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13540169596672058},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.unmc.edu:coph_slce-1076","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unmc.edu/coph_slce/77","pdf_url":"https://digitalcommons.unmc.edu/coph_slce/77","source":{"id":"https://openalex.org/S7407097584","display_name":"DigitalCommons@UNMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59130452","host_organization_name":"University of Nebraska Medical Center","host_organization_lineage":["https://openalex.org/I59130452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Capstone Experience: Master of Public Health","raw_type":"text"},{"id":"mag:2965357362","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.unmc.edu/coph_slce/77/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.unmc.edu:coph_slce-1076","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unmc.edu/coph_slce/77","pdf_url":"https://digitalcommons.unmc.edu/coph_slce/77","source":{"id":"https://openalex.org/S7407097584","display_name":"DigitalCommons@UNMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59130452","host_organization_name":"University of Nebraska Medical Center","host_organization_lineage":["https://openalex.org/I59130452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Capstone Experience: Master of Public Health","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2965357362.pdf","grobid_xml":"https://content.openalex.org/works/W2965357362.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7123780639","https://openalex.org/W2972734714","https://openalex.org/W3089248040","https://openalex.org/W2903485472","https://openalex.org/W3111176672","https://openalex.org/W2808720960","https://openalex.org/W4210812049","https://openalex.org/W2100672365","https://openalex.org/W7134187885","https://openalex.org/W3044593093"],"abstract_inverted_index":{"Introduction":[0],"Molecular":[1],"subtypes":[2],"of":[3,17,74,80,99,132,189,198,232,275],"breast":[4,283],"cancer":[5],"(BC)":[6],"are":[7,61,250],"well-established":[8],"prognostic":[9],"markers":[10],"in":[11,27,217,253,257,278],"early-stage":[12,87],"BC":[13,88,102,260,281],"patients.":[14,184,261],"The":[15],"addition":[16],"radiation":[18,267],"therapy":[19,268],"(RT)":[20],"to":[21,150],"breast-conserving":[22],"surgery":[23,110],"has":[24],"improved":[25],"outcomes":[26,60,135],"this":[28],"patient":[29,239],"population,":[30],"with":[31],"conventional":[32],"fractionation":[33],"(CF)":[34],"and":[35,42,65,82,120,130,134,138,145,153,163,181,192,203,235,248],"hypofractionation":[36],"(HF)":[37],"regimens":[38,85],"displaying":[39],"comparable":[40],"morbidity":[41],"mortality.":[43],"However,":[44],"most":[45],"studies":[46],"have":[47],"not":[48],"taken":[49],"into":[50],"account":[51],"molecular":[52,69,75,213,276],"subtype.":[53,70],"Thus,":[54,262],"it":[55],"is":[56],"still":[57],"unknown":[58],"if":[59],"similar":[62,206],"between":[63,118,207],"CF":[64,81,180,249],"HF":[66,83,183,187,247],"for":[67,86,266],"each":[68],"Herein,":[71],"the":[72,78,175],"effects":[73],"subtype":[76,277],"on":[77,212],"efficacy":[79],"radiotherapy":[84],"patients":[89,103,173],"receiving":[90],"adjuvant":[91],"RT":[92,115],"was":[93,122,228],"investigated.":[94],"Methods":[95],"A":[96],"retrospective":[97],"review":[98],"stage":[100,191,227,259,280],"I/II":[101],"who":[104],"received":[105],"surgical":[106],"intervention":[107],"(breast":[108],"conservation":[109],"or":[111,219],"mastectomy)":[112],"followed":[113],"by":[114],"at":[116],"UNMC":[117],"2010":[119],"2017":[121],"conducted.":[123],"Demographics,":[124],"tumor":[125],"characteristics,":[126],"treatment":[127],"data":[128],"(course":[129],"dose":[131],"radiotherapy),":[133],"information":[136],"(progression":[137],"survival)":[139],"were":[140,148,157,188,205,221,241],"collected.":[141],"Cumulative":[142],"incidence":[143],"function":[144],"Kaplan-Meier":[146],"testing":[147],"used":[149],"assess":[151],"recurrence":[152,256],"survival,":[154],"respectively.":[155],"Variables":[156],"then":[158],"further":[159],"analyzed":[160],"using":[161],"univariate":[162],"multivariable":[164,224],"COX":[165],"proportional":[166],"hazard":[167],"models.":[168],"Results":[169],"In":[170],"total,":[171],"311":[172],"met":[174],"inclusion":[176],"criteria,":[177],"including":[178],"211":[179],"100":[182],"Patients":[185],"undergoing":[186],"lower":[190],"grade,":[193],"but":[194],"increased":[195],"age.":[196],"Rates":[197],"locoregional":[199,255],"recurrence,":[200,202],"distant":[201,233],"survival":[204,220],"cohorts.":[208],"When":[209],"stratifying":[210],"based":[211],"subtype,":[214],"no":[215],"differences":[216],"recurrences":[218],"observed.":[222],"On":[223],"analysis,":[225],"only":[226],"a":[229,263],"significant":[230],"predictor":[231],"failure":[234],"survival.":[236],"Conclusions":[237],"Although":[238],"numbers":[240],"low,":[242],"these":[243],"findings":[244],"suggest":[245],"that":[246],"equally":[251],"efficacious":[252],"controlling":[254],"early":[258,279],"hypofractionated":[264],"regimen":[265],"should":[269],"be":[270],"considered":[271],"an":[272],"option":[273],"regardless":[274],"following":[282],"conserving":[284],"surgery.":[285]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2019-08-13T00:00:00"}
