{"id":"https://openalex.org/W296527740","doi":null,"title":"Bioreactivity: Regulation of Neuronal Responsiveness--Role of Locus.","display_name":"Bioreactivity: Regulation of Neuronal Responsiveness--Role of Locus.","publication_year":1987,"publication_date":"1987-07-12","ids":{"openalex":"https://openalex.org/W296527740","mag":"296527740"},"language":"en","primary_location":{"id":"pmh:ADA186354","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA186354","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110364496","display_name":"Barry L. Jacobs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Barry L. Jacobs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110364496"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00835357,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.050999999046325684,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/noradrenergic-neurons","display_name":"noradrenergic neurons","score":0.9279999732971191},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sustained-attention","display_name":"sustained attention","score":0.7089999914169312},{"id":"https://openalex.org/keywords/bioreactivity","display_name":"bioreactivity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/arousal","display_name":"arousal","score":0.515999972820282},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.6779999732971191},{"id":"https://openalex.org/keywords/anxiolytics","display_name":"anxiolytics","score":0.9259999990463257},{"id":"https://openalex.org/keywords/anxiogenic-drugs","display_name":"anxiogenic drugs","score":0.9980000257492065},{"id":"https://openalex.org/keywords/appetitive-conditioning","display_name":"appetitive conditioning","score":0.9359999895095825},{"id":"https://openalex.org/keywords/aversive-conditioning","display_name":"aversive conditioning","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stressors","display_name":"stressors","score":0.8600000143051147},{"id":"https://openalex.org/keywords/single-unit-recording","display_name":"single-unit recording","score":0.5889999866485596},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.9629029631614685},{"id":"https://openalex.org/C36951298","wikidata":"https://www.wikidata.org/wiki/Q379784","display_name":"Arousal","level":2,"score":0.7375681400299072},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7252930402755737},{"id":"https://openalex.org/C205044023","wikidata":"https://www.wikidata.org/wiki/Q4778117","display_name":"Anxiogenic","level":4,"score":0.6261782050132751},{"id":"https://openalex.org/C192769605","wikidata":"https://www.wikidata.org/wiki/Q1418914","display_name":"Vigilance (psychology)","level":2,"score":0.603577733039856},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.5696240067481995},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.5655813217163086},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.4812469184398651},{"id":"https://openalex.org/C3017459112","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter systems","level":3,"score":0.47427305579185486},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.441045880317688},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.42855238914489746},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.4259307384490967},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.3673593997955322},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.30441492795944214},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.16741374135017395},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13623806834220886}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:ADA186354","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA186354","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},{"id":"mag:296527740","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a186354.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1954301870","https://openalex.org/W2079733308","https://openalex.org/W1608244379","https://openalex.org/W4293082421","https://openalex.org/W7039387291","https://openalex.org/W2016014417","https://openalex.org/W2014459859","https://openalex.org/W1535038405","https://openalex.org/W2034431198","https://openalex.org/W7002086424"],"abstract_inverted_index":{"In":[0,143],"mammals,":[1],"a":[2,70,93,129],"group":[3],"of":[4,10,50,72,96,99,107,120,135,151],"neurons":[5,103,137],"localized":[6],"in":[7,28,55,69,148,167,172],"an":[8,161],"area":[9],"the":[11,14,40,86,97,133,149,183],"brainstem":[12],"called":[13],"locus":[15,100],"coeruleus":[16],"utilize":[17],"norepinephrine":[18],"as":[19,178],"their":[20],"neurotransmitter":[21],"and":[22,32,57,66,111,122,140,153,169],"are":[23],"believed":[24],"to":[25,104,182],"be":[26,83,176],"important":[27,162],"attention,":[29],"vigilance,":[30],"anxiety,":[31],"arousal.":[33],"Studies":[34],"supported":[35],"by":[36,48,117],"this":[37,113,165],"grant":[38],"over":[39],"past":[41],"2":[42],"1/2":[43],"years":[44],"explored":[45],"these":[46,136],"issues":[47],"means":[49],"chronic":[51],"single":[52],"unit":[53],"recordings":[54],"unrestrained":[56],"unanesthetized":[58],"cats.":[59],"The":[60],"work":[61],"has":[62,67],"been":[63,79],"highly":[64],"productive":[65],"resulted":[68],"number":[71],"major":[73],"findings,":[74],"most":[75,145],"or":[76,81,180],"which":[77,131],"have":[78,91,126],"published":[80,84],"will":[82],"within":[85],"next":[87],"six":[88],"months.":[89],"We":[90,125],"completed":[92],"detailed":[94],"analysis":[95],"response":[98,114],"coeruleus-noradrenergic":[101],"(LC-NE)":[102],"repetitive":[105],"presentation":[106],"simple":[108],"sensory":[109],"stimuli":[110],"how":[112],"is":[115],"altered":[116],"systemic":[118],"administration":[119],"anxiolytic":[121],"anxiogenic":[123],"drugs.":[124],"also":[127],"finished":[128],"study":[130],"examined":[132],"activity":[134],"during":[138],"appetitive":[139],"aversive":[141],"conditioning.":[142],"our":[144,158],"comprehensive":[146],"investigations":[147],"series":[150],"environmental":[152],"physiological":[154],"challenges":[155],"(stressors).":[156],"Overall,":[157],"experiments":[159],"indicate":[160],"role":[163],"for":[164],"system":[166],"vigilance":[168],"bioreactivity,":[170],"especially":[171],"situations":[173],"that":[174],"can":[175],"regarded":[177],"challenging":[179],"successful":[181],"organism.":[184]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2016-06-24T00:00:00"}