{"id":"https://openalex.org/W2965166374","doi":"https://doi.org/10.1128/iai.00339-19","title":"Multi-omics Analyses Reveal Synergistic Carbohydrate Metabolism in Streptococcus mutans-Candida albicans Mixed-Species Biofilms","display_name":"Multi-omics Analyses Reveal Synergistic Carbohydrate Metabolism in Streptococcus mutans-Candida albicans Mixed-Species Biofilms","publication_year":2019,"publication_date":"2019-08-05","ids":{"openalex":"https://openalex.org/W2965166374","doi":"https://doi.org/10.1128/iai.00339-19","mag":"2965166374","pmid":"https://pubmed.ncbi.nlm.nih.gov/31383746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6759298"},"language":"en","primary_location":{"id":"doi:10.1128/iai.00339-19","doi":"https://doi.org/10.1128/iai.00339-19","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.00339-19","pdf_url":"https://iai.asm.org/content/iai/87/10/e00339-19.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://iai.asm.org/content/iai/87/10/e00339-19.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044093604","display_name":"Kassapa Ellepola","orcid":"https://orcid.org/0000-0003-3806-9807","observed_orcids":["https://orcid.org/0000-0003-3806-9807"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"K. Ellepola","raw_affiliation_strings":["Center of Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA","Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore"],"raw_orcid":"https://orcid.org/0000-0003-3806-9807","affiliations":[{"raw_affiliation_string":"Center of Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I75420490"]},{"raw_affiliation_string":"Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103200114","display_name":"Thuyen Truong","orcid":"https://orcid.org/0000-0003-4172-3670","observed_orcids":["https://orcid.org/0000-0003-4172-3670"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"T. Truong","raw_affiliation_strings":["Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015046953","display_name":"Yuan Liu","orcid":"https://orcid.org/0000-0003-0213-606X","observed_orcids":["https://orcid.org/0000-0003-0213-606X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Liu","raw_affiliation_strings":["Biofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040052837","display_name":"Qifeng Lin","orcid":"https://orcid.org/0000-0002-1501-8700","observed_orcids":["https://orcid.org/0000-0002-1501-8700"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Q. Lin","raw_affiliation_strings":["Protein and Proteomic Centre, Department of Biological Sciences, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein and Proteomic Centre, Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035388851","display_name":"Teck Kwang Lim","orcid":"https://orcid.org/0000-0001-7461-4628","observed_orcids":["https://orcid.org/0000-0001-7461-4628"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"T. K. Lim","raw_affiliation_strings":["Protein and Proteomic Centre, Department of Biological Sciences, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein and Proteomic Centre, Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004431867","display_name":"Yew Mun Lee","orcid":"https://orcid.org/0000-0002-8360-7689","observed_orcids":["https://orcid.org/0000-0002-8360-7689"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Y. M. Lee","raw_affiliation_strings":["Protein and Proteomic Centre, Department of Biological Sciences, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein and Proteomic Centre, Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069706353","display_name":"Tong Cao","orcid":"https://orcid.org/0000-0002-7994-9627","observed_orcids":["https://orcid.org/0000-0002-7994-9627"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"T. Cao","raw_affiliation_strings":["Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049350077","display_name":"Hyun Koo","orcid":"https://orcid.org/0000-0001-9143-2076","observed_orcids":["https://orcid.org/0000-0001-9143-2076"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. Koo","raw_affiliation_strings":["Biofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0001-9143-2076","affiliations":[{"raw_affiliation_string":"Biofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110841921","display_name":"Chaminda Jayampath Seneviratne","orcid":"https://orcid.org/0000-0003-0816-538X","observed_orcids":["https://orcid.org/0000-0003-0816-538X"]},"institutions":[{"id":"https://openalex.org/I157582758","display_name":"SingHealth","ror":"https://ror.org/04me94w47","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I157582758"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210097409","display_name":"SingHealth Duke-NUS Academic Medical Centre","ror":"https://ror.org/00xcwps97","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I157582758","https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210097409","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210144008","display_name":"National Dental Centre of Singapore","ror":"https://ror.org/03w6pea42","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210144008"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"C. J. Seneviratne","raw_affiliation_strings":["National Dental Centre Singapore, Oral Health ACP, SingHealth Duke NUS, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Dental Centre Singapore, Oral Health ACP, SingHealth Duke NUS, Singapore","institution_ids":["https://openalex.org/I157582758","https://openalex.org/I165932596","https://openalex.org/I4210097409","https://openalex.org/I4210126319","https://openalex.org/I4210144008"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5049350077","https://openalex.org/A5110841921"],"corresponding_institution_ids":["https://openalex.org/I157582758","https://openalex.org/I165932596","https://openalex.org/I4210097409","https://openalex.org/I4210126319","https://openalex.org/I4210144008","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":9.2915,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":{"value":0.98777506,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"87","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.16670000553131104,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.08399999886751175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-mutans","display_name":"Streptococcus mutans","score":0.9850000143051147},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":1.0},{"id":"https://openalex.org/keywords/multispecies-biofilms","display_name":"polymicrobial biofilms","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dental-plaque","display_name":"dental plaque","score":0.753000020980835},{"id":"https://openalex.org/keywords/dental-caries-in-children","display_name":"dental caries in children","score":0.9179999828338623},{"id":"https://openalex.org/keywords/carbohydrate-metabolism","display_name":"carbohydrate metabolism","score":0.8820000290870667},{"id":"https://openalex.org/keywords/interkingdom-interactions","display_name":"cross-kingdom interactions","score":0.7250000238418579},{"id":"https://openalex.org/keywords/quantitative-proteomics","display_name":"quantitative proteomics","score":0.7419999837875366},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.8730000257492065},{"id":"https://openalex.org/keywords/multi-omics","display_name":"multi-omics","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8646112680435181},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7708256840705872},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.7493121027946472},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.7482025027275085},{"id":"https://openalex.org/C2778430296","wikidata":"https://www.wikidata.org/wiki/Q131452","display_name":"Streptococcus mutans","level":3,"score":0.7271606922149658},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7114440202713013},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5024619102478027},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.48439937829971313},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4198138117790222},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3009756803512573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15883463621139526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07491469383239746}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003731","descriptor_name":"Dental Caries","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003731","descriptor_name":"Dental Caries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005936","descriptor_name":"Glucans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005964","descriptor_name":"Glucosyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005964","descriptor_name":"Glucosyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D013559","descriptor_name":"Symbiosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050260","descriptor_name":"Carbohydrate Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.00339-19","doi":"https://doi.org/10.1128/iai.00339-19","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.00339-19","pdf_url":"https://iai.asm.org/content/iai/87/10/e00339-19.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6759298","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6759298","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:31383746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31383746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/205948","doi":null,"is_oa":false,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/205948","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Elements","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1128/iai.00339-19","doi":"https://doi.org/10.1128/iai.00339-19","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.00339-19","pdf_url":"https://iai.asm.org/content/iai/87/10/e00339-19.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1782879786","display_name":null,"funder_award_id":"R221-000-086-511","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"},{"id":"https://openalex.org/G2329969998","display_name":"S. mutans-C. albicans interactions synergize the virulence of cariogenic biofilms","funder_award_id":"R01DE025220","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2965166374.pdf"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W572376732","https://openalex.org/W988015238","https://openalex.org/W1860863466","https://openalex.org/W1930313341","https://openalex.org/W1967864456","https://openalex.org/W1980587680","https://openalex.org/W1993113670","https://openalex.org/W1998619281","https://openalex.org/W2001386357","https://openalex.org/W2002997358","https://openalex.org/W2008886111","https://openalex.org/W2020647627","https://openalex.org/W2050745388","https://openalex.org/W2063001525","https://openalex.org/W2071429757","https://openalex.org/W2076269601","https://openalex.org/W2076461284","https://openalex.org/W2088369864","https://openalex.org/W2098949965","https://openalex.org/W2098977307","https://openalex.org/W2104246257","https://openalex.org/W2105087827","https://openalex.org/W2107971163","https://openalex.org/W2108585852","https://openalex.org/W2108975142","https://openalex.org/W2127327761","https://openalex.org/W2133813359","https://openalex.org/W2135581618","https://openalex.org/W2141458291","https://openalex.org/W2143984409","https://openalex.org/W2149628120","https://openalex.org/W2154818633","https://openalex.org/W2157712594","https://openalex.org/W2159675211","https://openalex.org/W2168393075","https://openalex.org/W2168787650","https://openalex.org/W2169102247","https://openalex.org/W2171030481","https://openalex.org/W2175150345","https://openalex.org/W2219527059","https://openalex.org/W2407425396","https://openalex.org/W2522661577","https://openalex.org/W2581603352","https://openalex.org/W2622761324","https://openalex.org/W2625463353","https://openalex.org/W2626920017","https://openalex.org/W2751884637","https://openalex.org/W2766396640","https://openalex.org/W2784379180","https://openalex.org/W2802913174","https://openalex.org/W2884470214"],"related_works":["https://openalex.org/W4411706326","https://openalex.org/W4376278989","https://openalex.org/W2622761324","https://openalex.org/W4411085937","https://openalex.org/W2154818633","https://openalex.org/W4308736353","https://openalex.org/W7109543069","https://openalex.org/W2006485017","https://openalex.org/W2080370588","https://openalex.org/W4402147226"],"abstract_inverted_index":{"Candida":[0],"albicans":[1,39,62],",":[2],"a":[3,25,46],"major":[4],"opportunistic":[5],"fungal":[6],"pathogen,":[7],"is":[8],"frequently":[9],"found":[10],"together":[11],"with":[12,19,53,65],"Streptococcus":[13],"mutans":[14,67],"in":[15,51,68],"dental":[16],"biofilms":[17],"associated":[18],"severe":[20],"childhood":[21],"caries":[22],"(tooth":[23],"decay),":[24],"prevalent":[26],"pediatric":[27],"oral":[28],"disease.":[29],"However,":[30],"the":[31],"impact":[32],"of":[33,60],"this":[34],"cross-kingdom":[35],"relationship":[36],"on":[37],"C.":[38,61],"remains":[40],"largely":[41],"uncharacterized.":[42],"Here,":[43],"we":[44],"employed":[45],"novel":[47],"quantitative":[48],"proteomics":[49],"approach":[50],"conjunction":[52],"transcriptomic":[54],"profiling":[55],"to":[56],"unravel":[57],"molecular":[58],"pathways":[59],"when":[63],"cocultured":[64],"S.":[66],"mixed":[69],"biofilms.":[70]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":29},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-08-13T00:00:00"}