{"id":"https://openalex.org/W2965084964","doi":"https://doi.org/10.1002/adhm.201900661","title":"Host\u2013Guest Polypyrrole Nanocomplex for Three\u2010Stimuli\u2010Responsive Drug Delivery and Imaging\u2010Guided Chemo\u2010Photothermal Synergetic Therapy of Refractory Thyroid Cancer","display_name":"Host\u2013Guest Polypyrrole Nanocomplex for Three\u2010Stimuli\u2010Responsive Drug Delivery and Imaging\u2010Guided Chemo\u2010Photothermal Synergetic Therapy of Refractory Thyroid Cancer","publication_year":2019,"publication_date":"2019-08-07","ids":{"openalex":"https://openalex.org/W2965084964","doi":"https://doi.org/10.1002/adhm.201900661","mag":"2965084964","pmid":"https://pubmed.ncbi.nlm.nih.gov/31389191"},"language":"en","primary_location":{"id":"doi:10.1002/adhm.201900661","doi":"https://doi.org/10.1002/adhm.201900661","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.201900661","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102828616","display_name":"Xiaotu Ma","orcid":"https://orcid.org/0000-0002-6233-2145","observed_orcids":["https://orcid.org/0000-0002-6233-2145"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaotu Ma","raw_affiliation_strings":["Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China","University of Chinese Academy of Sciences, Beijing, 100049 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, 100049 P. R. China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023443389","display_name":"Xiaoda Li","orcid":"https://orcid.org/0000-0002-5276-0701","observed_orcids":["https://orcid.org/0000-0002-5276-0701"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoda Li","raw_affiliation_strings":["Medical and Health Analysis Center, Peking University, Beijing, 100191 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Health Analysis Center, Peking University, Beijing, 100191 P. R. China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041589562","display_name":"Jiyun Shi","orcid":"https://orcid.org/0000-0001-7220-9637","observed_orcids":["https://orcid.org/0000-0001-7220-9637"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiyun Shi","raw_affiliation_strings":["Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101232187","display_name":"Meinan Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meinan Yao","raw_affiliation_strings":["Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191 P. R. China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437262","display_name":"Xu Zhang","orcid":"https://orcid.org/0000-0002-8098-8893","observed_orcids":["https://orcid.org/0000-0002-8098-8893","https://orcid.org/0000-0003-3407-5353","https://orcid.org/0000-0003-4179-9552"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Zhang","raw_affiliation_strings":["Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191 P. R. China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101469694","display_name":"Rui Hou","orcid":"https://orcid.org/0000-0003-0610-2561","observed_orcids":["https://orcid.org/0000-0003-0610-2561"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Hou","raw_affiliation_strings":["Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191 P. R. China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106406468","display_name":"Nan Shao","orcid":"https://orcid.org/0009-0004-8323-8416","observed_orcids":["https://orcid.org/0009-0004-8323-8416"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Shao","raw_affiliation_strings":["Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qi Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Luo","raw_affiliation_strings":["Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077681133","display_name":"Yu Gao","orcid":"https://orcid.org/0000-0002-1137-7669","observed_orcids":["https://orcid.org/0000-0002-1137-7669"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Gao","raw_affiliation_strings":["Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045002695","display_name":"Shuaifan Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuaifan Du","raw_affiliation_strings":["Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191 P. R. China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101607362","display_name":"Xiaolong Liang","orcid":"https://orcid.org/0000-0002-6617-7285","observed_orcids":["https://orcid.org/0000-0002-6617-7285"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaolong Liang","raw_affiliation_strings":["Department of Ultrasound, Peking University Third Hospital, Beijing, 100191 P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-6617-7285","affiliations":[{"raw_affiliation_string":"Department of Ultrasound, Peking University Third Hospital, Beijing, 100191 P. R. China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100380518","display_name":"Fan Wang","orcid":"https://orcid.org/0000-0002-4166-5776","observed_orcids":["https://orcid.org/0000-0002-4166-5776"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fan Wang","raw_affiliation_strings":["Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China","Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Protein and Peptide Pharmaceuticals, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"raw_affiliation_string":"Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191 P. R. China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100380518","https://openalex.org/A5101607362"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210112540","https://openalex.org/I4210141942"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":2.1115,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.8651192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"8","issue":"17","first_page":"e1900661","last_page":"e1900661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polypyrrole-nanoparticles","display_name":"polypyrrole nanoparticles","score":0.902999997138977},{"id":"https://openalex.org/keywords/doxorubicin-delivery","display_name":"doxorubicin delivery","score":0.9419999718666077},{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":0.8379999995231628},{"id":"https://openalex.org/keywords/photoacoustic-imaging","display_name":"photoacoustic imaging","score":0.8700000047683716},{"id":"https://openalex.org/keywords/chemo-photothermal-therapy","display_name":"chemo-photothermal therapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/theranostic-nanoplatform","display_name":"theranostic nanoplatform","score":0.8119999766349792},{"id":"https://openalex.org/keywords/radioiodine-refractory-thyroid-cancer","display_name":"radioiodine-refractory thyroid cancer","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cardiotoxicity-reduction","display_name":"cardiotoxicity reduction","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C182606246","wikidata":"https://www.wikidata.org/wiki/Q7187926","display_name":"Photothermal therapy","level":2,"score":0.9002825617790222},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7072700262069702},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5480756759643555},{"id":"https://openalex.org/C2778823387","wikidata":"https://www.wikidata.org/wiki/Q179254","display_name":"Gelatin","level":2,"score":0.5355052947998047},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5292025804519653},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5032581686973572},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.4914053678512573},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.4785661995410919},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42917096614837646},{"id":"https://openalex.org/C2777742735","wikidata":"https://www.wikidata.org/wiki/Q7187921","display_name":"Photothermal effect","level":3,"score":0.42101335525512695},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41008636355400085},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3865409195423126},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3854833245277405},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26453161239624023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2642853260040283},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2639881372451782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15692782402038574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08153906464576721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074084","descriptor_name":"THP-1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010789","descriptor_name":"Phototherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057446","descriptor_name":"Hydrodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/adhm.201900661","doi":"https://doi.org/10.1002/adhm.201900661","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.201900661","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},{"id":"pmid:31389191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31389191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced healthcare materials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1233081394","display_name":null,"funder_award_id":"81621063","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2405069548","display_name":null,"funder_award_id":"81427802","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G303490290","display_name":null,"funder_award_id":"2016YFA0201400","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G3225860909","display_name":null,"funder_award_id":"81771846","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3244238570","display_name":null,"funder_award_id":"81420108019","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3338746233","display_name":null,"funder_award_id":"81201186","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3419229977","display_name":null,"funder_award_id":"81822022","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3549604229","display_name":null,"funder_award_id":"2017YFA0205600","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4111920485","display_name":null,"funder_award_id":"BYSY2015023","funder_id":"https://openalex.org/F4320325739","funder_display_name":"Peking University Third Hospital"},{"id":"https://openalex.org/G5555909780","display_name":null,"funder_award_id":"81571810","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7436515000","display_name":null,"funder_award_id":"81630045","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G750235456","display_name":null,"funder_award_id":"2013M530014","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320325739","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1955496890","https://openalex.org/W1964110679","https://openalex.org/W1965636780","https://openalex.org/W1967401897","https://openalex.org/W1969084610","https://openalex.org/W1975036635","https://openalex.org/W1984185945","https://openalex.org/W1999456866","https://openalex.org/W2000536297","https://openalex.org/W2008288095","https://openalex.org/W2014167355","https://openalex.org/W2023296765","https://openalex.org/W2036832917","https://openalex.org/W2059692362","https://openalex.org/W2063470712","https://openalex.org/W2088816791","https://openalex.org/W2105649347","https://openalex.org/W2116838015","https://openalex.org/W2120645909","https://openalex.org/W2129128202","https://openalex.org/W2129246923","https://openalex.org/W2133144844","https://openalex.org/W2136132417","https://openalex.org/W2144801453","https://openalex.org/W2299169526","https://openalex.org/W2325704890","https://openalex.org/W2396725152","https://openalex.org/W2461427772","https://openalex.org/W2518267890","https://openalex.org/W2605138217","https://openalex.org/W2605633428","https://openalex.org/W4211107646","https://openalex.org/W6601234468","https://openalex.org/W6608319164","https://openalex.org/W6816036555"],"related_works":["https://openalex.org/W4360977270","https://openalex.org/W7165630061","https://openalex.org/W4221133791","https://openalex.org/W4388776656","https://openalex.org/W7128493923","https://openalex.org/W2889067092","https://openalex.org/W3007488119","https://openalex.org/W4405528994","https://openalex.org/W3012301709","https://openalex.org/W4416666059"],"abstract_inverted_index":{"Despite":[0],"the":[1,5,42,58,83,89,139,145,162,168,171,177,194],"good":[2],"prognosis":[3],"of":[4,47,86,112,148,170],"low-risk":[6],"thyroid":[7,18,187,197],"cancer,":[8,188],"there":[9],"are":[10,39,80,155],"no":[11],"truly":[12],"effective":[13],"treatments":[14],"for":[15,41,186],"radioactive":[16],"iodine-refractory":[17],"cancer.":[19],"Herein,":[20],"a":[21,28,66,108],"novel":[22],"theranostic":[23],"nanoplatform,":[24],"as":[25,27,82,107],"well":[26],"smart":[29],"doxorubucin":[30],"(DOX)":[31],"delivery":[32,114],"system":[33],"is":[34,175],"fabricated.":[35],"Gelatin-stabilized":[36],"polypyrrole":[37,49],"nanoparticles":[38,87,117,137],"reported":[40],"first":[43,90,178],"time.":[44],"The":[45,116,153],"combination":[46],"gelatin-stabilized":[48],"and":[50,61],"cyclodextrin-DOX":[51],"complexes":[52],"enabling":[53],"three-stimuli-controlled":[54],"drug":[55,63,76,113,129],"delivery,":[56],"including":[57],"enzyme-sensitive,":[59],"pH-sensitive":[60],"photothermal-sensitive":[62],"release,":[64],"exhibiting":[65],"new":[67],"way":[68],"to":[69,132,180,192],"equip":[70],"photothermal":[71],"agents":[72],"with":[73,127],"precisely":[74],"controlled":[75],"delivery.":[77,130],"Anti-galectin-3":[78],"antibodies":[79],"utilized":[81],"targeting":[84],"molecules":[85],"in":[88,163,196],"time,":[91],"which":[92],"surprisingly":[93],"increase":[94,144],"intracellular":[95],"DOX":[96,149],"uptake":[97],"by":[98,151],"enhanced":[99],"clathrin-mediated":[100],"endocytosis,":[101],"showing":[102,189],"galectin-3":[103],"can":[104],"be":[105],"employed":[106],"highly":[109],"efficient":[110],"target":[111],"systems.":[115],"achieve":[118],"excellent":[119],"photoacoustic":[120,182],"imaging":[121],"effect,":[122],"enabled":[123],"chemo-photothermal":[124,184],"combined":[125,165],"therapy":[126,185],"pinpointed":[128],"Compared":[131],"free":[133],"DOX,":[134],"these":[135],"multifunctional":[136],"decrease":[138],"heart":[140],"damage,":[141],"but":[142],"greatly":[143],"tumor/heart":[146],"ratio":[147],"concentration":[150],"12.9-fold.":[152],"tumors":[154],"completely":[156],"eradicated":[157],"without":[158],"any":[159],"recurrence":[160],"after":[161],"vivo":[164],"therapy.":[166,199],"To":[167],"best":[169],"authors'":[172],"knowledge,":[173],"this":[174],"also":[176],"report":[179],"apply":[181],"imaging-guided":[183],"great":[190],"potential":[191],"solve":[193],"dilemma":[195],"cancer":[198]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-08-13T00:00:00"}
